role of cancer stem cell

... size of tumour, because of the much smaller number of stem cells, clonal evolution is predicted to be faster in stem cells compared to non -stem cells What are the mechanisms by which one cancer cell ... by comparison of the relative strength of selection with non -stem cells could furthermore provide a method of testing the relative strength of selection of stem cells and non -stem cells and thereby ... of a cancer cell clone, aid in overcoming an anti -cancer defence mechanism, or aid in the competitive advantage of a given cell clone Mutations favourable to the growth of a cancer cell may of...

Ngày tải lên: 13/08/2014, 16:20

... the current awareness of the cancer stem- cell concept, it is of importance to examine the prognostic and predictive effects of these cancer stem- cell markers in colorectal cancers Currently, there ... cancer development In particular, we intend to: (i) study the prognostic and predictive effect of cancer stem cell markers in colorectal cancers (ii) examine the associations of cancer stem cell ... the cancer stem- cell concept, tumours are not merely simple monoclonal expansions of transformed cells, but complex tissues where 12 abnormal growth is driven by a minority of cancer stem cells...

Ngày tải lên: 03/10/2015, 20:57

... Leenders G: Cellular and molecular biology of the prostate: stem cell biology Urology 2003, 62:11-20 Bonkhoff H: Role of the basal cells in premalignant changes of the human prostate: a stem cell concept ... P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... basal/ stem cells Patch1 and Smo were found highly expressed in the P63+ basal /stem cells of the pCX-shh-IG-injected prostates, being located in the cell membrane of P63+ basal cells in regions of...

Ngày tải lên: 10/08/2014, 05:21

... Page 13 of 13 18 Seo DC, Sung JM, Cho HJ, Yi H, Seo KH, Choi IS, Kim DK, Kim JS, ElAty AMA, Shin HC: Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer ... Abbreviations NSCLC: non-small cell lung carcinoma; LCNEC: large cell neuroendocrine carcinoma; LCC: large cell carcinoma; SCLC: small cell lung carcinoma; CSC: cancer stem cell; LC: liquid chromatography; ... variety of malignant tumor cells In particular, AK1C1, and AK1C3 are reported in human non-small cell lung carcinoma (A549) cells [21], and a high expression of AL1A1 in lung cancer cell lines,...

Ngày tải lên: 10/08/2014, 09:22

... According to the hierarchical model of cancer, the origin of the cancer stem cells may be long-lived somatic stem cells Therefore, markers of “normal” stem cells are being sought with the expectation ... neoplastic mechanism of liver cancer stem cells Conclusions This work provides an in vivo model for the study of mechanisms of neoplastic transformation of liver cancer stem cells by separately ... carcinogenesis and differentiation of normal stem cells strongly suggest that miRNA may be involved in the transformation of normal stem cells into cancer stem cells Therefore, screening for differences...

Ngày tải lên: 10/08/2014, 10:20

... Journal of Experimental & Clinical Cancer Research 2010, 29:174 http://www.jeccr.com/content/29/1/174 cancer stem cells http://www.mirbase.org/ Thus, the identification of cancer stem cell- related ... tumorigenic breast cancer cells with stem/ progenitor cell properties from a breast cancer cell line, and Huang [17] screened side population (SP) cells from a breast cancer cell line Here, we ... regulatory factor in cancer cells, even cancer stem cells Another example is miR21, which has been reported to have extensive roles and is expressed in embryonic stem cells [29], neuronal cells [30] and...

Ngày tải lên: 10/08/2014, 10:20

... malignancies are driven by a cancer stem cell compartment [8] The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within ... theory If LgR5 marks stem cells, there are many of LgR5 negative non -stem cells, which are nevertheless cycling Therefore a combination of clonal selection and cancer stem cell model, as previously ... 5% of BE According to our hypothesis, that the intestinal stem cell marker LgR5 might also be suited to identify cancer stem cells, these might be the actively cycling Barrett (cancer) stem cells...

Ngày tải lên: 10/08/2014, 10:21

... migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells Stem Cells 2007, 25:520-528 Reya T, Morrison SJ, Clarke MF, et al: Stem cells, cancer, and cancer stem cells ... for cancer therapy These controversies can be attributed to many factors such as ratio of MSCs to cancer cells, nature of tumour cells and cancer stem cells, integrity of immune system, number of ... C: (×400) Area of cell drop out with stem cells, D: (×400) No nodularity & liver appears normal, few collections of round to oval stem cells in lobules Page of 11 Figure Detection of MSCs labeled...

Ngày tải lên: 10/08/2014, 10:21

... primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing concentrations of PTL Cells ... and stem cell self-renewal Results Identification of gene products associated with a cancer stem cell phenotype By comparing RNA expression patterns from stem and committed cells, independent of ... Functional annotation of the cancer stem cell expression signature Functional annotation of the cancer stem cell expression signature (a,b) Functional concepts over-represented in cancer relative to...

Ngày tải lên: 14/08/2014, 08:21

... of stem cells 1.4.1 Embryonic stem cells 1.4.2 Somatic stem cells 1.4.3 Stem cells and cancer 14 1.5 Neural development 16 1.6 Neural stem cells ... neural stem cells 20 1.6.2 Adult neural stem cells .24 1.6.3 Neural stem cell applications .26 1.7 Methods to study neural stem cells 28 1.7.1 Identifying neural stem cells ... subsequent round of cell division produces the 16 -cell morula consisting of a small group of internal cells surrounded by a larger group of external cells Most of the external cells go on to form...

