sensitivity of impact estimates to alternative model specifications

... hepatocytes (Fig 2C) Effects of activity and concentration of phosphorylase-a on glycogen synthesis To test the role of the phosphorylated form of phosphorylase independently of changes in total ... ? hepatocytes To test the role of phosphorylase activity, as distinct from the phosphorylation state of the enzyme, we used 1,4-dideoxy-1,4-imino-d-arabinitol (DAB), a potent inhibitor of phosphorylase ... Higher sensitivity of glycogen synthesis to phosphorylase-a in fa ⁄ fa hepatocytes To test whether impaired glycogen synthesis in hepatocytes from fa ⁄ fa rats can be explained by an altered sensitivity...

Ngày tải lên: 30/03/2014, 11:20

... also a feedforward response of stomata to atmospheric water vapour deficit (Cowan, 1977; Cowan and Farquhar, 1977; Farquhar, 1978) Implications of sensitivity of foliage to vapour pressure deficit ... budgets of the stand have been theoretically discussed by Choudhury and Monteith ing (1986) Sensitivity of stomata to water vapour is thus a key feature to regulate the water budget of plants ... consequence of the sensitivity of r to VPD, the forest appeared c ical to show a recurrent diurnal pattern of coupling with the lower atmosphere, with Q regularly decreasing from typical values of 0.9...

Ngày tải lên: 08/08/2014, 18:21

... MIC to FLU in response to C&S to 10 Total duration of appropriate treatment – Days of empiric treatment until availability of C&S results Days of antibiotic treatment if switched from FLU to MIC ... 0.2 to 0.8 Golan and colleagues [22] 0.48 0.35 to 0.65 Morrell and colleagues [12] (inverse) to 10 to 14 Guideline recommendations of 14 days reduced to 10 days to account for mortalities Days of ... treatment of candidemia, and to avoid introducing additional uncertainty into the model by using unsupported estimates, we were unable to include this component of health care costs into our calculations...

Ngày tải lên: 13/08/2014, 16:21

... $9.6 million loan to MDRC; • Bloomberg Philanthropies provides a $7.2 million grant to MDRC to guarantee a portion of the investment; • MDRC oversees the day -to- day implementation of the project ... Social Impact Bonds? • A Social Impact Bond is an investment vehicle designed to encourage private funding for promising social programs – Taps into new funding opportunities – Private investors ... a loan to MDRC, a leading non-profit • The Goldman Sachs loan to MDRC will ensure successful implementation of the ABLE program at Rikers • Bloomberg Philanthropies will make a grant to MDRC...

Ngày tải lên: 15/02/2014, 13:20

... used to test the so-called joints in the system A Model of Aesthetic Experience Here we pre~ent a stripped down version of Leder el al 's (2004, 2005) model of aesthettc expenence The model of ... account of the model as these exist elsewhere ,(Leder el al., 2004, 2005) Second, we will compare this model to Chatterjee s (2003) model of visual aesthetics, developed specifically to address ... colleagues' (2004) proposal is an information-processing model of aesthetic judgment of visual works of art Here we chose to focus on the model of aesthetic experience because we were particularly...

Ngày tải lên: 19/02/2014, 17:20

... dependencies are often undesirable, since the influence of one spurt on the other is often weak or too difficult to capture with our model Hence, we made a Markov assumption by limiting context to an arbitrarily ... the structure of our model to obtain a more general one Such a model is shown in Figure 1(b), a Bayesian network model that is well-understood and that has precisely defined semantics To this Bayesian ... features used to train the maximum entropy model mentioned previously To rank all speakers (aside from the B speaker) and to determine how likely each one is to be the A speaker of the adjacency...

Ngày tải lên: 20/02/2014, 16:20

... a model that classifies each word token, for example using a 495 part -of- speech tagger, instead of assigning the same class to all tokens of a given type The bitext preprocessor for our word -to- word ... though the word -to- word model was trained on less than one fifth the amount of data that was used to train the IBM model Since it doesn't store indirect associations, our word -to- word model contained ... a set of links between word tokens in the bitext We define a l i n k t o k e n to be an ordered pair of word tokens, one from each half of the bitext A l i n k t y p e is an ordered pair of word...

Ngày tải lên: 22/02/2014, 03:20

... likely to be sensitive to changes in the yield curve A Model of Bank Behavior Discussed in this section is a model of the effects of interest-rate and credit risk changes using the mismatching of ... bank profitability Our second objective is to use a large set of data, consisting of quarterly bank and financial market data from first quarter 1986 to second quarter 2003, to evaluate the model ... Because of the size and diversity of the group of commercial loan specialists and the grouop of small nonspecialists, each is further broken down into three groups on the basis of the size of their...

Ngày tải lên: 15/03/2014, 14:20

... organization to tag the feedback of the product to their customer Once the tag has been done then this tag will then be visible to the Friend List of the customer in the News Feed The benefit of the ... researcher also examined the impact of this social influence in terms of increase in the sales and revenue Analyzing the user behavior on the internet is one of the most critical factors that help in making ... major benefit of this marketing is the trust of the product which is very important in today competitive market RESEARCH METHODS This paper focuses on the product review of customers on social...

Ngày tải lên: 15/03/2014, 22:20

... multifactor index model to examine empirically the joint sensitivity of the rates of return of common stocks of large US banking institutions to interest rate, exchange rate and market risk factors ... vector of the nominal rate of stock returns at time t, E is a vector of expected stock returns at time t, F is a vector of risk factors with mean zero and unitary variance, S is a matrix of the ... significance of the sensitivity of bank stock returns to the assumed risk factors within the context of a multifactor index model In this section, we examine the pricing of these factors in the...

