see recommendation in section 1 3 1

... Guidance 12 1. 1 Referral, diagnosis and preoperative assessment 12 1. 2 Providing information and psychological support 13 1. 3 Surgery to the breast 13 1. 4 Surgery to the ... 1. 9 Biological therapy 18 1. 10 Assessment and treatment of bone loss 19 1. 11 Radiotherapy 19 1. 12 Primary systemic therapy 22 1. 13 Complications of local treatment ... with DCIS following adequate breast conserving surgery and discuss with them the potential benefits and risks (see recommendation in section 1. 3 .1) Radiotherapy after mastectomy 1. 11. 3 Offer adjuvant...

Ngày tải lên: 22/03/2014, 16:21

... Arshad 19 93 2.24 [1. 51, 3. 32] Broor 20 01 3 .11 [0.05, 18 3. 77] Ekwo 19 83 1. 32 [0.75, 2 .32 ] Ferris 19 85 1. 69 [1. 46, 1. 96] Forastiere 19 92 1. 21 [0.99, 1. 48] Koch 20 03 1. 66 [1. 12, 2.47] Marbury 19 96 1. 50 ... Ekwo 19 83 1. 59 [0. 73, 3. 44] Ferris 19 85 1. 36 [1. 11, 1. 66] Forastiere 19 92 1. 34 [1. 03, 1. 75] Ogston 19 85 2.76 [1. 28, 5.96] Ogston 19 87 1. 74 [1. 33 , 2.27] Rylander 19 95 2. 23 [1. 23, 4.05] Taylor 19 87 ... Ferris 19 85 1. 85 [1. 56, 2.20] Forastiere 19 92 1. 32 [1. 06, 1. 65] Gardner 19 84 1. 25 [0. 81, 1. 93] Koch 20 03 2 . 13 [1. 31 , 3. 47] Margolis 19 97 1. 40 [0. 93, 2 .10 ] Nuesslein 19 99 1. 08 [0 .17 , 6.80] Ogston 19 85...

Ngày tải lên: 12/08/2014, 13:22

... ± 16 6 39 9 ± 19 4 P < 10 -11 P < 10 -8 P-tau 10 6 ± 55* 64 ± 28 P < 10 -4 MMP -1 0.024 ± 0. 016 0.0 21 ± 0. 01 ns MMP -3 0. 716 ± 0 .35 0.700 ± 0 .36 ns MMP-9 0.902 ± 0 .39 0.859 ± 0 .35 ns TIMP -1 0. 035 ± 11 .7 ... elderly individuals AD HC Group difference Demographics Number 38 34 Age 76 ± 77 ± ns Gender (F/M) 23 /15 24 /10 ns MMSE 19 ± 29 ± P < 10 -12 63% ( 13 %) 24% (3% ) P < 10 -4 Ab42 T-tau 30 7 ± 91 938 ± 542 ... 0 .35 ns TIMP -1 0. 035 ± 11 .7 0.0 41 ± 13 .0 P < 0.05 MMP -1/ TIMP -1 0.697 ± 0 .35 0.564 ± 0.25 ns MMP -3/ TIMP -1 MMP-9/TIMP -1 21. 1 ± 9.7 26.9 ± 11 .9 18 .1 ± 9.8 22.7 ± 11 .8 ns P < 0.05 APOE ε4 heterozygote...

Ngày tải lên: 22/03/2014, 14:20

... KG1 and Jurkat cells were maintained in RPMI -16 40 medium (Sigma) Each medium contained 10 % heat-inactivated fetal bovine serum, penicillin G (10 0 UÆmL )1) , and streptomycin sulfate (10 0 lgÆmL )1) ... R (19 71) The enzymatic degradation of hemoglobin to bile pigments by macrophages J Exp Med 13 3, 12 64 12 81 Shibahara S, Yoshida T & Kikuchi G (19 78) Induction of heme oxygenase by hemin in cultured ... compilation ª 2006 FEBS Y Ding et al 24 25 26 27 28 29 30 31 32 33 34 35 36 Yoshida T (19 95) Heme oxygenase-2 Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2...

Ngày tải lên: 19/02/2014, 05:20

Ngày tải lên: 07/08/2014, 15:20

... Oksenberg JR, Steinman L The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease Science 20 01, 294, 17 31 - 1 735 Denhardt DT, Guo X Osteopontin: a protein with diverse ... Korea (02-PJ1-PG10 2 13 05-00 03) References Attur MG, Dave MN, Stuchin S, Kowalski AJ, Steiner G, Abramson SB, Denhardt DT, Amin AR Osteopontin: an intrinsic inhibitor of inflammation in cartilage ... present study In rats having spinal cord infiltrates of inflammatory cells during EAN, intense CD44 immunostaining was detected in astrocytes, suggesting that OPN could bind to astrocytes in the subpial...

