signalling molecules as selective targets for therapeutic strategies in multiple myeloma
Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx
Ngày tải lên :
06/03/2014, 09:22
... given SR protein or hnRNP protein The one relying on RNA interference appears particularly interesting Indeed, short interfering RNAs are not only an exciting new tool in molecular biology, but also ... A1 Suboptimal splicing at 3¢ss A1 is necessary for virus replication Increased splicing at 3¢ss A1 results in the accumulation of vif mRNA and increased inclusion of exon within spliced viral mRNA ... splicing, in combination with other antiviral strategies, may be a useful new tool in the fight against HIV ⁄ AIDS More recently, a novel strategy using small molecules that inhibit splicing by...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
Ngày tải lên :
28/03/2014, 23:20
... triggering receptor kinase activity and signaling pathways involving the binding of ezrin to ezrin–radixin–moesin proteins, and thus actin cytoskeleton binding and Ras activation HGF elicits metastatic ... short cytoplasmic tail of CD44 binds to ankyrin and ezrin–radixin–moesin proteins, providing a link to the cytoskeleton, as well as to merlin, which abrogates this binding However, the multiple ... receptor for HA CD44 proteins exist in three states with respect to HA binding: nonbinding; nonbinding unless activated by physiological stimuli; and constitutively binding [17–19] HA induces signaling...
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báo cáo hóa học: " Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies" doc
Ngày tải lên :
20/06/2014, 00:20
... urine values were creatinine-corrected for each sample (the isocyanate concentrations were expressed in μg per g of creatinine) Urinary creatinine was determined in grams per liter (g/L) using ... points To deliver spot urine samples the patients were given sterile 100 mL polyethylene plastic containers and were asked to wash the hands before voiding to avoid dust failing into the sampling ... ± 420 ppb-min (for the high exposure group) FEV1 was measured before exposure, in 10 intervals within the first hour, then every hour until h as well as 24 h after exposure The urine samples...
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
Ngày tải lên :
09/08/2014, 03:24
... Mundy Figure In vitro effects Simvastatin, mevastatin and atorvastatin (but not pravastatin) were found to have identical effects to those seen with lovastatin Cerivastatin, however, was 10–100-fold ... and in vivo in rats Cerivastatin improved cortical bone strength in ovariectomized rats when used in doses as low as 0.1 mg/kg/day, and it significantly increased bone mineral density, bone formation ... GE, Carley W: Cerivastatin increases cortical bone formation in OVX rats J Bone Min Res 2000, 15(suppl):s549 Oxlund H, Andreassen TT: Simvastatin given orally to adult rats increases the compressive...
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Báo cáo y học: "Vasculature deprivation – induced osteonecrosis of the rat femoral head as a model for therapeutic trials" ppsx
Ngày tải lên :
13/08/2014, 23:20
... fibroblasts, osteoblasts and osteoclasts in addition to supplying the extra oxygen that is indispensable for meeting the increased metabolic demands of regenerating tissues Given that vascularization ... contours measured by magnetic resonance imaging Indices within the normal range are measured in children with stage I Perthes disease These indices decrease in patients with stage II and III disease ... ranking as high as 0.9 being occasionally encountered There is no equivalent information in the Medline database with http://www.tbiomed.com/content/2/1/24 which these structural changes in remodeling...
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Báo cáo sinh học: " HCV entry receptors as potential targets for siRNA-based inhibition of HCV" ppt
Ngày tải lên :
14/08/2014, 19:23
... protocol was used for viral inoculation as described previously [11,12,42-44] Briefly, for these experiments serum from HCV-3a patients containing a high viral titer (> × 108 IU/ml) was used as principle ... was carried out by the SDS 3.1 software (Applied Biosystems Inc, USA) Each individual experiment was performed in triplicate Western blotting To determine the effect of siRNAs on HCV E2 protein ... course of infection Moreover, different studies exhibit the feasibility of targeting host cell factors involved in infection, as they are not prone to mutations, as potential targets for siRNA...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
Ngày tải lên :
25/10/2012, 11:10
... the loading of pravastatin into erythrocytes was directly proportional with increase of drug concentration in the incubation medium, in the 2-10 mg/ml concentration range This finding is in concurrence ... sustained release phase with hemoglobin release similar pattern Pravastatin release in PBS is rapid process compared to release in plasma and after glutaraldehyde treatment It reaches 83% in PBS ... statins including inhibition of the metabolism [5], administration of statins with certain juices [6] or inhibition of Pgp [3] Unfortunately these strategies are frequently associated with increase...
