role of infection in pathogenesis of multiple sclerosis
Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives, causing ... exhibiting insignicant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminal avoprotein fragment in the single polypeptide chain structurally resembling NADPH-P450 ... (1983) Mechanisms of extrahepatic bioactivation of aromatic amines: the role of hemoglobin in the N-oxidation of 4-chloraniline In Extrahepatic Drug Metabolism and Chemical Carcinogenesis (Rydstrom,...
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báo cáo hóa học: "The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis" pot
Ngày tải lên :
18/06/2014, 19:20
... recent review of exercise intervention studies in persons with MS, found Figure Quality of life scores in people with multiple sclerosis Quality of life scores in people with multiple sclerosis Error ... physical stress in multiple sclerosis Brain Behav Immun 2003, 17(6):473-481 White LJ, Castellano V, Mc Coy SC: Cytokine responses to resistance training in people with multiple sclerosis J Sports ... pain and medication use [33] Theories of primary fatigue in MS include hypo-functioning within the central nervous system [34], reduced glucose metabolism in the cortical regions of the brain...
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báo cáo hóa học: " Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis" ppt
Ngày tải lên :
19/06/2014, 22:20
... observed, corresponding to the acute inflammatory phase of the disease [62] Interestingly, we did not observe any changes in the number of infiltrating lymphocytes in the spinal cord of diazoxide-treated ... in pancreatic beta-cells, where an increase in plasma glucose promotes a calciumdependent release of insulin due to the closing of KATP channels as a result of glycolysis-mediated increases in ... lymphocytic infiltration into the spinal cord during EAE To determine whether diazoxide treatment affected T and B lymphocyte infiltration into the spinal cord of EAE mice, immunoflorescence using anti-CD3...
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báo cáo hóa học:" Health-related quality of life in relapsing remitting multiple sclerosis patients during treatment with glatiramer acetate: a prospective, observational, international, multi-centre study" pdf
Ngày tải lên :
20/06/2014, 15:20
... continued vs patients who discontinued GA In individual patients an increase in LMS-QoL score of or more points was classified as improvement, decrease of or more points as worsening Within each ... composite and quality of Life in Avonex-treated Relapsing multiple sclerosis patients (FLAIR) study group: Improvement of healthrelated quality of life in relapsing remitting multiple sclerosis patients ... relevant for individual MS patients In general, changes of 10% to 15% in clinical outcomes may be considered meaningful We choose a minimum of 15% of the mean baseline LMSQoL score in the total...
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báo cáo hóa học:" The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis" pdf
Ngày tải lên :
20/06/2014, 16:20
... recent review of exercise intervention studies in persons with MS, found Figure Quality of life scores in people with multiple sclerosis Quality of life scores in people with multiple sclerosis Error ... physical stress in multiple sclerosis Brain Behav Immun 2003, 17(6):473-481 White LJ, Castellano V, Mc Coy SC: Cytokine responses to resistance training in people with multiple sclerosis J Sports ... pain and medication use [33] Theories of primary fatigue in MS include hypo-functioning within the central nervous system [34], reduced glucose metabolism in the cortical regions of the brain...
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báo cáo hóa học: " The burden of multiple sclerosis: A community health survey" pot
Ngày tải lên :
18/06/2014, 22:20
... Cost of multiple sclerosis by level of disability: a review of literature Mult Scler 2005, 11:232-239 Burden of illness of multiple sclerosis: Part I: Cost of illness The Canadian Burden of Illness ... quality of life of people with multiple sclerosis Disabil Rehabil 2001, 23:516-521 Minden SL, Frankel D, Hadden LS, Srinath KP, Perloff JN: Disability in elderly people with multiple sclerosis: ... Comparison of a generic to disease-targeted health-related quality -of- life measures for multiple sclerosis J Clin Epidemiol 1997, 50:557-569 Kurtzke JF: Rating neurologic impairment in multiple sclerosis: ...
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báo cáo hóa học:" The burden of multiple sclerosis: A community health survey" potx
Ngày tải lên :
20/06/2014, 16:20
... Cost of multiple sclerosis by level of disability: a review of literature Mult Scler 2005, 11:232-239 Burden of illness of multiple sclerosis: Part I: Cost of illness The Canadian Burden of Illness ... quality of life of people with multiple sclerosis Disabil Rehabil 2001, 23:516-521 Minden SL, Frankel D, Hadden LS, Srinath KP, Perloff JN: Disability in elderly people with multiple sclerosis: ... Comparison of a generic to disease-targeted health-related quality -of- life measures for multiple sclerosis J Clin Epidemiol 1997, 50:557-569 Kurtzke JF: Rating neurologic impairment in multiple sclerosis: ...
