role of reactive oxygen species and apoptosis
báo cáo khoa học: " Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets" ppsx
Ngày tải lên :
12/08/2014, 03:20
... xenobiotic and ROS signalling are discussed Results Patterns of accumulation of singlet oxygen, superoxide radical and hydrogen peroxide The transfer of plantlets after weeks of growth to control and ... 57:711-738 Asada K: Production and scavenging of reactive oxygen species in chloroplasts and their functions Plant Physiol 2006, 141(2):391-396 Bowler C, Slooten L, Vandenbranden S, De Rycke R, Botterman ... detection of hydrogen peroxide and singlet oxygen: its use for the assay of reactive oxygen species produced in vivo Plant J 2007, 50(3):475-487 Chao L, Zhou QX, Chen S, Cui S, Wang ME: Single and...
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Báo cáo y học: " Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads" potx
Ngày tải lên :
12/08/2014, 23:22
... the effect of VPA on apoptosis, PBMCs (1.106) isolated from BLVinfected and control sheep were cultivated in the absence and the presence of mM VPA (Sigma/Aldrich) and the percentages of apoptotic ... specific hallmark of apoptosis, we confirmed these conclusions by Annexin V labeling experiments (data not shown) We next measured the levels of intracellular reactive oxygen species (ROS) using ... Control % of 8-OHdG positive B cells Red CM-XROS 60 Profile of fluorescence intensities 50 40 30 20 10 Control Figure of Analysis DNA oxidative damage Analysis of DNA oxidative damage After 24 h of...
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Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines pot
Ngày tải lên :
16/03/2014, 18:20
... Determination of intracellular reactive oxygen species as function of cell density Methods Enzymol 352, 91–100 44 Zuo, L & Clanton, T.L (2002) Detection of reactive oxygen and nitrogen species in ... for energy supply and for maintenance of an appropriate redox environment [17,18] Analysis of q0 cells has provided insights into oxygen metabolism [13,17,19–21] and the role of mitochondria in ... the CELLQUEST software program (Becton-Dickinson) Fig GSH and GSSG concentrations and ratio of GSH2 : GSSG in q+ and q0 cells from osteosarcoma (bone), rhabdomyosarcoma (muscle) and lung carcinoma...
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báo cáo khoa học: "Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells" pdf
Ngày tải lên :
10/08/2014, 10:20
... Belinsky SA, Lin Y: A critical role of luteolininduced reactive oxygen species in blockage of tumor necrosis factoractivated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer ... Generation of reactive oxygen species and induction of apoptosis Journal of carcinogenesis 2009, 8:9 26 Lin Y, Shi R, Wang X, Shen HM: Luteolin, a flavonoid with potential for cancer prevention and ... types of tumors The sensitization effect of saikosaponin was mainly through enhancing the cisplatin-induced apoptosis, which was accompanied by enhanced activation of caspase and the cleavage of...
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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells doc
Ngày tải lên :
18/02/2014, 13:20
... understanding of the apoptotic mechanisms is required for the prevention and treatment of many diseases [2] Reactive oxygen species (ROS), a group of highly reactive molecules, including singlet oxygen, ... cell apoptosis was dependent on ROS generation and that oridonin-induced autophagy blocked apoptosis Furthermore, the roles of p38 and nuclear factor-kappa B (NF-jB) in oridonin-induced apoptosis ... Effects of NF-jB and p38 on oridonin-induced L929 cells apoptosis and OS generation The cells were incubated in the presence of absence of 20 lM PDTC or 10 lM SB 203580 for h prior to the addition of...
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báo cáo hóa học:" Airborne particulate matter PM2.5 from Mexico City affects the generation of reactive oxygen species by blood neutrophils from asthmatics: an in vitro approach" docx
Ngày tải lên :
20/06/2014, 00:20
... Medicine and Toxicology 2009, 4:17 Figure by neutrophils in contact with PM2.5 In vitro generation of reactive oxygen and nitrogen species In vitro generation of reactive oxygen and nitrogen species ... susceptibility of lipids to oxidation was used to calculate the sample size According to the mean comparison formula [15] with a standard deviation of 157.53 and a difference of 616, Za of 95% and a Zb of ... modification of molecules and/ or disruption of cellular structures and tissue injury [9] Due to high MPO activity, the generation of hypochlorous acid (HOCl) and reactive nitrogen species (RNS)...
