role of oxidative stress and inflammation

... preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice Methods and results: Eight-week-old C57BL/6 J mice (n=24) were ... of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice Hui-Ting Wang1, Chu-Feng Liu1†, Tzu-Hsien ... Journal of Translational Medicine 2012, 10:145 http://www.translational-medicine.com/content/10/1/145 RESEARCH Open Access Effect of obesity reduction on preservation of heart function and attenuation

Ngày tải lên: 02/11/2022, 09:23

... explain the role of oxidative stress in mediating its bio- logical effects. This model suggests that low levels of oxidative stress induce protective effects (tier-1) by the activation of antioxidant ... level and the urin- ary excretion of 8OHdG can be considered as a measure of the whole-body oxidative stress [20-22]. The presence of 8OHdG in urine seems to originate mostly from the oxidation of ... average of 13 years, minimum of 2 years), and nine were Sauvain et al. Journal of Occupational Medicine and Toxicology 2011, 6:18 http://www.occup-med.com/content/6/1/18 Page 4 of 13 smokers. None of

Ngày tải lên: 20/06/2014, 00:20

... influence of short-term incubations with BioMed Research International high glucose on the NO/cGMP pathway in VSMC and the potential role of oxidative stress We also aimed at evaluating the role of ... glucose-induced, oxidative stressmediated impairment of the NO-cGMP signalling in VSMC, since one of the main mechanisms linking high glucose and oxidative stress is the glucose-induced activation of PKC, ... “Oleic acid increases synthesis and secretion of VEGF in rat vascular smooth muscle cells: role of oxidative stress and impairment in obesity,” International Journal of Molecular Sciences, vol 14,

Ngày tải lên: 02/11/2022, 08:46

... 3.  PCA score plots of proteome data in sclerotia and hyphae PCA plots compared between sclerotia and hyphae were shown in (A) (IS and IH), (B) (DS and DH) and (C) (MS and MH), and among sclerotial ... label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus Bing Li1, Xiaofang Tian2, Chunlan Wang1, Xu Zeng1, ... stimulus, such as oxidative stress and environmental adaption, which are significant for sclerotia initiation and development Differentially expressed proteins in sclerotia and hyphae of P umbellatus. 

Ngày tải lên: 19/03/2023, 15:29

... γ-radiation (HR and RH groups, respectively) decreased the levels of MDA, NO, DNAF and Ca2+ but increased GSH level and the activities of SOD, CAT and XO as compared to R group and this indicates ... Faculty of? ?Science, Alexandria University, Alexandria, Egypt Full list of author information is available at the end of the article © The Author(s) 2017 This article is distributed under the terms of ... (NO) in mitochondrial matrix] and cellular antioxidant defenses as GSH and the activities of SOD and CAT were determined in testis homogenate In addition lipid profile and total protein (TP) as well

Ngày tải lên: 04/12/2022, 16:05

... the presence of oxidative stress in degenerating cartilage, and the resultant telomere erosion and dysfunction of chondrocytes in vitro and in vivo, suggesting a role for oxidative stress in the ... Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function ... the analysis of cellular activity, telomere length and telomerase activity was conducted Oxidative stress in human articular cartilage We compared the degree of oxidative stress (antioxidative potential)

Ngày tải lên: 09/08/2014, 06:22

... obtained protein bands were scanned and quantified with the aid of Image J software (NIH, Bethesda, MD, USA). Oxidative stress and proinflammatory cytokines analysis The renal prod uction of superoxide ... ameliorated oxidative stress in the STZ-induced type 1 diabetic kidneys The indicators of oxidative stress including the co ntents of superoxide anion, malondialdehyde , and carbonyl protein, and protein ... TNF-a and IL-6 levels in the diabetic kidneys. Conclusions: Our findings suggest that RSV protects against oxidative stress, exhibits concurrent proinflammation and anti -inflammation, and up-regulates

