sarcomas of soft tissue and bone

... Soft tissues include muscles, tendons, fat, fibrous tissue, synovial tissue, vessels, and nerves Approximately 60% of soft tissue sarcomas arise in the extremities, ... associated with the development of osteosarcoma in those who survive the retinoblastoma and of soft tissue sarcomas unrelated to radiation therapy Other soft tissue tumors, including desmoid ... new cases of soft tissue sarcomas occurred in the United States in 2007 The annual age-adjusted incidence is 3.0 per 100,000 population, but the incidence varies with age Soft tissue sarcomas...

Ngày tải lên: 07/07/2014, 02:20

... and subcutaneous tissue Rhabdomyosarcomas, Ewing's sarcoma, and other small-cell sarcomas tend to be more aggressive and are more responsive to chemotherapy than other soft tissue sarcomas Gastrointestinal ... leiomyosarcomas, are now recognized as a distinct entity within soft tissue sarcomas Its cell of origin resembles the interstitial cell of Cajal, which controls peristalsis The majority of malignant ... alveolar soft part sarcoma Radiographic Evaluation Imaging of the primary tumor is best with plain radiographs and MRI for tumors of the extremities or head and neck and by CT for tumors of the...

Ngày tải lên: 07/07/2014, 02:20

... modalities Surgery Soft tissue sarcomas tend to grow along fascial planes, with the surrounding soft tissues compressed to form a pseudocapsule that gives the sarcoma the appearance of a well-encapsulated ... leiomyosarcomas Dacarbazine also has some modest activity Taxanes have selective activity in angiosarcomas, and vincristine, etoposide, and irinotecan are effective in rhadomyosarcomas and Ewing's sarcomas ... time-consuming, and less expensive Adjuvant Chemotherapy Chemotherapy is the mainstay of treatment for Ewing's primitive neuroectodermal tumors (PNET) and rhabdomyosarcomas Meta-analysis of 14 randomized...

Ngày tải lên: 07/07/2014, 02:20

... confined to the same soft tissue compartment as the initial tumor), and tumors designated B are extracompartmental (i.e., extending into the adjacent soft tissue compartment or into bone) The tumor ... desmoplastic fibroma, of fibrous tissue origin; hemangioma, of vascular origin; and giant cell tumor, of unknown origin Malignant Tumors The most common malignant tumors of bone are plasma cell ... common benign bone tumors include enchondroma, osteochondroma, chondroblastoma, and chondromyxoid fibroma, of cartilage origin; osteoid osteoma and osteoblastoma, of bone origin; fibroma and desmoplastic...

Ngày tải lên: 07/07/2014, 02:20

... appearance), and a cuff of periosteal new bone formation at the margin of the soft tissue mass (Codman's triangle) A CT scan of the primary tumor is best for defining bone destruction and the pattern of ... 45% of all bone sarcomas, is a spindle cell neoplasm that produces osteoid (unmineralized bone) or bone About 60% of all osteosarcomas occur in children and adolescents in the second decade of ... intramedullary and soft tissue extension A chest radiograph and CT scan are used to detect lung metastases Metastases to the bony skeleton should be imaged by a bone scan Almost all osteosarcomas are...

Ngày tải lên: 07/07/2014, 02:20

... Metastatic to Bone Bone is a common site of metastasis for carcinomas of the prostate, breast, lung, kidney, bladder, and thyroid and for lymphomas and sarcomas Prostate, breast, and lung primaries ... account for 80% of all bone metastases Metastatic tumors of bone are more common than primary bone tumors Tumors usually spread to bone hematogenously, but local invasion from soft tissue masses ... Ewing's sarcoma (and other members of a family of tumors called PNETs) Most PNETs arise in soft tissues; they include peripheral neuroepithelioma, Askin's tumor (chest wall), and esthesioneuroblastoma...

