role of platelet derived growth factor receptor a pdgfra

... Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y: Gain of function mutations of c-kit in human gastrointestinal ... MI, Heukamp LC, Larsson O, Tanaka S, Kawai A, Wardelmann E, Buettner R, Pietsch T, Hartmann W: Insulin-like growth factor- 1 receptor acts as a growth regulator in synovial sarcoma J Pathol 2008, ... 58:5432-8 Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ: Insulin-like growth factor- I receptor/ human epidermal growth factor receptor Pantaleo et al Journal of Translational Medicine 2010, 8:117...

Ngày tải lên: 18/06/2014, 16:20

... patient achieves long-lasting remission on maintenance trastuzumab therapy We also speculate that the specific localization of breast cancer metastases may be a factor given that many of the cases ... epidermal growth factor receptor 2; MBC: metastatic breast cancer Authors’ contributions JS collected and analyzed the data of the study and wrote the manuscript AD collected the data of the patient, ... to eight years, and in all cases, maintenance therapy was based on trastuzumab One of these cases also illustrates the risk of withdrawing trastuzumab treatment when the patient had experienced...

Ngày tải lên: 11/08/2014, 02:22

... et al: Hypoxia-mediated induction of acidic/basic fibroblast growth factor and plateletderived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells Proc Natl Acad ... P, Zarka V, Durand-Gasselin I, Monti G, Balabanian K, Garcia G, Capron F, Coulomb-Lhermine A, Marfaing-Koka A, Simonneau G, et al: Chemokine RANTES in severe pulmonary arterial hypertension Am ... Republic of China Authors’ contributions All authors have read and approved the manuscript JM contributed in writing manuscript, quantitated medial wall thickness and participated in data analysis;...

Ngày tải lên: 12/08/2014, 13:22

... involved in angiotensin II type receptor- mediated transactivation of the EGFR and activation of their downstream signalling pathways, as demonstrated upon abrogation of these phenomena by CaM antagonists ... SJ, Calandrella SO & Barrett KE (2000) Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells is mediated by intracellular Ca2+, ... region of the receptor to neutral amino acids (asparagine or alanine) also results in tyrosine kinase-mute receptors [48,59] A detailed analysis by performing alanine-scanning mutagenesis of each...

Ngày tải lên: 06/03/2014, 09:22

... kinase When considering tyrosine kinases that are activated downstream of the EGF receptor, we regarded Src family kinases as possible candidates, as these kinases are activated downstream of all ... receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa) rapidly dissociates and leaves the EGF receptor inactive after internalization into early ... K., Takeshita, T., Kasai, H., Sasaki, Y., Tanaka, N., Asao, H., Kikuchi, K., Yamada, M., Chen, M., O’Shea, J.J & Sugamura, K (2000) STAM2, a new member of the STAM family, binding to the Janus...

Ngày tải lên: 17/03/2014, 11:20

... 31 damage and nuclear factor- kappaB activation Invest Ophthalmol Vis Sci 2009, 50:3512-3519 Kurihara T, Ozawa Y, Nagai N, Shinoda K, Noda K, Imamura Y, Tsubota K, Okano H, Oike Y, Ishida S: Angiotensin ... response after photodynamic therapy: Role of vascular endothelial growth factor Misa Suzuki1,2,3, Yoko Ozawa1,2*, Shunsuke Kubota1,2, Manabu Hirasawa1,2, Seiji Miyake1, Kousuke Noda4, Kazuo Tsubota2, ... List of abbreviations VEGF, vascular endothelial growth factor; VEGFR1, vascular endothelial growth 16 factor receptor 1; PI3K, Phosphoinositide 3-kinase; AMD, age-related macular degeneration;...

Ngày tải lên: 19/06/2014, 22:20

... related to VEGF such as human placental growth factor and plateletderived growth factor Interassay and intra-assay variances were less than 10% The minimum detectable concentration of VEGF was ... inhibition of angiostatic factors rather than a further increase of VEGF Angiostatic factors are often cleaved enzymatically from extracellular matrix proteins [40] Among these extracellular matrixderived ... with some avascular areas, mild disorganization of the capillary architecture and absent or some ramified capillaries Finally, the late pattern criteria were irregular enlargement of capillaries,...

