... these three arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each module. ... of the hexameric form, but not for the ATP-induced motion of the middle domain. Results The conserved arginines are not involved in nucleotide binding To examine the roles of conserved arginines, ... the roles of the arginines in individual AAA+ modules were not elucidated. The role of the other conserved arginine (P2) in AAA-1 was also unclear. Here, we investigated in detail the roles of...
Ngày tải lên: 06/03/2014, 00:20
... contained regions of intrinsic disorder. One example of an ordered hub, calmodulin, makes use of a flexible hinge to facilitate binding diversity. Each of these classes and their roles in protein–protein ... in interaction with Cdk2 and cyclin A: 1, domain 1 interacting with cyclin A; 2, a linker helix involved in binding both cyclin A and Cdk2; 3, domain 2 inter- acting with Cdk2 [122]. Blue and dark ... determine what fraction of protein– protein interaction in regulatory networks relies on intrinsic disorder. Abbreviations CaM, calmodulin; Cdk, cyclin-dependent protein kinase; CKI, Cdk inhibitor...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... their main roles focus on ectodomain shedding and nonpro- teolytic functions, such as binding to adhesion mole- cules, integrins and interacting with phosphorylation sites for serine ⁄ threonine ... through integrins because the shedding of E-cadherin results in b-catenin translocation to the nucleus, leading to cell proliferation [23]. It is worth noting that the inactive proform of TGF-b, ... tetracyclines, lacking antibiotic activities, may inhibit MMPs by binding to metal ions such as zinc and calcium. This family of inhibitors, including metastat (COL-3), minocycline and doxycycline, cause...
Ngày tải lên: 15/03/2014, 00:20
Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
... of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. 40 Laemmli UK (1970) Cleavage of structural proteins during the assembly of head of ... Goodwin PH & Hsiang T (2005) Induction of glutathione S-transferase genes of Nicotiana benth- amiana following infection by Colletotrichum destructi- vum and C. orbiculare and involvement of ... the maintenance of a high-affinity CDNB-binding site. However, the substitu- tion E117K gives rise to mutants showing increased k cat values for CDNB, suggesting that Lys117 might positively in uence...
Ngày tải lên: 15/03/2014, 09:20
Summary phd thesis in philosophy roles of the government in the integration of economic growth with ecological environment protection in vietnam nowadays
Ngày tải lên: 14/07/2014, 13:34
Different roles of functional residues in the hydrophobic binding site of two sweet orange tau pps
Ngày tải lên: 07/08/2014, 01:20
Báo cáo y học: "Elucidation of the potential roles of matrix metalloproteinases in skeletal biology" pps
Ngày tải lên: 09/08/2014, 01:21
báo cáo khoa học: " Beneficial effects of physical activity in an HIVinfected woman with lipodystrophy: a case report" ppsx
Ngày tải lên: 10/08/2014, 23:20
Advances in Relationship Marketing Thought and Practice: The Influence of Social Network Theory
... little influence on trust formation Questions for future research Questions for future research integrating SNT and marketing integrating SNT and marketing ã Marketing across cultures Marketing ... Social Networking Sites – Blogging Blogging – Podcasting Podcasting – Instant Messaging Instant Messaging Interdisciplinary research opportunities are plentiful! Interdisciplinary research ... networks influence behavior and outcomes in an industrial marketing context in an industrial marketing context ã Typical Methods Typical Methods Interviews and surveys (consumer marketing) Interviews...
Ngày tải lên: 24/10/2013, 20:15
Tài liệu Time trends in leisure time physical activity and physical fitness in elderly people: 20 year followup of the Spanish population national health survey (1987-2006) docx
... the final manuscript. Authors’ information None Competing interests The authors declare that they have no financial competing interests and non-financial competing interests. Conflict of interest: ... Identification of these factors can help to identify individuals at risk for physical inactivity. Background In recent years, there has been an increase of aging in the society [1]. The aging of the ... non-institutionalized population residing in main family dwellings (house- holds) of Spain and is mainly performed by the Minist ry of Health and Consumer Affairs and the National Statis- tics Institute (Instituto Nacional...
Ngày tải lên: 14/02/2014, 06:20
Tài liệu THE ROLES OF AMINO ACID CHELATES IN ANIMAL NUTRITION pdf
... net utilization of minerals. Absorption of mineral ions is dependent upon numerous factors, including the levels of the elements ingested, the age of the animal, Ph of the intestinal contents and environment, ... Paul Cuplin 27. THE USE OF ZINC AMINO ACID CHELATES IN HIGH CALCIUM AND PHOSPHORUS DIETS OF RAINBOW TROUT 424 Ronald W Hardy and Karl D. Shearer 28. THE EFFECTS OF IRON AMINO ACID CHELATE IN CULTURE ... INTESTINAL ABSORPTION OF MINERALS H. DeWayne Ashmead Albion Laboratories, Inc. Hugo Zunino University of Chile The Periodic Table contains at lrast 104 elements, 81 of which are considered minerals.() With certainty seventeen...
Ngày tải lên: 15/02/2014, 16:20
Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... role of AP-2a and AP-2e in chondrogenesis. Overview of the differen- tiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of ... syndrome has over- lapping features, such as orofacial clefting and occa- sional lip pits, with Van der Woude syndrome, in which disruption of an AP-2a-binding site within an interferon regulatory ... transcription factor AP-2 involved in DNA binding. J Mol Biol 301, 807–816. 9 Wankhade S, Yu Y, Weinberg J, Tainsky MA & Kan- nan P (2000) Characterization of the activation domains of AP-2 family transcription...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 ... played prominent roles in the maintenance of species during evolution through its differential effects in either protecting against cell death or, conversely, in promoting cell death in stage-specific ... HSF4-binding regions and of the transcriptional status of genes located around the HSF4-binding regions. This result is thus suggestive of a structural effect of HSF4 on chromatin. In the absence of...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... C-terminal actin-binding submod- ule (CABS) that contains a novel G-actin-binding domain, which we call a verprolin homology 2 C-terminal (VH2-C) domain; and a second submod- ule comprising the ... VH2-N) which we previously showed does contain an actin- binding domain (this actin-binding domain has not yet been mapped) [23]. We name the actin-binding domain that we have identified VH2-C and VH2-N ... C-Vrp1p 364)817 may explain why mutations in the N-terminal actin-binding WH2 domain (WH2-1) or even deletion of the entire N-terminal module of Vrp1p did not significantly perturb the activity of Vrp1p in polarization...
Ngày tải lên: 18/02/2014, 16:20
Bạn có muốn tìm thêm với từ khóa: