scripting the delegation of active directory

Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx

Ngày tải lên : 19/02/2014, 16:20

... determine the roles of these DHSs on the transcription of Ig-b gene and on the maintenance of the active chromatin state Results Generation of DT40/Cre cells with a long deletion in one allele of the ... II (Fig 4A) demonstrated the essential role of this region in the transcription of the Ig-b gene Deletion of region III decreased the expression of Ig-b mRNA to 40% of the expression in predeletion ... autoradiogram of the Southern hybridization Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns are shown as in Fig 2A Positions of the...

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Báo cáo y học: " Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study" pdf

Ngày tải lên : 09/08/2014, 14:22

... DMARD-refractory active RA Given the selective antimastocyte mechanism of action of masitinib, the results of this study help to further establish the critical role of MCs in the pathogenesis of active ... following the reintroduction of treatment Analysis of AEs with respect to the dose of their occurrence (data not shown) showed that no clear dose-toxicity relationships exist, with the exception of ... treatment of active RA Masitinib, in contrast, is a weak inhibitor of BCR-ABL (and is also either an inactive or a weak inhibitor of other known cardiotoxic kinases such as Src and vascular endothelial...

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báo cáo khoa học: " The BLISS cluster randomised controlled trial of the effect of ''''active dissemination of information'''' on standards of care for premature babies in England (BEADI) study protocol [ISRCTN89683698]" pdf

Ngày tải lên : 11/08/2014, 05:22

... input at the planning phase of the study KJ, DD and EP helped in the concept and design of the workshop/intervention days of the study Trial randomisation was carried out by DA, FC and DE at the Medical ... three-quarters of the sample said they recalled receiving the dissemination package, and most of these reported using the slide package, finding it useful for raising awareness of the clinical issues ... changes in the care of premature babies in England Objective The main aim of this study will be to use the rigour of a randomised controlled trial in an evaluation comparing the effects of different...

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báo cáo khoa học: " The BLISS cluster randomised controlled trial of the effect of ''''active dissemination of information'''' on standards of care for premature babies in England (BEADI) study protocol [ISRCTN89683698]" pot

Ngày tải lên : 11/08/2014, 16:20

... input at the planning phase of the study KJ, DD and EP helped in the concept and design of the workshop/intervention days of the study Trial randomisation was carried out by DA, FC and DE at the Medical ... three-quarters of the sample said they recalled receiving the dissemination package, and most of these reported using the slide package, finding it useful for raising awareness of the clinical issues ... changes in the care of premature babies in England Objective The main aim of this study will be to use the rigour of a randomised controlled trial in an evaluation comparing the effects of different...

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Báo cáo y học: "The Effect of Active Warming in Prehospital Trauma Care during Road and Air Ambulance Transportation - a Clinical " pot

Ngày tải lên : 13/08/2014, 23:20

... the two groups in distribution of clothing thickness or wetness, the extent of undressing, the incidence of whole body fixation, the amount of intravenous fluids transfused or the incidence of ... interpretation of data and writing of the manuscript O H: Design of the study, aquisition of data, analysis and interpretation of data and writing of the manuscript P N: Interpretation of data and ... temperature in the field (10-12) After visual inspection of the outer ear to rule out any injuries, the sensor was gently placed in the middle of the ear canal In addition to the outer soft cell foam...

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Microfluidic methods for the crystallization of active pharmaceutical ingredients

Ngày tải lên : 09/09/2015, 11:29

... which the further growth of the cluster results in a reduction of overall free energy Such clusters then tend to grow spontaneously [22], [23] The rate of formation of these clusters - the rate of ... surface properties and the geometry of the microchannel, the presence of surfactants and the properties of the immiscible phases [120]–[123] By choosing the right combination of the aforementioned ... and the hydrodynamics in the system [72], [73] Their study suggests that beside the ratio and the relative temperatures of the two phases [72] the presence of internal circulation within the...

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Module 2: Overview of Microsoft Windows 2000 Active Directory

Ngày tải lên : 22/10/2013, 16:15

... understand the purpose and structure of Active Directory At the end of this module, you will be able to: „# Describe the role of Active Directory in Windows 2000 „# Describe the logical structure of Active ... to the purpose and structural components of the Active Directory directory service in Microsoft® Windows® 2000 At the end of this module, students will be able to: „# Describe the role of Active ... :LQGRZV#5333#6HFXULW\#6XEV\VWHP What is the role of Active Directory in Windows 2000? Active Directory is the directory service for Windows 2000 Active Directory stores all of the objects that make up a Windows...

