... an important role in transporting passengers and cargo. Especially in transporting passengers in urban area, long distance, container, inter – area cargo, etc….The first line of VietNam Railways ... Hanoi and arrive at Lao Cai train station in the early morning. Trains also leave in the evening from Lao Cai and arrive in the morning in Hanoi.Traveling within Sapa: Sapa is a small town ... History of VietNam trains: The first train in Indo-china running from Sai Gon to Cho Lon on 27 December 1881 In National Communication and Transpor system, VietNam Railway came into being later...
... ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44]. These factors are involved in ethanol-induced ... . Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma ... signaling. This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in HepG2 cells [19]. Int....
... China Statistics Yearbook, China Financial Yearbook and People’s Bank of ChinaStatistics Quarterly bulletin.B. Development of direct financing and indirect financing marketsproviding financing ... in exploring on-line banking business as well as in promotingnon-bank financial institutions. Efforts should be made in upgrading financialoperations and financial services, and in conducting ... developing countries. He suggests that as financial 7F. Roleof the government, central bank and international financialinstitution in institution building1. Roleof the governmentAs an indispensable...
... shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, ... signaling is independent of Toll-interleukin 1 receptor domain-containing adaptorprotein. Drug Metab Dispos 36, 95–101.10 Ghose R, Guo T & Haque N (2009) Regulation of geneexpression of hepatic ... USA). Binding of all of the anti-bodies was detected using an ECL detection system (iNtRONBiotechnology, Seoul, Korea) in accordance with the manu-facturer’s instructions. The intensity of the...
... renewed interest in examining the indications for BCG vaccination in theUnited States included consideration of the wide range of vaccine efficacies deter-mined by clinical trials and estimated in ... should continue to be included in ongoing testing programs if their skin-testresults are <5 mm induration. Those vaccinees who have positive tuberculin skin-testreactions (≥5 mm of induration) ... indicated, administering preventive therapy to thosepersons who have positive tuberculin skin-test results. The preferred method of skintesting is the Mantoux tuberculin skin test using 0.1 mL of 5...
... would involve the following determinations: in terms of producing information about possible invest-ments and allocating capital, the financial (a) developing and analyzing measures of the ... REPORT 2013 1 GLOBAL FINANCIAL DEVELOPMENT REPORT 2013Rethinking the Role of the State in FinanceWashington, D.C. GLOBAL FINANCIAL DEVELOPMENT REPORT 2013 BENCHMARKING FINANCIAL SYSTEMS AROUND ... governments. (In) efficiency mea-sures for institutions include indicators such as overhead costs to total assets, net interest margin, lending-deposits spread, noninterest income to total income,...
... them to maintain higher net interestmargins. Indeed, during most of the 1990s, the net interest margin of small banks held steady at over 4.5 percent, while the net interest margin of large banks ... begins by pointing out that bankingindustry observers expect the number of community banks to declineTable 10AVERAGE RETAIL BANKING FEES BY SIZE OF INSTITUTION(2001, in dollars)Type of ... largerbanks in making small business loans. Loan officers at small banks cantake into account a wide variety of factors in reviewing applications forsmall business loans, including the character of...
... from mining operations can contain silt and rock particles and sur-factants. Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, ... dis-charge can contain a wide range of contaminants and originate from a myriad of sources. Some of the biggest generators of toxic industrial waste include mining, pulp mills, tanneries, sugar ... examples of persistent environmental damage caused by the discharge of toxic mine waste. In Papua New Guinea for ex-ample, companies discharge millions of tons of contaminated mine waste into...
... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati,OH, USA) constantly maintained at 1% O2. Culturemedium ... cultured in DMEM containing 10% fetal bovineserum. OP9 cells were grown in aMEM containing 20%fetal bovine serum. C2C12 cells were maintained in DMEMcontaining 10% fetal bovine serum.Adipogenic ... serumand IDM (10 lgặmL)1insulin, 1 lm dexamethasone, and0.5 mm IDM). Cells were then maintained in DMEM con-taining 10% fetal bovine serum and 1 lgặmL)1insulin. Themedium was replaced...
... calcium-independentphospholipase A2participates in ER stress-inducedINS-1 insulinoma cell apoptosis by promoting cera-mide generation via hydrolysis of sphingomyelins byneutral sphingomyelinase. Biochemistry 46, ... leading to the accumulation of sphingomyelin [27]. Because one of the pathwaysfor ceramide recycling is the sphingomyelin pathway, itis conceivable that in addition to the accumulation of Fig. ... protein contain-ing motifs consistent with a rolein the intracellular transport of cholesterol to post-lysosomal destinations.Cells from NPC subjects show a decrease in acidsphingomyelinase activity,...
... Ceris incorporated, hydrolyzed to sphingosine and thenrecycled into intracellular Cer itself, and that accumu-lation of Cer contributes to the induction of apoptosis[20]. However, the signaling ... rolein skin woundhealing. After a skin injury, PPARb expression is rap-idly elevated in the epidermis at the wound edges; dele-tion of a single PPARb allele results in delayed woundhealing ... culturedhuman keratinocytes [14]. In this study, we examined the interaction betweenCerK and PPARb, and its rolein regulating keratino-cyte survival. We report that in a mouse keratinocytecell line upregulation...
... detected atthe dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex-changing and exchanging HHP-RNase were prepared start-ing from 1Z7X. ... detected at the dimerinterface of the models or in the surroundings of themutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the7RSA structure ... Protein–lipidic membrane complexes of RNaseAA, RNase AA-G, RNase AA-GG, and HHP-RNase wereprepared using models of these dimers. The models of RNase A covalent dimers in the nonexchanging conforma-tion...
... substratebinding process. This provides strong evidence thatN-glycans, in particular their terminal structures, areinvolved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... that N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the roleof theterminal ... that of DDN, showing a value of only5.5 h. In contrast, the stability of NNN containingonly mannosidic N-glycans after treatment with dMMFig. 4. In uence of dMM on plasma membrane trafficking...
... language behavior are introduced by including neurally motivated pro- cessing control as the focus ofmodel definition and by including behaviorially defined con- straints, both normal and ... computational linguistics which in- cludes neurally-motivated constraints in the design of models of natural language processing. Furthermore, the knowledge representations in- cluded in such models ... understanding of brain function, contributes significantly to our increased under- standing of representations which have been de- fined within linguistics, psycholinguistics, neurolinguistics,...