roles of collagen in dupuytren s disease

Ngày tải lên: 22/03/2014, 16:20

... severity to assess changes after an intervention using videotaped sessions of five 10-meter walks including turns A previous study reported the directionally restricted effects of gait training ... clinician-rated measures assessing frequency and severity of FOG, as well as situations that elicit freezing, such as walking through narrow spaces and turning, since very few freezing events ... Fahn S: Motor blocks in Parkinson s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations Parkinsonism...

Ngày tải lên: 19/06/2014, 08:20

... symptoms as distinct and different diseases, and others have given its name to diseases differing essentially from it" [1] For instance, dementia with Lewy bodies and Parkinson 's disease are ... errors in separating idiopathic Parkinson 's disease from other causes of the akinetic-rigid syndrome, or errors in differentiating dementia from confusional states, depression and even ageing, ... finally addressing dementia itself So, the diagnostic process in patients with PD and suspected dementia involves two steps: the diagnosis of dementia and differential diagnosis of its cause A deficit...

Ngày tải lên: 08/08/2014, 21:20

... Wnt 11 D2 Pooled W D D2 E M H2 L R T W Control Control Control Disease Disease Disease Disease Disease Disease Disease Disease Disease 5/37 4/17 1/3 0/28 1/4 0/16 0/9 0/16 0/2 2/9 5/22 11/19 9/37 ... Clin 1999, 15(1):87-96, vii Gudmundsson KG, Arngrimsson R, Sigfusson N, Bjornsson A, Jonsson T: Epidemiology of Dupuytren' s disease: clinical, serological, and social assessment The Reykjavik Study ... as APC may be altering the sensitivity of DD cells to Wnt signalling We are presently assessing the activity of GSK-3β in DD to determine if upstream signalling molecules are regulating kinase...

Ngày tải lên: 11/08/2014, 08:20

... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples ... ApoE-containing lipoparticles via the ATP-binding cassette family of active transporters regulates Ab deposition PDAPP mice overexpressing murine ATP-binding cassette family of active transporters are...

Ngày tải lên: 16/02/2014, 09:20

... diseases including HD and Parkinson disease, and in other neuropsychiatric disorders such as schizophrenia [27] Cannabinoid receptors therefore are important modulators of brain function and loss ... transcripts such as CB1 in striatal neurons Since it is known that the length of the CAG repeat affects the onset of HD in humans and in mice, we first confirmed that the rate of decrease in steady-state ... reverse transcriptase reaction Several expressed sequence tags (EST) and cDNA CB1 clones have been listed in GenBank that contain sequence on both sides of the CB1 intron Each of these ESTs have...

Ngày tải lên: 16/03/2014, 18:20

... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... phosphorylate eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272...

Ngày tải lên: 16/03/2014, 22:20

... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... known as frequent ‘contaminants’ in the process of searching binding proteins, the in vivo evidence for the relationship between ROCO proteins and cytoskeletons in D discoideum suggests a need ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a specific inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with...

Ngày tải lên: 23/03/2014, 04:20

... was subjected to HPLC assay Figure HPLC analysis of the synthesis and release of DA by RPE cells HPLC analysis of the synthesis and release of DA by RPE cells.(A) HPLC analysis of standard of ... References 10 Twelves D, Perkins KS, Counsell C: Systematic review of incidence studies of Parkinson 's disease Movement Disord 2003, 18:19-31 Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin ... used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at p < 0.05 Results RPE-CM protects against rotenone and...

Ngày tải lên: 18/06/2014, 15:20

... an increased fall risk in older adults in general, as well as in patients with PD [9-13], suggesting that this aspect of gait may have clinical utility as an aid in fall risk assessment More specifically, ... the forces underneath the foot as a function of time The system consists of a pair of shoes and a recording unit Each shoe contains load sensors that cover the surface of the sole and measure the ... Glatt S, Vetere-Overfield B, Hassanein R: Falls and Parkinson 's disease Clin Neuropharmacol 1989, 12:98-105 Bloem BR, Hausdorff JM, Visser JE, Giladi N: Falls and freezing of gait in Parkinson 's disease: ...

Ngày tải lên: 19/06/2014, 10:20

... the soles Vibration intensity is similar to that of portable devices such as cell phones and beepers, operating in the vibration mode VD was mounted on shoe insoles inserted into the shoes The ... the soles during the stance phase of the step, but not during the swing phase Preliminary results were previously published as an abstract [16] Materials and methods Eight subjects with a clinical ... characteristics in the Parkinson 's disease and control groups during 6-minute walking with and without stepsynchronized vibration stimulation Locomotion Parameters Parkinson 's Disease Group Control...