Ngày tải lên: 10/08/2014, 05:21

... representation of the potential ant -inflammatory role of IL-33 in adipose tissue inflammation. Tissue damage caused by factors such as high free fatty acids, ER stress, oxidative stress, and inflammation ... biology of IL-33 remain to be solved, including its nuclear effects and processing and release of IL-33 from cells. Furthermore, given the FREE FATTY ACIDS ER STRESS OXIDATIVE STRESS INFLAMMATION ... Ashley.Miller@glasgow.ac.uk Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, GBRC, University of Glasgow, Glasgow G12 8TA, UK Miller Journal of Inflammation 2011,

Ngày tải lên: 11/08/2014, 03:20

... presence of 1014–1016 oxidantmolecules/puff of cigarette smoke [1] 4-hydroxy-2- nonenal, a highly reactive and diffusible end product of lipid peroxidation, is a known marker of oxidative stress and ... earlier findings of the ability of cigarette smoke to induce oxidative stress by generation of reactive oxygen species and decrease intracellular GSH levels (without an increased levels of GSSG) in ... endogenous levels of glutathione status and the amount of 4-HNE is formed IL-8 and IL-6 are important in the recruitment and activation of inflammatory cells The induction of these proinflammatory

Ngày tải lên: 12/08/2014, 16:20

... International Journal of Medical Sciences 2018; 15(13): 1486-1501 doi: 10.7150/ijms.27181 Research Paper Comparison of Oxidative Stress Effects on Senescence Patterning of Human Adult and Perinatal Tissue-Derived ... contribute significantly to DNA damage and cellular senescence [28-30] According to the free radical or oxidative stress theory of aging [31], oxidative stress incurs when the cellular antioxidant ... susceptibility to oxidative stress Although hMSCs appear to efficiently handle oxidative stress, nevertheless they undergo premature senescence in vitro when exposed to H2O2 [32,33] Understanding hMSC

Ngày tải lên: 15/01/2020, 02:05

... to various stresses, redox dependent chaperone/peroxidase function and the role played by this enzyme in protecting Anabaena from oxidative stress were addressed Along with oxidative stress, alr4641/Alr4641 ... its protective role in overcoming oxidative stress Results Abiotic stresses induce alr4641/Alr4641 expression in Anabaena Expression of alr4641 in response to different oxidative stress inducing ... Xie X, Liu W, Fu Z Effects of copper sulfate, hydrogen peroxide and N-phenyl-2-naphthylamine on oxidative stress and the expression of genes involved photosynthesis and microcystin disposition

Ngày tải lên: 26/05/2020, 23:53

... Concurrent treatment of the rats of groups VII, VIII and IX with α-tocopherol and copper sulphate, α-tocopherol and flubendiamide, and α-tocopherol and combination of flubendiamide and copper, respectively, ... cellular damaging effects of flubendiamide and copper due to generation of oxidative stress Depletion of GSH occurs as a result of excessive GSH consumption during oxidative stress [70, 71] Further, ... searching of literature, conceiving of research plan and execution of research work AP planning of the experimental design for in vitro study AR supervision of the oxidative stress biomarkers study and

Ngày tải lên: 30/05/2020, 21:22

... the indirect consequences of bubaline pediculosis on buffalo health in context of oxidative stress and mineral imbalance and immuno regulations are equally important and remain less explored Accumulating ... phagocytosis and reactive oxygen species generation) Mast cells can modulate thyroid function Therefore, evaluation of oxidative stress and mineral imbalance along with mast cell activity and neuroendocrine ... interactions and immuno-pathology of bubaline pediculosis Therefore, the present study was aimed to evaluate the oxidative stress, mineral balance, and mast cell activity containments of sucking

Ngày tải lên: 20/09/2020, 19:30

... CPT-induced oxidative stress and not reduced DNA damage Our results also reveal the novel finding that knockdown of ATG5 protein reduces both basal oxidative stress and drug-induced oxidative stress ... http://www.biomedcentral.com/1471-2407/13/500 oxidative stress The use of BSO allowed for the investigation of the impact of oxidative stress alone on cell death and autophgay induction Autophagy-competent ... target of selective autophagy [22] and we suspect that autophagy inhibition may affect levels of endogenous antioxidants With observed CPT-induced oxidative stress in this study and reports of oxidative