Ngày tải lên: 07/08/2014, 18:20

... ,E xiM ,J uhZ 51 13 31 - 62 31 ,072 ,59 91 ecneicS sisotpopa no sesanik PAM 83p -KNJ dna KRE fo stceffe gnisoppO EM grebneerG ,JR sivaD ,J duaegniaR ,M snekciD ,Z aiX 41 6 71- 9 61 , 13 ,2002 tsevnI lonummI ... miK ,S oeH ,K gnuJ ,M nhA ,T nihS 21 6 21 -3 21 ,6 31 ,4002 mehcoiB J yawhtap gnilangis KNJ/KPAS fo selor lacigoloisyhP T adataK ,T adaW ,H anihsiN 11 2 03- 592 , 71 ,30 02 stnegA tsoemoH lugeR loiB J ... setanegomoh ehT rezinegomoh a ni sekorts 02 htiw )nitpepuel lm/gµ 01 ,ninitorpa lm/gµ 01 ,FSMP Mm ,4OV3aN Mm ,04-p tedinoN %1. 0 ,lCaN Mm 0 21 ,sirT Mm 04( reffub sisyl ni dezinegomoh saw evren...

Ngày tải lên: 07/08/2014, 18:21

... 0.87 1. 08 1. 00 0.99 NA 0. 91 0.98 0. 83 0. 91 NA -0.04 0 .10 0 .17 0.08 0.08 0.97 1. 16 1. 23 1. 10 0 .12 1. 12 0.97 0.98 0.95 -0.04 -0 .15 0 .19 0.25 0 .15 0.22 1. 13 1. 51 1 .32 1. 35 0 .15 1. 26 1. 44 1. 22 1. 23 ... Difference* 32 34 39 40 NA 0.78 0. 83 1. 35 NA 0.76 0.96 1. 13 NA 0.02 -0 . 13 0.22 -0 .12 0. 91 0.89 NA -0. 21 0.76 0.87 NA 0.09 0 .15 0.02 NA 0 .12 0.88 0.97 1. 41 0 . 13 0.84 1. 11 1.46 -0. 01 0.04 -0 .14 -0.05 ... 0.87 1. 51 0. 91 1.70 -0.04 -0 .19 0.99 1. 36 1. 01 1.65 -0.02 -0.29 1. 05 1. 97 1. 22 2 .15 -0 .17 -0 .18 48 48 0.50 NA 0.44 NA 0.06 NA 0.49 0 .37 0.85 0.07 -0 .36 0 .30 0.66 1. 20 0.49 1. 05 0 .17 0 .15 49 1. 08...

Ngày tải lên: 12/08/2014, 16:20

... (32 .1% ) 18 (15 .0%) 60 (48.8%) 10 .0 (7.0 - 13 .0) 9.5 (7.0 -12 .0) 10 .5 (7.8 -14 .0) 63 (25.9%) 28 ( 23. 3%) 35 (28.5%) 0 .36 2 14 .8 (12 .2 -18 .0) 13 .9 (11 .9 -15 .8) 16 .0 ( 13 .2 -19 .3) < 0.0 01 54.8 ± 8.7 56 .3 ... (0.8%) (4 .1% ) 0. 2 13 Renal dysfunctionb (3. 7%) (3. 3%) (4 .1% ) 1. 000 Chronic smokingc 79 (32 .5%) 40 (33 .3% ) 39 ( 31 . 7%) 0.787 Alcoholismd 34 (14 .0%) 21 (17 .5%) 13 (10 .6%) 0 .11 9 Habitual benzodiazepine ... 0. 736 I 53 ( 21. 8%) 24 (20.0%) 29 ( 23. 6%) II 12 6 ( 51. 9%) 63 (52.5%) 63 ( 51. 2%) III 53 ( 21. 8%) 26 ( 21. 7%) 27 (22.0%) IV 11 (4.5%) (5.8%) (3. 3%) I 77 ( 31 . 7%) 45 (37 .5%) 32 (26.0%) II III 13 1 ( 53. 9%)...

