roles of ugts in metabolism and disposition of carcinogens
MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... Herbal Medicine, Ministry of Education Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, 100050 China QING PING HAN Department of Chemistry ... Utilization of Chinese Herbal Medicine, Ministry of Education Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, 100050 China MINGSHE ZHU ... Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an ... temporary shut-off mechanism during unfavorable conditions [35,36] Little is known about the interaction of AP-2 and its binding partners in cartilage However, at least CBP ⁄ p300-interacting transactivator ... tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene...
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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... basis of incorrect pairing of sister chromatids and of the lack of integrity of the synaptonemal complex in Hsf2) ⁄ ) spermatocytes is a pending question [62] Role of HSF1 in the quality control of ... importance of elucidating the mechanism discriminating various HSEs for HSF2 recruitment in development This latter study [73] underlines possible roles of HSF2 in the organization of chromatin and of...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... domain structure Schematic of Vrp1p showing the Vrp1p truncations and mutant proteins used in this study and their various known domains: actin-binding domains, Hof one trap (HOT) domain, and ... previously showed does contain an actinbinding domain (this actin-binding domain has not yet been mapped) [23] We name the actin-binding domain that we have identified VH2-C and VH2-N because it is ... polymerization in the generation or maintenance of a polarized distribution of cortical patches Las17p and type I myosins promote the assembly of actin monomers into short actin filaments by binding and...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... residue in the L1 loop is involved in the functional DNA binding during strand exchange Tryptophan-scanning mutagenesis of the HsRad51-L1 loop To gain further information about DNA binding by ... Roles of the HsRad51 L1 and L2 loops D231W (L1 loop) Table Changes in the fluorescence of tryptophan probes inserted in the L1 and L2 loop upon binding of nucleotides and DNA The fluorescence of ... identified in these eukaryotic and archaeal proteins (Fig 1A) Like the case of bacterial RecA, the L1 and L2 loops of the eukaryotic Rad51 proteins face A Roles of the HsRad51 L1 and L2 loops inside of...
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Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx
... significant increase in integrin alpha6 and decrease in integrin alpha v and beta4 expression levels In the presence of fibronectin and/ or HGF, a significant increase in integrin alpha3 and alpha5 expression ... NFjB and sphingosine kinase We have studied the role of sphingosine kinase in PMA-induced activation of NFjB (p65) We found that PMA-induced NFjB binding was dependent on intracellular calcium and ... Ca2+-saturated and apocalmodulin with sphingosine, sphingosine-1-phosphate and ceramide, in vitro binding assays were carried out Changes in fluorescence of the tyrosine residues of calmodulin as well as of...
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Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... structure in terms of cyanide binding in the Fe(III) complex Redox potentials Fig Soret and visible optical absorption spectra of Fe(III) (solid line), Fe(II) (broken line) and Fe(II)-CO (dotted line) ... protein Additionally, spin states of the Fe(III), Fe(II) and Fe(II)-CO complexes of Asp40 mutants were similar to those of the wild-type enzyme in that all mutant proteins were in the six-coordinated ... Cyanide binding Kinetic and equilibrium studies on cyanide binding provide valuable information on the haem distal structure of Ec DOS PAS [17] As the structure of the cyanide-bound complex of FixL...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... arose resin a second chromatography step using the same resin was required (gradient of 15–150 mm NaCl contained in L buffer A) to obtain pure protein Redox potentiometry, ligand binding and stopped-flow ... ligand and substrate binding For those members that contain a His-His pair, there has been no report of a systematic analysis of the contribution of each histidine residue to binding and catalysis ... be involved in ligand binding and counterpart residues in related enzymes and also the location of the tyrosine residue implicated as proton donor in OYE B constant for enzyme-ligand complexes,...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... (s) Fig Binding of n-Src and NR2A C-tail proteins (A–F) Surface plasmon resonance showing binding of wild-type and mutant n-Src proteins at concentrations of 0–400 nM to NR2A C-tail protein immobilized...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf
... Transcript profiling of auxin-responsive genes M Jain and J P Khurana responses, which indicates crosstalk between stress and auxin signaling In the recent past, the identification of F-box proteins (TIR1 ... as auxin receptors has been a milestone in our understanding of the molecular mechanisms of auxin signaling pathways These F-box proteins are components of E3 ligase and target Aux ⁄ IAAs, in particular ... representing hierarchical clustering of average log signal values of auxin-induced (A) and auxin-repressed (B) genes in various tissues ⁄ organs and developmental stages (mentioned at the top of each...
