sarco endoplasmic reticulum golgi apparatus

... inhibition of the endoplasmic reticulum Ca2(+)-ATPase Proc Natl Acad Sci USA 87, 2466–2470 43 Palmer AE, Jin C, Reed JC & Tsien RY (2004) Bcl-2mediated alterations in endoplasmic reticulum Ca2+ ... Bcl-2 increases the permeability of the S ⁄ ER to Ca2+ [38] through its interaction with sarco ⁄ endoplasmic reticulum calcium ATPase (SERCA), which is responsible for pumping Ca2+ from the cytosol ... Schoneich C (2004) Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic ⁄ endoplasmic reticulum Ca2+-ATPase (SERCA) Biochem J 383, 361–370 40 Gordon PB, Holen I, Fosse...

Ngày tải lên: 07/03/2014, 09:20

... stimuli [11,12] Both isoforms have been shown to localize at the nuclear envelope and in the endoplasmic reticulum (ER) of endothelial cells [13] In addition, immunoelectron microscopy studies demonstrated ... periphery and structures within the cytosol, sites presumed to be the nuclear envelope, ER and Golgi apparatus These include studies on rat mast cells [15], Chinese hamster ovary cells [16,17], ... cPLA2-a relocates to intracellular membrane compartments that are distinct from the ER and the Golgi apparatus More importantly, we demonstrate that, at this specific site, cPLA2-a colocalizes with...

Ngày tải lên: 16/03/2014, 18:20

... nucleus) and karyoplasts, containing the nucleus, the Golgi apparatus and the REs [48] Cytoplasts generated in this manner lack a Golgi apparatus, and importantly, cannot regenerate one [47] ... D, Stow JL, Goud B & Gleeson PA (2007) The trans -Golgi network golgin, GCC185, is required for endosome-to -Golgi transport and maintenance of Golgi structure Traffic 8, 758–773 34 Amessou M, Fradagrada ... endogenous protein TGN38, which cycles between Golgi and plasma membrane via REs [31,32] Unlike TGN38, traffic of StxB from endosomes to Golgi is dependent upon the Golgin, GCC185 [31,33–35] Here we examine...

Ngày tải lên: 16/03/2014, 04:20

... co localize with Golgi markers golgin 97 (Figure 1D, E, and 1F, 5-hour sample shown) and BODIPY-ceramide (Figure 1G, H, and 1I, hour sample shown) The golgins in general are Golgi- localized proteins, ... might traffic from the plasma membrane to the endoplasmic reticulum; one involving transport through the Golgi, and the other not involving the Golgi Page of (page number not for citation purposes) ... not with the more stringent Golgi markers, golgin 97 (D, E, F, 5SV40 co localizes with β-COP (A, B, C, 3-hour sample), but not with the more stringent Golgi markers, golgin 97 (D, E, F, 5hour sample)...

Ngày tải lên: 20/06/2014, 04:20

... Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death J Lipid Res 47, 2726–2737 10 Wang D, Wei Y & Pagliassotti MJ (2006) Saturated fatty acids promote endoplasmic reticulum ... (2007) Signal integration in the endoplasmic reticulum unfolded protein response Nat Rev Mol Cell Biol 8, 519–529 530 37 Zhang K & Kaufman RJ (2008) From endoplasmicreticulum stress to the inflammatory ... 2278–2284 13 Wei Y, Wang D, Topczewski F & Pagliassotti MJ (2006) Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells Am J Physiol Endocrinol...

Ngày tải lên: 14/02/2014, 22:20

... Kujawa M & DeMartino GN (2006) Valosin- 1218 12 13 containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway ... (2006) The role of a novel p97 ⁄ valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum- associated degradation J Biol Chem 281, 35359–35368 Nagahama M, Suzuki M, Hamada ... motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum Proc Natl Acad Sci USA 98, 14422–14427 17 Zhong X, Shen Y, Ballar P, Apostolou A,...

Ngày tải lên: 18/02/2014, 13:20

... targeted to the IMM, whereas the leaderless ABC transporter is exclusively inserted into endoplasmic reticulum (ER) membrane Despite these presequence-dependent trafficking routes, the membrane ... leaderless MDL1 is detected in tubulo-vesicular membranes belonging to or deriving from the endoplasmic reticulum M, mitochondria; N, nucleus; V, vacuole conflicting results We therefore set out ... & Sakaguchi M (2005) Switching the sorting mode of membrane proteins from cotranslational endoplasmic reticulum targeting to posttranslational mitochondrial import Mol Biol Cell 16, 1788–1799...

