... aims In principle ,the main activities ofthe service will be based around education and improving standards of sexual health medicine within the primary care organisation as well as offering ... training • Base line experience working as a clinical assistant e Evidence of maintenance of competencies The GPwSI would be expected to maintain his or her competencies through continued professional ... arrangements, including links with others working inthe same clinical area in primary care, at PCT level and in acute trusts The GPwSI will be accountable to the PCT Board with clinical responsibility...
... urticaria, just as the histology ofthe two groups is strikingly similar.27,45 All of these findings provide a basis for further investigation ofthe pathogenesis and treatment of this disease.46–48 ... prominent inthe lesions of chronic urticaria than inthe late-phase response Cytokine Production after Stimulation with PMA–Ionomycin: Phenotypic Characterization ofthe Cytokine-Producing Subpopulation ... against the eosinophil low-affinity IgE receptor (CD23), which activate eosinophils and induce histamine release by eosinophie cationic protein (ECP), major basic protein (MBP), or other eosinophil...
... seemingly paradoxical result can be explained inthe following way The chance of finding a seed-match and of producing a local alignment of significant similarity rises with the length ofthe ... clock, the ratio ofthe number of changes specific to the human lineage to those specific to the chimpanzee lineage gives an estimate ofthe Neandertal-human divergence With prior knowledge ofthe ... (Figure S3 in Additional file 1) Therefore, requiring a minimum distance in bitscore between the best and second best hit is Page of 15 very effective in removing most ofthe remaining reads that...
... summarizing the main points ofthe study, particularly the major findings ofthe research, presenting the limitations ofthe study and giving some suggestions for further research Summary ofthe ... as the medium of instruction in stead of using the target language Inthe lessons the role ofthe teacher dominates the role of students That is, the teacher often spends too much time presenting ... conclusion, the study consists of three chapters The introduction presents an overview ofthe study including the rationale ofthe study, the aim ofthe study, the scope ofthe study, the research...
... DEPARTMENT OF MECHANICAL ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE ii PREFACE This thesis is submitted for the degree of Master of Engineering inthe Department of Mechanical Engineering, National ... with the constraints ofthe MEMS silicon fabrication route However, thechallenges facing such coatings are the high cost involved in solid coating, example diamond or carbon coating, and the inability ... layer of masking tape covers the Si disc during grinding to protect the surface from any scratches Water is allowed to flow during the process to reduce any thermal effect during grinding and at the...
... and c*(ppm) are the concentrations ofthe adsorbate inthe activated carbon and inthe solution, that are in equilibrium with each other By logarithmizing the equation (1) and plot the calculated ... types of kinetics models have been used to evaluate the flow ofthe process: the outer mass transfer [3], the pseudo 1st order and the pseudo 2nd order [4] By plotting the experimental point and the ... 0.240(1/ppm) 3.3.Kinetics investigation Each volume of 1500 ml with determined initial concentration of dyestuffs is prepared for the kinetics investigations Two concentrations ofthe dyestuffs (20ppm...
... One ofthe main challengesinthedeliveryofpoorlysolubledrugs via the pulmonary and parenteral route is the limited number of approved excipients The development of novel excipients may offer ... Paclitaxel, a poorly water- soluble molecule with antineoplastic activity, was originally Route- Specific ChallengesintheDeliveryofPoorly Water- SolubleDrugs 11 formulated in form of a nonaqueous ... water- soluble molecules The volume begins with an analysis ofthe various challenges faced inthedeliveryofpoorly water- soluble molecules according to therouteof administration, i.e., oral,...
... countries inthe region source the vaccine from India Keeping abreast with the contemporary developments research efforts are going on in addressing the major challenge of increasing the duration of ... vaccine coverage, age of vaccinates, maintenance ofthe cold chain during vaccine shipping and application, and training of vaccinators for proper vaccine delivery Addressing these elements are prerequisite ... application ofthe vaccine Farm managers in Kenya maintain vaccination times a year as it proved to be effective in preventing clinical FMD even inthe presence of infected buffalo and sick wildlife in...
... prognostic indicator in fulminant hepatitis in patients without encephalopathy upon admission [10,11] Inthe present study, we examined 11 proinflammatory genes in patients receiving therapy inthe ... ofthe diagnostic accuracy of CRP and mRNA levels (a) Change in circulating CRP mRNA expression during the clinical course in ICU Upregulation of CRP mRNA was induced at POD by the surgical intervention ... for the prognosis of fulminant hepatitis Hepatol Int 2008, 2:213-221 Wong FH, Huang CY, Su LJ, et al: Combination of microarray profiling and protein-protein interaction databases delineates the...
... MUPT The SMUP is determined by using the firing times ofthe main spike of each individual MUP firing within a MUPT and relating these to the potential observed at a surface electrode overlying the ... in which d is the dimensionality (the number of input features) inthe problem As can be seen in (2), this factor drops out inthe construction ofthe discriminant through the application of ... number of samples assigned to each target class; inthe case of Table these are MUPTs, inthe remaining tables these are muscles The value at the foot ofthe “Per-class accuracy” column is simply the...
