simultaneous prediction of efficacy and side effects

... with the conception and design of the study, helped to supervise the staff and helped to draft the manuscript OA and GHP helped with the conception and design of the study and helped draft the ... of melatonin administration on night shift workers in an actual workplace setting [26] The purpose of this study was to compare the efficacy of melatonin (5 mg) and placebo in the treatment of ... provided by staff and students at Imam and Baharloo Hospital/ Tehran University of Medical Sciences 10 11 12 13 14 15 16 References Coffey L, Skipper J, Jung F: Nurses and shift work: effects onjob...

Ngày tải lên: 10/08/2014, 09:20

... evaluation of the therapeutic response and side effects is often reported by the parents of the child with ADHD This may also lead to some correlation between therapeutic and side effects The aim of ... therapeutic and side effects as well as correlation in parental assessment of therapeutic and side effects We also postulated that if the correlation between therapeutic and side effects is at ... frequencies of the 17 side effects, as well as the frequencies of severe side effects, between the placebo and active conditions Repeated measures analysis of variance (ANOVA) was used to detect the effects...

Ngày tải lên: 11/08/2014, 15:22

... and optimization of fuel cells, improve long-term performance and lifetime, the introduction of cheaper materials and fabrication techniques, and the design and development of novel architectures ... at the cathode side and hydrogen at the anode side, and j is water vapour in both cases Nitrogen is the third species at the cathode side The Maxwell-Stefan diffusion coefficients of any two species ... right hand side, accounts for the heat exchange to and from the solid matrix of the GDL The gas phase and the liquid phase are assumed to be in thermodynamic equilibrium, i.e., the liquid water and...

Ngày tải lên: 05/09/2013, 14:58

... tens of thousands of individual primary scientific papers and reviews describing the isolation, structural characterization, pharmacological effects and biochemical targets of thousands of plant-derived ... through reduction of the sidechain double bond or of the carboxyl (to yield aldehydes and alcohols); formation of glycosides with sugars; formation of carboxylic acid esters with sugars and other compounds ... isoscoparin, neocarlinoside, schaftoside and neoschaftoside); oestrogenic (wogonin); and oviposition stimulants (luteolin 7-(6"-malonylglucoside) and vicenin-2) Biflavones A number of biflavones are...

Ngày tải lên: 17/02/2014, 05:20

... LAGRANGIAN ANALYSIS AND PREDICTION OF COASTAL AND OCEAN DYNAMICS Written by a group of international experts in their field, this book is a review of Lagrangian observation, analysis and assimilation ... Patrick Fagan LAGRANGIAN ANALYSIS AND PREDICTION OF COASTAL AND OCEAN DYNAMICS Edited by ANNALISA GRIFFA Rosenstiel School of Marine and Atmospheric Science University of Miami Istituto di Scienze ... University of Delaware ARTHUR J MARIANO Rosenstiel School of Marine and Atmospheric Science University of Miami ¨ ¨ TAMAY M OZG OKMEN Rosenstiel School of Marine and Atmospheric Science University of...

Ngày tải lên: 05/05/2014, 14:42

... diameters of about 200 nm and lengths of ␮m The FE-SEM images of nanorod ZnO pigment are shown in Fig 2(g) and (h) It is found that the product is composed of well-dispersed Fig XRD patterns of the ... a large scale, and all of the nanorods have diameters of about 50 nm and lengths of 300 nm Fig (i–k) exhibits the FESEM images of nanoparticle-decorated ZnO pigment The surface of ZnO pigment ... ZnO band gap and this phenomenon is one of the most important ZnO characteristics [14] The particle sizes of scale-like and submicrorod ZnO pigments are in the optimum range of 0.25–0.45 ␮m, and...

Ngày tải lên: 06/05/2014, 13:23

... availability of the possible simultaneous measure of kinematics data and fMRI, offering an innovative and extremely flexible experimental set-up for a better understanding of neural correlates of motor ... computed Movements of the hand which was required to stand still were considered significant when SDs > 0.5 cm, and were considered mirror movements when R > 0.5 Kinematics acquisition and data analysis ... subject, movements of the foot which was required to stand still were considered significant when SD > 4°, which means > 5% of the moving ankle range of motion, and were considered mirror movements...