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Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... Role of cysteines in oligomerization – effects of introducing an additional cysteine In a previous study, we found that mutating residue 19 in the t peptide of Torpedo AChE considerably increased ... Ba and Bb, suggesting a predominant in uence of the catalytic domains on oligomerization This may be due in part to the difference in N-glycosylation of AChE and BChE, which carry four and nine ... anchoring of cholinesterases NeuroSignals 11, 130–143 ´ Massoulie J & Bon S (2006) The C-terminal T peptide of cholinesterases: structure, interactions, and in uence on protein folding and secretion...
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Báo cáo khoa học: Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells Soumen Bera1, Theo Wallimann2, Subhankar Ray1 and Manju Ray1 potx
... estimation of proline and ornithine J Biol Chem 199, 91–95 45 Van Pilsum JF, Martin RP, Kito E & Hess J (1956) Determination of creatine, creatinine, arginine, guanidinoacetic acid, guanidine, and methyl-guanidine ... arginase I and ODC direct ornithine towards polyamine synthesis and the mitochondrial enzymes arginase II and ornithine aminotransferase favor the channeling of ornithine to proline ⁄ glutamine ... homocysteine to methionine Tissue metabolism of arginine and methionine is of high importance for the effective regulation of cell death and survival in normal as well as in tumor cells Polyamines...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development ... release of negative regulators of angiogenesis, such as angiostatin, tumstatin, endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, ... MMPs and ADAMs Activity Effect Proteolytic Degrade physical barriers Cleavage of IGF-binding proteins Shedding of membrane-anchored ligands of EGFR (HB-EGF, TGF-a and amphiregulin) Shedding of...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... in our knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of ... controlled in vivo by specific interactions between FadD29 and PKS15 ⁄ on the one hand, and FadD26 and the FasI system on the other hand Further investigations, including protein interaction studies and ... deficient in PGL production To determine the role of fadD26 in the biosynthesis of DIMs and PGL in M bovis BCG, lipids were extracted from PMM137 and analyzed by TLC Disruption of fadD26 in M bovis...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... important aspect of small business finance the financial intertwining investors and intermediaries of owners and their businesses (Ang 1992) Outside often put considerable weight on the financial conditions ... lending, interest rates, and venture capital pricing and of the financial intermediaries external equity and debt to small business are analyzed intermediation and monitoring of external equity and ... contracting Consolidation of Financial Institutions Mergers and acquisitions mechanism (Berlin and Mester 1998) and the Supply of Small Business Credit (M&As) of banks and other financial institutions...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... occludens-domain-containing proteins such as syntenin, Ga-interacting protein (GAIP)-interacting C-terminus ⁄ synectin and calcium ⁄ calmodulin-associated serine kinase, since the C2 region contains a ... syndecans, and are endopeptidases belonging to the family of metzincins (zinc endopeptidases) which contain three major multigene families: seralysins, astacins and a disintegrin and metalloproteinase ... HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc Interaction between cysteine–zinc maintains proMMPs in an inactive state by preventing a water molecule from binding to...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... Lys4 of histone H3 tail polyamines polyamines aromatic amines aromatic amines aromatic amines L-amino acids glycine, sarcosine sarcosine gene expression regulation polyamines metabolism vitamin ... protein–protein and DNA–protein interactions [36] The name of this domain derives from its original identification in the proteins SWI3, Rsc8 and Moira, which are ATP-dependent chromatin remodeling ... is in agreement with the domain organization in the first line The third line shows a summary of the identified linear motifs (after filtering processing taking in account the accessibility of the...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... binding kinetics of the PAS domain of Ec DOS, as it does in myoglobin and hemoglobin Examination of the effects of these hydrophobic amino acids on the kinetics of O2 and CO binding to the Ec DosH ... phase of the L99F mutant was independent of the O2 concentration b Measurement of the rate of O2 binding was not feasible because of low heme binding affinity and instability of the protein with ... known that CO-binding and O2-binding access channels of myoglobin and hemoglobin are composed of hydrophobic amino acid residues [11] The hydrophobic characteristics of these axial ligands facilitate...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... phosphorylation and dephosphorylation, a processing unit Fig E2 and E3BP domains and their binding interactions E2 subunit domains: L1, N-terminal lipoyl domain; L2, inner lipoyl domain; B, E1 binding domain; ... connections indicate binding interactions to the catalytic components (E1 and E3), kinase isoforms (PDK1, PDK2, PDK3, PDK4) and Ca2+-binding of PDP1 in translating and transmitting effector signals, and ... oligomer-forming, acetyl-transferase-catalyzing inner domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted...
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