simulation of physiological processes

... is the n x n Jacobian matrix, defined as: Ofl Oxl Of Ox Of Of Oxl Ox2 Ox Of, Oxl J~ Ofl Ox2 Of n Ox2 c'~2 c~,, -2Cvs~ W3 = Cv3Y3 (2.48) Ofl 0/gl 0U2 Of Ou= 0f2 Ou2 igUl 0 r2 J 0 At3 2W3 Wa xs ... 3.4 Conservation of mass in a bounded volume The principle of the conservation of mass will be invoked in just about every process simulation Often 24 Simulation of Industrial Processes for Control ... We find the eigenvalues by setting the determinant to zero: , Of, , Ou2 0 Of Of n Out (2.2) u l"1 Oft " Out to the form: Ox Ofl Of Of , while the n x ! input-Jacobian matrix, Jn, is defined as:...

Ngày tải lên: 01/04/2014, 11:14

... Integration of simulation tools Selection of simulation software Summary References 33 41 46 50 55 57 58 STATE FLOWSHEETING 59 3.1 Fundamentals of steady state flowsheeting 3.2 Degrees of freedom ... specifications of products The optimal combination of so many aspects gives highly integrated processes The design of complex processes implies the availability of adequate conceptual methods and of powerful ... Open software architecture 2.4.3 Internet simulation 2.5 Selection of a simulation software 2.6 Summary 2.7 References 34 Chapter 2: Introduction in Process Simulation 2.1 C O M P U T E R SIMULATION...

Ngày tải lên: 02/04/2014, 15:49

... of biophysical processes at the following levels of organization: molecular dynamics simulations based on the atomic structure of biomolecules; hierarchical models of the collective motions of ... kinetics, while the time steps of an atomic-level simulation are on the order of femtoseconds Running atomic-level simulations for the entire length of a physiological simulation time step would ... The integration of structure-based predictions of protein function into systems models of molecular networks The development of kinetic models of cell signalling coupling them to physiological...

Ngày tải lên: 11/04/2014, 09:47

... of biophysical processes at the following levels of organization: molecular dynamics simulations based on the atomic structure of biomolecules; hierarchical models of the collective motions of ... kinetics, while the time steps of an atomic-level simulation are on the order of femtoseconds Running atomic-level simulations for the entire length of a physiological simulation time step would ... The integration of structure-based predictions of protein function into systems models of molecular networks The development of kinetic models of cell signalling coupling them to physiological...

Ngày tải lên: 06/08/2014, 13:22

... level comes from the lower level of coarse graining Of course, what Gary would eventually like to resolve, going from one set of simulations to the next hierarchy of simulations, is starting from ... number of other processes The Anrep e¡ect comes out So also will change in the frequency of stimulation I could go on with a whole range of things as examples It seems that one of the functions of ... business computing Development of large software packages My ¢nal comments concern the process of developing scienti¢c software The codes involved in simulation software are becoming larger and...

Ngày tải lên: 06/08/2014, 13:22

... systems consist of an interaction of processes operating on a wide range of spatial and temporal scales It is impossible to compute the e¡ects of all the interactions at any level of this spatial ... value of producing a minimal model, both from the point of view of the mathematical insight that it provides, and also from the practical point of view of being able to use a reduced form of a ... result, which is one of the most powerful uses of a model, how we know that this is a faithful and generic outcome of the model and not simply the result of very special choice of model parameters,...

Ngày tải lên: 06/08/2014, 13:22

... the nature of the pharmaceutical industry Often, 14 years pass between the initiation and culmination of a project (the release of a new drug), and there is a pipeline of thousands of compounds ... hypothesis of the pathophysiology of the disease and the relevance of a particular novel target was developed as part out of a modelling exercise It is still this process The promise of what modelling ... Metabolism of complex carbohydrates Metabolism of complex lipids Metabolism of cofactors and vitamins Metabolism of secondary metabolites Degradation of xenobiotics Environmental information processing...

Ngày tải lên: 06/08/2014, 13:22

... continuum models McCulloch: One of the features of XML is that it is extensible Some of the models that you cited are actually extensions of previous models They are often not simple extensions, ... functioning of cells in terms of myriad biochemical pathways Of special signi¢cance are pathways involved in cellular signalling Understanding how signal transduction occurs in cells is of paramount ... strategies employed in the AfCS 2002 ‘In silico’ simulation of biological processes Wiley, Chichester (Novartis Foundation Symposium 247) p 104^118 The response of a mammalian cell to input is mediated...

Ngày tải lên: 06/08/2014, 13:22

... models of the heart: closing the loop between experiment and simulation In: ‘In silico’ simulation of biological processes Wiley, Chichester (Novartis Found Symp 247) p 129^143 ‘In Silico’ Simulation ... models, application of numerical solvers to perform simulations, and analysis of simulation results A key feature of the Virtual Cell is that it permits the incorporation of realistic experimental ... KW, Meyer R 1998 Control of L-type calcium current during the action potential of guineapig ventricular myocytes J Physiol 513:425^442 ‘In Silico’ Simulation of Biological Processes: Novartis Foundation...

Ngày tải lên: 06/08/2014, 13:22

... last part of Fig illustrates the relationship of Applications and MathModels to Simulations The implementation of a simulation is kept separate from the model speci¢cations and several simulations ... equation (ODE) for the rate of change of i, Ri, depends on the concentrations of the reactants and products In general, Ri can depend on the concentrations of any of the molecules in the system ... relation to some of the work on cardiac modelling These are aspects of modelling that we need to bring out as one of the great strengths Loew: This is sort of equivalent to the idea of lowering the...