Ngày tải lên: 14/08/2014, 07:21

... performed using SAS version 9.2 (SAS Institute Inc., Cary, NC, USA) 85.2 57.5 (8 .1) 35 .2 46 .3 30 .34 (5. 41) 14 .8 40.7 44.5 91. 7 (22.4) 77.8 74 .1 Median (IQR) duration of surgery (minutes) 19 0 (45) ... the final manuscript Page of 12 13 14 15 16 17 18 Competing interests ADR is a co-inventor of the Endotoxin Activity Assay DJK and ADR have served as consultants to Spectral Diagnostics Inc (Toronto, ... Shock 20 01, 16 (Suppl 1) :39 - 43 Elin RJ, Robinson RA, Levine AS, Wolff SM: Lack of clinical usefulness of the limulus test in the diagnosis of endotoxemia N Engl J Med 19 75, 2 93: 5 21- 524 Romaschin AD,...

Ngày tải lên: 14/08/2014, 07:21

... 20 03; 11 1: 12 39 - 43 Moretti ME, Caprara D, Coutinho CJ, et al Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study J Allergy Clin Immunol 20 03; 11 1: 479-4 83 Centers ... significantly lower than that given in our first study (RR =2 .39 , 95% CI 1. 433 .38 ) For the period 2002-2004 (inclusive), we identified 19 11 infants exposed to loratadine – only two had hypospadias ... http://www.sos.se/FULLTEXT /11 2/20 03 -11 23/ 2002 -11 2 -3. pdf [Internet] National Board of Health and Welfare, Centre for Epidemiology Registration of Congenital Malformations in the Swedish Health Registers...

Ngày tải lên: 31/10/2012, 17:03

... Science 19 95; 270: 18 11- 1 815 63 Choe H, et al The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV -1 isolates Cell 19 96;85 :11 35 -11 48 Int J Med Sci 2004 1( 3) : 15 2 -16 4 16 3 64 ... Tissue Int 19 91; 49 (suppl): S 11- S14 51 Epstein FH Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis N Engl J Med 19 95; 33 2(5): 30 5- 31 1 52 ... depletion EMBOJ 19 94; 13 : 11 89 -11 96 70 Nguyen L, et al Interleukin -1 stimulates bone resorption and inhibits bone formation in vivo Lymphokine Cytokine Res 19 91; 10 : 15 - 21 71 Panagakos FS, et...

Ngày tải lên: 03/11/2012, 09:54

... If yn 1 = then from (y1 , , yn 1) ∼ (2, 3, , 2, 3, 3) we get (y1 − 2)3n−2 + (y2 − 3) 3n 3 + + (yn−2 − 3) 3 − = Hence, (y1 − 2)3n−2 + (y2 − 3) 3n 3 + + (yn 3 − 2 )3 + yn−2 − = (3) (y1 − 2)3n−4 + ... 3. 25 3 and a1, a2, a3 are roots of the following system of three equations X3 = 1 (s1 ) = a1 X1 + a2 X2 + a3 X3 2 µ2 (s2 ) = a1 X1 + a2 X2 + a3 X3 3 3 (s3 ) = a1 X1 + a2 X2 + a3 X3 , where 1 ... P (Xk = 5)P (Xk +1 = 0) +P (Xk = 1) P (Xk +1 = 3) + P (Xk = 4)P (Xk +1 = 3) ] 1 10 10 10 10 = µk 1 (sk 1 )( + + + 2 2 2 2 10 10 1 10 + 5 + 5 + 5 + 5) 2 2 2 2 2 31 = 10 µk 1 (sk 1 ) Therefore, by...

Ngày tải lên: 13/02/2014, 03:20

... g w e r e c o n t r o l l e d for (only 31 msec in the "minimal inferencing" condition vs 38 5 msec in the "inferencing" condition) Many studies have, in the past, viewed s y n t a x as b e i ... a P r o c e s s in Comprehension J.V.L.V.B., 13 , 512 - 21 ACKNOWLEDGEMENTS Kimball, J 19 73 Surface Structure 2, 15 -47 The w o r k r e p o r t e d here was carried out w h i l s t in the S c h o ... L & Fodor, J.D 19 78 The Sausage Machine: A new - s t a g e P a r s i n g Model In C o g n i t i o n , 6, 2 91- 32 5 H a v i l a n d , S & Clark, H.H 19 74 What's New? Acquiring New Information as...

Ngày tải lên: 22/02/2014, 09:20

... products) Substrate G1-pNP G2-pNP G3-pNP G4-pNP G5-pNP G4-pNP G5-pNP G6-pNP G7-pNP 24 40 42 98 63 44 26 13 13 12 10 10 10 G1 G2 G3 G4 G5 36 46 34 40 G5-CNP 64 10 0 54 41 28 46 33 37 26 24 11 patterns have ... BLA Apparent binding energy value ()5 .1 kJÆmol )1) can be found at the minimum of ‘Difference’ The calculated binding energy at subsite )6 ( )12 .2 kJÆmol )1) indicates a remarkably good interaction ... from OTKA T 032 005 and FKFP-0426/2000 10 11 12 13 14 REFERENCES Phillips, D (19 66) The three-dimensional structure of an enzyme molecule Sci Am 215 , 78–90 Robyt, J.F & French, D (19 70) Multiple...

