simple insights from the beginnings of magnetic resonance in molecular biology

... distinct monoclonals, two of them preventing, the third one accelerating the development of the disease [40] The effect of each reagent on the signaling activated by CD4 via the p56lck interacting ... pocket, a discontinuous region at the interface between the inner and the outer domain of gp120 [52] On the other hand, the lateral face of the D1 CD4 domain is implicated in MHC-class II interaction, ... depletion of the CD4 T lymphocytes is the hallmark of the progression of HIV infection and, in the absence of antiviral treatment, the main contributor to the development of opportunistic infections...

Ngày tải lên: 18/06/2014, 15:20

... Most of the increase in CO2 emissions from gas-fired plants was offset by the decline in CO2 emissions from petroleumand coal-fired plants The amount of CO2 emissions from the combustion of fossil ... Emissions from the Generation of Electric Power in the United States increased in 1999 in these States, reducing the need for fossil-fueled generation and contributed to keeping CO2 emissions low in the ... electricity varies according to the quality of the fuels, defined by their carbon content and the associated heating value (Btu).15 The Btu content of fuels is a determinant of the number of kilowatthours...

Ngày tải lên: 29/06/2014, 02:20

... differences between domains γ1 of AAG and abrin-a occurred in N-terminal The Nterminal of the AAG A-chain is one residue shorter than that of the abrin-a A-chain and the first five terminal residues are ... also minimizes energy based scores [42] Parameters used in DOCK were modified from the paper of protein docking and complementary principle [43] The atomic coordinates of the refined agglutinin ... studying the structure and function of these RIPs [21,23,24] And the results showed that Pro199 in A- (or C-) chain of AAG impair the activity of protein synthesis inhibition because of steric hindrance...

Ngày tải lên: 10/08/2014, 05:21

... promote the migration and invasion capacity of these cells [14] These effects were inhibited when cells were treated with TWEAK in the presence of the NF-κB inhibitor pyrro­ lidine dithiocarbamate In ... Research in the past years has unraveled the multiple mechanisms that enable NF-κB to support ovarian carcinogenesis, including that this pathway confers some of the properties of OCSCs These findings ... A2780 cells In addition, they showed that blocking IKKβ activity through either small-molecule inhibition or siRNA can inhibit anchorage-independent growth and the capacity of the cells to invade...

Ngày tải lên: 11/08/2014, 12:20

... REVIEW The Development of Auditing Profession in China Shortly after the founding of the People’s Republic of China in 1949, the auditing profession in China disappeared entirely due to the public ... THE DETERMINANTS OF AUDITOR SWITCHING FROM THE PERSPECTIVE OF CORPORATE GOVERNANCE IN CHINA costs of raising capital and hiring a low-quality auditor to maintain the gains from the opaqueness ... expropriation of minority shareholders’ interests thereafter As a result, the auditing profession and the stock market may be able to develop smoothly in China In line with the continuing progress of the...

Ngày tải lên: 06/01/2015, 19:43

... the purpose of “opinion shopping” in order to mitigate the negative impact of the unclean audit report on the firm's stock price in the market, and on the self-interests of the management or the ... act in the best interest of the owners One of the binding mechanisms is the auditing function performed by independent professionals over the operations and information disclosures provided by the ... auditors during the period from the beginning of 2001 to the end of 2004.4 There are two main reasons to limit the sample firms that made auditor switches in this time period The first one is the availability...

Ngày tải lên: 06/01/2015, 19:43

... housing census of Vietnam in 2009 (UNFPA), indicating the alarming status of growing gender imbalance in Vietnam; Gender issues in migration (IOM) pointing out the differences in the amount of ... be seen in the continuous practice of wedding challenge, demonstrating the inferior position of women in the family and in the community, as well as the importance of having sons.” Being fully ... Thus, in reality, rather than believing that the division of labor has shed the burden on the women’s shoulders, from the point of view of EM people, the issue of “who does what” originates from the...

Ngày tải lên: 30/10/2015, 09:33

... asked to indicate how distressed they were by feelings of hopelessness, lack of interest, worrying, feeling blue, feeling lonely, blaming themselves, feeling trapped, crying easily, having a poor ... criteria of physical functioning and two criteria of cognitive functioning to identify those functioning in the top third of the age group The selection criteria included the following: (a) no ... living spouses at both time points were included, yielding a sample of 439.1 Table summarizes the sociodemographic and psychological characteristics of the sample at the time of the first interview...

Ngày tải lên: 06/03/2014, 15:20

... Side-chain packing in the regions responsible for the stability of HT c-552, and the corresponding regions in the wild-type PA c-551 and its quintuple mutant The mutated residues in the quintuple ... determining the structural origin of protein stability Experimental data on the stability and 3D structure of these proteins in addition to their amino-acid sequences will provide valuable information ... to the polypeptide chain [5] The amino-acid sequence (Fig 1) and main chain folding (Fig 2) of HT c-552 from this thermophile closely resemble those of the 82-amino-acid cytochrome c-551 from...