Ngày tải lên: 19/06/2014, 08:20

... complications of inhaled corticosteroid use in asthma: Collaboration of American College of Chest Physicians American Academy of allergy, asthma, and immunology, and American College of allergy, asthma, and ... dose studies for the evaluation of the side effects Adrenal and thymus involution as well as lung and heart tissue receptor occupancy was measured to assess side effects Corticosterone levels in ... each group and presented with error bar as standard deviation) Fig Multi-day side effects (adrenal involution) dose response (N [ for each group and presented with error bar as standard deviation)...

Ngày tải lên: 21/06/2014, 18:20

... Page of 10 Figure Subject Randomization Of 652 subjects enrolled in the double-blind treatment period, 488 were randomized (1:1:1:1) to paliperidone palmitate (fixed dose of 39, 156, or 234 mg) and ... RR: The cost of relapse and the predictors of relapse in the treatment of schizophrenia BMC Psychiatry 2010, 10:2 Glick ID, Bossie CA, Alphs L, Canuso CM: Onset and persistence of antipsychotic ... article as: Bossie et al.: Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: post-hoc analyses of a randomized, double-blind clinical trial...

Ngày tải lên: 11/08/2014, 15:22

... categorical and Student’s T-tests for continuous data PANSS total, PANSS subscales, GAF-S, medication, side effects, “frequency of testing out and pushing limits”, “intensity of testing out and pushing ... isolation and calmness by staying in the patient room/wing of the PICU or move to the main part of the ward ensuing exposure to other patients, more staff-members and increased amounts of sensory and ... of testing out and pushing limits”, “need to set limits”, all prescribed medication, side effects, formal restrictions (restrictions regarding visits and telephone), staff contact time, use of...

Ngày tải lên: 11/08/2014, 16:23

... use two alignments A1 and A2 of sequences n m k k s1 … s1 and s … s , where s1 is a ncRNA and s is its target sequence For convenience, we adopt the convenk tion of RNAcofold and assume that the ... structures s and s of s1 and s2, respectively Because we use the numbering convention of RNAcop p fold, the union s ∪ s of the two partial structures p p s and s is the partial structure of s1&s2 ... sequences of the two sequences s1, s2 using the additional linker symbol & as done in RNAcofold For Step of the scoring, we calculate the expected accuracy of the ensemble of structures σ of s1&s2,...

Ngày tải lên: 12/08/2014, 17:20

... and negative likelihood ratios for different cutoff points of the model and for day values of oxygenation index and PaO2/FiO2 ratio are presented in Table Missing data precluded calculation of ... real-world setting of a population-based cohort of patients One of the objectives of our prediction model was to aid in decision making and clinical trial design with regard to the timing of tracheostomy ... different ends of the spectrum of poor prognosis in patients with ALI Improvement in the accuracy of prediction in future prospective studies will require careful consideration not only of factors...

Ngày tải lên: 13/08/2014, 03:21

... Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway Clinical and Molecular ... ebastine, or fexofenadine; 21.1% of respondents reported much less efficacy than with their previous treatment; and 25.2% reported slightly less efficacy (Figure 1) In total, 6.9% of respondents ... desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine BMC Fam Pract 2003, 4:10 Prenner BM, Capano D, Harris AG: Efficacy and tolerability of loratadine versus fexofenadine...

Ngày tải lên: 13/08/2014, 13:22

... acquisition of data, analysis and interpretation of data, and drafting of the manuscript TB contributed to the acquisition of data, the conception and design of the study, and critical revision of the ... Cockcroft-Gault formula [29], NYHA functional class, and serial measurements of BNP and NT-proBNP as continuous variables Comparison of time course of BNP and NT-proBNP levels between survivors and ... Basel, Switzerland) [23] The intra-assay coefficients of variation are 2.4% and 1.8% at 355 and 4,962 pg/mL, respectively, and the respective interassay coefficients of variation are 2.9% and 2.3%...