Ngày tải lên: 08/03/2014, 09:20

... crystalline structure (Fig 2B b) Since the orientation of b 111 N in Si lattice has the lowest energy, this orientation dominates the growth direction and the final extending direction of SiNW (Fig 3A) ... observed as shown in Fig 3A In addition, the asformed SiNW is easily oxidized with an oxide shell of 1 3 nm according to the Eq (2) (Fig 3A) 3. 2 Sulfide-assisted growth of SiNWs (3) Si is proffered ... C.S Lee, S.T Lee, Adv Mater 12 (2000) 13 43 [10 ] J.J Niu, J.N Wang, Chem Vap Depos 12 (2006) [11 ] J.J Niu, J Sha, X.Y Ma, J Xu, D.R Yang, Chem Phys Lett 36 7 (20 03) 528 [12 ] R.Q Zhang, T.S Chu, H.F...

Ngày tải lên: 16/03/2014, 15:09

... Press, 19 80 [Marshall 83] lan Marshall Choice of Grammatical Word-Class Without Global Syntactic Analysis: Tagging Words in the LOB Corpus Computers in the llumanities, vol 17 , pp 13 9 -15 0, 19 83 86] ... Constraints Proc of the 2nd International Workshop on Parsing Technologies, Cancun, February 19 91 Karlsson 90] Fred Karlsson Constraint rammar as a Framework for Parsing Running Text The 13 th C ... in reducing sentence-wide interpretations (leaving an easy job even for a deterministic parser), but it was not very good in individual word tagging disambiguation These two sub-goals of raging...

Ngày tải lên: 18/03/2014, 02:20

... ϕ 1 ιCpn−2 ϕpn 1 : |ρ∗n 1 T (C)Cpn 1 | → |ρ∗n−2 T (C)Cpn−2 |, p p pn−2 n 1 p C V = ϕ 1 τC pn−2 ϕpn−2 : |ρ∗n−2 T (C)Cpn−2 | → |ρ∗n 1 T (C)Cpn 1 |, p p pn 1 n 1 p and the map µ given by µ=µ ρ∗n 1 ... multiplicative section given by an = (a, 0, , 0) Lemma 3 .1. 1 pWn (R) If p is odd then V (1) ≡ −pn and −1n ≡ 1 modulo Proof By naturality, we may assume that R = Z Now, 1 w(pn + V (1) ) = p (1, + pp 1 , ... first relation follows Next, Lemmas 3 .1. 1 and 3 .1. 2 show that π eK = −p · θK (π) ≡ V (1) θK (π) = V ((θK (π))p ) (1) ≡ V (θK (π p )) = V (1) θK (π) = Vπ (1) , (1) where θK (x) denotes the image of...

Ngày tải lên: 22/03/2014, 15:21

... 9-cis-retinal Km kcat kcat/Km (lM) (min )1) (mM )1 min )1) 11 ± 1. 8 ± 0.2 16 5 ± 35 4 .1 ± 0.9 2.7 ± 0 .1 660 ± 14 5 21 ± 5a 19 0 ± 25a 8980 ± 235 0a 13 ± 17 ± 13 10 ± 215 15 ± 19 0 ± 12 800 ± 17 40 11 -cis-retinal ... (lM) (min )1) (mM )1 min )1) 15 ± 0. 31 ± 0.02 21 ± 16 ± 3. 4 ± 0 .1 215 ± 55 21 ± 18 ± 860 ± 15 5 26 ± 7.4 ± 0.5 285 ± 80 28 ± 34 ± 12 15 ± 13 5 13 -cis-retinal Km kcat kcat/Km (lM) (min )1) (mM )1 min )1) NA ... (mM )1 min )1) 11 ± 0.89 ± 0.06 81 ± 23 23 ± 3. 6 ± 0.4 16 0 ± 40 36 ± 4a 475 ± 44a 13 200 ± 2020a ± 1. 1 23 ± 2900 ± 455 21 ± 34 0 ± 15 16 100 ± 2400 11 -cis-retinol Km kcat kcat/Km (lM) (min )1) (mM )1 min )1) ...

Ngày tải lên: 23/03/2014, 12:20