Ngày tải lên: 24/03/2014, 03:21

... elements, including early administration of mitomycin-C, inclusion of cisplatin and prolonged doxifluridine administration besides the intraperitoneal therapy Thus, it remains to be proven if the survival ... the OFF arm The median OS in the OFF arm was 28 weeks, and that of the FF arm was 13 weeks, thereby fulfilling the study hypothesis There was also a significant prolongation of PFS in the treatment ... examined intermittent administration of oxaliplatin in minimizing neurotoxicity from oxaliplatin The Combined Oxaliplatin Neurotoxicity Prevention Trial (CONcePT) randomized patients receiving...

Ngày tải lên: 10/08/2014, 22:20

... trial of gemcitabine and oxaliplatin alone or in combination with biweekly cetuximab in the first-line treatment of advanced biliary cancer: Interim analysis of the BINGO trial J Clin Oncol (Meeting ... presentations in gastrointestinal oncology from 2009 annual meeting of ASCO The key findings are summarized as the followings, and will lead to paradigm change in clinical practice Adding trastuzumab ... Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of...

Ngày tải lên: 10/08/2014, 22:20

... in the ZEAL study The large sample size in ZODIAC may explain the significant improvement in PFS even though the PFS was almost the same in both studies Evaluation of secondary endpoints in the ... testing for making decisions in the firstline treatment setting cannot be recommended at this time Lastly, there is hope for improving outcomes in the Page of 11 second-line setting given the ... positive data from the ZODIAC trial The important finding in this trial has demonstrated the improvement of PFS and RR from vandetanib translated into the clinically meaningful delay in symptom...

Ngày tải lên: 10/08/2014, 22:21

... MRI of the affected region, together with whole skeleton bone scintigraphy and CT of the chest MRI is essential in the determination of the true extent of the tumor It is important to bear in mind ... predominantly affecting young patients of the ages five to 20 years It involves the diaphyses of long bones and occurs Figure CT image of the patient’s foot, revealing a soft-tissue mass originating ... Reinus WR, Wilson AJ: Quantitative analysis of the plain radiographic appearance of Ewing’s sarcoma of bone Invest Radiol 1997, 32:59-65 10 Reinus WR, Gilula LA: Radiology of Ewing’s sarcoma: Intergroup...

Ngày tải lên: 10/08/2014, 23:20

... The SNR increase is firstly explained in theory with the conclusion that SNR can be increased by increasing the number of coils in the array provided that the mutual coupling can be removed Then ... Therefore the heating effect is not very sensitive to the radius of the needle In a practical invasive treatment, the radius of the needle can be determined by the requirement of the needle insertion ... Figure 2.3: The YOZ cutting plane of the model in FEKO 18 Figure 2.4: The incident directions of the plane wave in the two cases The blue arrow represents the incident direction while the red...

Ngày tải lên: 09/09/2015, 10:20

... 1.2.3 Innate immunity 1.2.3.1 The iron-withholding strategy as a component of innate immunity 1.3 The iron-binding proteins involved during infection and inflammation 1.3.1 The transferrin family ... Fe2+ enters the core of the apoferritin, after which it is oxidized to Fe3+ by the catalytic action of the amino acid side-chains of the H-chain 1.3.2.2 Secreted ferritins Ferritin was demonstrated ... growth in media containing these iron-binding proteins or human serum (Takase et al., 2000) However, whether or not other iron-binding proteins in human serum are also targets of siderophores remains...

Ngày tải lên: 04/10/2015, 17:06

... activity of ODC gene [29], which is involved in polyamine synthesis It is likely that the cell cyclearresting action of CY in the stomach in this study was due to the activation of p53 and therefore ... therefore leading to the suppression of the c-Myc/ODC pathway All these findings could explain the mechanism of CY on repression of cell proliferation in the gastroduodenal mucosae In general, ... was therefore not surprising that CY administration resulted in a decrease in the proliferating cell number in both the gastric and duodenal tissues Indeed the decrease in cell proliferation in...

Ngày tải lên: 02/11/2012, 10:19

... bird, still he was soaring through the air, gleefully riding the wind currents down the side of the mountain When they reached the valley floor and neared the shoreline of the lake, a giant clamor ... pyramid shaped mountains flanked the opposite side of the incredible fissure Feeling compulsively drawn to the edge of the chasm, she gazed into the absorbing darkness The billowing blue smoke was ... have arrived at the most opportune moment! We are about to witness the fall of Tenochtitlan and the beginning of a new epoch in the history of the world!" The wanderer felt a tug of apprehension...

Ngày tải lên: 06/11/2012, 17:33

... about the human who took the photo of the toilet Having each of these fields remain separate from the others means the content can be sorted according to any of these fields; also, each of the fields ... Drupal From the Library of Athicom Parinayakosol This page intentionally left blank From the Library of Athicom Parinayakosol Front End Drupal Designing, Theming, Scripting Emma Jane Hogbin Konstantin ... create the page you see—one of which might be content The flow chart in Figure 1.2 shows the same information that is displayed in the Web site in Figure 1.1, but in terms of the hierarchy of each...

Ngày tải lên: 24/12/2013, 09:17