role of vitamin d receptor activators

... polymorphisms of VitD receptor (VDR) and VitD binding protein (DBP) have been identified that modulate the development of tuberculosis [96] The genotype tt (detected by Taq I digestion) is associated with ... shown to be elevated in induced sputum of COPD patients and a causative role has been suggested in the development of COPD [90] VitD also to attenuates TNFalpha induced upregulation of MMP-9 in keratinocytes ... with the development of COPD are largely speculative: 1) The association of VitD deficiency and reduced lung function could depend on the calcemic effects of VitD The vital capacity and total...

Ngày tải lên: 12/08/2014, 13:22

... association was observed between individual VDR gene polymorphisms and the overall odds of hand OA However, the VDR aa genotype posed an almost doubled odds of symmetrical hand OA (OR = 1.93, 95% ... associated with high bone mass [30], posed a nearly twofold increased odds of symmetrical hand OA as compared with the AA genotype associated with lower bone mass In contrast, the odds of this disease ... of hand OA are presented in Table The presence of the aT haplotype alone was associated with an increased odds of symmetrical OA (OR = 1.58, 95% CI = 0.88–2.85) and with a decreased odds of osteophytes...

Ngày tải lên: 09/08/2014, 07:20

... indicates that CD4 and CD8 are heavily down regulated during the study The loss of CD4 and CD8 receptors may be a conPage of (page number not for citation purposes) Journal of Translational Medicine ... derived from the method described by KJ Dumas and JR Scholtz [2] For each subject, six test sites of 2-cm diameter were selected on predetermined lesions, and a circular adhesive device was placed ... calculated with standard assumptions about independence, equivariance and normality Due to heteroscedacity, the logarithm of the following response variables was used: CD3, CD4, CD45, and Ki-67 SCID...

Ngày tải lên: 18/06/2014, 15:20

... buffered saline (PBS), and then resuspended into antibiotic-free cell culture medium H pylori was added to AGS cells at bacterium/cell ratio of 150:1 or 300:1, and cultured for the indicated time ... time periods Single-stranded oligonuceltides (ODNs) were produced commercially (GIBCO BRL, Rockville, MD, USA) ODNs were phosphorothioate-modified to reduce intracellular nuclease digestion Antisense ... (Figure 4A) Cell death of H pylori-infected cells was augmented by treatment of SBTI concentration-dependently H pylori-induced DNA fragmentations increased by treatment of 0.5 μM of SBTI (Figure...

Ngày tải lên: 18/06/2014, 16:20

... Characteristics of the study subjects according to the genotypes of the Apa I, Bsm I, and Fok I VDR polymorphisms VDR, vitamin D receptor; SD, standard deviation Table Genotype and allele frequencies of Apa ... haplotype and periodontal disease that we observed was independent of current smoking status and the prevalence of diabetes as a statistical adjustment did not diminish the influence of the VDR haplotype ... number of teeth present, and prevalence of diabetes VDR, vitamin D receptor; OR, odds ratio; CI, confidence interval DISCUSSION We examined the relationship between ApaI, BsmI, and FokI VDR polymorphisms...

Ngày tải lên: 08/08/2014, 16:23

... Materials and methods This study was conducted in accordance with the principles embodied in the Declaration of Helsinki and was approved by the ethical committees of the Ramathibodi Hospital, Mahidol ... skin, gonads, and activated T and B lymphocytes, have the nuclear receptor for 1,25-dihydroxyvitamin D3 (VDR) Thus, it is not surprising that 1,25-dihydroxyvitamin D3 has a multitude of biologic ... droxyvitamin D3 directly inhibits synthesis and secretion of IL2 [15,16] and IFN-γ [17,18] and also inhibits immunoglobulin production [19] Genomic actions of 1,25-dihydroxyvitamin D3 are mediated...

Ngày tải lên: 09/08/2014, 07:20

... studies on vitamin D variation during HAART; therefore we studied vitamin D status in a longitudinal cohort study of AIDS patients during the first year of HAART Methods Page of “severe renal disease” ... increase of lipids and the pre-HAART vitamin D status or with the type of HAART Discussion Our study shows a high prevalence of vitamin D deficiency in HIV-infected individuals as observed by others ... decrease of 25(OH )D plasma concentration after 12 months on HAART Similarly to our findings, Van den Bout-van den Beukel [21] described a prevalence of vitamin D deficiency of 62% in dark-skinned individuals...