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Handbook of Multiple Sclerosis pdf
Ngày tải lên :
29/06/2014, 09:20
... importance of an understanding of the development and maintenance of neurons and their supporting structures is crucial to an understanding of the pathogenesis of multiple sclerosis and of repair ... Berlin, Springer, 1983 14 Princeas JW, Kwon EE, Cho E-S, Sharer LR Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques In: Scheinberg L, Raine CS, eds Multiple ... meeting of the New York Academy of Sciences (119) in 1965; in 1983, they were refined to include the results of investigations (120) In the same year the National Multiple Sclerosis Society of...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"
Ngày tải lên :
26/10/2012, 09:39
... None of the patients had a resting heart rate > 100 bpm We did not evaluate catecholamine levels in any of these patients Symptoms of Multiple Sclerosis Visual disturbances in the form of episodic ... form of episodic blurring of vision were seen in 4/9(44%) patients Sensory disturbances including numbness, tingling, pins and needles sensation in extremities were seen in 4/9(44%) patients Gait ... period of (22 months) from the diagnosis of the multiple sclerosis Daily activities and lifestyle in our study patients Treatment aimed at minimizing symptoms was initiated in each patient following...
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Báo cáo y học: "Increased plasma homocysteine levels in patients with multiple sclerosis and depression" ppsx
Ngày tải lên :
08/08/2014, 23:21
... or lack of the vitamin B12 cofactor for this methylation reaction [27] Methionine, in turn, is the precursor of S-adenosylmethionine, the methyl donor in a host of methylation reactions in the ... From a methodological point of view, it should be pointed out that BDI, in common with other depression screening instruments, has certain limitations in the evaluation of MS patients due to a ... monocyte-lymphocyte interaction and inhibiting tumour necrosis factor (TNF)α and interleukin (IL)1β production [29,30] The clinical implications of our finding are not entirely clear Since Hcy is associated...
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Báo cáo khoa hoc:" Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a" pps
Ngày tải lên :
11/08/2014, 08:20
... Results in BioMedicine 2004, 3:4 17 18 http://www.jnrbm.com/content/3/1/4 The INFB Multiple Sclerosis Study Group: Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: Clinical ... responses in multiple sclerosis: clinical and pathological correlations Brain 2002, 125:1462-1473 PRISMS Study Group: Randomised double-blind placebo-controlled study of interferon β-1a in relapsing-remitting ... antigen in cerebrospinal fluid as a possible index of cell injury in the nervous system J Neurol Sci 1980, 44:259-263 Panitch H, Hirsch R, Schindler J, Johnson K: Treatment of multiple sclerosis...
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The role of ORF3 protein in the molecular pathogenesis of porcine circovirus 2 infection
Ngày tải lên :
10/09/2015, 08:38
... characterisation of the role of ORF3 in the molecular and the systemic pathogenesis during the PCV2 infection in cell culture, mice model and in natural infection in piglets Mutant PCV2 lacking the expression ... growth kinetics of PCV2 108 Figure 26 Role of ORF3 in the release of PCV2 from infected cells……… …111 Figure 27 Role of ORF3 induced apoptosis on the In Vivo spread of PCV… 113 Figure 28 Role of Macrophages ... conditions also play a role in determining the pathogenicity of the PCV2 infection (Ramamoorthy et al., 2009) This thesis describes the role of ORF3 in the pathogenesis of the PCV2 virus infection at the...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
Ngày tải lên :
14/02/2014, 18:20
... shown that interactions between KCs and endotoxin comprise the initiating event leading to hepatotoxicity in liver injury, including endotoxemia and ischemia ⁄ reperfusion injury [14] In our studies, ... receptor signaling is independent of Toll-interleukin receptor domain-containing adaptor protein Drug Metab Dispos 36, 95–101 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... MA, USA) Binding of all of the antibodies was detected using an ECL detection system (iNtRON Biotechnology, Seoul, Korea) in accordance with the manufacturer’s instructions The intensity of the...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
Ngày tải lên :
14/02/2014, 19:20
... colonization of the corpus mucosa as a consequence of increased acid tolerance, or indirectly, via promoting enhanced in ammation Interestingly, infection of gerbils by H pylori led to the development of ... a central role in the pathogenesis of H pylori in vivo H pylori in vitro infection models: T4SS-dependent but CagA-independent cellular signalling In addition to the above discussed in vivo models, ... presence of distinct EPIYA-independent domains within CagA that play essential roles in protein targeting and alteration of host-cell transcription signalling pathways Another important consequence of...
