single marker analysis for case control data

... estimated from the data for that condition holds as well for the unreplicated one If neither condition has replicates, one can still perform an analysis based on the assumption that for most genes, ... estimate of the variance for gene i from just the data available for this gene This assumption allows us to pool the data from genes with similar expression strength for the purpose of variance ... scale, wr(q)/q2 (see Equation (9)) for technical replicates, the red curves for biological replicates (solid lines, dT data set, dashed lines, RH data set) The data density is shown by the histogram...

Ngày tải lên: 09/08/2014, 22:23

... simulated and real data analysis we compute P-values for each approach considered Starting from these P-values, we use the Benjamini-Hochberg approach for obtaining q-values [23] for FDR control We note ... Numerical Analysis for Statisticians New York: Springer Verlag; 1999 doi:10.1186/gb-2010-11-11-r112 Cite this article as: Boca et al.: Patient-oriented gene set analysis for cancer mutation data Genome ... mutations for the null hypothesis For example, suppose that one of the tumors contained 60 mutations The 60 mutations were randomly assigned to 60 different genes A similar permutation was performed for...

Ngày tải lên: 09/08/2014, 22:23

... simulated and real data analysis we compute P-values for each approach considered Starting from these P-values, we use the Benjamini-Hochberg approach for obtaining q-values [23] for FDR control We note ... Numerical Analysis for Statisticians New York: Springer Verlag; 1999 doi:10.1186/gb-2010-11-11-r112 Cite this article as: Boca et al.: Patient-oriented gene set analysis for cancer mutation data Genome ... mutations for the null hypothesis For example, suppose that one of the tumors contained 60 mutations The 60 mutations were randomly assigned to 60 different genes A similar permutation was performed for...

Ngày tải lên: 09/08/2014, 22:23

... anorexia data set (5 controls per case) , the anorexia data set with or randomly selected controls per case, and the anorexia data with no controls or only randomly-selected control per case combined ... 0.77 = 23%) for a current study with one control per case to almost no reduction (1 - 0.97 = 3%) for a current study with five controls per case For a fixed number of controls per case in the ... Study Design for Epidemiological studies 1.2 Ideas for re-using existing data 1.3 Re-using existing case- control data 1.4 Re-using existing nested case- control data ...

Ngày tải lên: 12/10/2015, 17:36

... in the controls than in the cases because insufficient numbers of controls could be found for some of the more senior patients Concomitant use of PPIs was significantly higher in the controls ... higher in the controls than in the cases (cases 14 (13.5%) and controls 77 (27.1%); p = 0.005) Use of selective COX-2 inhibitors was comparable (cases 17 (16.4%) and controls 50 (17.6%); p = 0.77) ... http://arthritis-research.com/content/10/6/R144 Table Demographic characteristics, medical history and current medication for cases and controls Cases (n = 104) Controls (n = 284) OR 95% CI p Value Age at diagnosis (years) 70.4 (16.7) 67.1...

Ngày tải lên: 09/08/2014, 01:22

... after HL as compared to primary BC, we conducted a case- control analysis for patients with invasive tumors We excluded from our case- control analysis all women with ductal carcinoma in-situ (DCIS) ... were DCIS For invasive tumors, four tumors were T1 and two tumors were T2 Axillary lymph nodes were positive for two, negative for two, and unknown for two tumors The case- control analysis (Table ... the treatment of choice for BC after HL Our case- control analysis showed that mastectomy was the predominant surgery among the lymphoma group (86%) as compared to the control group (32%) The...

Ngày tải lên: 09/08/2014, 09:22

... to obtain HWE P values for the case and control groups separately, each dataset was uploaded separately Single marker analysis Contingency tables were created for each SNP using the JMP 5.0 software ... statistical analysis website [35] We also performed logistic regression analysis for the rs729749 SNP, in order to adjust for age, sex and living area Logistic regression analysis was conducted for a ... genotype analysis SNP id Case/ control rs729749 Case CC 0.69 (256) CT 0.26 (95) TT 0.05 (18) Control CC 0.57 (141) CT 0.40 (98) TT 0.04 (9) Case AA 0.81 (244) AG 0.15 (46) GG 0.03 (10) Control...

Ngày tải lên: 09/08/2014, 10:21

... was 25 ± kg/ m2 for patients and 24 ± kg/m2 for control individuals There was no statistically significant difference between the two groups The ages of the patients and the control individuals ... University, and single nucleotide Page of (page number not for citation purposes) polymorphism (SNP) Research Center of RIKEN, and informed consent was obtained from patients and control individuals ... analyses The distributions of genotypes in all knee OA and control groups conformed to Hardy-Weinberg equilibrium Statistical analysis Standard χ2 analysis- of-contingency tables were used to compare...

