safety of nanoparticles in medicine

... methods in a single nanoparticle probe one can drastically improve the multiplexing capabilities of protein probes The group of Prof Mirkin has designed a sophisticated multifunctional Page of (page ... that nanoparticles exist in the same size domain as proteins makes nanomaterials suitable for bio tagging or labelling However, size is just one of many characteristics of nanoparticles that itself ... Alternative cylindrically shaped nanoparticles can be created by employing metal electrodeposition into nanoporous alumina template [30] Depending on the properties of the template, nanocylinder radius...

Ngày tải lên: 11/08/2014, 00:22

Ngày tải lên: 08/03/2014, 14:20

... reconstruction of solid constituents of the human body Considering the huge value of the numerical density of nanosized domains contained in microheterogeneous systems, in principle, a relevant number of ... enhancement of correlation times of the solute molecules signiWcant change of the intrinsic reactivity of the solubilized species14 re-organization of Wnite amounts of solute in nanoscopic domains leading ... water involves an increase of the interlamellar distance, being water localized in the hydrophilic domain As the width of this domain increases, it becomes more and more easy to break the ‘‘inWnite’’...

Ngày tải lên: 04/06/2014, 15:18

... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman ... presynaptic dopamine autoreceptor agonists (in spite of being efficacious in the treatment of psychosis) might potentially increase the risk for exacerbation of psychosis through stimulation of postsynaptic ... aripiprazole had an increase in bodyweight of more than 7% versus five in the placebo group Only 4% in the aripiprazole group had high prolactin levels at endpoint in comparison to 11% in the placebo...

Ngày tải lên: 08/08/2014, 23:21

... according to whether the reason for discontinuation of the prior TNF antagonist had been lack of response, loss of response, or intolerance Analyses pertaining to the reason for discontinuation included ... experienced clinically important improvements in their diseases after 12 weeks of adalimumab therapy during these two large, open-label clinical studies The safety profile of adalimumab was similar in patients ... Crohn disease in Europe, Canada, the United States, and other world regions [17] In two open-label clinical studies, we investigated the effectiveness and safety of adalimumab in treating patients...

Ngày tải lên: 12/08/2014, 14:22

... discontinuations for AEs most often occurred during the first 26 weeks of treatment Our study confirmed that infections are the most common type of AE in RA patients receiving the combination of infliximab ... infliximab, if indicated, without increasing the chance for discontinuation or occurrence of an AE, including infections The results also suggest that corticosteroids not prevent infliximab-induced ... prevent one of the outcomes defining a SAE An IR was defined as any AE that occurred during an infusion, within one hour after an infusion, or was considered by the investigator to be infusion-related...

Ngày tải lên: 12/08/2014, 14:22

... Spirometry training was given prior to initiating the study and a repeat training session was given during the initiation visit Spot checks on the calibration of spirometers were conducted during the ... exacerbation of COPD was defined as a complex of respiratory events/symptoms with duration of or more days (from patient's diary card) requiring a change in treatment (including patient-initiated increases) ... end of the 12-week treatment period Trough FEV1 response was defined as the change from baseline at the end of the 24-hour dosing interval (i.e 10 minutes prior to drug administration) Baseline...

Ngày tải lên: 12/08/2014, 15:20

... up-titration of the initial remifentanil µg/kg per hour infusion in 1.5 µg/kg per hour increments (at intervals) was permitted if clinically indicated Assessment of the offset of the effects of remifentanil ... within 12 hours before the start of remifentanil administration, together with measurement of plasma and urinary creatinine concentration, using the following equation: CLcr (ml/min) = [Cr]urine ... pharmacodynamic and safety profiles of remifentanil administered by continuous intravenous infusion for up to 72 hours in ICU patients with varying degrees of renal impairment The study was conducted in accordance...

Ngày tải lên: 12/08/2014, 20:20

... of treatment to prevent secondary brain insult [19,20], arresting bleeding and maintaining hemodynamic stability are of even greater importance in hemodynamically unstable patients with TBI In ... Marwaha N, Singh D, Varma N, Mathuriya SN: Change in tissue thromboplastin content of brain following trauma Neurol India 2005, 53:178-182 Stein SC, Smith DH: Coagulopathy in traumatic brain injury ... rFVIIa in such injuries, due to the release of tissue factor (TF) in the brain and the prevalence of consumption coagulopathy or disseminated intravascular coagulation in brain injuries [34,35]...

Ngày tải lên: 13/08/2014, 08:20

... result of anthropogenic activities, runoff, weathering, and abrasion, is of growing concern [2] ENPs are stabilized in environmental waters containing electrolytes because of their surface coating ... cytochromes may result in ROS generation Surface adsorption of NOM and polysaccharides in the medium as well as of proteins in living cells inevitably occurs upon introduction of ENPs [2] Ambient ... that was employed to investigate the role of combinatorial environmental factors in the behavior and fate of zinc oxide (ZnO) NPs in aqueous systems The effects of six covarying environmental factors,...

Ngày tải lên: 09/09/2015, 08:18

... treatments because of combinations of medical comorbidity, slow or inadequate anxiety relief, intolerable side effects, and drugdrug interactions.15–22 Pregabalin—a novel medicine approved in Europe for ... characterized by highaffinity binding to the α2-δ subunit protein of voltagegated calcium channels.23 Pregabalin has a predictable, linear pharmacokinetic profile across its dosing range, and it is ... the first clinical assessment at week This early onset of effect is seen in all doses of pregabalin compared to placebo in all short-term clinical trials conducted in GAD,49 indicating a robust...

