role of population pharmacokinetics in clinical pharmacology

... functioning of the patient in terms of the impact of disease is "an essential part of clinical diagnosis, a major determinant of therapeutic choices, a measure of their efficacy, and a guide in planning ... measurement and feedback of HRQoL has as of yet not been widely implemented in clinical practice This may be explained by the initial lack of convincing data regarding the effectiveness of standardized ... reported include general lack of time, money and human resources, impracticality of instruments, disruption of clinical routine, lack of IT support and health professionals' lack of knowledge in this...

Ngày tải lên: 18/06/2014, 19:20

... functioning of the patient in terms of the impact of disease is "an essential part of clinical diagnosis, a major determinant of therapeutic choices, a measure of their efficacy, and a guide in planning ... measurement and feedback of HRQoL has as of yet not been widely implemented in clinical practice This may be explained by the initial lack of convincing data regarding the effectiveness of standardized ... reported include general lack of time, money and human resources, impracticality of instruments, disruption of clinical routine, lack of IT support and health professionals' lack of knowledge in this...

Ngày tải lên: 20/06/2014, 16:20

... disequilibrium plot of of STAT1-STAT4 region in a Japanese population and Linkage(SNPs) first screening the52 tag single nucleotide polymorpopulation and first screening of 52 tag single nucleotide ... background of SLE may be greater in the Japanese population than in Americans of European descent Competing interests RRG, GH, and TWB are employees of and hold stocks or shares in Genentech, Inc (South ... accelerated nephritis and increased mortality in the absence of high levels of autoantibodies [25] STAT4 has been shown to be involved in the induction of IFNγ, differentiation of Th1 and Th17 cells,...

Ngày tải lên: 09/08/2014, 13:22

... maintenance of vessel integrity Angiopoietin-1 (Ang-1) and Ang-2 are ligands of the endothelial receptor tyrosine kinase Tie-2, which is a key regulator of endothelial function [14] Binding of circulating ... selected by parents or guardians in the neighborhood of the index case as part of a larger study investigating genetic susceptibility in IPD [32] In a small number of children, parental con- Mankhambo ... group of patients requiring aggressive treatment or characterize those eligible for entry to a randomized clinical trial of adjunctive therapies Interventions that target the inhibition of inflammatory...

Ngày tải lên: 13/08/2014, 20:22

... ANK3 Gene title cofactor of BRCA1 integrin, beta staufen, RNA binding protein, homolog (Drosophila) high mobility group nucleosomal binding domain ankyrin 3, node of Ranvier (ankyrin G) Signal Log ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray results ... ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced...

Ngày tải lên: 31/10/2012, 15:28

... viewed as limited in raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural ... more typical of male behaviours Of interest is the inclusion of ‘‘control’’ as a significant feature of the transactional style, common in definition of leadership in the 1990s In contrast, women ... superiority in utilising effective leadership styles of interaction with their subordinates and organisational outcomes, actually translates into a dramatic increase in the numbers of women being appointed...

Ngày tải lên: 08/10/2013, 15:56

... The role of FDI in institution building Over the past 20 years, foreign financial institutions, mainly foreign banks have played an important role in the opening up of Chinese financial industry ... technology, in exploring on-line banking business as well as in promoting non-bank financial institutions Efforts should be made in upgrading financial operations and financial services, and in conducting ... China Statistics Yearbook, China Financial Yearbook and People’s Bank of China Statistics Quarterly bulletin B Development of direct financing and indirect financing markets providing financing...

Ngày tải lên: 18/10/2013, 07:15

... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... receptor signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36, 95–101 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... MA, USA) Binding of all of the antibodies was detected using an ECL detection system (iNtRON Biotechnology, Seoul, Korea) in accordance with the manufacturer’s instructions The intensity of the...

Ngày tải lên: 14/02/2014, 18:20

... boosted by administering a tuberculin skin test week to year after the initial postvaccination skin test; ongoing periodic skin testing also might prolong reactivity to tuberculin in vaccinated persons ... inadequate data defining the susceptibility status of study populations; uncertain comparability of control populations; incomplete assessment of ongoing exposure to contagious TB patients; inadequate ... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered...

Ngày tải lên: 15/02/2014, 13:20

... Rethinking the Role of the State in Finance Global Financial Development Report 2013 Rethinking the Role of the State in Finance Washington, D.C © 2012 International Bank for ... important role, especially in providing supervision, ensuring healthy competition, and strengthening financial infrastructure Incentives are crucial in the financial sector The main challenge of financial ... possible countercyclical role of state-owned financial institutions, and the role of the state in promoting information sharing—all topics that are examined in the current Global Financial Development...