Ngày tải lên: 06/08/2014, 13:22

... modelling often exhibits this degree of modularity, making it necessary to incorporate a group of protein components together It will be one of the major challenges of mathematical biology to use simulation ... within sight, and is one of the challenges of the immediate future The potential of such simulations for teaching, drug discovery, device development and, of course, for pure physiological insight ... progressive addition of one mechanism after another involved is revealing is that you have unravelled part of the logic of life, part of the reason for the robustness of that particular physiological...

Ngày tải lên: 06/08/2014, 13:22

... models of human physiology based on patient-speci¢c quantitative descriptions of anatomical structures and models of biophysical processes which reach down to the genetic level 2002 ‘In silico’ simulation ... standardized description of spatially varying parameters at the organ level is equally important within the cell for models of cellular processes The hierarchy of models A major objective of the Physiome ... This relates to the study of gene regulation, where proteins often regulate their own production or that of other proteins in a complex web of interactions The biochemistry of the feedback loops...

Ngày tải lên: 06/08/2014, 13:22

... software implementation perspective We have joined together two very distinct areas of experimental research using our technology platform to couple separate models into a single simulation of ... e¡ect of PKA would not otherwise have been predicted, which is quite remarkable Secondly, this 5% delay is predicted to arise from second FIG (Opposite) Simulation of second messenger control of ... dynamic model of the cardiac ventricular action potential: I Simulations of ionic currents and concentration changes Circ Res 74:1071^1096 Luo CH, Rudy Y 1994b A dynamic model of the cardiac...

Ngày tải lên: 06/08/2014, 13:22

... factor of the degradation rate σ (t ) is an exponential function of time σ (t ) = e at +b In view of Eq (12.8) (12.13) 291 292 12 Modeling and Simulation of Microbial Depolymerization Processes of ... considered in modeling and simulation of depolymerization processes of PEG [11–13] Unlike exogenous type depolymerization processes in which monomer units are separated from terminals of molecules, molecules ... conversion from the class of (M + L)-molecules to the class of M molecules due to the β -oxidation 285 286 12 Modeling and Simulation of Microbial Depolymerization Processes of Xenobiotic Polymers...

Ngày tải lên: 25/10/2013, 08:20

... direction of the fibres deviates from the longitudinal direction of the tree The deformation of wood during drying is to a large extent dependent on the direction of the fibres In the present simulation, ... illustrate the capabilites of simulation of deformation development When interest is focused on studying the deformation parallel to a cross section of a board, a two-dimensional simulation may be performed ... (1993) Study of the relation between flatwise and edgewise modulus of elasticity of sawn timber for the purpose of improving mechanical stress grading methods Diploma work, University of Hamburg,...

Ngày tải lên: 08/08/2014, 18:21

... expression of eight of the nine WRKY genes was suppressed after activation of OsWRKY13 with or without pathogen infection, suggesting that some of the WRKY proteins might be expressional inhibitors of ... gene and suppressed expression of the gene [13] Consistent with suppressed expression of a subset of AP2/ EREBP and MYB types of transcription factors, the promoters of the downregulated genes in ... file Hierarchical clustering display of expression profile of rice WRKY family genes in OsWRKY13-activated lines The figure shows the expression profile of rice WRKY family genes in OsWRKY13-activated...

Ngày tải lên: 12/08/2014, 03:20

... University of Singapore I Acknowledgements modest way of showing my gratitude to them National University of Singapore II Table of Contents Table of Contents Acknowledgements I Table of ... combinations National University of Singapore IX List of Tables List of Tables Table 1.1 List of possible shapes of recorded magnetization distribution Table 4.1 L2 norm errors of FFTM and Hybrid FEM/BEM ... components of dM of Landau-Lifshitz equation; (b) asymptotic dt behavior of Landau-Lifshitz equation 30 Fig 2.4 (a) Spherical components of dM of Gilbert equation; (b) asymptotic dt behavior of...

Ngày tải lên: 15/09/2015, 17:10

... Figure 3-11 2D plot of 4th order room with walls 28 Simulation of a MIMO wireless system – John Fitzpatrick Figure 3-12 3D plot of 4th order room with walls 29 Simulation of a MIMO wireless system ... • m = row dimension of a • n = column dimension of a • w = returns the vector of singular values of a • v = returns the right orthogonal transformation matrix 33 Simulation of a MIMO wireless ... the number of transmitting antennas, which is three in this Simulation of a MIMO wireless system – John Fitzpatrick case Each of the lower bit rate sub streams are transmitted from one of the antennas...

Ngày tải lên: 20/11/2012, 11:36

... technique, Luleå University of Technology, Luleå, Sweden 2006, Master of Science in engineering physics, Luleå University of Technology, Luleå, Sweden 2006: Major field of study: heat transport ... diameter of 0.04 m and the shank spacing (pipe centre to pipe centre) is 0.05 m A total of 634,200 hexahedron and wedge-shaped volume element cells are used in the model The large amount of cells ... International Journal of Energy and Environment (IJEE), Volume 1, Issue 3, 2010, pp.399-410 402 simulation except the density, which uses the Boussinesq approximation during THT modelling All simulations...

Ngày tải lên: 05/09/2013, 14:58

... cost † Speed Using simulation allows us to find results of experiments in a speedy manner Simulation permits time compression of a system over an extended period of time † Simulation modeling ... number of variates generated as a Poisson variate 13.7 Case Studies This section presents examples on the simulation of wireless networks These are the simulation of an IEEE 802.11 wireless LAN, simulation ... the basics of simulation modeling and its application to wireless networking We started by introducing the fundamentals of discrete-event simulation, the basic building block of any simulation...

Ngày tải lên: 29/09/2013, 21:20