Ngày tải lên: 10/08/2014, 05:21

... polymorphisms of the VDR gene Gender, age, body mass index (BMI), MS diagnosis versus controls, smoking duration and lumbar spine/total hip BMD were included in the model as independent variables ... single-nucleotide polymorphisms in VDR, but found an interaction between dietary intake of vitamin D and the VDR Fok-I polymorphism on MS risk Specifically, individuals with the ff genotype had decreased ... or osteoporosis, and 81 control individuals matched for sex and age All patients satisfied the Mc Donald criteria for MS diagnosis [17] None of the case and control individuals were receiving...

Ngày tải lên: 11/08/2014, 07:21

... manuscript proofreading and editing Page of 10 Author details Department of Medicine, National Jewish Health, and the University of Colorado Denver, Denver, CO, USA 2Department of Immunology, ... lipopolysaccharide-deficient mutant of Neisseria meningitidis J Endotoxin Res 2000, 6:411-415 21 Dziarski R, Gupta D: Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive ... hrs of Mp infection, helenalin significantly reduced Mp-induced SPLUNC1 production (Figure 4A), and tended (p = 0.07) to reduce NF-B p65 activity (Figure 4B) To demonstrate a direct role of NF-B...

Ngày tải lên: 12/08/2014, 11:23

... studies Food intake patterns: Effect of vitamins on the risk of developing COPD and associated mortality Varraso et al in a study of 72,043 women identified 754 cases of newly diagnosed COPD [44] ... protective role of vitamins against COPD but did not measure vitamins in serum or with a FFQ Therefore conclusions about the special role of any vitamin in COPD could not be obtained Vitamin D and COPD ... polymorphisms, vitamins, FEV1, vitamin C, vitamin E, vitamin D, vitamin A, b-carotene, and vitamin supplements Further articles were identified from the reference lists of the included articles In order...

Ngày tải lên: 12/08/2014, 13:22

... physiological consequences of increased LPA levels and role of LPA receptors in asthma To address the role of LPA receptors in Th2-mediated inflammation, we have used a well described Schistosoma mansoni ... Berdyshev E, Usatyuk PV, He D, Natarajan V: Role of acylglycerol kinase in lysophosphatidic acid-induced transactivation of epidermal growth factor receptor and expression of cyclooxygenase and ... administration of PGE2 induced various side effects, including cough, enhanced mucus production, and sensory nerve stimulation [36] To determine the role of LPA receptors expression and PGE2 production in...

Ngày tải lên: 12/08/2014, 14:20

... summarized and analyzed the data, and edited the manuscript MW and AM designed the experiment, analyzed the data, and edited the manuscript ML, EW, MD, HVA, and DLT analyzed the data and edited the ... shock under conditions with high endogenous AVP plasma levels Additional material Additional file 1: Supplemental Digital Content Additional information on the methods and procedures applied in ... Boulevard, Galveston, TX 77550, USA Authors’ contributions SR designed and performed the experiment, summarized and analyzed the data, and wrote the manuscript CE designed and performed the experiment,...

Ngày tải lên: 13/08/2014, 21:21

... misfolding of the polypeptide chain may occur and this may be refolded, degraded or they may form toxic aggregates (Adapted from Bross & Gregerson Protein Misfolding and Disease, Methods in Molecular ... fatty acid oxidation defects96, the misfolded proteins are highly unstable and degraded rapidly resulting in what is termed a ‘loss -of- function’ pathology related to the decrease in the steady amount ... an inhibitor of NCoR misfolding, significantly down regulated Flt3 level and promoted differentiation of AML-M5 derived cell lines These findings indicated that aberrant expression of Flt3 in AML-M5...