Ngày tải lên: 21/08/2016, 18:51

... rate of RWs participating into training courses on radiation safety remains low (79.3% of RWs participating into training courses) Knowledge attitudes and practices meeting the requirements of ... reached Efficacy index in the intervention group was 21.3% The efficacy of intervention was 20% Table 3.39 Efficacy of intervention changing rates of symptomes and diseases in skin of radiation workers ... nuclear medicine Unit are operating The high technology used in the nuclear medicine Unit also increased significantly, with 31 SPECT machines, SPECT/ CT machines, machines PET/CT machines with...

Ngày tải lên: 01/11/2016, 22:32

... data are often either missing or incomplete Criteria for including hospitals, individuals, and data elements into specific systems are often inconsistent, resulting in difficulties in comparing and ... issues, injury prevention includes strategies on many levels, such as preventing the injury event in the first place (e.g., avoiding drinking and driving, removing hazards in the home), preventing ... for example, installing a child safety seat, using booster seats, and installing and maintaining a working smoke alarm 27 BACKGROUND What Costs can be Saved by Preventing Child Injury? Besides...

Ngày tải lên: 30/03/2014, 03:20

... focus of risk assessment would be to target the health of animals and the safety of food products (of animal origin) In the example of nanomaterials used for binding mycotoxins in feed ingredients ... carried out in China and India The use of nanoforms of agrochemicals offers a number of potential benefits in terms of reduced use of chemicals, but may also raise concerns over exposure of agricultural ... application of nanobarcodes incorporated into printing inks or coatings has shown the potential for use in tracing the authenticity of the packaged product (Han et al., 2001) 29 Food quality indicators...

Ngày tải lên: 28/05/2014, 15:03

... Fundamentals of Digital Imaging in Medicine Roger Bourne Fundamentals of Digital Imaging in Medicine 13 Roger Bourne, PhD Discipline of Medical Radiation Sciences Faculty of Health Sciences University of ... represent using positive integers within the bit depth available There are several ways of addressing these needs using binary encoding 2.3.4.1 Signed and Unsigned Integers In signed integer encoding ... the intensity and color information for each printing element On a sophisticated inkjet printer there may be ten different inks available and the print head may be capable of ejecting hundreds of...

Ngày tải lên: 05/06/2014, 12:05

... spectrum of rhinovirus serotypes in human cells in vitro [1921] Administration of soluble ICAM-1 and MAbs in human clinical trials had indeed achieved reduction in symptoms, but did not prevent the incidence ... medical means of RSV prevention [11-13] Prevention of Human Rhinovirus infections Human rhinovirus (HRV) causes over 80% of the common cold in the fall [14] Developing vaccines against HRV is unfeasible ... anti-ICAM-1 MAbs in preventing HRV infection as measured by reduction of cytopathic effects and HRV viral titers [26] The preclinical findings of CFY196 bode well its efficacy in human since MAb 1A6, from...

Ngày tải lên: 18/06/2014, 22:20

... spectrum of rhinovirus serotypes in human cells in vitro [1921] Administration of soluble ICAM-1 and MAbs in human clinical trials had indeed achieved reduction in symptoms, but did not prevent the incidence ... medical means of RSV prevention [11-13] Prevention of Human Rhinovirus infections Human rhinovirus (HRV) causes over 80% of the common cold in the fall [14] Developing vaccines against HRV is unfeasible ... anti-ICAM-1 MAbs in preventing HRV infection as measured by reduction of cytopathic effects and HRV viral titers [26] The preclinical findings of CFY196 bode well its efficacy in human since MAb 1A6, from...

Ngày tải lên: 20/06/2014, 04:20

... beyond those of staged arthroplasty There are reports of increased perioperative morbidity, including pulmonary, cardiac, neurologic, gastrointestinal and wound complications, deep vein thrombosis, ... regarding the relative risk of undergoing simultaneous bilateral TKA because of inconsistent terminology and variable study design Obesity (body mass index ≥30 kg/m2) is a strong predictor of bilateral ... significant differences, including significant increases in operative time for bilateral cases (127.4 minutes vs 112.7 minutes, P < 01), tourniquet time (116.0 minutes vs 110.4 minutes, P = 01), and...

Ngày tải lên: 20/06/2014, 04:20

... worsening of an existing clinical condition (infectious or noninfectious) within months of initiation of ART Toxicity was graded according the system mentioned in the WHO ART scale-up guidelines ... baseline and every months or as clinically indicated Creatinine clearance (CrCl) was calculated using the Cockroft-Gault formula Virologic failure was defined as inability to achieve or maintain ... from the grading system of Division of AIDS, National Institute of Allergic and Infectious diseases, USA) The regimen was discontinued (substituted with nonoffending ARV drugs) in cases of grade...

Ngày tải lên: 20/06/2014, 08:20

... the sum of radii of particles 3.1.2 The same directions of polarization of all nanoparticles in aggregates We examined structure of aggregates in which vectors of polarization of all nanoparticles ... polarization of nanoparticles respecting the structure, the magnetic forces have insignificant influence on the rate of aggregation of the particles Conclusion We examined the influence of structure of nanoparticles ... Random directions of polarization of nanoparticles in aggregates Unstructured model of ordering of nanoparticles in an aggregate has been computed by averaging and by summation of magnetic forces...

Ngày tải lên: 20/06/2014, 22:20