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A three phase voltage type PWM rectifier with the function of an active power filter

Ngày tải lên : 03/01/2014, 19:44

... represents the sine term of the n -th harmonic component of i,, Though the AC components are also contained in the output signal of the integrator, they can be made small by the integral action of the ... part D, ofFig This part represents the harmonic detector for phase U in Fig The upper part of D, detects the sine term of the n -th harmonic component of the U- phase load current il, , and the lower ... of PWM Signals respect to Using the PWM signals S, , S, and S , , the six s of the PWM rectifier areswitched switches s, on and off in the following manner to generate the PWh4 waveforms of the...

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Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

Ngày tải lên : 16/02/2014, 09:20

... molecules of the asymmetric unit of the wild-type structure Neither the mutation nor the different crystallization conditions evoked structural differences The crystal was grown in the presence of phytate, ... well The hydrogen bond between the backbone nitrogen atom of Asp291 and the 3phosphate of the substrate is the only interaction with the protein backbone; all other contacts are formed using the ... Although phytate is the natural substrate of PhyK, we not observe phytate binding at the active site Instead, there is electron density for three sulfate ions at the active sites of the four protein...

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Tài liệu Báo cáo khoa học: Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase Investigations of the putative catalytic glutamate–arginine pair and of residues responsible for substrate speciﬁcity docx

Ngày tải lên : 19/02/2014, 02:20

... the binding of the feedback inhibitor dTTP and the position of Mg2+ in the active site Mg ion that coordinates the phosphates of dTTP (Fig 3) Discussion Mutation of residues in the active site ... for the chemotherapeutic treatment of cancer and viral diseases because they catalyse the addition of the ﬁrst phosphate group to the nucleoside analogue This primes the nucleoside for further ... not show any activity must therefore be a consequence of the reactivity of the functional group and further support the hypothesis that E52 acts as an initiating base in the reaction R105 mutations...

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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

Ngày tải lên : 19/02/2014, 12:20

... and 235 [9] Of theses residues, only Arg213 is in the vicinity of the active site of RTA In order to establish the role of arginyl residues around the active site of RTA in the binding of rRNA, ... C1 of the hexanucleotide is at the bottom left and the target adenine is at the top of each model The sidechains of RTA are shown in blue (A) Model has the tetraloop bound in the active site of ... and, as such, these mutants could not be puriﬁed To assess the effect of substitutions made at each of the arginyl residues on catalytic activity of RTA, the ability of each of the puriﬁed RTA...

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Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx

Ngày tải lên : 21/02/2014, 15:20

... differences in the C-terminal part of the enzyme (Fig 2A) where 13 of 44 amino acids are different Therefore, chimeric enzymes with the N-terminal part from the human and the C-terminal part from the murine ... were constructed by use of the EcoRV and SacI sites in the cDNA and were then used to transform 293-cells The region responsible for the different degree of association of the human and murine enzyme ... about one tenth of the speciﬁc activity of the oligomeric complex [15] For the recombinant human enzyme the nonassociated form also appeared to be dimers of the 138 kDa subunit, since their Mr was...

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Tài liệu Báo cáo Y học: Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis docx

Ngày tải lên : 22/02/2014, 04:20

... hevamine, the oxygen atom of the N-acetyl group of the )1 sugar is positioned close to the C1 atom of the )1 sugar, and is hydrogen bonded to Tyr183 Asp125 makes a hydrogen bond to the nitrogen atom of ... judged by SDS/ PAGE The activity of the pure recombinant protein was 80% of that of the wild-type protein in both the lysozyme and chitinase assays Attempts to further purify the recombinant hevamine ... colloidal chitin than with the pentasaccharide Evidently, the interaction between colloidal chitin and the enzyme inﬂuences the active site properties The cause of these differences is not known...

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Báo cáo khóa học: Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase docx

Ngày tải lên : 07/03/2014, 14:20

... positioned in the ÔupÕ position rows and shows that in the presence of the substrate, rotation of Asp142 towards Glu144 lowers the pKa of the latter by 0.8 pH units The calculated effects of the D140N ... for the position of residue 142 [34] The pKa calculations indicate that the only candidate for a residue determining the basic arm of the pH-activity proﬁle of the D142N mutant is Glu144 The ... these residues are not described well and there is no example of mutational analysis of all of these residues in the same enzyme To obtain an insight into how the many conserved residues in the...