Ngày tải lên: 22/03/2014, 17:20

... Perceptions of general HIV/AIDS impact 96 Impact on employee profile 97 Impact on employee costs 98 Impact on demand and supply of skills 100 Business response 101 Employee perceptions of HIV/AIDS impact ... Profile of respondents compared to the national profile of employees in the private security sector 28 Table 3.4 Profile of study participants from the private security firms vs national profile ... sector It is clear that a thorough understanding of the economic sectors, and their skills and demographic profiles, is fundamental to an understanding of the impact of HIV/AIDS on various sectors...

Ngày tải lên: 22/03/2014, 18:20

... introduction of a Pro near the central region of a-helical antimicrobial peptides reduces the a-helical structure This partial disruption of the structure appears to contribute to selective cytotoxicity ... Pro residues largely contribute to the ability of antimicrobial peptides to kill various types of microbial cells and to form transmembrane helices, the role of the internal kink induced by Pro ... the means of duplicate measurements from three independent assays Table Amino-acid sequences and molecular masses of the model peptides Observed mass was from Kratos Kompact MALDI TOF MS Structural...

Ngày tải lên: 23/03/2014, 10:21

... complementary to TBB in CK2 than in CDK2 (a total of ˚ molecular surface area of 476 A2 is buried on binding TBB ˚ to CK2 compared with a total of 444 A2 on binding to pCDK2) When tested against a panel of ... green, TBB bromine atoms are magenta) (C) Superposition of TBB bound to pCDK2 (carbon atoms, green; bromine atoms, cyan) and TBB bound to CK2 (carbon atoms, dark green; bromine atoms, magenta) There ... shift towards the exit of the cavity, the nonpolar contacts from CK2 to TBB are slightly more numerous (73 contacts) than those of CDK2 to TBB (52 contacts) The closer fit of TBB to the ATP site of...

Ngày tải lên: 23/03/2014, 21:20

... outside of the United States, there exists a need to expand portions of the Port of Corpus Christi both in terms of capacity and efficiency In order to adequately expand the Port of Corpus Christi to ... State of Texas Estimation of Direct Impacts As the term implies, Direct Impacts are those impacts which are directly associated with the actual POCCA project To quantify the direct impacts of the ... three of Figure (From Martin study) to arrive at the total effects of the additional movement of freight1 Figure 4, Revenue Impact Estimates from Martin Study Please note that revenue (output)/ton...

Ngày tải lên: 23/03/2014, 21:20

Ngày tải lên: 30/03/2014, 01:20

... (Figure 2B and 2C) led to a similar and profound G1 arrest in all BRAFV600E mutant cell lines regardless of their in vitro sensitivity to PLX4032 PLX4032 leads to apoptotic death in sensitive ... characteristics of functioning as specific inhibitors of the BRAFV600E mutated kinase with a favorable profile compared to wild type kinases [9,22] Understanding the patterns of sensitivity and ... Translational Medicine (to AR); and the Dermatology Foundation, the STOP CANCER Foundation and the Burroughs Welcome Fund (to RSL) Author Details 1Department of Medicine, Division of Hematology/Oncology,...

Ngày tải lên: 18/06/2014, 16:20

... validity of existing models and measures, since most of the discussion tends to reflect only the academic point of view [13] Even though investigating the ageing process has been a topic of increased ... Exploratory and Confirmatory Factor analysis were performed to assess whether the Brazilian data fit the international pooled model Finally, an IRT approach, in particular, that of the Rasch model ... The basis of scalogram analysis In Measurement and prediction Edited by: Stouffer SA Princeton, NJ: Princeton University Press; 1950 Smith EV Jr: Detecting and evaluation of the impact of multidimensionality...

Ngày tải lên: 18/06/2014, 22:20

... Another way of examining cross-hybridization of the mouse liver mRNA would be to apply the mouse mRNA to the microarray in the absence of human mRNA However, the purpose of this study was to determine ... mouse model and outline a series of experiments that can be adapted to study the level of cross-species hybridization in any chimeric tissue, thus facilitating the use of genomics in these model ... promoter [4-7] Expression of the uPA transgene in the mouse liver causes a gradual depletion of the mouse hepatocytes Transplantation of normal human hepatocytes into these SCID-beige/AlbuPA...

Ngày tải lên: 20/06/2014, 01:20

... of the implants were counted Osseointegration was defined as bone -to- implant contact and calculated as the ratio of the number of bone pixels relative to the total number of pixels (bone + soft ... perimeter of the implant Additionally, the Page of relative numbers of bone pixels were measured at varying distances (up to 0.24 mm) radially outward from the perimeter of the implant to detect ... alpha of 0.05, assuming a standard deviation of up to 11% Results from four quadrants were averaged to obtain the net osseointegration and presence of bone for each section level Multifactorial...

Ngày tải lên: 20/06/2014, 04:20

... validity of existing models and measures, since most of the discussion tends to reflect only the academic point of view [13] Even though investigating the ageing process has been a topic of increased ... Exploratory and Confirmatory Factor analysis were performed to assess whether the Brazilian data fit the international pooled model Finally, an IRT approach, in particular, that of the Rasch model ... The basis of scalogram analysis In Measurement and prediction Edited by: Stouffer SA Princeton, NJ: Princeton University Press; 1950 Smith EV Jr: Detecting and evaluation of the impact of multidimensionality...

Ngày tải lên: 20/06/2014, 16:20