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báo cáo khoa học: " Reactive oxygen species and transcript analysis upon excess light treatment in wild-type Arabidopsis thaliana vs a photosensitive mutant lacking zeaxanthin and lutein" pps
Ngày tải lên :
11/08/2014, 11:22
... Maier M, Landthaler M, Szeimies RM, Baumler W: The role of singlet oxygen and oxygen concentration in photodynamic inactivation of bacteria Proceedings of the National Academy of Sciences of the ... individual detection of hydrogen peroxide and singlet oxygen: its use for the assay of reactive oxygen species produced in vivo Plant Journal 2007, 50:475-487 88 de Torres M, Sanchez P, Fernandez-Delmond ... between singlet oxygen- and hydrogen peroxide-dependent signaling of stress responses in Arabidopsis thaliana Proceedings of the National Academy of Sciences of the United States of America 2007,...
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Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species
Ngày tải lên :
24/08/2014, 12:59
... SCHOOL Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species For the degree of Master of Science Choose your degree ... THE ROLE OF STAT3 AND REACTIVE OXYGEN SPECIES A Thesis Submitted to the Faculty of Purdue University by America Bethanne Newnum In Partial Fulfillment of the Requirements for the Degree of Master ... University, August 2012 Bone Metabolism: The Role of STAT3 and Reactive Oxygen Species Major Professor: Jiliang Li Signal Transducers and Activators of Transcription (STAT3), a transcription factor...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
Ngày tải lên :
05/03/2014, 23:20
... inability of MB and LPS to induce any impairment in mitochondrial function after h of treatment RCR and states 2, 3, and FCCP rates of MB- and LPStreated cells were the same as those of unstimulated ... cellular ROS and reactive nitrogen species (RNS) production The increased production of reactive species was apparent after h of stimulation Since UCP2 is described as a regulator of ROS production, ... mechanism of action of MDP on the mitochondrial bioenergetics system and since mitochondria are an important source of ROS production and especially of superoxide anion, we investigated the effect of...
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Báo cáo khoa học: Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species pptx
Ngày tải lên :
16/03/2014, 06:20
... chain of this residue forming hydrogen bonds with oxygens of the 3-phosphate; NH1 and NH2 of Arg105 form hydrogen bonds with the 4-OH and 5-OH of the inositol moiety; and the aromatic ring of Tyr59 ... Ser310 and Ser328 form hydrogen bonds with the side chains of Glu211 and Arg267, respectively (Fig 11) It is known that phosphorylation of Ser303 and Ser328 plays a crucial role in disruption of ... a-helices of TPR1 and TPR2 (position of TPR2) and Asn204 in the b-hairpin (position 34 of TPR3), are highly conserved among p67phox and its related proteins (Fig 14) In addition, substitution of Glu...
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Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants" pps
Ngày tải lên :
09/08/2014, 08:23
... the nomenclature of free radicals, the term 'reactive oxygen species' (ROS) has prevailed, although ROS can be differentiated into reactive nitrogen species and other oxidant species The relationship ... biochemistry and molecular biology Edited by: Burdon RH Amsterdam: Elsevier; 1991:20 Henrotin YE, Bruckner P, Pujol JP: The role of reactive oxygen species in homeostasis and degradation of cartilage ... controls released 1,100 pg of VEGF per ml of medium and cartilage explant controls released 540 pg of VEGF per ml of medium Treatment with PMA at concentrations of 5, 10 and 20 μg/ml increased VEGF...
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Role of neutrophil NADPH oxidase derived reactive oxygen species (ROS) in innate immune responses
Ngày tải lên :
21/05/2016, 22:38
... dissertation List of tables List of tables Table List of antibodies used for flow cytometry analysis 20 Doctoral dissertation Summary SUMMARY I have investigated the role played by reactive oxygen species ... ROS? ROS include a number of chemically reactive partially reduced forms of oxygen including O2−, H2O2, and HO• These ROS are substantially more reactive than molecular oxygen which is itself a ... peritoneal inflammation Many different models of peritoneal inflammation exist and each of them has its own kinetics of cellular influx and of development of the inflammatory response To try to place...
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Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"
Ngày tải lên :
25/10/2012, 11:18
... and acts as a promoter for both the heavy and light strands of the mtDNA, and contains essential transcription and replication elements The D-loop region is a hot spot for mtDNA alterations and ... cells and mtDNA mutations have been found in Hp infected gastric ulcer and carcinoma tissues [12,13] However, the role of ROS in the Hp induced mtDNA mutations is still unknown and the impacts of ... in the detection of absorbance The experiment was repeated times and data were expressed as Χ± SD Detection of CagA and VacA protein using SDS-PAGE and Western Blot Detection of cell viability...