Ngày tải lên: 09/08/2014, 06:22

... Arimitsu J, Hagihara K, Shima Y, Narazaki M, Tanaka T, Kawase I, Sano H, Ogata A: Imatinib mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference ... Breit SN: Identification of the major fibroblast growth factors released spontaneously in inflammatory arthritis as platelet derived growth factor and tumour necrosis factor- alpha Clin Exp Immunol ... M, Abe T, Takeuchi T: Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet- derived growth factor...

Ngày tải lên: 12/08/2014, 12:20

... photomicrographs of HPAEC after TUNEL staining are shown in Fig 4c Active caspase-3 immunoassay of HPAEC Active caspase-3 was detected with a human active caspase-3 immunoassay Stimulation with ... Immunohistochemistry of the lung section Anti-human caspase-3 rabbit polyclonal antibody (Novocastra Laboratories, Newcastle, UK), anti-human Bax rabbit polyclonal antibody (Oncogene, San Diego, CA), antihuman AIF ... F, Anders S, Mentlein R: Pulmonary expression of vascular endothelial growth factor in sepsis Arch Pathol Lab Med 2003, 127:331-335 Koyama S, Sato E, Tsukadaira A, Haniuda M, Numanami H, Kurai...

Ngày tải lên: 12/08/2014, 15:21

... epidermal growth factor (EGF) receptor ⁄ extracellular signalregulated kinase ⁄ and EGF receptor ⁄ Akt pathway for proliferation Mol Cancer Ther 3, 465–472 Amann J, Kalyankrishna S, Massion PP, ... metastasis G Wang et al against ERK1 ⁄ and phospho-ERK1 ⁄ were from Chemicon International, Inc (CA, USA) Antibody against Akt was from BioVision, Inc (CA, USA), and antibody against phospho-Akt was from ... later, MTT was added to each well for h at 37 °C, and then replaced by dimethylsulfoxide Absorbance was read at 570 nmolÆL)1 The data are presented as percentage of growth relative to the negative...

Ngày tải lên: 07/03/2014, 00:20

... of inflammation following coagulation activation requires the participation of platelets, probably via PAR-4 signaling, as well as the formation of fibrin Activation of one pathway alone is insufficient ... footpad inflammation of platelets in soluble tissue factor- induced footpad inflammation Immune thrombocytopenia was induced in protease activated receptor PAR-4+/+ mice by a single antiplatelet antibody ... the main pathway by which proteases activate mouse platelets in vivo Role of footpad inflammation induced hirudin, factor VII inhibitor and ancrod in soluble tissue facRole of hirudin, factor...

Ngày tải lên: 09/08/2014, 10:23

... with asthma exacerbation J Allergy Clin Immunol 1995, 95:843–852 Amishima M, Munakata M , Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y: Expression of epidermal growth factor and epidermal ... epidermal growth factor receptor immunoreactivity in the asthmatic human airway Am J Respir Crit Care Med 1998, 57: 1907–1912 Takeyama K, Fahy JV, Nadel JA: Relationship of epidermal growth factor receptors ... 63:153–167 Takeyama K, Dabbagh K, Lee H-M, Agusti C, Lausier JA, Ueki IF, Grattan KM, Nadel JA: Epidermal growth factor system regulates mucin production in airways Proc Natl Acad Sci USA 1999, 96:3081–3086...

Ngày tải lên: 12/08/2014, 18:20

... Inc., Minneapolis, MN, USA) Plasma uPA activity was evaluated with a uPA Activity Assay kit (Chemicon International, Temecula, CA, USA) Statistical analysis Statistical analysis was performed ... Ebihara I, Hirayama K, Kaneko S, Nagai M, Ogawa Y, Fujita S, Usui J, Mase K, Yamagata K, Kobayashi M: Vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in septic shock patients ... http://ccforum.com/content/15/1/R11 Page 10 of 11 Table Univariate and multivariate analyses of predictive factors for the presence of concomitant multi-organ dysfunction Univariate analysis Multivariate analysis Variables...

Ngày tải lên: 14/08/2014, 07:21

... survival and growth signaling pathways such as the Ras-MAPK pathway and PtdIns3K ⁄ Akt pathway, as a consequence of inactivation of EGFR [10–13] The PtdIns3K ⁄ Akt pathway is downregulated in ... prepared at the indicated time points after the AG1478 addition and analyzed for caspase activity by using a fluorometric substrate-based assay Each point is the mean of triplicate samples, and the bar ... nM AG1478 Lysates were prepared at the indicated time points after the AG1478 addition and analyzed for caspase activity by using a fluorometric substrate-based assay Each point is the mean of...

