role of multifunctional fadd fas associated death domain adaptor in drug addiction
Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx
Ngày tải lên :
22/02/2014, 07:20
... because of the inadequacy of the analytical tools employed in earlier work using a 14C label In all the cases in which such a scrambling was observed it was usually ascribed to a lack of fidelity of ... removal of one of its hydrogens (path b) The outcome of the two competing deprotonation paths is illustrated in Fig for the predominant ES complex A of a sample of IPP carrying a 13 C label in its ... due to long range coupling involving vicinal isoprenoid moieties Due to the line broadening, the precision of signal integration is substantially reduced However, within the experimental limits,...
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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
Ngày tải lên :
07/03/2014, 06:20
... a two -domain architecture: the first is the catalytic domain, composed of an ABC (ABCb) and a RecA-like subdomain, and contains the nucleotide-binding site; the second is the helical domain (ABCa), ... dimerization of its nucleotide-binding domains Nature 433, 876–880 52 Vogan KJ & Gros P (1997) The C-terminal subdomain makes an important contribution to the DNA binding activity of the Pax-3 paired domain ... to determine in which NBD the 8-azido-nucleotides were trapped in these proteins To answer this question, we took advantage of the trypsin-sensitive region situated in the linker domain of Abcb1a...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
Ngày tải lên :
16/03/2014, 23:20
... evidence of correct pairing of the interchain disulfide bridges in the recombinant sample [11] The kinetics of the N-terminal arms swapping in the P19A-BSRNase is comparable to that of BS-RNase ... 50% The recombinant dimers were obtained predominantly in their nonswapped forms; the extent of exchange of the N-termini, as evaluated by selective reduction of the interchain disulfide bridges ... scanning microcalorimetry, and an investigation of the kinetics of swapping of all variant dimers in comparison with that of the parent protein mutations are underlined) For the mutant P19A/L28QmBS...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
Ngày tải lên :
30/03/2014, 11:20
... are unsure of the mechanism of DNA-induced stabilization of the protein, and whether it is related to the normal RNA-binding function of coat protein, as RNA binding had no effect The increased ... value of the spectral center of mass of dlFG emission in the presence of DNA returned almost completely to the initial value, but again we observed an increase in light scattering, suggesting FEBS ... investigated these questions in this work We sought to determine the role of protein–RNA and protein–protein interactions in virus stability, measuring the effects of urea, GdnHCl and high pressure...
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Báo cáo khoa học: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival docx
Ngày tải lên :
30/03/2014, 14:20
... a role in neuronal protection in status epilepticus Inhibition of ERK1/2 activation with SL327 increased mortality in rats with pilocarpine-induced seizures [35] Ó FEBS 2004 Interestingly, in ... depolarization in trophicdeprived neurons (reviewed in [2]) Importantly, as the studies indicating a lack of ERK1/2 involvement in antiapoptotic signaling used a variety of neuronal cells, the role of ERK1/2 ... neurons against apoptosis induced by DNA damage [15,16] In these studies, DNA damage was induced by genotoxic anticancer drugs, camptothecin or cisplatin (CPDD) Interestingly, cisplatin is highly...
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the role of neutrinos, strings, gravity, and variable cosmological constant in particle physics
Ngày tải lên :
24/04/2014, 17:07
... existence of a length parameter contained in my version of the generalized theory of gravitation (1) The Expansion of the universe with increasing acceleration is explained by recalling Einstein’s ... Kovesi-Domokos PROBING THE NATURE OF NEUTRINOS AT PION FACTORIES 13 Ali R Fazely INCLUSIVE NEUTRINO AND ANTINEUTRINO REACTIONS IN IRON AND AN INTERESTING RELATION 25 Stephan L Mintz NATURE’S ... The Role of Neutrinos, Strings, Gravity, and Variable Cosmological Constant in Elementary Particle Physics This page intentionally left blank The Role of Neutrinos, Strings, Gravity,...
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báo cáo hóa học:" Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB" pptx
Ngày tải lên :
18/06/2014, 15:20
... cases with intensive staining of CD133 had higher percentage of CD133+ tumor cells Several nests with intensive CD133 staining, so-called "hotspot" could always be seen within the field of cancer ... within an adenocarcinoma nest could actively proliferate and form a group of cells, which invaded into the surrounding tissue, so-called "budding", and showed negative or weak staining against ... normal intestinal epithelium could be found in 72 out of 104 specimens used for this study The CD133 expression of normal intestinal epithelium was only found in out of the 72 specimens Referring...
