severe brain damage in premature babies
Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
Ngày tải lên :
07/03/2014, 03:20
... neurons in vitro [26]. Experimental research in the field
of ischemia was mainly prompted by observations indi-
cating that CBs could attenuate glutamate-induced
injury by inhibiting glutamate ... neuroprotective effect of the
cannabinoid agonist WIN-55212 in an in vitro model
of hypoxic-ischemic brain damage in newborn rats.
Pediatr Res 60, 169–173.
43 Cernak I, Vink R, Natale J, Stoica B, Lea ... studies have
examined the putative protective or toxic effects of drugs interacting with
cannabinoid receptors or have measured the brain levels of endocannabi-
noids in in vitro and in vivo models...
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Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
Ngày tải lên :
07/03/2014, 03:20
... K
& Gearing A (2001) Immunohistochemistry of matrix
metalloproteinases in reperfusion injury in rat brain:
activation of MMP-9 linked to stromelysin-1 and
microglia in cell cultures. Brain Res ... blood brain barrier; COX-2, cyclooxygenase-2; ICAM-1, intercellular adhesion molecule 1; ICE, interleukin-1b-converting enzyme; IL,
interleukin; IL-1ra, interleukin-1 receptor antagonist; iNOS, inducible ... biologically active interleukin-1 beta by meprin B.
Cytokine 31, 394–403.
140 Pinteaux E, Inoue W, Schmidt L, Molina-Holgado F,
Rothwell NJ & Luheshi GN (2007) Leptin induces
interleukin-1beta release...
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Báo cáo y học: "A k2A-positive Klebsiella pneumoniae causes liver and brain abscess in a Saint Kitt’s ma"
Ngày tải lên :
26/10/2012, 09:53
... ampicillin and intermediate
to ampicillin/sulbactam. It was sensitive to the
cephalosporins (cefazolin, cefotaxime, and cefepime),
the fluoroquinolones (ciprofloxacin, levofloxacin), the
aminoglycosides ... (amikacin, gentamicin, and tobra-
mycin), meropenem, pipercillin/tazobactam and
trimethoprim/sulfa. At this point, the patient was
started on meropenem. The initial CT scan of the
brain done ... absence of underlying hepatobiliary diseases, and
the presence of other invasive complications includ-
ing endophthalmitis, suppurative meningitis, brain
abscess, necrotizing fasciitis, and...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
Ngày tải lên :
18/02/2014, 11:20
... arises is: why are pericytes
abundant in the brain vasculature? Brain pericytes
may perform specialized roles involved in the develop-
ment and maintenance of brain vessels. First and fore-
most, ... pre-exist-
ing vessels). Indeed, the vascular network of the brain
is predominantly formed by angiogenesis. During this
Keywords
astrocyte; barriergenesis; blood brain
barrier; brain angiogenesis; ... modulate neurovascular coupling and
maintain several parts of brain homeostasis. In this
minireview, we focus on the active functions of astro-
cytes in regards to brain vasculature. Anatomically,
most...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc
Ngày tải lên :
18/02/2014, 11:20
... among
tissues in the body, and the risk of edema to brain
functions should be carefully considered. Brain edema
may increase pressure in the cranial cavity and brain
tissue, resulting in suppression ... vascular leaks
during the clinical course of brain diseases or during
the treatment of brain ischemia using pro-angiogenic
medicine.
Acknowledgements
This work was supported by Grant -in- Aid Special ... VEGF-D, binds and activates this
receptor, resulting in the proliferation and migration
of lymph ECs and lymphangiogenesis [13].
Angiogenesis in brain diseases
Brain stroke
Stroke is induced through:...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx
Ngày tải lên :
18/02/2014, 11:20
... reinter-
preted in the context of angiogenesis in the brain. Is it
possible that some of the acute neurovascular events in
the brain after stroke represent an endogenous attempt
by the brain ... remodeling. A sys-
tematic understanding of these responses may eventu-
ally lead us to discover new targets for treating brain
injury after stroke.
Early neurovascular damage in stroke
In the ... stroke. During the early acute phase of neurovascular injury, blood–
brain barrier perturbations should predominate with key roles for various
matrix proteases. During the delayed phase, brain angiogenesis...
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Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects docx
Ngày tải lên :
05/03/2014, 21:20
... is explained by including SSBD terms in the
model where r
2
values increase. Sulcal CSF enters next in predicting Trails B,
followed by DWMH; in contrast, DWMH enters next for predicting SHAR,
followed ... Ͻ.001
*SSBD indicates subclinical structural brain disease; Trails B, Trail-Making
Test
48-50
to measure sequencing abilities; DWMH, deep white-matter
hyperintensities; vCSF, ventricular cerebrospinal ... with the finding of regional dif-
ferences. The regional prominence of posterior atrophy
with age in healthy subjects is, to our knowledge, a new
finding and is particularly intriguing given...