Ngày tải lên: 12/09/2015, 21:26

... representativeness of the case series 394 The role of cancer registries The registry may, however, carry out its own case–control studies using its database, comparing one type of cancer with a selection of ... registries in cancer control The cancer registry is an essential part of any rational programme of cancer control Its data can be used in a wide variety of areas of cancer control ranging from etiological ... ratios (i.e., the frequency of cancers of a particular site in relation to the total number of cancer cases—see Sections 4.3.5 and 11.1.6 for a discussion of this type of measure) They may also...

Ngày tải lên: 15/02/2014, 04:20

... study of embryonic stem cells TE N Hattori and K Shiota ICM PGC TS cells Placental cells 77 ES cells 49 EG cells Embryonic cells Fig Epigenetic distances between ES cells and other stem cells ... methylation profiles Epigenetic study of embryonic stem cells Differences in DNA methylation profiles between ES and other stem cells Comparing ES cells with other stem cells established from developing ... biology and cell biology is the establishment of embryonic stem (ES) cells, which maintain the ability to form all types of cells in the body, and can differentiate into a variety of cell types...

Ngày tải lên: 23/03/2014, 07:20

... TABLE OF CONTENTS Development of Hematopoietic Repopulating Cells from Embryonic Stem Cells The In Vitro Differentiation of Mouse Embryonic Stem Cells into Neutrophils 10 Development and Analysis of ... Murine Embryonic Stem Cells 11 Development of Lymphoid Lineages Embryonic Stem Cells In Vitro from 12 Probing Dendritic Cell Function by Guiding the Differentiation of Embryonic Stem Cells 13 Gene ... microscopic inspection of live cells EPL cell cultures are inspected for the homogeneous formation of EPL cell colonies (Fig 2) and the loss of all colonies of ES cell morphology Cells can be stained...

Ngày tải lên: 11/04/2014, 00:32

... characteristics of stem cells: (A), Symmetric cell division leads to self-renewal of stem cells; (B), Asymmetric cell division leads to replacement of the stem cell and production of a sister cell, exemplified ... that modified stem cells could be used in cell therapy for Parkinson’s disease 42 Therapeutic Uses of Stem Cells But, as with other proposed stem- cell therapies, an autologous source of cells that ... over stem cell research: politics The next two chapters of the volume are devoted to the politics of stem cell research Larry Goldstein discusses stem cell politics prior to the passage of Proposition...

Ngày tải lên: 11/06/2014, 12:52

... light microscopy of NSC in implanted tex of E16 Sprague-Dawley rat embryos culture on of neural stem cell (NSC) at passage three derived from the composite Representative image of scanning electron ... immunohistochemical staining of BrdU and S-100 Representative images of immunohistochemical staining of BrdU and S-100 A: Localization of darkly brownish stained BrdU+ cells to transected tissues of rabbits having ... 7042014 of the National Science Foundation of Beijing, China, the 50573044 of the National Natural Science Foundation of China and the 2005CB623905 of the National Basic Research Program of China...

Ngày tải lên: 18/06/2014, 15:20

... translational stem cell research Cell Stem Cell 2008, 3:607-9 122 International Consortium of Stem Cell Networks: Global Regulation of Human Embryonic Stem Cell Research and Oocyte Donation [http:// www.stemcellcentre.edu.au/PDF/ ... here lies in implantation of hepatic stem cells, or in implantation of hepatic cells obtained by differentiation of a different type of stem cell, such as mesenchymal stem cells Other applications, ... Induced pluripotent stem cells Induced pluripotent stem cells (iPSCs) from somatic cells are revolutionizing the field of stem cells Obtained by reprogramming somatic stem cells of a patient through...

Ngày tải lên: 18/06/2014, 16:20

... isolation of a type of precancerous stem cells from dendritic cell- like leukemic mice and the establishment of this precancerous stem cell line The precancerous stem cells had stem cell- like ... distinguish precancerous stem cells from primary cancer stem cells First is the location Precancerous stem cells mainly exist in precancerous lesions, but primary cancer stem cells exist in primary cancer ... population of radioresistant subset remains unclear Page of Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells...

Ngày tải lên: 18/06/2014, 19:20

... Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body [32,33] CD8+ T cells play a major role in immune surveillance of ... the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells not labeled ... Figure Efficacy of NK cell depletion with anti-asialo GM1 antibody Efficacy of NK cell depletion with anti-asialo GM1 antibody The frequency of CD3- CD49b+ NK cells in the spleens of A BALB/c mice...

Ngày tải lên: 19/06/2014, 08:20

... isolation of a type of precancerous stem cells from dendritic cell- like leukemic mice and the establishment of this precancerous stem cell line The precancerous stem cells had stem cell- like ... distinguish precancerous stem cells from primary cancer stem cells First is the location Precancerous stem cells mainly exist in precancerous lesions, but primary cancer stem cells exist in primary cancer ... population of radioresistant subset remains unclear Page of Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells...

Ngày tải lên: 20/06/2014, 03:20

... Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body [32,33] CD8+ T cells play a major role in immune surveillance of ... the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells not labeled ... Figure Efficacy of NK cell depletion with anti-asialo GM1 antibody Efficacy of NK cell depletion with anti-asialo GM1 antibody The frequency of CD3- CD49b+ NK cells in the spleens of A BALB/c mice...

Ngày tải lên: 20/06/2014, 04:20