simulation parameter estimation and time dependent sensitivity analysis

... containing mm dithiothreitol as standard Regulation analysis To study the dynamics of regulation in time, integrative time- dependent regulation analysis was used [10] Timedependent hierarchical regulation ... form of time- dependent regulation analysis (Eqns and 5) The results for the two perturbations are shown in Fig (shift from glucose limitation to nitrogen starvation and glucose excess) and Fig ... Experimental time- dependent regulation analysis K van Eunen et al and for three parallel experiments, the steady-state fluxes were estimated Averages and SD were calculated separately for the numerator and...

Ngày tải lên: 18/02/2014, 06:20

... days, hours), and are not applicable to continuous time results In intensive care unit studies, however, minutes are rarely important and the data could safely be rounded to hours Time- dependent ... D’Agostino RB, Lee M-L, Belanger AJ, Cupples LA, Anderson K, Kannel WB: Relation of pooled logistic regression to time dependent cox regression analysis: the Framingham heart study Stat Med 1990, ... properly incorporating time- dependent covariates in this context using competing risks models [1] The model we have suggested more fully exploits these important covariates and relaxes the assumptions...

Ngày tải lên: 13/08/2014, 08:21

... brown, green, red and purple lines) versus the experimental data (×) 6.1 Model uncertainty and its parameterization A1 ODE decomposition parameter estimation (A) and two-phase estimation 152 (B) ... Metabolic Flux Analysis and Flux Balance Analysis) and those focused on the properties of the entire space of possible flux distributions (e.g., Extreme Pathway Analysis and Elementary Mode Analysis) ... and their individuality comes from different values of model parameters This property keeps the model structure case-independent and simplifies the method development for model analysis and parameter...

Ngày tải lên: 09/09/2015, 10:08

... daunorubicin or 60 nM WP631 for 2, 24 and 72 h, respectively Data are the mean ± SD for three independent experiments The difference in the time- dependent uptake, between and 72 h, was statistically significant ... distribution was analyzed using propidium iodide and flow cytometry Panels D and E display a flow cytometry analysis of cells stained with Annexin-V-Fluos and propidium iodide in the presence of daunorubicin ... spectrofluorecence analysis of lysates of cells treated with either drug Daunorubicin was captured by the cells more rapidly, and in a greater amount, than WP631 at any time analyzed between and 72 h (Fig...

Ngày tải lên: 20/02/2014, 23:20

... complex segregation analysis was introduced by Elston and Stewart (1971) and Morton and MacLean (1974) Complex segregation analysis combines three factors into a mixed model for analysis of phenotypes ... linkage between a major gene and polygenes, on the power of detecting a major gene and on parameter estimation Behavior of the mixed model of segregation analysis (Morton and MacLean, 1974) was compared ... SALP and PAP use different parameterization of effects, parameters were converted to two genotypic means ( and Aaa gene frequency of the PAA ), dominant allele (p), and polygenic (ufl) and environmental...

Ngày tải lên: 09/08/2014, 18:22

... the initiation of the response and the time at which this was maximal (Figure 4B) and (3) a combination of (1) and (2), i.e the total time between drug addition and maximal effect (Figure 4C) ... article as: Billington and Hall: Real time analysis of b2adrenoceptor-mediated signaling kinetics in Human Primary Airway Smooth Muscle Cells reveals both ligand and dose dependent differences ... containing 10% fetal calf serum and glutamine (2 mM) and incubated at 37°C in 5% CO2 and 95% air Cells isolated and cultured in this way have been extensively characterised and shown to retain many...

Ngày tải lên: 12/08/2014, 13:22

... in a time- dependent manner, via scavenger receptor SR-A- and CD36-mediated processes, and that the uptake of lipid and protein occurs in synchrony Furthermore, it is shown that both lipid and ... (e.g Ne-carboxymethyl-lysines and Ne-carboxyethyl-lysines and pentosidine) being known to accumulate with age on tissue proteins, and at an increased rate in LDL and atherosclerotic lesions in ... [28,29], and does not affect the relative cholesterol, cholesteryl ester, phospholipid or triglyceride composition of the particles (Table 1) In contrast, significant time- and concentration-dependent...

Ngày tải lên: 19/02/2014, 02:20

... Anti-gp120 Ig and anti-FLAG Ig identified bands corresponding to proteins with a molecular mass equivalent to  43 kDa and 85 kDa for D2L and  39 kDa and 80 kDa for D2S (Fig 1) No bands were detected ... expression of HIV- and FLAG-tagged D2L and D2S receptors in Sf9 cells To achieve this, mAbs directed against gp120 (clone 11/4C) and the FLAG sequence were used, and Fig shows the band pattern visualized ... EcoRI and NdeI, and the DNA fragments and the HIV tag were ligated The ligation mixture was subjected to PCR to selectively amplify tagged receptor whilst, at the same time, adding an XhoI site and...

Ngày tải lên: 21/02/2014, 00:20

Ngày tải lên: 23/03/2014, 05:23

... of the observable parameters (data), the a priori information on model parameters, and the information on the physical correlations between observable parameters and model parameters can all ... problems, and the analysis of uncertainty (sometimes called ‘error and resolution analysis ), can be performed in a fully nonlinear way (but perhaps with a large amount of computing time) In all ... termed observable parameters and the quantities {mα } were termed model parameters, we can call {x A } the physical parameters or simply the parameters The manifold X is then named the parameter manifold...