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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
Ngày tải lên :
18/06/2014, 16:20
... Lollini PL, Nanni P, Picci P, Scotlandi K: Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing’s sarcoma cells Clin ... Scotlandi K: Preclinical in vivo study of new insulin-like growth factor-I receptor–specific inhibitor in Ewing’s sarcoma Clin Cancer Res 2007, 13:1322-1330 Benini S, Manara MC, Baldini N, Cerisano ... found in WT GISTs [40] The most exciting future perspectives are first to study the biological role of IGF1R in GISTs in in vitro and in vivo models, and second to investigate the receptor’s clinical...
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Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
Ngày tải lên :
09/08/2014, 01:24
... the role of cytokines in RP, either in patients or in the corresponding animal models In the CIA model, several cytokines have been shown to play major roles in the inflammatory process, anti-inflammatory ... as influx of cells and antibody production In addition, to investigate the role of inflammatory mediators in MIRP, we immunized mice devoid of IL-10 in order to determine whether this cytokine, ... proinflammatory ones The cytokine interleukin-10 (IL-10) has been in focus for many years in autoimmune arthritis and in other autoimmune diseases The human recombinant protein is currently being...
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Báo cáo lâm nghiệp: " The role of glutamine synthetase, glutamate synthase and glutamate dehydrogenase in ammonia assimilation by the mycorrhizal fungus Pisolithus tinctorius" ppt
Ngày tải lên :
09/08/2014, 04:20
... thus there was no incorporation of ammonia into glutamate by GDH After h the glutamine concentration peaked and remained stable, indicating feedback control of GS Inhibition of aminotransferases ... extracts were found to contain significant amounts of arginine, which is thought to play a major role in nitrogen storage Arginine was the most abundant amino acid in the nitrogen-starved mycelia ... marked increase in the and glutamine pools after h in the fresh medium (Fig 3a) Glutamate levels remained constant after h but the glutamine concentration continued to increase up to h indicating...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
Ngày tải lên :
09/08/2014, 06:23
... owing to the absence of its modulatory role in inhibiting FcγR activation [39] Similarly, in RA several lines of evidence have implicated FcRs, in particular IgG-binding receptors (FcγRs), in ... suggesting a more general mechanism of these receptors in inflammatory diseases Maintaining autoantibody titers through FcRn-mediated recycling One of the most striking characteristics of the ... C5a anaphylatoxin is a major regulaγ tor of activating versus inhibitory FcγRs in immune complexinduced lung disease J Clin Invest 2002, 110:1823-1830 Fearon DT: Seeking wisdom in innate immunity...
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Báo cáo khoa học: "Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data rom randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)" pdf
Ngày tải lên :
09/08/2014, 10:20
... extent of COX-2 staining was scored from to 3, and the intensity of staining scored from to The scores were then multiplied together and the final scores classified as follow: 0, negligible staining; ... staining; 1–4, weak staining; 5–8, moderate staining; and 9–12, strong staining For the purpose of statistical analysis, the cohort was grouped into tumors with negligible or weak staining (N = 34) versus ... with increased acute and long term morbidities [1,2] Increasing effort has been directed toward developing molecular targeted therapies for the treatment of NPC with increasing interest in cyclooxygenase-2...
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Báo cáo y học: " Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation" ppt
Ngày tải lên :
09/08/2014, 10:23
... by administration of the thrombin inhibitor hirudin and an inhibitor of FVIIa Depletion of fibrinogen by ancrod also attenuated inflammation in this model These findings confirm that fibrin formation ... Available online http://arthritis-research.com/content/10/2/R42 Figure Figure Role of fibrin in soluble tissue factor-induced inflammation Fibrin Role of fibrin in soluble tissue factor-induced inflammation ... significantly diminished in PAR-4-deficient mice and underlines the important role of fibrin in inflammation These may be mediated by fibrininduced macrophage secretion of proinflammatory cytokines such...