Ngày tải lên: 09/08/2014, 10:23

... in the controls than in the cases because insufficient numbers of controls could be found for some of the more senior patients Concomitant use of PPIs was significantly higher in the controls ... higher in the controls than in the cases (cases 14 (13.5%) and controls 77 (27.1%); p = 0.005) Use of selective COX-2 inhibitors was comparable (cases 17 (16.4%) and controls 50 (17.6%); p = 0.77) ... http://arthritis-research.com/content/10/6/R144 Table Demographic characteristics, medical history and current medication for cases and controls Cases (n = 104) Controls (n = 284) OR 95% CI p Value Age at diagnosis (years) 70.4 (16.7) 67.1...

Ngày tải lên: 09/08/2014, 13:22

... EDR Data Elements 11 Table 2-2 Ford EDR Data Elements 12 Table 2-3 Data Elements in Ford Power Control Modules with Electronic Throttle Control 15 Table 2-4 Data ... the EDR Data Elements Prioritization Exercise 83 Table 3-21 EDR Data Element Priority for Roadside Safety Analysis 84 Table 3-22 Recommended EDR Data Elements for Highway Crash Data Analysis ... and recommended database formats for candidate EDR data element needs The databases included U.S national accident databases, state accident databases, specialized roadside safety databases, and...

Ngày tải lên: 19/02/2014, 03:20

... Kruskal-Wallis tests Double data entry was performed, which were then compared, validated and subsequently corrected Data entry was performed concurrently with data collection, and the database was managed ... questionnaires, after patients had signed the informed consent forms Additional information was obtained from medical records Figure Algorithm for selection of patients for the study of factors associated ... before the onset of cough A study case was defined as a patient who presented a delay in initiating treatment and a control as a patient who did not present a delay in initiating treatment For...

Ngày tải lên: 06/03/2014, 04:20

... synthetic framework for international event analysis – IDEA (Integrated Data for Event Analysis) – outline its conceptual structure and major variables, and discuss current data development that ... style and grammar Unit of Analysis Syntactically, the unit of analysis for the Reader is the independent clause; that is, the Reader identifies discrete event reports FOR E V E N T S A N A LY S ... specific event forms, limiting the scope of the necessary human review This clause unit of analysis is an important characteristic of current machine coding technology for developing events data With...

Ngày tải lên: 23/03/2014, 13:20

... Analysis 400 ,) Knowledge Base 402 Planning for Data Analysis: Developing a Before and After Data Collection Analysis Plan 402 PRO.JECT EXERCISE: Looking Forward, Then Back 405 Summary 405 Key Terms ... program Study Guide for Statistics and Data Analysis for the Behavioral Sciences Instructors (or students) can order a study guide to accompany Statistics and Data Analysis for the Behavioral ... Data Box I.A: What Is or Data? • Tools for Inference: David L:s Problem College Choice INTRODUCTION: STATISTICS AND DATA ANALYSIS AS TOOLS FOR RLSLARC~LRS n my view statistics has no reason for...

Ngày tải lên: 29/03/2014, 04:21

... protocol for shifting between execution models presents an intriguing future avenue of research THE CASE FOR NONDETERMINISM Before making the case for disallowing nondeterministic behavior in database ... propose performing transactional processing in a distributed database without concurrency control by executing transactions serially in a single thread on each node (where a node in some cases can ... protocols for replicated databates SIGMOD Rec., 28(2):97–108, 1999 [8] S Elnikety, S Dropsho, and F Pedone Tashkent: uniting durability with transaction ordering for high-performance scalable database...

Ngày tải lên: 30/03/2014, 13:20

... managerial capacity for TB control at all levels within the health system This had a direct effect on program performance, particularly on all aspects of TB case management, TB case notification, ... Educational Handbook for Health Personnel WHO Offset Publication no.35: World Health Organization, Geneva; 1998 Training for Better TB Control: Human Resource Development for TB Control - a Strategic ... district and provincial level; (ii) availability of trained staff for TB control for hospitals; and (iii) the development of a TB component for the curricula in basic training institutions The key activities...

Ngày tải lên: 18/06/2014, 17:20

... ultrasound is a more sensitive method for the detection of polycystic ovaries In the TVUS data used for statistical analysis were the mean of observed values for the left and right ovaries Page ... to acquisition of data EDN have made substantial contributions to analysis and interpretation of data; MT participated in the design of the study and performed the statistical analysis CL have ... anthropometric/metabolic parameters has been performed in PCOS subjects and control women Table Metabolic and cardiovascular risk parameters in control women and in women with PCOS PCOS Control N = 24 N = 12 86.29...

Ngày tải lên: 20/06/2014, 07:20

... ∈ Dk , Dk × −∞, Ck for some k ∈ N As in the previous case, we may show by similar arguments that x2k , x2k ∈ Ω3 Therefore, in the last four cases, we may apply the first two cases to conclude ... < λ, axn b c for and by induction < x2k , x2k < λ for all k ∈ N Thus, by 1.3 , xn b c / − a The proof is n ∈ N In view of 1.10 and 1.11 , limk → ∞ x2k limk → ∞ x2k complete The Case Where λ ... different parts of the plane Therefore the following derivations will seem to be repetitive Fortunately, the principles behind our derivations are quite similar, and therefore some of the repetitive...

Ngày tải lên: 21/06/2014, 11:20