Ngày tải lên: 19/06/2014, 10:20

... Progression of Parkinson s Disease Figure stimuli Schematization of responsiveness of PD subjects to visual Schematization of responsiveness of PD subjects to visual stimuli The diagram represents schematically ... controls in response to an attentional stimulus (increasing stride length, decreasing cadence), would suggest that, in advanced stages of disease, as a consequence of progression of motor symptoms, ... number of subjects included in the AS condition (data missing in four out of 15 PD subjects for AS), two distinct statistical comparisons have been performed: 1) baseline vs BOF vs FOF, 2) baseline...

Ngày tải lên: 19/06/2014, 10:20

... models of human disease generally have similar pathological findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, ... steps in the complement cascade All of these regulatory proteins are produced in the human brain, but less is known about their CNS synthesis in other species [31] The status of some of these regulatory ... and proteins in the Alzheimer 's disease brain Brain Res Mol Brain Res 2000, 81:7-18 Janus C, Phinney AL, Chishti MA, Westaway D: New developments in animal models of Alzheimer 's disease Curr Neurol...

Ngày tải lên: 19/06/2014, 22:20

... characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... Increased neuronal COX-2 expression leads to increased expression of cell cycle mediators in post mitotic neurons, as shown using a transgenic mouse model with increased neuronal COX-2 expression ... 25 26 Pasinetti GM, Aisen PS: Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer 's disease brain Neuroscience 1998, 87:319-324 Combrinck M, Williams J, De Berardinis MA, Warden...

Ngày tải lên: 19/06/2014, 22:20

... tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible ... engagement of an ensemble of cell surface receptors initiates a tyrosine kinase-based signaling cascade Tyrosine phosphorylation of the Vav-GEF results in the activation of downstream Rac1 GTPase Recently, ... Despite these promising findings, the use of statins in prospective clinical trials has yielded unsatisfactory results, failing to dramatically improve cognitive function or reduce serum plasma...

Ngày tải lên: 19/06/2014, 22:20

... domains for discussion in the focus groups of PD patients with off-time: feelings of anxiety, mood swings, loss of interest, fatigue and autonomic or gastrointestinal symptoms (such as excessive ... Component Summary; PD: Parkinson s disease; PDQ-8: Parkinson s Disease Questionnaire-8; RMSEA: root mean square error of approximation; SCOPA-DC: Scales for Outcomes of Parkinson s disease Diary ... breaks, and excessive sweating as a result of very simple tasks such as walking while shopping were also frequently mentioned by patients There was strong endorsement of these symptoms appearing in...

Ngày tải lên: 20/06/2014, 15:20

... boxy-terminal subunit of Sip1 (anti-Sip1 C-ter) antibodies in patients with Behçet 's disease (BD), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), vasculitis, inflammatory bowel disease ... distinct autoimmune diseases characterized by the presence of serum anti-endothelial cell antibodies such as BD, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), various forms of ... process involves apoptosis need further investigations Apoptosis of endothelial cells may be initially induced by inflammation or oxidative stress caused by intrinsic or extrinsic factors In this...

Ngày tải lên: 09/08/2014, 08:22

... As part of an ongoing interdisciplinary study between cardiologists, radiologists and radiation oncologists, Hodgkin 's disease survivors will be invited for extensive cardiologic tests including ... Despite these efforts to reduce radiation-induced late toxicity, of which heart disease is one aspect, oncologists and cardiologist are still seeing survivors of Hodgkin 's disease treated in ... [7] In a subsequent series of trials, involved-field doses of 20 Gy and 30 Gy were compared in low-risk and intermediate-risk groups and early analyses in intermediate-risk patients suggest equivalence...

Ngày tải lên: 09/08/2014, 10:20

... atherosclerotic process, as well as its reversibility, have been confirmed in various clinical settings, including systemic vasculitis, rheumatoid arthritis, systemic lupus erythematosous and systemic ... both clinical disease activity and use of corticosteroids, albeit in an interrelated manner Because the degree of inflammation cannot safely be assessed in BD using surrogate markers, such as serum ... days Clinical assessment and vascular studies were repeated on day The present study was conducted, using both case-controlled cross-sectional and prospective interventional approaches, to dissect...

Ngày tải lên: 09/08/2014, 10:21

... immune system has also been identified in the disease [1,6] Furthermore, involvement of TLRs has been shown in other systemic autoimmune diseases [16] In the present study, expression levels of TLR2 ... by using Scion image analysis and image processing software (NIH Image Engineering, Bethesda, MD, USA) Statistical analysis Mann-Whitney U-test, Kruskal-Wallis test with post-hoc Scheffe 's test, ... HO-1 expression by using specific small interfering RNA resulted in upregulation of synthesis of proinflammatory cytokines, including interleukin-6, interleukin-8 and TNF, which have been shown to...

Ngày tải lên: 09/08/2014, 10:22