Ngày tải lên: 18/02/2014, 16:20

... intracellular organelles [9] and is involved in the trafficking of integral membrane proteins from the Golgi apparatus This function is inhibited by a phospholipase D inhibitor although overexpressed phospholipase ... immunocytochemistry Extensive colocalization with protein disulfide isomerase hints at a localization in the endoplasmic reticulum (Fig 6) although an obvious retrieval signal is missing The human phospholipases ... inherits seven putative glycosylation sites which could only be glycosylated if it enters the endoplasmic reticulum The N-terminal 38 amino acid residues lack consensus sites for N-glycosylation (Fig...

Ngày tải lên: 19/02/2014, 17:20

... procaspase-8-associated protein in the endoplasmic reticulum J Cell Biol 139, 327–338 Annaert, W.G., Becker, B., Kistner, U., Reth, M & Jahn, R (1997) Export of cellubrevin from the endoplasmic reticulum is controlled ... G.C (2002) The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum Proc Natl Acad Sci USA 99, 4331–4336 Nguyen, M., Breckenridge, D.G., Ducret, A & ... Ng, F.W & Shore, G.C (1998) Bcl-XL cooperatively associates with the Bap31 complex in the endoplasmic reticulum, dependent on procaspase-8 and Ced-4 adaptor J Biol Chem 273, 327–338 19 Polevoda,...

Ngày tải lên: 20/02/2014, 23:20

... (proSP-C)] are associated with interstitial lung disease (ILD), misfolding of proSP-C in the endoplasmic reticulum (ER), cellular toxicity, and reduced levels of mature SP-C in the alveoli [7–11] ... & Beers MF (2005) A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase activation Am J Respir Cell Mol Biol ... associated with familial British and Danish dementia, in chondromodulin, associated with chondrosarcoma, and in proSP-C [12] These proteins are all made as transmembrane precursors that are processed...

Ngày tải lên: 07/03/2014, 05:20

... reconstituted from purified components of the endoplasmic reticulum membrane Cell 75, 615–630 Simon SM & Blobel G (1991) A protein-conducting channel in the endoplasmic reticulum Cell 65, 371– 380 Crowley ... the manuscript References Rapoport TA (2007) Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes Nature 450, 663–669 van den Berg B, Clemons WM Jr, ... Liao SR, Worrell VE, Reinhart GD & Johnson AE (1994) Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore Cell 78, 461–471 Crowley KS, Reinhart GD & Johnson...

Ngày tải lên: 07/03/2014, 06:20

... localization to the endoplasmic reticulum RNA 14, 445–453 Marquardt T, Hebert DN & Helenius A (1993) Posttranslational folding of influenza hemagglutinin in isolated endoplasmic reticulum- derived ... into the yeast endoplasmic reticulum Proc Natl Acad Sci USA 92, 9643–9646 50 Molinari M & Helenius A (2000) Chaperone selection during glycoprotein translocation into the endoplasmic reticulum Science ... chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum Nature 370, 373–375 Randow F & Seed B (2001) Endoplasmic reticulum chaperone gp96 is required for innate immunity...

Ngày tải lên: 07/03/2014, 06:20

... indicated that glycoproteins have moved from the ER compartment to at least the medial Golgi apparatus and trans -Golgi apparatus, where complex sugars are added Analysis of CD4–TMD ⁄ CT protein on SDS ... di-lysine endoplasmic reticulum retention motifs Science 263, 1629–1631 Teasdale RD & Jackson MR (1996) Signal-mediated sorting of membrane proteins between the endoplasmic 1070 15 16 17 reticulum ... 15 16 17 reticulum and the Golgi apparatus Annu Rev Cell Dev Biol 12, 27–54 Zarei MM, Eghbali M, Alioua A, Song M, Knaus HG, Stefani E & Toro L (2004) An endoplasmic reticulum trafficking signal...

Ngày tải lên: 07/03/2014, 16:20

... degradation Fagioli C & Sitia R (2001) Glycoprotein quality control in the endoplasmic reticulum Mannose trimming by endoplasmic reticulum mannosidase I times the proteasomal degradation of unassembled ... the Golgi apparatus [14] This enzyme initiates the phosphorylation of mannose in the N-linked oligosaccharide side chains of lysosomal enzymes, yielding mannose-6-phosphate (M6P) In the trans -Golgi ... Biol Chem 274, 5861– 5867 Cabral CM, Choudhury P, Liu Y & Sifers RN (2000) Processing by endoplasmic reticulum mannosidases partitions a secretion-impaired glycoprotein into distinct disposal...