Ngày tải lên: 18/02/2014, 13:20

... Goodell AL, Lasky JA & Hoffman MR (1992) Reversible binding of platelet- derived growth factor- AA-AB, and – BB isoforms to a similar site on the ‘slow’ and ‘fast’ conformations of alpha 2-macroglobulin ... (1986) Chromatin binding of epidermal growth factor, nerve growth factor, and platelet- derived growth factor in cells bearing the appropriate surface receptors Proc Natl Acad Sci USA 83, 3728–3732 ... of primary human brain tumors Neurosurgery 28, 216–222 Ranieri E, Gesualdo L, Grandaliano G, Maiorano E & Schena FP (2001) The role of alpha-smooth muscle actin and platelet- derived growth factor- beta...

Ngày tải lên: 19/02/2014, 07:20

... deprivationinduced PC12 cell death and DNA fragmentation Survival assays (MTT-based assay) and DNA fragmentation ELISAs were performed as described in Materials and methods, and the data are presented ... analysis of binding of IGF-I, IGF-II and mutant IGF analogue to rhIGF1R Data were analysed using BIAevaluation software 3.0 and ®tted to a Langmuir : binding model as outlined in Materials and methods ... dissociation constant (Kd) was determined from the calculation of kd/ka, where ka is the association rate and kd is the dissociation rate Relative Kd is equal to Kd of IGF-I/Kd of IGF analogue Dashes...

Ngày tải lên: 08/03/2014, 22:20

... growth factor signaling Nat Genet 39, 503–512 Nagashima T, Shimodaira H, Ide K, Nakakuki T, Tani Y, Takahashi K, Yumoto N & Hatakeyama M (2007) Quantitative transcriptional control of ErbB receptor ... EGFR-mitogen-activated protein kinase (MAPK) cascade are particular major targets [7–10] Therefore, quantitative transcriptional outcomes, in addition to qualitative ones, may be altered if EGFR kinase activity ... receptors of ErbB [2,3] Additionally, the potency and dynamics of EGFR signaling are adaptively tuned via biochemical parameters such as affinity constants, catalytic activities, the concentration...

Ngày tải lên: 30/03/2014, 01:20

... 661– 668 (2004) Y Tabata, K Yamada, S Miyamoto, I Nagata, H Kikuchi, I Aoyama, M Tamura, Y Ikada, Biomaterials 19, 807–815 (1998) I Ishii, H Mizuta, A Sei, J Hirose, S Kudo, Y Hiraki, J Bone Joint ... (GF-AFC, live-cell protease substrate and bis-AAF-R110, dead-cell protease substrate) to the assay buffer This reagent was added to a 96-well plate After at least 30 of incubation at 37 °C, the resulting ... Basic FGF is a protein with a length of 155 amino acids and an isoelectric point of 9.6, which makes it stable in a weak basic solution Therefore, NH4OH as a base catalyst for the hydrolysis and...

Ngày tải lên: 22/06/2014, 00:20

... sVEGFR-1 has a strong antagonistic activity and neutralises the effects of VEGF; it plays a pivotal role in the generation of vascular diseases such as pre-eclampsia and intrauterine growth retardation ... equivalents Statistical analysis Data were analysed with the following nonparametric statistical methods: Mann–Whitney (unpaired data) and Wil- coxon (paired data) tests for comparison of groups, ... groups, and Spearman's rank correlation test for assessment of the relationships between quantitative variables P values of less than 0.05 were considered significant All quantitative data are expressed...

Ngày tải lên: 09/08/2014, 01:23

... Quantitative immunohistochemical analysis of transfroming growth factor alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck Cancer 1996, 78:1284-1292 ... performed the statistical analysis EHH and AP participated in case selection and provided patient material for analysis DAW participated in case selection and identification LK carried out conception, ... commercially available antisera (#M3563, clone H11, DAKO Corporation, Carpinteria, CA) Detection was performed using a standard biotin streptavidin detection system (DAKO, Carpinteria, CA) All stains...

Ngày tải lên: 09/08/2014, 09:20