... enhancement inthe frequency of arthritis inthe T cell-deficient mice and the B cell-deficient mice suggest that these cells might play regulatory roles inthe initiation of disease 100 90 % of incidence ... have important roles either during the initiation phase of arthritis or inthe perpetuation and exacerbation ofthe disease after the onset, or they might simply maintain immunity to CII and ... antigenpresenting cells/ml, 10 µg/ml rat CII) followed by weeks of resting in medium containing IL-2 At the time of re-stimulation, an aliquot ofthe cell line was tested for antigen specificity...
... measured at the level ofthe practice and predictor variables measured at either the level ofthe practice or the level ofthe individual The theoretical models will be tested using standard ... J, Walker A, Johnston M, Pitts N: Changing the behaviour of healthcare professionals: the use of theory in promoting the uptake of research findings J Clin Epidemiol 2005, 58:107-112 Bradshaw ... further developed by Sniehotta [40], who proposes the two distinct dimensions of plans: action planning (planning the initiation of a behaviour) and coping planning (planning what to Page of...
... measured at the level ofthe practice and predictor variables measured at either the level ofthe practice or the level ofthe individual The theoretical models will be tested using standard ... J, Walker A, Johnston M, Pitts N: Changing the behaviour of healthcare professionals: the use of theory in promoting the uptake of research findings J Clin Epidemiol 2005, 58:107-112 Bradshaw ... further developed by Sniehotta [40], who proposes the two distinct dimensions of plans: action planning (planning the initiation of a behaviour) and coping planning (planning what to Page of...
... definitively identified postoperatively We offer an overview ofthe role of imaging and suggest that both the local anatomy and the organisation ofthe cystic structure be borne in mind inthe ... Isolated intrathoracic cystic hygroma is a rare finding; less than 1% of all cystic hygromas are purely mediastinal in origin Inthe majority of cases, these are located inthe anterior mediastinum ... system They are reported to occur in between in 6000 and in 16,000 live births They can occur anywhere inthe body, but 75% involve the posterior neck, 20% the axilla and 1% the mediastinum, groin...
... (right) and haematoxylin and eosin staining of a day 12 placenta section (left) with the main layers ofthe placenta indicated (B) Higher magnification ofthe areas framed in A Abbreviations: frbc: ... subunits and the CWLC domain involved in SU-TM interaction indicated in red; the hydrophobic signal peptide and fusion peptide and the transmembrane domain are shaded in light gray, and the putative ... fv) All of these characterize the definitive labyrinthine placenta [9,11] ORF A 1900 bp specific amplicon could be obtained from the Lepus species, but neither from the Sylvilagus nor from the Ochotona...
... for the establishment ofthe initial infection, and they predominate inthe majority of drug-naïve patients (prevalence, > 80%) [33-36] However, in roughly 50% of all infected individuals, the ... localized inthe extracellular domain of gp41 is consistent with the idea that gp41 may act as a scaffold in order to maintain the stability ofthe gp120/gp41 complex, and therefore finally influencing ... those of co-circulating R5-tropic clones, indicating the presence of CXCR4 tropism determinants also in domains different from V3 [41] Interestingly, the threonine in position 96 that we find mutated...
... performing the studies and analysing the data The understanding ofthe precision of a new device is vital prior to accepting it into clinical practice and prior to using it for significant therapeutic ... assessing the combined error ofthe two This has been studied extensively with ITD and the variance can range from 5% to 15% depending on the technique used The main limitation of this ± 30% cutoff, ... confusion in how to interpret studies and therefore in whether (or not) to accept new measuring or monitoring devices into routine clinical practice Validation of cardiac output monitoring devices Ideally,...
... especially inthe early phases of integration This had the effect of initially reducing the confidence ofthe inexperienced medical staff in managing ART, and reinforced fears around safety of ART ... quality ofthe ongoing HIV program Challenges for the future ofthe program The integrated HIV programme in Pool is faced with a number ofchallenges Most significantly, the numbers of people living ... the benefits and the means of minimising the risks of testing were required Benefits of introducing HIV/AIDS activities into medical programs 'Towards Universal Access' While there is clear international...
... spine pain [11] Definition of non specific Thoracic spine pain Midline back pain – for the purposes of this trial, the pain will be bound by the lateral margins ofthe thorax laterally and the ... asked to indicate which point along the line best represents their pain intensity The distance from the no-pain end to the mark made by the participant is their pain intensity score The Oswestry ... stainless steel instruments The promoters ofthe Graston Technique [4] claim that the instruments are much like tuning forks as they reportedly resonate inthe clinician's hands allowing the clinician...
... a deeper insight into the mechanism of their interactions and thus helping inthe design of potent new ChE inhibitors The interaction mode ofthe selected pose within the active sites of ChEs ... overlapping regions Apart from minor differences, a major diversity inthe ligand-AChE complexes was the variation inthe positioning ofthe side chain of Phe330 The divergence inthe orientation of ... BChE, including numerous aromatic regions present inthe latter but not inthe former Both ChEs have their active sites at the base of enzyme cleft of about 20 Å depth In AChE, the binding of the...