... shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, ... signaling is independent of Toll-interleukin 1 receptor domain-containing adaptorprotein. Drug Metab Dispos 36, 95–101.10 Ghose R, Guo T & Haque N (2009) Regulation of geneexpression of hepatic ... USA). Binding of all of the anti-bodies was detected using an ECL detection system (iNtRONBiotechnology, Seoul, Korea) in accordance with the manu-facturer’s instructions. The intensity of the...
... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati,OH, USA) constantly maintained at 1% O2. Culturemedium ... cultured in DMEM containing 10% fetal bovineserum. OP9 cells were grown in aMEM containing 20%fetal bovine serum. C2C12 cells were maintained in DMEMcontaining 10% fetal bovine serum.Adipogenic ... serumand IDM (10 lgặmL)1insulin, 1 lm dexamethasone, and0.5 mm IDM). Cells were then maintained in DMEM con-taining 10% fetal bovine serum and 1 lgặmL)1insulin. Themedium was replaced...
... calcium-independentphospholipase A2participates in ER stress-inducedINS-1 insulinoma cell apoptosis by promoting cera-mide generation via hydrolysis of sphingomyelins byneutral sphingomyelinase. Biochemistry 46, ... leading to the accumulation of sphingomyelin [27]. Because one of the pathwaysfor ceramide recycling is the sphingomyelin pathway, itis conceivable that in addition to the accumulation of Fig. ... should have a key rolein our under-standing of the mechanisms of the disease. We proposethat pathology data will, in most cases, be moreinsightful than clinical data in defining the disease.This...
... rolein skin woundhealing. After a skin injury, PPARb expression is rap-idly elevated in the epidermis at the wound edges; dele-tion of a single PPARb allele results in delayed woundhealing ... culturedhuman keratinocytes [14]. In this study, we examined the interaction betweenCerK and PPARb, and its rolein regulating keratino-cyte survival. We report that in a mouse keratinocytecell line upregulation ... important rolein keratinocyte sur-vival during skin wound healing, and PPARb expres-sion is elevated at injury sites [10,15]. We investigatedwhether skin barrier disruption by tape-strippingwould...
... substratebinding process. This provides strong evidence thatN-glycans, in particular their terminal structures, areinvolved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... that N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the roleof theterminal ... folding of newly synthesizedproteins in the ER. If N-glycosylation is inhibited,some glycoproteins fail to fold or assemble efficiently,resulting in a prolonged retention in the ER and anincreased...
... questions in pointing out the value of applying a CN methodology to cross- linguistic study. In explaining the representation issues for French, we will first, briefly provide background in current ... hension of French, will form the basis of the discussion. 4.1 Word Boundaries in On-Line Comprehension of French Because of the parallel activation of all meanings of each recognized word in ... and in what contexts these morphemes are affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these...
... apoproteins of the PSIIcomplex; 4, apoproteins of LHCII.Ó FEBS 2002 Sulfolipid maintains PSII in Chlamydomonas (Eur. J. Biochem. 269) 2355 Roleof sulfoquinovosyl diacylglycerol for the maintenance of ... analysis of hf-2 in detail and the attempt tocompensate the deficiency of SQDG in hf-2 by the culture in the presence of SQDG to elucidate that SQDG participate in PSII activity in C. reinhardtii.MATERIALS ... addition on PSII activity of hf-2and the wild-type in C. reinhardtii in the presence of various concen-trations of diuron. The values of PSII activities are the means of threeindependent experiments...
... decreasing for 53% of the sample, it has been increasingfor 36%, and has been stable for the remaining 11%. An increase in indebtedness (of 80% in average) is associated with a 14% decrease in production, ... to soft finance have regularly played a strong rolein sustaining firmswith low actual level of demand. Here inventory reflects changes over the past sixmonths;- exp-prod is an indication of ... a higher probability of postingprofits. However, a regime of soft budget constraints may also allow loss-making firms tobuild up inventories, thus supporting their level of output. Hence we...
... LinguisticsThe Roleof Information Retrieval in Answering Complex QuestionsJimmy LinCollege of Information StudiesDepartment of Computer ScienceInstitute for Advanced Computer StudiesUniversity of MarylandCollege ... USAjimmylin@umd.eduAbstractThis paper explores the roleof informa-tion retrieval in answering “relationship”questions, a new class complex informa-tion needs formally introduced in TREC2005. Since ... questionswere first introduced in TREC 2003, a simplesentence-ranking algorithm outperformed all butthe highest-scoring system (Voorhees, 2003). In addition, viewing the task of answering relation-ship...
... added to the incubation media. In both casestime-dependent inactivation was observed, which is indi-cative of irreversible binding to one/several of the sulfhydrylmoieties involved in the enzymatic ... recombinant proteinformed primarily in inclusion bodies. Successive washes of inclusion bodies with 4Murea and 5% (v/v) Triton X-100removed most of the contaminating proteins, producing ahomogeneous ... todetermine the functional roleof the amino acid residuesinvolved in each. The present report describes the cloningand subsequent functional refolding, using a bacterialexpression system, of the...
... purposes of the public library are toprovide resources and services in a variety of media to meet the needs of individuals andgroups for education, information and personaldevelopment including ... measurementãInputãOutputãBenchmarking www.kb.seThe Book ChainREADINGReadersDISTRIBUTIONBooksellers /LibrariesPRINTINGPrintersPUBLICATIONEditorsCREATIONAuthors www.kb.seServices ... measurementãPerformance indicatorsãUsage indicatorsãResource indicatorsãHuman resource indicatorsãQualitative indicatorsãCost indicatorsãComparative indicators www.kb.seAccess to informationãAccess...
... reduction in acreage of hay, pasture, and small grains whichwould have kept more land in resource conserving cover vegetation [9]. An increase in planting of soybeans in rotation ... more runoff potential. More drain tile is installed every year - 20,000 miles in Minnesota alone in 2000. This hastens the amount of water draining from the soil andincreases ... al. / Introductionparticularly in Eastern Europe, drained hundreds of thousands of hectares of wetlands forproduction. Fortunately for wildlife, since the beginning of the...
... securities increase their value once the development of the general price index, being among one of the few profitable ways of investing in conditions of rising inflation. The influence given by international ... their rolein financing the real economy is not negligible - although it is found behind the banking system – observing an increase since 2009, and continuing with a lower rate of growth in 2010. ... main aim of this article is to present the influence of investment funds on the economic growth in Romania between 2007 and 2010. Unfortunately some of the main findings of the paper are: insignificant...
... contains two DNA bindinginhibitory domains flanking the Ets domain: the central 87amino acid inhibitory domain is poorly conserved a ndvirtually specific to ERM, and the C-terminal domain that ... complexeswith in vitro translated ERM which could be supershifted bythe antibody, indicating the presence of ERM binding site(s) in each of the three probes. We also examined the pattern of complexes ... transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cellsThe roleof Ets factors in the regulation of presenilin 1Martine Pastorcic1and Hriday K. Das1,2,31Department of Pharmacology...
... fairly serious problem of not being able to calculate recall.Each of these failures contributes to an increasedamount of inappropriately indistinguishable trans-lations in the analysis presented ... MTEvaluation in speech recognition, because translations have adegree of variation in terms of word choice and in terms of variant ordering of some phrases.Bleu attempts to capture allowable variation in word ... without any genuine im-provement in translation quality. In Sections 3.1and 3.2 we examine ways of synthetically produc-ing such variant translations.3.1 Permuting phrasesOne way in which variation...