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Báo cáo khoa học: Post-ischemic brain damage: NF-jB dimer heterogeneity as a molecular determinant of neuron vulnerability pdf
Ngày tải lên :
07/03/2014, 03:20
...
IKK
inhibitors
p50
cRel
IκB
cRel
p65
IκB
NF-κB signalling in brain ischemia
AMPA
kainate
Fig. 1. NF-jB signaling in ischemia, In brain ischemia, NF-jB
becomes rapidly activated in response ... p65
dimer participates in the pathogenesis of post-ischemic injury by inducing
pro-apoptotic gene expression, c-Rel-containing dimers increase neuron
resistance to ischemia by inducing anti-apoptotic ... 921–931.
28 Bakalkin GYA, Yakovleva T & Terenius L (1993) NF-
kappa B-like factors in the murine brain. Developmen-
tally-regulated and tissue-specific expression. Brain Res
Mol Brain Res 20, 137–146.
29...
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Báo cáo khoa học: Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment pptx
Ngày tải lên :
07/03/2014, 03:20
... inhibit
microglia activation. Minocycline is indeed able to
reduce brain infarct volumes in preclinical models
[61], as well as neurological impairment in stroke
patients [62]. Interestingly, it has recently ... response
in different stroke models [58–60].
Recently, the tetracycline, minocycline, has been
proposed as a clinically relevant tool to limit post-
ischemic brain damage because of its ability to inhibit
microglia ... regarding the molecular mechanisms underlying
the detrimental role of the enzyme in ischemic brain
injury [31,32]. Indeed, although we know in part the
mechanisms activated by PARP-1 and triggering
neurotoxicity,...
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Báo cáo Y học: Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes docx
Ngày tải lên :
08/03/2014, 22:20
... out, in this respect, that erythrocyte
ageing was initially believed to be the main determinant of
isoaspartate formation in membrane proteins [6]. Our
results are in line with a different interpretation, ... esterification in
intact erythrocytes was assayed by incubating them in the presence of
[
3
H]methionine according to the in situ procedure (see Materials and
methods).
Ó FEBS 2002 Protein methylation in ... circulating erythrocyte population. In other words, the
increase in altered residues resulting from protein deamida-
tion/isomerization reactions show a premature onset with
erythrocyte ageing, in...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot
Ngày tải lên :
15/03/2014, 19:20
... mRNA binding to cytosolic and poly-
some proteins in brain and peripheral tissues. Brain Res. Mol. Brain Res. 58, 170–177.
39. Lauger, P. (1991) Na,K-ATPase, in Electrogenic Ion Pumps, Sinauer, ... mechanism could explain the observed
increases in glucose utilization and lactate production, without a concomitant increase
in O
2
consumption upon brain stimulation (4–7,48,49). Since neurons consume ... transport
into neurons (53,56). Upon activation of neurons with Glu in the presence of 4-CIN,
tissue lactate accumulation could be observed (Fig. 3). 4-CIN induced lactate accumu-
lation in brain slices,...
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Transboundary Damage in International Law potx
Ngày tải lên :
16/03/2014, 13:20
... law” as manifested
in State behavior and cooperative undertakings. Always realistic, she
reminds us in this respect of the countervailing self-interest of States
in exercising sovereignty over ... Industrial fumes produced in
one State move across the border into a neighboring State, forming ‘‘acid
rain” that ruins the forest
s and crops in that other Stat
e.
As explained above, the media ... arbi-
tral awards,
30
principles of public international law have proved insuffi-
cient in coping with increasingly complicated matters arising from trans-
boundary damage. Some early scholarly works...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
Ngày tải lên :
23/03/2014, 07:20
... previously
reported in the whole brain of rats following transient
focal brain ischemia [15]. However, in that study, no
information was collected about the alterations
induced by the ischemic insult in different ... receptor
binding in the striatum (Fig. 5).
Interestingly, acute treatment with E
2
(0.20 mgặkg
)1
,
intraperitoneal), given 1 h before the ischemic insult,
resulted in a significant reduction of brain infarct
volume ... by
decapitation, and the brains were rapidly removed. Eight
serial sections from each brain were cut at 2 mm intervals
from the frontal pole using a rat brain matrix. To measure
ischemic damage, brain slices...
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