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Báo cáo khoa học: Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis The role of glutathione doc
Ngày tải lên :
29/03/2014, 23:20
... the role of the level of mutant protein in the response of the GSH pathway In agreement with this, in transgenic G93ASOD1 mice, expressing very high levels of mutant protein, a decrease in mRNA ... expression of G93ASOD1 In lowG93A-tTA cells (dox)), the involvement of GCL in the increase in GSH was further confirmed by measuring GCL activity, which was 16.44 ± 0.31 nmolÆ min)1Æmg)1 of protein, ... show low activity in ALS [12,13], suggesting that normal handling of GSH may be altered However, GSH binding sites in the spinal cord and GSH levels in cerebrospinal fluid were high in SALS patients...
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Báo cáo sinh học: " Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection" pdf
Ngày tải lên :
18/06/2014, 18:20
... siRNA against CD151 on PRRSV infection Effect of6 Effect of siRNA against CD151 on PRRSV infection (A) To examine the effect of siRNA against CD151 on PRRSV infection, siRNA was transfected into ... [43,44,46] In account of our novel observation of RNA binding activity of CD151, we looked for RNA binding domains on CD151 protein by bioinformatic analysis, we could not find any known RNA binding ... infection Effect of7 Effect of anti-CD151 Ab on PRRSV infection To examine the effect of anti-CD151 Ab on PRRSV infection, immunofluorescence antibody assay was performed MARC145 cells were incubated...
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báo cáo hóa học: " Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis" doc
Ngày tải lên :
18/06/2014, 19:20
... because, in certain countries such as the USA, remaining in full-time employment is an important determinant of obtaining insurance for reimbursement of treatment costs Again, the impact of glatiramer ... Falini A, Comi G, Filippi M: fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection Human brain mapping 2007, 28(5):373-382 Khan O, Mackenzie ... Long-Term Study of Brain (1)H-MRS Study in Multiple Sclerosis: Effect of Glatiramer Acetate Therapy on Axonal Metabolic Function and Feasibility of Long-Term (1)H-MRS Monitoring in Multiple Sclerosis...
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Báo cáo hóa học: "Adaptive robot training for the treatment of incoordination in Multiple Sclerosis" doc
Ngày tải lên :
19/06/2014, 08:20
... changes in movement kinematics We found no significant effects of Robot Training (baseline vs baseline 2) As regards the effect of Subject Training (baseline vs wash-out), we found a decrease in the ... B: Preliminary Trial of Carisoprodol in Multiple Sclerosis Practitioner 1964, 192:540-542 39 Alusi SH, Worthington J, Glickman S, Bain PG: A study of tremor in multiple sclerosis Brain 2001, ... regards changes within one session, to distinguish between the changes in performance occurring during the Robot Training phase from those occurring during the Subject Training phase, we directly...
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Báo cáo hóa học: " Objective assessment of motor fatigue in multiple sclerosis using kinematic gait analysis: a pilot study" docx
Ngày tải lên :
19/06/2014, 08:20
... fatigue in multiple sclerosis Multiple Sclerosis Council for Clinical Practice Guidelines; 1998 35 Iyengar V, Santos MJ, Ko M, Aruin AS: Grip force control in individuals with multiple sclerosis ... Marinelli F, Pisani A, Fieschi C: Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, ... dimension of the FSMC but not with its cognitive dimension supports the specificity of the fatigue index for the motoric aspect of fatigue in multiple sclerosis Interestingly, the fatigue index correlated...
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báo cáo hóa học: " Effect of pioglitazone treatment in a patient with secondary multiple sclerosis" doc
Ngày tải lên :
19/06/2014, 22:20
... Defining the clinical course of multiple sclerosis: results of an international survey National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis ... CNS inflammation and demyelination, resulting in axonal and neuronal damage [1] The thiazolidinedione class of drugs were developed for the treatment of type diabetes and act by improving insulin ... fatigue and cognitive decline In 1994, a trial of interferon β-1b was discontinued because of increased spasticity, and she was not a candidate for glatiramer She had no history of diabetes, cardiovascular,...
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