Ngày tải lên: 14/08/2014, 07:21

... HANOI UNIVERSITY OF SCIENCE TECHNISCHE UNIVERSITAT DRESDEN NGUYEN TIEN CU SIMULTANEOUS REMOVAL OF ARSENIC AND AMMONIA FROM GROUNDWATER BY PHYTOFILTRATION WITH CATTAILS (TYPHA ... BY PHYTOFILTRATION WITH CATTAILS (TYPHA SPP.) CULTIVATION MASTER THESIS FIELD: WASTE MANAGEMENT AND CONTAMINATED SITE TREATMENT SUPERVISOR: ASSC DR LE VAN CAT HANOI-2008 MỤC LỤC MỤC LỤC DANH MỤC...

Ngày tải lên: 09/01/2015, 08:53

... terms of low cost, small-scale treatment, simple operation and maintenance Moreover, requirements of simultaneous removal of both arsenic and ammonia should necessarily be taken into account Phytofiltration ... contaminants ) 1.4 Phytofiltration Systems 1.4.1 Characteristics of Phytofiltration Systems a/ Phytofiltration: Phytofiltration, the use of plant with extensive root systems and high accumulation ... are perennial and have a high capacity of biomass production and contaminant storage [R.R Brooks, 1998] They are widely distributed on the shorelines of lakes and streams and in wetland ecosystems...

Ngày tải lên: 09/01/2015, 08:53

... IR/07/045 Simultaneous Determination of PAHs and PCBs by GCMS Analysis The National Grid and other Ordnance Survey data are used with the permission of the Controller of Her Majesty’s Stationery Office ... Survey carries out the geological survey of Great Britain and Northern Ireland (the latter as an agency service for the government of Northern Ireland), and of the surrounding continental shelf, ... method for the simultaneous separation and identification of PAHs and PCBs by GCMS was successfully developed by this laboratory The programming of associated software to identify and differentiate...

Ngày tải lên: 09/09/2015, 09:39

... the complexity of science and profundity of life Prof Too’s lessons extended far beyond the laboratory – from politics and current issues to virtues of integrity, honest work and humility Especially ... and gene expression In order to gain a better understanding of the effects of microenvironment on cell behaviors and vice versa, interdisciplinary approaches involving the use of principles and ... CHARACTERIZATION OF BIOPOLYMER AND THE EFFECTS OF MECHANICAL PROPERTIES OF EXTRACELLULAR MATRIX ON CELL BEHAVIORS WONG LONG HUI (B.Eng.(Hons.), NTU) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...

Ngày tải lên: 09/09/2015, 11:28

... weight of 807.5 or two molecules with a weight of 270 and 537.5 H-NMR spectrum of CMX-13-5 was shown to resemble the 1H- NMR spectra of a bicyclic hexapeptide isolated by the group of Itokawa and ... increased with the age of the mice, with the majority of the untreated and DMSO control mice dying of renal failure at 16-24 weeks of age Treatment of the MRL-lpr/lpr mice with CMX-13 and dexamethasone ... express my sincere gratitude and appreciation to my supervisors Professor Yap Hui Kim and Associate Professor Ang Siau Gek, from the Department Paediatrics and the Faculty of Chemistry, respectively,...

Ngày tải lên: 12/09/2015, 09:55

... between goods consumption and leisure The left hand side is the marginal rate of substitution between goods consumption and leisure, while the right hand side is the inverse of the real wage after ... determine the optimal paths of the shadow prices of physical and human capital (dynamic efficiency of resource allocation) The λ and µ are shadow prices of physical capital and human capital respectively ... decreases the rate of return to the investment activities of the private sector and leads to a permanent decline in the rate of capital accumulation and in the rate of growth Devereux and Love (1994)...

Ngày tải lên: 05/10/2015, 19:03