Ngày tải lên: 16/02/2014, 10:20

... them to maintain higher net interest margins Indeed, during most of the 1990s, the net interest margin of small banks held steady at over 4.5 percent, while the net interest margin of large banks ... key role serving certain types of communities and providing certain types of banking services ECONOMIC REVIEW • SECOND QUARTER 2003 17 Definition of a community bank There is no single definition ... Banking Industry,” Journal of Banking and Finance, August Sullivan, Richard J 2000 “How Has the Adoption of Internet Banking Affected Performance and Risk in Banks? A Look at Internet Banking in...

Ngày tải lên: 16/02/2014, 11:20

... Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, mercury and arsenic The contaminants in mine waste may be Cooling waters used in industrial ... Figure 19 in the timing and intensity of rainfall, or the period of time without rain, as well as affecting the quality of water in rivers and lakes through changes in the timing and volume of peak ... filtration, and increases the groundwater contamination 38  Figure 13: Mining effects on rainfall drainage Acid Mine Drainage (AMD) is the number one environmental problem facing the mining industry...

Ngày tải lên: 17/02/2014, 10:20

... or without hematoxylin staining In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O2 Culture ... initiated at 48 h post-transfection by maintaining the cells in culture medium containing 2% horse serum Cells were fixed on day of differentiation and stained with hematoxylin and eosin One of ... DMEM containing 10% fetal bovine serum OP9 cells were grown in aMEM containing 20% fetal bovine serum C2C12 cells were maintained in DMEM containing 10% fetal bovine serum Adipogenic differentiation...

Ngày tải lên: 18/02/2014, 08:20

... should have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This ... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... transport of cholesterol to post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the...

Ngày tải lên: 18/02/2014, 14:20

... 3821 Role of CerK in PPARb-induced keratinocyte survival K Tsuji et al Fig Schematic model illustrating the role of CerK in cell survival mediated by PPARb in mouse keratinocytes Under injury ... keratinocytes [14] 3816 In this study, we examined the interaction between CerK and PPARb, and its role in regulating keratinocyte survival We report that in a mouse keratinocyte cell line upregulation ... important role in keratinocyte survival during skin wound healing, and PPARb expression is elevated at injury sites [10,15] We investigated whether skin barrier disruption by tape-stripping would induce...

Ngày tải lên: 18/02/2014, 18:20

... Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the hinge loop residues Likewise, the models of nonexchanging and exchanging HHP-RNase ... values of EIE were recorded at 30° intervals of r from to 360°; (d) the inclination of the dimer major axis with respect to the z axis, hence to the membrane plane, was changed (by inclination of ... detected at the dimer interface of the models or in the surroundings of the mutated residues The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure...

Ngày tải lên: 19/02/2014, 06:20

... substrate binding process This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... terminal structures of the N-glycans of GAT1, N-glycosylation processing of NNN was inhibited by 1-deoxymannojirimycin (dMM) Inhibition by dMM leads to the formation of NNN molecules containing ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation...

Ngày tải lên: 19/02/2014, 17:20

... training data to measure the impact of each of the four subsets of features explained in Section Table shows the cross validation results when cumulatively adding each set of features Applying ... to gain most of the precision back (without sacrificing this recall) by adding the new features The new lexical features including negative prefixes and binary tf-idf features primarily increased ... at: http://incubator.apache.org/opennlp/ Berry de Bruijn, Colin Cherry, Svetlana Kiritchenko, Joel Martin, and Xiaodan Zhu 2011 MachineLearned Solutions for Three Stages of Clinical Information...

Ngày tải lên: 20/02/2014, 05:20

... results Because of the parallel activation of a l l meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active ... often generic and mark masculine, feminine, or plural (Gross, 1977; Goffic and McBride, 1975) And furthermore, these same articles often are not translated into meaning preserving sentences in ... appropriate masculine/feminine indicators (Jayez, 1982) The issues are not whether human brains work in a universal fashion, but instead raise questions of how interpreted levels of representation,...

Ngày tải lên: 21/02/2014, 20:20

... advertising and promotion in increasing tobacco use in the population, especially among youth; (5) the targeting of “at-risk” populations, including youth, women, and ethnic and racial minorities, ... use,12,13 underscoring the urgency of examining the media’s role in global tobacco marketing At the same time, the media have an equally powerful role in influencing individuals and policymakers and ... combining sponsorship, brand merchandising, brand stretching, packaging, point -of- sale promotions, and product placement, across a broad range of channels ranging from event marketing to the Internet.22,23...

Ngày tải lên: 06/03/2014, 01:20