Ngày tải lên: 05/11/2020, 05:24

... (JNK), and p38 kinases, are MAPK cascades activated by cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress [9, 10] As a consequences of these, ... glutathione peroxidase (GPx), and catalase [5, 8] Overproduction of ROS or a reduced level of antioxidants, or both, lead to oxidative damage of membrane proteins, lipids, and DNA Imbalance in the ... carried out to investigate the effects of curcumin on oxidative stress and redox-sensitive kinases in high fructose- and high-fat-fed rats Sixty rats were randomly divided into six groups with

Ngày tải lên: 01/11/2022, 09:55

... levels and GRAE also normalized depleted/amplified anti-oxidant enzymes in swim stress and ethanol stress- induced animals Gastric mucin damage was recovered up to 77% and 74% in swim stress and ... regarding the cause of gastric hyperacidity and ulcers Stress appear to play a major role as indicated by a set of studies which emphasizes that any patient irrespective of the nature of the disease, ... episodes of healing and re-exacerbations [23] Stress- induced ulcer better resembles clinical ulcers in chronicity, severity and practicality of experiencing stress due to varietal patterns of lifestyle

Ngày tải lên: 02/11/2022, 10:41

... cops (TC) and office workers (OW) Higher levels of oxidative stress and inflammation markers in serum of ARD subjects were observed as compared to OW and TC Uni and multivariate analyses of metabolites ... results demonstrate existence of exposure specific metabotypes in biofluids of ARD, OW and TC groups Monitoring serum oxidative stress and inflammation markers and urine metabolites by NMR may ... this study, we monitored serum oxidative stress and immunological markers and untargeted urine metabolic profiling of ARD subjects as case and office workers: OW and traffic cops: TC as controls,

Ngày tải lên: 19/11/2022, 11:46

... likely due to dysregulation of apoptosis1 Therefore, the induction of other forms of cell death like mitotic catastrophe, senescence and especially autophagy, is necessary and fundamental to conquer ... to trigger oxidative stress- mediated cell death, induce apoptosis and inhibit cell proliferation Meanwhile, Western blotting revealed that combined disposure induced the formation of autophagosomes ... multidisciplinary approach4 So far, the combination of phototherapy and chemotherapy is considered to be an efficient method to lessen the dose of chemotherapeutic drugs and reduce the harmful side effect5,6

Ngày tải lên: 04/12/2022, 14:58

... expression of MBP and CNP, similar to that observed at 21% O2 These data indicate that culturing OPCs at 21% O2 negatively affects development and maturation Both enhanced oxidative stress and reduced ... O4, O1, MBP, CNP, arborization), oxidative stress (nitrotyrosine Western blot, NRF2 and SOD2 expression), apoptosis (TUNEL), proliferation (Ki67), and expression of transcription factors regulated ... development via oxidative stress and reduced expression of HIF-1α Christina Brill1, Till Scheuer1,2, Christoph Bührer1, Stefanie Endesfelder1 & Thomas Schmitz1 The premature increase of oxygen tension

Ngày tải lên: 04/12/2022, 15:55

... of oxidative stress and TGF-β1.  To assess the regulation of endothelial phenotype by shear stress, we exposed endothelial cells to laminar shear stress at a magnitude of 20 dynes/cm2 Shear stress ... While the individual roles of NFkB, p38 MAPK, ERK5 and TGF-β​pathways in endothelial dysfunction are well delineated, an understanding of the orchestration of these pathways and their crosstalk ... TGF-β​stimulation and its regulation by shear stress remain unknown The levels of oxidative stress and TGF-β​1 increase upon vascular damage4,16 However, the molecular mechanisms by which shear stress regulates

Ngày tải lên: 19/03/2023, 15:41