Ngày tải lên: 31/03/2014, 15:24

... relaxation times (1/2 RT and LRT) included time constant, τ1, and "sensitivity" parameter, km, with mean changes of 6.7 and -5.1 ms (magnitudes not significantly different) for the 1/2 RT and 19.8 and ... the six parameters, but the primary influence(s) based on Tukey's groupings were a time constant parameter and the gain [29], parameters τc and A (PF: 71.7 and 55.6 %, respectively) and τc (FTI: ... and km (two time constant and the "sensitivity" parameter) had significant influences on force time properties, only partially supporting previously published parameter definitions Further, parameter...

Ngày tải lên: 19/06/2014, 10:20

... hand, the parameter- effects curvature only influences the uniform coordinate assumption and depends on the specific parameterization of the problem Hence, a reparameterization may change the parameter- effects ... assumption needs to be fulfilled and 1−α only ΓN needs to be small compared with 1/ FP,N −P 4.2 Analysis of the parameter estimation problem In the following, the parameter estimation problem is analyzed ... each component is generated randomly between and 2π For each link, channel parameter estimation is performed and soft information based on the linearization method and on the likelihood method...

Ngày tải lên: 20/06/2014, 22:20

... instants Given a time series x(t), let μt and σt denote the mean value and standard deviation of the series at time t, respectively The autocorrelation between two time points t1 and t2 is mathematically ... Cohen, Time- Frequency Analysis, Prentice Hall, Englewood Cliffs, NJ, USA, 1995 [6] M B Priestley, Spectral Analysis and Time Series, vol 2, Academic Press, New York, NY, USA, 1981 [7] S Adak, Time- dependent ... neighborhoods (a) in the coordinates of two time instants and (b) in the coordinates of the center time location and the time index difference (1) The time- varying spectrum, as an energy density...

Ngày tải lên: 21/06/2014, 16:20

... MSE(b) −10 −20 −30 −40 The detection and parameters estimation of multicomponent LFM signal can be realized by the CPF The principle of detection and parameters estimation of single LFM signal is ... likelihood joint estimation of frequency and frequency rate,” IEEE Transactions on Aerospace and Electronic Systems, vol 22, no 6, pp 708–715, 1986 [2] R M Liang and K S Arun, Parameter estimation ... 200 Monte Carlo simulations, the measured MSEs (dB) of each parameter and the theoretical MSEs (dB) just as (21)–(23) are shown in Figures and SNR (dB) (c) Figure 3: MSEs of parameter estimates...

Ngày tải lên: 21/06/2014, 22:20

... and PAPR effects in more detail and after that we will describe the reference spectral power mask and related simulations and results 5.1 PAPR analysis and simulated results For the analysis and ... factor ρ = 0.1 and filter order NRRC = 64 We have chosen two different scenarios for simulations For the PAPR and spectral leakage simulations we have used four times oversampling, r = 4, and for the ... symbol estimation and compensation processes, we obtain our ˆ first feedback data symbol estimates d1 , to be used for soft bit estimation The operations inside the pd and elimiter estimation and...

Ngày tải lên: 21/06/2014, 23:20

... and we conclude the paper with Section Notation The letter t represents the time- domain variable, and k is the frequency-domain variable Bold letters denote the matrices and column-vectors, and ... the time- and frequency-selective channel can be modeled as Fourier basis expansions Thereafter, this model was intensively investigated and applied in block transmission, channel estimation, and ... and the FFT demodulated signals at the subcarrier k of the ith OFDMA symbol can be rewritten as u(i, k) Q Subband Subband ··· Whole frequency band of OFDMA Information sequence in subband...

Ngày tải lên: 21/06/2014, 23:20

... sensors in the system and is identified by a number between and 30 We chose P = and a sample of the random matrix D for N = sensors, given below The sensor readings are given in dBm and are column vectors ... Number of sensor Figure 4: Sensitivity analysis for 25 sensors 6.3 Experiment 3: the influence of the noise on optimal placement 6.2 Experiment 2: sensitivity analysis This time we considered a different ... number of sensors and the same data matrix as in Section 6.1 The optimal sensor placement was different and the results of the sensitivity analysis for M = 25, N = 6, P = 6, σ = 1, and sensors placed...

Ngày tải lên: 22/06/2014, 19:20

... X Ma, and G B Giannakis, “Space -time coding and Kalman filtering for time- selective fading channels,” IEEE Transactions on Communications, vol 50, no 2, pp 183–186, 2002 B D O Anderson and J B ... , a random interleaver, and a BPSK symbol mapper The channel is generated according to (9) and (11) for two different fading rates fd T = 0.02 and fd T = 0.005 The results shown in Figures and ... iterative algorithm for joint code-aided estimation and detection on a time- varying flat-fading MIMO channel with spatial correlation The tightly coupled estimation and detection algo- This work has...

Ngày tải lên: 22/06/2014, 23:20

... approach and time- domain frequency-invariant beamspace (TD-FIBS) approach, respectively In this paper, new broadband DOA estimation approaches are proposed by designing a set of frequencydomain and time- domain ... constant over the design band The paper is organized as follows A brief review of broadband beamspace DOA estimation is presented in Section In Section 3, the frequency-domain and timedomain CMRBs are ... frequency-domain and time- domain processing methods for beamspace DOA estimation are presented Section presents simulation results confirming the efficiency of the proposed methods, and Section concludes...

Ngày tải lên: 22/06/2014, 23:20

... derived by independent component analysis and quantized the resulting projection coefficients as features Gu et al [24] used a multiorientation features via both spatial and frequency domains and a nonsymmetrical ... Gaussian and Salt and Pepper noises are considered for testing because Gaussian is a popular noise for testing the robustness of most systems and Salt and Pepper noise is composed of random pixels ... (which is dependent directly on FMR and FNMR and its smaller value with regard to the smaller values of FMR and FNMR intersection) is, the better the algorithm is [16] EER is about 1.0334% and 0.2687...

Ngày tải lên: 22/06/2014, 23:20