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Báo cáo khoa học: The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase pptx

Ngày tải lên : 07/03/2014, 17:20

... demonstrating the considerable stringency at the active site of mR1 with respect to catalytic activity On the other hand, our results show that l-ADP binds to the active site and l-ATP binds to both the ... Lineweaver–Burke plot of L-ADP inhibition of dGTP-dependent D-ADP reductase in the presence of mM D-ATP (B) Secondary plot of the slope values of A (C) LineweaverBurk plot of L-ADP inhibition of dGTP-dependent ... higher than the apparent Km for d-ADP of 91 lm (Fig 6A,B) As above, this probably reﬂects retention of the base and especially b-phosphate interactions at the active site and loss of the speciﬁc...

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A Concise History and Directory of the City of Norwich for 1811 pptx

Ngày tải lên : 08/03/2014, 00:20

... Alfred the Great, about the year 872; another in the early part of the reign of Athelstan about the year 925, and several others; besides three coins minted here of Ethelred, called the Unready, of ... enumeration of all the places of worship, belonging to the various congregations of Anabaptists, Methodists, &c of which there are many, chiefly in the northern part of the city The Excise-office, ... ornamented dome, and the effect of the whole, is remarkably striking The first stone of the Building was laid, by the celebrated Dr Taylor, on the 25th of February, 1754 The expence of the building which...

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Báo cáo khoa học: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus – the role of conserved residues in the active site pdf

Ngày tải lên : 15/03/2014, 11:20

... that these residues stabilize the distortion of the NAG3 residue In these interactions, we particularly focused on the Trp664 residue, which is located at the bottom of the active site cleft The ... conformational changes, but of the removal of negative charge at these residues Conformation of chito-oligosaccharides bound to the active site cleft For the structural determination of the AD2–substrate ... Stereo ﬁgures of the model of the bound substrate in the AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars and the side-chains of three acidic residues in the conserved...

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Báo cáo khoa học: Carbohydrate binding sites in Candida albicans exo-b-1,3-glucanase and the role of the Phe-Phe ‘clamp’ at the active site entrance ppt

Ngày tải lên : 15/03/2014, 23:20

... seen for the Phe triad in the structure of the mutant Exg:L3 complex Neither of the two sugar residues interacting with the Trp triad overlaps with the sugar seen in the Phe-Phe clamp of Exg Structural ... glucose of the bglucan substrate in the )1 subsite at the bottom of the active site pocket [20] The entrance to the active site pocket of Exg is ﬂanked by a pair of phenylalanyl residues, Phe144 ... solved the crystal structure of this GH5 enzyme in the presence of two different mechanismbased inhibitors, thereby revealing the close network of interactions that hold the terminal glucose of the...

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Báo cáo khoa học: Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site pot

Ngày tải lên : 16/03/2014, 18:20

... then participate in the reductase reaction The reverse of the isomerase reaction is thermodynamically favoured by the near irreversibility of the conversion of the 2-ketoacid to TS2 However the ... with the active site constructed from two monomers of a dodecamer In contrast, the active site of spinach KARI is wholly contained within each monomer of a tetramer Despite these differences, the ... were revealed when the crystal structure of the spinach enzyme was determined, ﬁrst in the presence of the inhibitor IpOHA [8] and later with product bound in the active site [9] There are several...

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Báo cáo Y học: The role of hydrophobic active-site residues in substrate speciﬁcity and acyl transfer activity of penicillin acylase pdf

Ngày tải lên : 17/03/2014, 23:20

... located ˚ at the bottom of the binding pocket at A from the nucleophilic serine, does influence the rate of formation of the acyl-enzyme, as judged by the effect of the mutations on the activity, ... removal of a phenyl group in the hydrophobic binding pocket leads to a reduced affinity for the phenyl group of the substrate The reduced affinity of the mutants for the phenyl moiety of the substrate ... formation of semisynthetic b-lactam antibiotics The X-ray structure of the complex of PA with PAA shows that the acyl binding site of PA is made up of several hydrophobic residues from the a and the...

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