Ngày tải lên: 07/07/2014, 02:20

... in 300 adults with soft tissue sarcomas Cancer 47:2391, 1981 [PMID: 7272893] NIH Consensus Development Panel on Limb Sparing Treatment of Adult Soft Tissue Sarcomas and Osteosarcomas JAMA 254:1791, ... Readings Borden EC et al: Soft tissue sarcomas of adults: State of the translational science Clin Cancer Res 9:1941, 2003 [PMID: 12796356] Helman LJ, Meltzer P: Mechanisms of sarcoma development ... may relieve pain and inhibit bone resorption, thereby maintaining bone mineral density and reducing risk of fractures in patients with osteolytic metastases from breast cancer and multiple myeloma...

Ngày tải lên: 07/07/2014, 02:20

... Karen H: Sarcoma of Soft Tissue and Bone Cancer 1991, 68:463-473 Brennan M, Singer S, Maki R, O’Sullivan B: Sarcomas of the soft tissues and bone In Cancer: Principles and Practice of Oncology Edited ... Recurrence-free Survival of Two Main Types of Soft Tissue Sarcoma The probability of survival along y- axis is plotted as function of time in months along x-axis for major sub-types of soft tissue sarcoma ... experience of sarcoma of soft tissues and bones in a tertiary care hospital and review of literature World Journal of Surgical Oncology 2011 9:51 Submit your next manuscript to BioMed Central and take...

Ngày tải lên: 09/08/2014, 01:24

... presence of factors that affect local vascularity to the soft tissues [8,13] Skin vascularity over the knee affects the rate of healing postoperatively and the risk of necrosis Since the beginning of ... the coverage of soft tissue defects following total knee arthroplasty, grade and according to Laing classification and more than cm width (including debridement tissues at the margins of the wound) ... was the top of the “iceberg” with a larger amount of necrosed tissue underneath the skin and subsequent larger amount of tissue to be removed with debridement Preoperative drawing of unilateral...

Ngày tải lên: 20/06/2014, 04:20

... presence of factors that affect local vascularity to the soft tissues [8,13] Skin vascularity over the knee affects the rate of healing postoperatively and the risk of necrosis Since the beginning of ... the coverage of soft tissue defects following total knee arthroplasty, grade and according to Laing classification and more than cm width (including debridement tissues at the margins of the wound) ... was the top of the “iceberg” with a larger amount of necrosed tissue underneath the skin and subsequent larger amount of tissue to be removed with debridement Preoperative drawing of unilateral...

Ngày tải lên: 20/06/2014, 07:20

... mouse and rat thymus A very similar capacity to interact and support the maturation of some population of lymphocytes and monocytes was noted for FSCs of bone marrow [5,7] and for FSCs of synovial ... RA-NLCs from both bone marrow and synovial tissue produced detectable levels of IL-6, IL-8, and granulocyte/macrophage colony-stimulating factor (GM-CSF), and the production of IL-6 and IL-8 was quite ... expression of CD35 or CD154 The surface phenotype of RA-NLCs was therefore similar to that of FSCs derived from synovial tissue and bone marrow cells from non-RA controls Namely, the phenotype of NLCs...

Ngày tải lên: 09/08/2014, 08:23

... the use of computers and software solutions to aid doctors in the analysis, diagnosis and treatment of various ailments and conditions Often, this aid comes in the form of digital imagery of various ... 65 Plot of the degree of match of a registered contour of the liver with the ground truth The average error is 2.211 65 5.10 Plot of the degree of match of a registered ... based on changes in texture will not work well because of the uniformity of the texture of soft tissue, as discussed in Sections 2.1.5 and 2.1.6 2.1.3 Region-based Segmentation Region based segmentation...

Ngày tải lên: 30/09/2015, 14:24

... of Orthopaedic Surgery and Research 2008, 3:36 The limb (and thus the)virtual cylinder is composed of soft tissue (mainly muscles and skin) and "hard" tissue (bone and bone marrow) The soft tissue ... delivery of nutrients and oxygen through blood flow to bone tissue [21] Interruption of normal bone and soft tissue blood flow has been shown to be responsible for the development of severe and common ... scintigraphic readings) Bone volumes, including the bone marrow (VB), were derived from the CT scan using an in-house software that performs segmentation of the bone and soft tissue for each CT slice,...