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Sexual Economics: Sex as Female Resource for Social Exchange in Heterosexual Interactions pdf
Ngày tải lên :
17/03/2014, 08:20
... divorcing husband could offer another woman in exchange for sex Thus, again, the view of sex as a female resource was implicit in his reasoning, but he did not have any scholarly basis for evaluating ... may invest material and social resources in her, such as by buying her gifts, paying for her food and entertainment, spending time with her, and declaring himself willing to commit to having ... of women paying men for sex In practice, hardly any man has much chance of supporting a drug habit or paying off his gambling debts by getting women to pay him for sex Atchison, Fraser, and Lowman...
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báo cáo hóa học:" Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer" doc
Ngày tải lên :
18/06/2014, 15:20
... activates its target genes, including cyclin-dependent kinase inhibitor 1A (p21), which binds to cyclin-dependent kinase (Cdk2) and cyclin-dependent kinase (Cdk4) Map was constructed with MapEditor ... screening result indicating CHK1 as a sensitizing target for improving Figure Validation of CHK1 as a sensitizing target to gemcitabine in pancreatic cancer cells Validation of CHK1 as a sensitizing ... identify genes involved in many biological functions [10-17] As kinases are becoming important drug targets for the treatment of cancer, the identification of kinases that act as sensitizing targets...
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Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx
Ngày tải lên :
09/08/2014, 01:21
... overexpressed in MS Immunohistochemistry confirmed this finding, and 5-lipoxygenase staining was mainly detected in cells resembling macrophages and monocytes The authors point out that 5-lipoxygenase ... Among these was osteopontin (OPN), a cytokine with pleiotropic functions including roles in inflammation and immunity to infectious diseases Previous work had attributed a key role to OPN in the regulation ... revealed increased expression of OPN adjacent to lesions observed in the brain tissue of MS patients, as well as in rodents that develop an experimental form of the disease [25] The induction...
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Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience" pdf
Ngày tải lên :
09/08/2014, 10:21
... improvement in clinical indicators of pain and disease activity A first randomized controlled trial in patients with knee OA demonstrated a good safety profile for one intra-articular injection ... the main endpoint (month 1) A tendency for improvement was noticed in the 150 mg group at day (in keeping with the short half-life of IL-1ra), suggesting that IL-1 inhibition may be therapeutically ... We performed a multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical response, safety, and tolerability of a single intra-articular injection of anakinra (50...
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Báo cáo y học: " Use of cracked maize as a carrier for NDV4 vaccine in experimental vaccination of chickens" pot
Ngày tải lên :
12/08/2014, 04:20
... dried NDV4 vaccine was reconstituted in mls of clean sterile non-chlorinated water The mls vaccine suspension was further diluted in 50 mls of clean non-chlorinated water and maintained in ice trough, ... important roles in such virus binding or adherence to food grain surface, hence the need for soaking such grains in water The V4 Vaccine coated on the soaked grains were seen to be viable for up to ... the V4 Vaccine Sampling periods (Days) N0 of birds Post Vaccination HI titer 12 14 12 21 12 during vaccination thereby reducing stress associated with handling birds for individual vaccination coupled...
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Báo cáo y học: " Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults" ppsx
Ngày tải lên :
13/08/2014, 21:21
... protein concentrations For the determination of procalcitonin concentration, the Liaison Brahms PCT assay (Diasorin S.p.A., Sallugia, Italy) was used C-reactive protein was measured by using the ... further marked increase in patients with severe sepsis In contrast, interleukin and C-reactive protein are markedly higher in postoperative patients, but no further increase is found in patients ... ± 26.5 Gastrointestinal cancer 18 Gastrointestinal disease 16 Cancer, other 12 Urogenital cancer Lung disease 11 0 Primary diagnosis Urogenital disease Other diseases Lung cancer Disease severity...
