... detected The authors came to the conclusion the XMRV is not a contributory factor inthe pathogenesis of CSF [10] In light of these results, the finding of XMRV in prostate tumours and CFS patients in ... detection of minimal traces of retroviruses but also detect sample contamination Indeed, contaminating retroviruses, mainly gammaretroviruses, have been found in numerous human cell lines (for ... transmitting the virus from mice to humans? As mentioned above, 3.7% of healthy controls from one study inthe USA were virus positive [3] Why is the virus common inthe USA but rare in Europe? Are there...
... was involved inthe interpretation of data AD participated inthe coordination ofthe study PM commented on drafts of paper AP was involved inthe conception ofthe study RH was involved inthe ... conception ofthe study and assisted in writing the manuscript All authors have read and approved the final version ofthe manuscript Competing interests The authors declare that they have no competing ... devised the concept for the paper, performed the statistical analysis, interpreted the data and drafted the manuscript BT was involved inthe coordination ofthe study and commented on drafts of paper...
... [9] thehuman genome contains 654 HERV-W elements, the majority of which are comprised of long terminal repeat regions (LTR) lacking internal sequence The remaining elements were classified into ... tion (B) ing influenza A/WSN/33 virus infection (A) cell-lines followExpression of HERV-W elements in humanor serum deprivaExpression of HERV-W elements inhuman cell-lines following influenza ... virus in all cell-lines tested Surprisingly, in U937, virus infection elevated the levels of transcripts from elements lacking 5'-U3 regulatory regions Inthe other cell types the degree of transactivation...
... in other words, the genetic variance due to the gene frequencies segregating inthepopulation at the generation in question In most situations, these are the parameters of interest because they ... are the breeding values ofthe sire and dam respectively and e D i is the mendelian sampling effect in individual i e is distributed normally with i ) A 0’ O or2A in a populationof infinite ... selection of parents and has value This is true on the assumptions of a very large number of loci and infinite size, ie no change inthe gene frequencies ofthe segregating loci for the trait The between-family...
... to allow the interfered receiving node to reduce the effect ofthe interference to a certain extent, or allow the pairing sender ofthe interfered receiving node to effectively utilize the non-causally ... using Gaussian numerical examples Having investigated the aspects of correlation (in the form of common information) and interference in a four-node WSN model, we further study the situations of ... building blocks of a network, the simple network models introduced inthe previous section usually involve only one or none ofthe three issues, i.e., the IC explicitly involves the issue of inference,...
... an initial t½ of 23.5-27 minutes and a terminal t½ of 14-22.4 hours About 98% ofthe gemcitabine dose is eliminated inthe urine within one week In addition, gemcitabine can be metabolized intracellularly ... through the 30- Chapter I: Literature Review minute infusion of gemcitabine This corresponds to the saturation ofthe rate-limiting enzyme deoxycytidine kinase inthe cell [18] In another study ... to be lack ofthe activating enzyme dCK Gemcitabine is not affected by the P-glycoprotein [71] In an in vivo induction of gemcitabine resistance mode, an increase in expression ofthe RRM1 subunit...
... inthe cytoplasm ofhuman epithelial cells ofthe gastrointestinal tract and liver, two central organs inthe regulation of iron metabolism [20,21] After their synthesis inthe endoplasmic reticulum, ... ferritin expression in nonpermeabilized (thin lines, – saponin) and permeabilized cells (thick lines, + saponin) cells cultured without and with iron as indicated (D) Perls’ staining of cytospins of ... revealed that the inhibition of cell growth was due to a decrease inthe percentage of cells inthe S and G2 ⁄ M phases ofthe cell cycle (Fig 3B) In a total of seven separate determinations, a...
... quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining inthe buffer Therefore, a fixed aliquot ofthe protein was incubated with the indicated probes, ... basic proteins it might be that either methylation ofthe lysine or specific substitutions inthe amino acid sequence, increasing the number of basic residues of lysine, arginine and histidine, could ... protein belonging to the GTPbinding elongation factor family, which promotes the GTPdependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis and the capture of deacylated...
... increase in binding capacity [25] Identification of nitration site inthe extracellular domain of ILT2 Inthe extracellular domain of ILT2, there are several Tyr residues that participate inthe ... this is the first report of a post-translational modification ofthe ILT2 protein The other member ofthe ILT family, LILRA4, has also been found nitrated within the domain Ig-like C2-type inhuman ... directly inthe interaction with HLA-G [3,19] and Tyr35 is located inthe very vicinity of Tyr38 These modifications should affect the binding pocket directly Furthermore, Tyr99 stabilizes the angle...
... by the observation that only a trace ofthe protein was left inthe unbound fraction Pre-incubation ofthe recombinant protein with FP abolished most of this binding, suggesting that binding of ... ofthe protein with FP These results also indicate that Pf1-Cys-Prx can bind to FP at pH 7.4, which is the pH ofthe parasite cytosol The fact that the majority of Pf1-Cys-Prx is present inthe ... 2.5% ofthe initial value When rPf1-Cys-Prx was added to the system, complete protection against inactivation was observed and the initial GS activity was maintained (116.5 ± 7.3% ofthe initial...