Ngày tải lên: 07/03/2014, 17:20

... unfolded proteins in the endoplasmic reticulum Cell 101, 451–454 Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG & Ron D (2002) IRE1 couples endoplasmic reticulum load to secretory ... site by the endoplasmic reticulum stress response J Biol Chem 275, 27013–27020 41 Yoshida H, Haze K, Yanagi H, Yura T & Mori K (1998) Identification of the cis-acting endoplasmic reticulum stress ... required for endoplasmic reticulum degradation in yeast EMBO J 15, 753–763 66 Gardner RG, Swarbrick GM, Bays NW, Cronin SR, Wilhovsky S, Seelig L, Kim C & Hampton RY (2000) Endoplasmic reticulum...

Ngày tải lên: 07/03/2014, 21:20

... symptoms ASA deficiency is frequently caused by missense mutations, which cause misfolding and endoplasmic reticulumassociated degradation (ERAD) of the respective ASAs [7] Because the pd allele is ... mutations as a cause of metachromatic leukodystrophy Degradation of arylsulfatase A in the endoplasmic reticulum Febs J 272, 1179–1188 Hess B, Saftig P, Hartmann D, Coenen R, LullmannRauch R, Goebel ... pathway Science 286, 1882–1888 10 Helenius A & Aebi M (2004) Roles of N-linked glycans in the endoplasmic reticulum Annu Rev Biochem 73, 1019–1049 11 Ritter C & Helenius A (2000) Recognition of local...

Ngày tải lên: 15/03/2014, 23:20

... regulates a subset of endoplasmic reticulum- resident chaperone genes in the unfolded protein response Mol Cell Biol 23, 7448–7459 21 Hollien J & Weissman JS (2006) Decay of endoplasmic reticulum- localized ... Tripartite management of unfolded proteins in the endoplasmic reticulum Cell 101, 451–454 Patil C & Water P (2001) Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein ... the endoplasmic reticulum into the cytosol Nat Rev Mol Cell Biol 3, 246–255 Sommer T & Jentsch S (1993) A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum...

Ngày tải lên: 16/03/2014, 11:20

... activity) and a Golgi marker (Golgi Ó FEBS 2003 a-mannosidase II activity) across the gradient indicated that fractions containing sufficiently pure ER, in terms of its separation from Golgi, were ... the Golgi complex by the action of Golgi a1,2-mannosidases, because the present results showed that only the 30-kDa form was present in the ER extract and the 27-kDa form was detected in the Golgi ... assembled elementary unit from ER to Golgi A vast flow of elementary units containing H–L dimers and fhx/P25 into Golgi may result in conditions where molecular numbers of Golgi a1,2mannosidases become...

Ngày tải lên: 16/03/2014, 16:20

... and endoplasmic reticulum quality control Biochimie 83, 757–762 Verbert, A & Cacan, R (1999) Trafficking of oligomannosides released during N-glycosylation: a clearing mechanism of the rough endoplasmic ... for 40 in 0.175 mM Glc, labeled for h, and chased in the culture medium (5 mM Ó FEBS 2003 Endoplasmic reticulum- associated degradation (Eur J Biochem 271) 401 Fig Reglucosylation of Man5GlcNAc2 ... glycoproteins, as demonstrated for ribophorin I [26] and unstable glycoproteins [6] Ó FEBS 2003 Endoplasmic reticulum- associated degradation (Eur J Biochem 271) 403 Fig Pattern of oligomannosides released...

Ngày tải lên: 16/03/2014, 16:20

... transport across the endoplasmic reticulum membrane FEBS J 275, 4471– 4478 Ng DTW, Brown JD & Walter P (1996) Signal sequences specify the targeting route to the endoplasmic reticulum J Cell Biol ... insertion into the endoplasmic reticulum membrane J Biol Chem 275, 6207–6213 Hegde RS, Voigt S & Lingappa VR (1998) Regulation of protein topology by trans-acting factors at the endoplasmic reticulum ... DA & Schekman R (1991) Assembly of yeast SEC proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex Nature 349, 806–808 18 Becker J, Walter...

Ngày tải lên: 22/03/2014, 15:21