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Báo cáo hóa học: " Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies" pot
Ngày tải lên :
18/06/2014, 16:20
... Bid, BH3 interacting domain death agonist; BIM, bcl-2 interacting mediator of cell death; CASP3,caspase-3; CASP8, Caspase 8; CCNA, cyclin A; CCND1, cyclin D1; CCND3, cyclin D3; CCNE, cyclin E; CCNE, ... cadherin 1;CDH8, cadherin 8; CDH13, cadherin 13; CDKN1B, cyclindependent kinase inhibitor 1B; CDKN1C, cyclin-dependent kinase inhibitor 1C; CDKN2A, cyclin-dependent kinase inhibitor 2A; COL1A2, ... DIABLO, direct IAP-binding protein with low pI; DVL, dishevelled; FADD, Fas-associating protein with death domain; GF, Growth Factor; GSK3β, glycogen synthase kinase beta; IL, interleukin; LRP, LDL...
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Báo cáo sinh học: " Matrix attachment regions as targets for retroviral integration" ppt
Ngày tải lên :
19/06/2014, 08:20
... integration into genes was identified for MoFe2 and SL3-3 at single insertion sites, although not for SL3-3 integrated at CISs Analysis was then performed to determine if preferred integration into ... pre-integration complex enters the nucleus, MAR binding proteins may bind and direct integration due to their affinity for binding to cellular MARs It is known that sequence insertion within or ... defines a MAR; however, MARs are commonly found to have intrinsic DNA bending properties, to contain transcription factor binding sites, AT-rich stretches, sites for topoisomerase I and II binding...
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báo cáo hóa học:" Matrix attachment regions as targets for retroviral integration" doc
Ngày tải lên :
20/06/2014, 04:20
... integration into genes was identified for MoFe2 and SL3-3 at single insertion sites, although not for SL3-3 integrated at CISs Analysis was then performed to determine if preferred integration into ... pre-integration complex enters the nucleus, MAR binding proteins may bind and direct integration due to their affinity for binding to cellular MARs It is known that sequence insertion within or ... defines a MAR; however, MARs are commonly found to have intrinsic DNA bending properties, to contain transcription factor binding sites, AT-rich stretches, sites for topoisomerase I and II binding...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
Ngày tải lên :
09/08/2014, 14:22
... value for drug development The pharmaceutical industry realized the unmet medical need for new therapeutics in lupus and has made a considerable investment in bringing new candidates to the clinic ... association with lupus disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated by the SLEDAI and ... future disease course Further studies on the response of chemokine score to therapeutic intervention will be essential for validating this approach for use in decision-making within clinical studies...
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báo cáo khoa học: " Chemically synthesized zinc finger molecules as nano-addressable probes for double-stranded DNAs" ppt
Ngày tải lên :
11/08/2014, 00:22
... binding and dissocia- tion events were measured in real time and binding curves (binding signal vs time) were obtained (Figures and 4) The curves were fitted using in- house built fitting routine ... measured for the first time the specific binding of synthetic single-motif zinc finger peptides to their specific binding sites in real time in vitro Figure shows a typical result obtained using ... zinc finger motif Scheme of a C2H2 zinc finger motif X denotes any amino acid; Z – hydrophobic amino acids [L, I, V, M, F, Y, W, C]; L is Leucine; C is Cysteine; H is Histidine The binding interface...
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Báo cáo y học: " N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD" pptx
Ngày tải lên :
12/08/2014, 14:20
... disease Approval was obtained from the Institutional Review board at UAB prior to conducting these studies All subjects provided informed consent Samples and health information were labeled using ... neutrophils contain many of the proteases involved in generation of PGP, including MMP's [31], and neutrophils were required for PGP production in a mouse model of LPSinduced keratitis [32] In this way, ... an index of neutrophilic airway inflammation, which correlates with disease severity and rate of decline in pulmonary function in COPD Such a biomarker would be of benefit as an endpoint in clinical...
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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
Ngày tải lên :
12/08/2014, 23:22
... factor; p/CIP: p300/CBP interacting protein; PRMT: Protein arginine methyltransferase; RBP-2: retinol-binding protein 2; RIZ1: retinoblastoma protein-interacting zinc-finger 1; SAS2: serum antigenic ... JHDM: JmjC domain containing histone demethylases; JMJD: Jumonji-domain containing; LSD1: lysine-specific demethylase 1; MLL: Mixed-lineage leukemia; JBP1: Janus kinase binding protein 1; MOF: males ... IL-2: InterLeukin 2; Ini1: Integrase-interacting protein 1; IRF: Interferon (IFN)Responsive Factor; JNK: c-Jun N-terminal Kinase; JmjC: Jumonji C; LBP-1: Lipopolysaccharide-Binding Protein 1;...
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