... pick them up On the other hand, the orphan receptor ligands are most probably produced locally inthe various tissues Because ofthe small volume ofthe cell, the production of a little amount of ... biosynthesis of androstadienol in humans (A) and pigs (B) does not require prior formation of 17a-OH-preg and DHEA The lack of androstadienol synthesis inthe presence of lM of ketoconazole (C), an inhibitor ... further demonstrates the specific implication of P450c17 inthe formation of this metabolite Formation of androstadienol by human and porcine P450c17, with and without cyt b5 Using porcine and human...
... General Statistics Office Last but not least, income in U.S dollars inthe strata ofthepopulation is increasingly expanding and growing It is the income of Vietnamese people who working for foreign ... ofthe Vietnam dong into U.S dollars, and reflect more authentic relationship of supply and demand inthe market on the basis of taking into account the trend ofthe currency fluctuations ofthe ... products in U.S dollars valued with hope to increase the modern and electronic commerce As the result, this is very worrying because the online business will become the main type of business in the...
... residues for binding the coenzyme The C-terminal domain has a largely a-helical structure, and serves mainly in substrate binding The active site is located inthe interdomain cleft, and contains a highly ... mm), and so the choice ofthe constant level of Fru was not critical for determination of DKm (1.23 0.15) The KIE data in Table are instrumental in delineating the kinetic mechanism of AfM1PDH ... value of $ 3, indicates that NADH binds to the enzyme prior to binding of Fru6P The absence of a KIE on kcat Km for the substrate binding rst is a clear requirement ofthe strictly ordered kinetic...
... [12,18,19], as well as inthe binding of protein substrates to sHsp [17] The importance of this part of molecule ofthe sHsp is supported by the fact that mutations inthe loop connecting the b5 and b7 ... (Figs and 8), the probability of its crosslinking is lower than the 5638 probability of crosslinking ofthe wild-type protein (Fig 4) The data available inthe literature indicate that the b5–b7 ... protein at the beginning of trypsinolysis and at the fixed time of trypsinolysis) against the time of incubation (Fig 8D) The apparent rate constants of trypsinolysis under these conditions were...
... refer to the sequences that are present inthe genome of interest and absent from the host genome as being ‘host-blind’ (human- blind, mosquito-blind, mouseblind, rat-blind, etc.) sequences The greater ... each serotype ofthe virus (present in all strains ofthe serotype), and (d) unique to each individual viral strain’s genome (present inthe strain and absent from all other strains) The results ... present in all ofthe dengue genomes n 16 Present in all dengue; absence inhuman not considered Human- blind one change away Human- blind two changes away Human- blind three changes away Human- blind...
... Website: www.unicef .in TheSituationof Children in India - A Profile TheSituationof Children in India A Profile TheSituationof Children in India - A Profile Contents Foreword Introduction Child ... children Karin Hulshof Representative, UNICEF India TheSituationof Children in India - A Profile TheSituationof Children in India A Profile Introduction India is home to the largest number of children ... again constitutes 20 per cent ofthe total number of live births inthe world Although the number of births is expected to gradually go down inthe coming years, the relative load of India in the...
... estimating the binding potential of [N-methyl-11C]mirtazapine inthe living human brain Methods: Distribution volumes of [N-methyl-11C]mirtazapine in brain regions were estimated using single- ... curvature ofthe plot throughout the duration of scanning impairs the estimation ofthe binding potential (see Figure 3) Since the binding of [N-methyl-11C]mirtazapine may be relatively slow in some ... distribution in brain regions, with the highest binding potentials inthe frontal and temporal cortices, intermediate binding potential inthe thalamus, and low binding potentials inthe striatum,...
... activity inthe amygdala in response to fearful expressions [10], suggesting inadequate emotion-processing inthe brain Finally, heritability might be an underlying third variable that explains the ... Netherlands, only studies inthe present review originated from CoRPS and 13 studies on Type D inthe general population were performed by other research groups The studies were conducted in populations ...
... individual in 11 aspects of life mapped to domains and sub-domains ofthe ICF: mobility within the home, mobility outside the home, self-care, looking after belongings, looking after the home, looking ... R, Croft P: The effect of age on the onset of pain interference in a general populationof older adults: Prospective findings from the North Staffordshire Osteoarthritis Project (NorStOP) Pain ... and age for the remaining nine aspects of life Persistence was greater in women than men for four aspects of life (looking after the home, looking after belongings, interpersonal interaction,...
... inthe realm of physical functioning, a finding also borne out by other authors [36,41-45] However, assessment of quality of life inthe female population shows lower scores inthe realm of both ... modification ofthe general quality of life [8-11] Whilst obesity has an obvious and often objectively measurable impact on the state of health ofthe individual, the influence of increased body ... adequate intervention [15,16] Accordingly, evaluation ofthe quality of life has become a focus of interest not only inpopulation studies, but also in clinical medicine [17], particularly in patients...