Ngày tải lên: 20/06/2014, 01:20

... management and outcome of treatment for soft tissue sarcomas Ann Oncol 2004, 15(2):307-315 Rydholm A: Centralization of soft tissue sarcoma The southern Sweden experience Acta Orthop Scand Suppl ... Thomas JM: Soft- tissue sarcomas in adults N Engl J Med 2005, 353(7):701-711 Lewis JJ, Leung D, Woodruff JM, Brennan MF: Retroperitoneal soft- tissue sarcoma: analysis of 500 patients treated and followed ... 73 primary and 28 recurrent sarcomas for a total of 101 contacts Sixty-five of 73 (89%) primary sarcomas had surgery, and 22 of 28 (79%) patients with recurrent disease were Page of considered...

Ngày tải lên: 09/08/2014, 03:22

... A case of SchwanSchwannoma of median nerve at palm:cross sectional area of Schwannoma of median nerve at palm: A case of Schwannoma: the picture shows an increased cross sectional area of median ... syndrome due to an atypical deep soft tissue leiomyoma: The risk of misdiagnosis and mismanagement World J Surg Oncol 2007, 5:92 Martinoli C, Bianchi S, Derchi LE: Tendon and nerve sonography Radiol ... contributions GGliterature review and preparation of draft manuscript MC, PC, and CPhelped in preparation of manuscript LPhelped in preparing the draft manuscript and edited the final version References...

Ngày tải lên: 09/08/2014, 07:21

... tumors account for 0.03% of all neoplasms [13,14], and 3.0% of all soft tissue tumors [15,16] Patients with familial adenomatous polyposis (FAP) have a 1000-fold increased risk of developing desmoid ... met the criteria of both Warren [28] and Ewing [29] for post-traumatic neoplasm http://www.wjso.com/content/6/1/28 Conclusion The cause -and- effect issue of desmoid or other soft tissue tumors goes ... tumor at the site of a previous rib fracture Traumatic injury has been implicated as a causative factor in the genesis of other soft tissues as well Radhi et al., [6] reported cases of diffuse centroblastic...

Ngày tải lên: 09/08/2014, 07:21

... lymphoma and primary CNS lymphoma [6] The incidence of NHL in HIV patients is 3% and lesions are usually high grade and extra nodal [4,5] Extranodal NHL of soft tissues is a rare disease and is ... appeared clean and regular in the absence of any evidence of infiltration, bone lesions and bone marrow involvement (Figure 1B) At the end of August she underwent a surgical excision of the lesion ... secondary lymphoma of bone: a case report with review of the literature Am J Orthop 1998, 27(2):128-34 Tehranzadeh J, O'Malley P, Rafii M: The spectrum of osteoarticular and soft tissue changes in...

Ngày tải lên: 09/08/2014, 07:21

... culture-positive cases of SA of the glenohumeral joint between 1986 and 2000, and 52% had a different primary site of infection identified, 70% of which were S aureuspositive and 17% of which were methicillin-resistant ... various models of arthritis and their respective degrading actions on collagen type I, II, and III and proteoglycan, which are important constituents of connective tissues and cartilage of the joints ... management of skin, soft tissue, and osteoarticular infections in children Curr Opin Pediatr 2006, 18:254-259 Roberts S, Chambers S: Diagnosis and management of Staphylococcus aureus infections of the...

Ngày tải lên: 09/08/2014, 08:23

... treatment of soft- tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant ... Eisenberg B: Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy ... Steinberg SM, Merino MJ, Rosenberg SA: Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity J Clin Oncol 1998, 16:197-203...

Ngày tải lên: 09/08/2014, 09:20

... radiotherapy for the treatment of soft tissue sarcomas of central anatomical sites Radiat Oncol Invest 1995, 3:30-96 Calvo FA, Azinovic I, Martinez R, Monge R: IORT in soft tissue sarcomas: 10 years experience ... Conclusion Our data and those taken from the literature show that soft- tissue sarcomas can be reasonably and successfully treated by radical surgery and a combination of brachytherapy IORT and EBRT However, ... majority of cases IORT is prescribed for gastric, pancreatic, bile duct and rectal cancers as well as for soft- tissue and bone sarcomas The total dose applied by IORT varies between 10 and 25 Gy...

Ngày tải lên: 09/08/2014, 10:20