role of salicylic acid in alleviating heavy metal stress

... of IFN-γ and IL-12p70 of all investigated donors Serum cytokine profiles of Cd- and Hg-exposed mice Figure shows serum profiles of IL-12p70 and IFN-γ analyzed by CBA in sera of mice exposed intraperitoneally ... that coincided with the increase in IL-12p70 levels However, in out of a total of 12 examined mice, where IL-12 release was induced, as in case of 5-week exposure to Cd acetate (Fig 4C), both of ... the former being able to offer the high throughput of EIA combined with the individual protein testing capacity of the Western blotting Discussion To extend our knowledge on heavy metal- elicited...

Ngày tải lên: 20/06/2014, 00:20

... (retaining their FAD prosthetic group) The mutants, in their oxidized state, show the typical spectrum of the FADcontaining avoproteins (line in Fig 2), an extinction coefcient at 455 nm of % ... band at % 600 nm following the binding of anthranilate (Fig 3, inset) and the shoulder at % 500 nm following the binding of benzoate (De497nm of 7500ặM)1ặcm)1 vs a gure of 2000 4000ặM)1ặcm)1 observed ... D-Phenylalanine D-Valine Cephalosporin C D-Tryptophan D-Proline D-Serine D-Alanine Table Substrate specicity of wild-type and Y238 mutants of D-amino acid oxidase All measurements were made in 50 mM...

Ngày tải lên: 17/03/2014, 17:20

... differences in the microenvironment of the isoalloxazine ring [21,22] Moreover, the structure of E301A FNR also showed interesting conformational changes in the side-chain of another glutamic acid residue, ... suggested that in E301A FNR the side-chain of E139 might in uence the properties of the flavin, assuming some of the functions carried out by E301 in the wild-type enzyme [22] In this context, ... presence of a negatively charged residue at this position is in some way involved in weakening the interaction between FNR and Fd In line with this, the conservative replacement of E139 by aspartic acid...

Ngày tải lên: 31/03/2014, 08:20

... suggest a role for LPA receptors in linking lung injury in the murine bleomycin model of pulmonary fibrosis Asthma is a chronic inflammatory disease of the airways involving T-lymphocytes and eosinophils ... lung, suggesting an antiinflammatory role of LPA in a murine model of acute lung injury [26] In addition to its anti-inflammatory effect, LPA regulated E-cadherin intracellular trafficking and airway ... key role in orchestrating inflammatory and structural changes of the airway in asthma by recruiting, activating and promoting inflammatory cells into the airway [38-40] In addition to cytokines,...

Ngày tải lên: 12/08/2014, 14:20

... ANK3 Gene title cofactor of BRCA1 integrin, beta staufen, RNA binding protein, homolog (Drosophila) high mobility group nucleosomal binding domain ankyrin 3, node of Ranvier (ankyrin G) Signal Log ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray results ... ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced...

Ngày tải lên: 31/10/2012, 15:28

... viewed as limited in raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural ... more typical of male behaviours Of interest is the inclusion of ‘‘control’’ as a significant feature of the transactional style, common in definition of leadership in the 1990s In contrast, women ... superiority in utilising effective leadership styles of interaction with their subordinates and organisational outcomes, actually translates into a dramatic increase in the numbers of women being appointed...

Ngày tải lên: 08/10/2013, 15:56

... The role of FDI in institution building Over the past 20 years, foreign financial institutions, mainly foreign banks have played an important role in the opening up of Chinese financial industry ... technology, in exploring on-line banking business as well as in promoting non-bank financial institutions Efforts should be made in upgrading financial operations and financial services, and in conducting ... China Statistics Yearbook, China Financial Yearbook and People’s Bank of China Statistics Quarterly bulletin B Development of direct financing and indirect financing markets providing financing...

Ngày tải lên: 18/10/2013, 07:15

... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... [22] ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23] Activated KCs cause oxidative stress on the surrounding tissue, releasing large ... receptor signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36, 95–101 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic...

Ngày tải lên: 14/02/2014, 18:20

... boosted by administering a tuberculin skin test week to year after the initial postvaccination skin test; ongoing periodic skin testing also might prolong reactivity to tuberculin in vaccinated persons ... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered ... Tuberculin Skin Testing and Interpretation of Results After BCG Vaccination Postvaccination BCG-induced tuberculin reactivity ranges from no induration to an induration of 19 mm at the skin-test site...

Ngày tải lên: 15/02/2014, 13:20

... Rethinking the Role of the State in Finance Global Financial Development Report 2013 Rethinking the Role of the State in Finance Washington, D.C © 2012 International Bank for ... important role, especially in providing supervision, ensuring healthy competition, and strengthening financial infrastructure Incentives are crucial in the financial sector The main challenge of financial ... possible countercyclical role of state-owned financial institutions, and the role of the state in promoting information sharing—all topics that are examined in the current Global Financial Development...