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báo cáo khoa học: "Overexpression of LCMR1 is significantly associated with clinical stage in human NSCLC" ppt
Ngày tải lên :
10/08/2014, 10:21
... H2O2 for 30 minutes, sections were digested with 0.1% trypsin at 37°C for 20 minutes After phosphate-buffered saline (PBS) washing, nonspecific antibody binding was blocked by incubating the slides ... tissue processing, such as fixation and embedding Because such background staining is almost nonspecific, occurring in the stromal tissue (including lymphocytes), we avoided it by counting only positive ... clinicopathological role in the lung cancer It will be of considerable interest to further understand these interactions and elucidate the intrinsic mechanisms, since one of the most important reasons of cancer...
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báo cáo khoa học: " Assessing the role of syringe dispensing machines and mobile van outlets in reaching hard-to-reach and high-risk groups of injecting drug users (IDUs): a review" ppt
Ngày tải lên :
11/08/2014, 18:20
... Characteristics of users of syringe vending machines in Berlin Sozial und Praventivmedizin 1994, 39(4):209-216 Leicht A: Characteristics and HIV-infection of users of syringe vending-machines and exchanging ... safety of syringe vending machines as a component of needle syringe programmes in community settings International Journal of Drug Policy (in press) 2007 Burrows D: Starting and managing needle ... of sterile injecting equipment and correspondingly higher prevalence of needle-syringe sharing, rapid turnover of prison populations and hence far more changes in injecting partners [56] Syringe...
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Báo cáo y học: "Marked disability and high use of nonsteroidal antiinflammatory drugs associated with knee osteoarthritis in rural China: a cross-sectional population-based survey" ppt
Ngày tải lên :
12/08/2014, 15:22
... walking up 10 steps without resting, stooping, crouching, or kneeling; cleaning chores around the house like folding quilts, sweeping, dusting, or straightening up; or preparing meals Ling et ... pain: herbal medicine, acupuncture, massage, other traditional Chinese medicine, nonsteroidal antiinflammatory drugs (including diclofenac (voltaren), fenbid, ibuprofen, sulindac (clinoril), naproxen ... conservative, as the patellofemoral joint was not included The absence of information on the patellofemoral joint may also help explain the low percentage of those with knee pain who have radiographic...
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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx
Ngày tải lên :
13/08/2014, 23:20
... chromosomal protein Its role as a pro-inflammatory cytokine in sepsis and rheumatoid arthritis has been described, and more recently its role in community-acquired infections and sepsis investigated ... HMGB1 as a cytokine in inflammation The mechanism of inflammation and damage is binding to toll-like receptor (TLR4), which mediates HMGB1-dependent activation of macrophage cytokine release This ... mingling molecules The diagnostic value of HMGB1 levels was investigated using ROC curve analysis in this study by Albayrak et al [5] The use of ROC analysis is an Page of appropriate method in...
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Báo cáo sinh học: " Cloning and expression profiling of the VLDLR gene associated with egg performance in duck (Anas platyrhynchos)" docx
Ngày tải lên :
14/08/2014, 13:21
... consists of five domains (Figure 1, 2): (i) six ligand binding motifs (S-D-E) and eight cysteine-rich repeats within the ligand binding domain; (ii) five YWXD motifs in the EGF precursor homology domain; ... number of cysteine-rich repeat sequences present in the ligand-binding domain i.e VLDLR has eight cysteinerich repeats and LDLR, only has seven [10,11] The Olinked sugar domain is a serine and ... domain; (iii) an O-linked sugar domain with clustered serine and threonine residues; (iv) a 23-aa sequence in the putative transmembrane domain and (v) a FDNPVY sequence in the cytoplasmic domain...
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the role of il-33 and il-17 family cytokines in periodontal disease
Ngày tải lên :
22/12/2014, 21:05
... mice but not in IL-17F deficient This suggested that IL-17A is playing a more pivotal role than IL-17F in the initiation of inflammation in EAE Indeed intraperitoneal injection of an anti-IL17A ... prominent role in the formation of dental biofilms (Bostanci, et al., 2007) Fimbriae of P gingivalis has also been shown to induce production of pro-inflammatory cytokines and chemokines, such ... P gingivalis possesses several inherent virulence factors which are capable of invoking damaging effects on host cells (Bostanci & Belibasakis, 2012) Gingipains are a group of cysteine proteinases...
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