Ngày tải lên: 09/09/2015, 18:55

... motif) ligand CCR chemokine (C-C motif) receptor CXCL chemokine (C-X-C motif) ligand Cy cyanine DC dendritic cell DcR decoy receptor DMEM Dulbecco’s modified Eagle’s medium DTH delayed-type hypersensitivity ... proteomics and degradomics, along with murine models have substantially widened our knowledge of the exceptionally differing and complicated role of MMPs in development and disease (Butler and Overall, ... first described members of the TNF superfamily (Ruddle et al., 1992) Members 23 of this superfamily of cytokines have varied functions and are generally considered to be primary mediators of immune...

Ngày tải lên: 10/09/2015, 09:29

... study compared effects of two vitamin D doses The daily dose of 1500 IU resulted in better blood glucose and, although did not absolutely decreased IR, did reduced IR increase for that period ... Review of vitamin D 1.1.1 Chemical nature and metabolism of vitamin D Vitamin D exists in two forms, Cholecalciferol (Vitamin D3 ) and Ergocalciferol (Vitamin D2 ) Vitamin D is converted to 25(OH )D ... Recommendations on vitamin D supplementation and treatment of vitamin D deficiency There has not been also a widespread concensus on vitamin D supplementation and treatment of vitamin D deficiency...

Ngày tải lên: 11/05/2016, 08:56

... Gsa was detected as a doublet of 47 kDa and 45 kDa (Fig 1, lanes of lower blots) In vivo injection of native CT or CT-B effected a rapid increase of both the 47 kDa and 45 kDa Gsa isoforms, with ... corresponding loss of the C-terminal KDEL peptide (Fig 7C) Indeed, whereas rapid production of Assessment of the KDEL peptide integrity of endosomal CT-A The results presented thus far established that ... ADP-ribosylation of Gsa [7] The 25 kDa fragment was consistently observed in endosomal hydrolysates of CT obtained at acidic pH, and was strictly cathepsin D- dependent; its detection coincided with 32P-labeling...

Ngày tải lên: 19/02/2014, 02:20

... had no effect on the number of falls [17] Epidemiology of vitamin D- related fractures In addition to vitamin D- related phosphocalcic regulation, the vitamin D- related fall rate reduction induces ... been demonstrated that, in elderly rats, vitamin D reduced inflammatory disorders and hippocampal degenerative processes, and was also responsible for decreased levels of the biological markers of ... muscles - would then be feasible Evidence of the effectiveness of vitamin D on falls and bone fractures Epidemiology of vitamin D- related falls From an epidemiological point of view, vitamin D insufficiency...

Ngày tải lên: 19/06/2014, 08:20

... acetabulum in parents of children with DDH, and a higher proportion of children with DDH and their first degree relatives were lax-jointed Based on this study, Wynne-Davis proposed two different gene ... between the vitamin D and oestrogen endocrine system have been described 1,25-Dihydroxyvitamin D3 (1,25-(OH) 2D3 ) and 17β-estradiol (E2) have a mutual effect on their biosynthesis [19,20] and receptor ... with and without vitamin D3 on circulating levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D Calcif Tissue Int 1998, 62:26-30 Suarez F, Rossignol C, Garabedian M: Interactive effect of estradiol...

Ngày tải lên: 11/08/2014, 08:21

... rapidly elevated in the epidermis at the wound edges; deletion of a single PPARb allele results in delayed wound healing [10] Furthermore, inflammation-induced apoptosis was found to be enhanced ... expression Stress-induced cell death is inhibited by the treatment of specific PPARb ligand: L-165,041 (LD) Cer has emerged as an apoptotic lipid mediator, and accumulation of Cer and apoptosis are ... expression of CERK mRNA in SP1 cells treated with LD was determined using real-time PCR CERK mRNA expression was increased by LD treatment in a dose-dependent (Fig 3Aa) and timedependent (Fig...

Ngày tải lên: 18/02/2014, 18:20

... been several difficulties in understanding the functional role of receptor cleavage and shedding Some mutations or small deletions of individual or groups of amino acids did not prevent receptor cleavage, ... expression of the b1 mutant receptor was observed when compared with the wild-type receptor (Fig 4B) We wondered whether shedding of the ectodomain would modify the trafficking of the receptor Therefore, ... previously mapped in the divergent E3 region of the receptor [15] We studied the function and trafficking of such truncated receptors, mimicking cleaved and shed receptors Moreover, we re-evaluated the...

Ngày tải lên: 21/02/2014, 00:20