Ngày tải lên: 16/02/2014, 10:20

... them to maintain higher net interest margins Indeed, during most of the 1990s, the net interest margin of small banks held steady at over 4.5 percent, while the net interest margin of large banks ... key role serving certain types of communities and providing certain types of banking services ECONOMIC REVIEW • SECOND QUARTER 2003 17 Definition of a community bank There is no single definition ... Banking Industry,” Journal of Banking and Finance, August Sullivan, Richard J 2000 “How Has the Adoption of Internet Banking Affected Performance and Risk in Banks? A Look at Internet Banking in...

Ngày tải lên: 16/02/2014, 11:20

... Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, mercury and arsenic The contaminants in mine waste may be Cooling waters used in industrial ... filtration, and increases the groundwater contamination 38  Figure 13: Mining effects on rainfall drainage Acid Mine Drainage (AMD) is the number one environmental problem facing the mining industry ... Figure 19 in the timing and intensity of rainfall, or the period of time without rain, as well as affecting the quality of water in rivers and lakes through changes in the timing and volume of peak...

Ngày tải lên: 17/02/2014, 10:20

... or without hematoxylin staining In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture ... initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum Cells were fixed on day of differentiation and stained with hematoxylin and eosin One of ... DMEM containing 10% fetal bovine serum OP9 cells were grown in aMEM containing 20% fetal bovine serum C2C12 cells were maintained in DMEM containing 10% fetal bovine serum Adipogenic differentiation...

Ngày tải lên: 18/02/2014, 08:20

... phospholipase A2 participates in ER stress- induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... transport of cholesterol to post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the ... should have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This...

Ngày tải lên: 18/02/2014, 14:20

... with annexin V and PI staining A significant increase in the percentages of annexin V ⁄ PIpositive cells was observed in cultures of wild-type keratinocytes undergoing serum starvation stress for ... keratinocytes [14] 3816 In this study, we examined the interaction between CerK and PPARb, and its role in regulating keratinocyte survival We report that in a mouse keratinocyte cell line upregulation ... important role in keratinocyte survival during skin wound healing, and PPARb expression is elevated at injury sites [10,15] We investigated whether skin barrier disruption by tape-stripping would induce...

Ngày tải lên: 18/02/2014, 18:20

... Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the hinge loop residues Likewise, the models of nonexchanging and exchanging HHP-RNase ... values of EIE were recorded at 30° intervals of r from to 360°; (d) the inclination of the dimer major axis with respect to the z axis, hence to the membrane plane, was changed (by inclination of ... detected at the dimer interface of the models or in the surroundings of the mutated residues The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure...

Ngày tải lên: 19/02/2014, 06:20

... substrate binding process This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... terminal structures of the N-glycans of GAT1, N-glycosylation processing of NNN was inhibited by 1-deoxymannojirimycin (dMM) Inhibition by dMM leads to the formation of NNN molecules containing ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...

Ngày tải lên: 19/02/2014, 17:20

... results Because of the parallel activation of a l l meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active ... often generic and mark masculine, feminine, or plural (Gross, 1977; Goffic and McBride, 1975) And furthermore, these same articles often are not translated into meaning preserving sentences in ... appropriate masculine/feminine indicators (Jayez, 1982) The issues are not whether human brains work in a universal fashion, but instead raise questions of how interpreted levels of representation,...

Ngày tải lên: 21/02/2014, 20:20

... Bioethics Institute The Johns Hopkins University Washington, DC Monograph 19 The Role of the Media Pamela Ling, M.D, M.P.H Assistant Professor in Residence Department of Medicine, General Internal ... use,12,13 underscoring the urgency of examining the media’s role in global tobacco marketing At the same time, the media have an equally powerful role in influencing individuals and policymakers and ... combining sponsorship, brand merchandising, brand stretching, packaging, point -of- sale promotions, and product placement, across a broad range of channels ranging from event marketing to the Internet.22,23...

Ngày tải lên: 06/03/2014, 01:20

... remaining 11% An increase in indebtedness (of 80% in average) is associated with a 14% decrease in production, and with a 2% rise in inventories Conversely, enterprises with a decrease level of indebtedness ... equal to ô ằ (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of Expected-Debt to be equal to ô ằ (not indebted and not going to be) by 13 points (34 minus 21) ... markets - demand-side constraints for most of them and access-to-input for the worst in this sub-pool Conversely, the overbearing influence of the financial constraints in the lower half is statistically...

Ngày tải lên: 06/03/2014, 08:20