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Báo cáo khoa học: Neuroglobin and cytoglobin expression in mice Evidence for a correlation with reactive oxygen species scavenging doc
Ngày tải lên :
23/03/2014, 09:21
... signal is seen after 48 h of hypoxia, and it gradually declines during reoxygenation Communal et al [23] and Liu et al [24] described the important role of apoptosis in heart and liver diseases, respectively ... upregulated upon 48 h of hypoxia, and that this increase is dependent on the tissue and the severity of hypoxia The mechanism of induction of Cygb is regulated by HIF-1 The aim of this study was ... dependency and the tissue specificity of Cygb and Ngb mRNA upregulation upon hypoxia and after reoxygenation In addition, we tried to shed light on the ROS-scavenging function of Ngb and on the...
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Báo cáo khoa học: Is there more to aging than mitochondrial DNA and reactive oxygen species? pot
Ngày tải lên :
29/03/2014, 22:21
... (1999) Effects of Ni(II) and Cu(II) on DNA interaction with the N-terminal sequence of human protamine P2: enhancement of binding and mediation of oxidative DNA strand scission and base damage ... apyrimidinic endonuclease APE ⁄ Ref1; SSB and DSB, single-strand break and double-strand break, respectively ase, may aid in the generation of abasic sites and single-strand breaks This model provides a ... respiring on both complex I- and complex II-linked substrates Biochem J 409, 491–499 33 Starkov AA (2008) The role of mitochondria in reactive oxygen species metabolism and signaling Ann NY Acad...
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Báo cáo Y học: Inactivation of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio alginolyticus by reactive oxygen species pot
Ngày tải lên :
31/03/2014, 21:21
... cell rupture and preparation of membrane vesicles of V alginolyticus cells were performed under exclusion of dioxygen In addition, the effect of enzymes that detoxify reactive oxygen species (superoxide ... NADH oxidation and Q reduction activities of 2.45 and 0.99 lmolÆmin)1Æmg)1, respectively [15] Inhibition and uncoupling of the Na+-NQR activity by dioxygen Characterization of redox cofactors in ... anaerobic chamber and flushed with N2 In order to investigate the influence of dioxygen and NADH on the activity of the Na+-NQR, membrane vesicles were prepared (A) in the presence of dioxygen without...
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Báo cáo y học: "Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation" pot
Ngày tải lên :
10/08/2014, 05:21
... acetylcholinesterase [67], GABAA and serotonin receptors [68] reported the neuroprotective role of glucose and combination of glucose and oxygen resuscitation and the damaging effects of oxygen supplementation ... control One hundred percentage of oxygen generated abnormally high levels of reactive oxygen species (ROS) which causes dysfunction of defensive Anju et al Journal of Biomedical Science 2011, 18:31 ... cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation Journal of Biomedical Science 2011 18:31 Submit your next manuscript to BioMed Central and take...
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Báo cáo y học: " Early The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils" pps
Ngày tải lên :
11/08/2014, 08:21
... influx of leukocytes in antigen-challenged Brown Norway rats [6], and the peptide is also potent inhibitor of human and rat neutrophil adhesion and migration [10,17,18] The primary role of the ... regulation of neutrophil apoptosis and the systemic inflammatory response syndrome Clin Sci (Lond) 2005, 108(5):413-424 Li C, Jackson RM: Reactive species mechanisms of cellular hypoxia-reoxygenation ... http://www.journal-inflammation.com/content/3/1/9 CD11b/c and CD49d 300 BSA feG OA OA & feG # MFI 200 100 * CD11b/c CD49d Figure Cell Surface Expression of CD11b/c and CD49d Cell Surface Expression of CD11b/c and CD49d The effect of antigen...
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Báo cáo khoa học: "A Reactive oxygen species: toxic molecules or spark of life" docx
Ngày tải lên :
12/08/2014, 23:21
... deactivation and the formation of adrenochromes, which are toxic themselves Of interest, in the first identification of SOD, one of the tests of the activity of the enzyme was the prevention of oxidation ... 1/10,000 of extracellular Ca2+ so as to avoid the interaction of Ca2+ and phosphate and bone formation Because of the large transmembrane gradient of Ca2+, the leak of small amounts of Ca2+ across ... not just random destructive species but regulators of metabolic processes and part of the chemistry of life [10,11] Furthermore, evidence of oxidative injury may be the end result of the inflammatory...
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Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx
Ngày tải lên :
13/08/2014, 05:22
... Program of the NIH, National Institute for Dental and Craniofacial Research References Detection of ROS in culture supernatant The amount of reactive oxygen species present in the supernatants of ... Brody AR: Asbestos-derived reactive oxygen species activate TGF-beta1 Lab Invest 2004, 84:1013-1023 Hildeman DA: Regulation of T-cell apoptosis by reactive oxygen species Free Radic Biol Med ... (green) represents dead and/ or late apoptotic cells (see C) B Profile of DHE fluorescence (ROS+) on FL-2 vs FSC of R1 and R2 cells The values are shown as the MFI of R1 and R2 cells (R1/R2) Data...
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