... calcium-independent phospholipase A 2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting cera- mide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. ... leading to the accumulation of sphingomyelin [27]. Because one of the pathways for ceramide recycling is the sphingomyelin pathway, it is conceivable that in addition to the accumulation of Fig. ... data suggesting that some of the genes involved in the genetics of Lewy body disease, have in common the fact that they impinge on ceramide metabolism. One shortfall of the present theory is the lack of...
Ngày tải lên: 18/02/2014, 14:20
Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx
... that arise in language behavior are introduced by including neurally motivated pro- cessing control as the focus of model definition and by including behaviorially defined con- straints, both ... Because of the parallel activation of all meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active ... and in what contexts these morphemes are affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these...
Ngày tải lên: 21/02/2014, 20:20
Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44]. These factors are involved in ethanol-induced ... . Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma ... signaling. This finding corroborates the interaction observed between various intracellular signaling pathways and apoptosis induced by 1mM concentration of ethanol in HepG2 cells [19]. Int....
Ngày tải lên: 31/10/2012, 15:28
The definitive book of body language
... situations (in movieland) wiped out the lives of innocents, or at least associated with it in my sometimes quaint way of looking at thing It consciously came back into my mind again, when Schindler's ... many fish eat other things instead of fish, thus making the chain of feeding way more intricate. But the concept remains: there is always some entity capable of putting things right. And believe ... you into and out of War. Enjoying the multitude of songs like for instance 'Princes of the Universe' by Queen, I'm now going to explain further how this all links together in...
Ngày tải lên: 09/08/2013, 16:10
The role of leadership theory in raising the profile of women in management
Ngày tải lên: 08/10/2013, 15:56
Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China
... China Statistics Yearbook, China Financial Yearbook and People’s Bank of China Statistics Quarterly bulletin. B. Development of direct financing and indirect financing markets providing financing ... in exploring on-line banking business as well as in promoting non-bank financial institutions. Efforts should be made in upgrading financial operations and financial services, and in conducting ... The role of FDI in institution building Over the past 20 years, foreign financial institutions, mainly foreign banks have played an important role in the opening up of Chinese financial industry....
Ngày tải lên: 18/10/2013, 07:15
Tài liệu The Definitive Book of Body Language doc
... much of their time ducking, dodging, avoiding, pretending, lying, hiding their emotions and feelings, using smokescreens or mirrors and waving to imaginary friends in the crowd. But we instinctively ... to 28 The Definitive Book of Body Language The key to reading body language is being able to understand a person's emotional condition while listening to what they are saying and noting the circumstances ... fake body language for a short period of time and even- tually the body will show contradictory signals that are independent of conscious actions. Many politicians are experts in faking body language...
Ngày tải lên: 21/12/2013, 02:19
Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos 36, 95–101. 10 Ghose R, Guo T & Haque N (2009) Regulation of gene expression of hepatic ... stimulation of these receptors activates in amma- tory responses characterized by the release of a wide range of proinflammatory cytokines, including IL-6 Sham GdCl 3 CLP GdCl 3 + CLP HMGB1 iNOS β-actin Fig....
Ngày tải lên: 14/02/2014, 18:20
Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... renewed interest in examining the indications for BCG vaccination in the United States included consideration of the wide range of vaccine efficacies deter- mined by clinical trials and estimated in ... should continue to be included in ongoing testing programs if their skin-test results are <5 mm induration. Those vaccinees who have positive tuberculin skin-test reactions (≥5 mm of induration) ... preventing pulmonary TB in adoles- cents and adults. These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered 6...
Ngày tải lên: 15/02/2014, 13:20
Tài liệu Rethinking the Role of the State in Finance doc
... would involve the following determinations: in terms of producing information about possible invest- ments and allocating capital, the financial (a) developing and analyzing measures of the ... REPORT 2013 1 GLOBAL FINANCIAL DEVELOPMENT REPORT 2013 Rethinking the Role of the State in Finance Washington, D.C. GLOBAL FINANCIAL DEVELOPMENT REPORT 2013 BENCHMARKING FINANCIAL SYSTEMS AROUND ... respondents seeing potential benefits in more stringent supervision of new finan- cial instruments in light of the crisis. A majority also see a scope for a more active role of the state in promoting technological...
Ngày tải lên: 16/02/2014, 10:20
Tài liệu The Role of Community Banks in the U.S. Economy pdf
... “Small Business Lending and the Changing Structure of the Banking Industry,” Journal of Banking and Finance, August. Sullivan, Richard J. 2000. “How Has the Adoption of Internet Banking Affected Performance ... larger banks in making small business loans. Loan officers at small banks can take into account a wide variety of factors in reviewing applications for small business loans, including the character of ... understanding issues facing community banks. I. THE CURRENT ROLE OF COMMUNITY BANKS The banking system in the United States has always been unique in the sense of containing large numbers of small...
Ngày tải lên: 16/02/2014, 11:20
Tài liệu SICK WATER? THE CENTRAL ROLE OF WASTEWATER MANAGEMENT IN SUSTAINABLE DEVELOPMENT pdf
... dis- charge can contain a wide range of contaminants and originate from a myriad of sources. Some of the biggest generators of toxic industrial waste include mining, pulp mills, tanneries, sugar ... from mining operations can contain silt and rock particles and sur- factants. Depending on the type of ore deposit being mined, tailings can also contain heavy metals like copper, lead, zinc, ... examples of persistent environmental damage caused by the discharge of toxic mine waste. In Papua New Guinea for ex- ample, companies discharge millions of tons of contaminated mine waste into...
Ngày tải lên: 17/02/2014, 10:20
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O 2 . Culture medium ... cultured in DMEM containing 10% fetal bovine serum. OP9 cells were grown in aMEM containing 20% fetal bovine serum. C2C12 cells were maintained in DMEM containing 10% fetal bovine serum. Adipogenic ... regulator of energy metabolism in the fat body of fruit flies [3]. In vertebrates, miR- 375 and miR-376, both of which are abundantly expressed in pancreatic b-cells, are involved in the con- trol of insulin...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt
... role in skin wound healing. After a skin injury, PPARb expression is rap- idly elevated in the epidermis at the wound edges; dele- tion of a single PPARb allele results in delayed wound healing ... cultured human keratinocytes [14]. In this study, we examined the interaction between CerK and PPARb, and its role in regulating keratino- cyte survival. We report that in a mouse keratinocyte cell line upregulation ... important role in keratinocyte sur- vival during skin wound healing, and PPARb expres- sion is elevated at injury sites [10,15]. We investigated whether skin barrier disruption by tape-stripping would...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... detected at the dimer interface of the models or in the surroundings of the hinge loop residues. Likewise, the models of nonex- changing and exchanging HHP-RNase were prepared start- ing from 1Z7X. ... strong, neutralizing action of the cytosolic RNase inhibitor (cRI), a 50-kDa protein containing 16 leu- cine-rich repeat motifs [7,8]. In fact, onconase from Rana pipiens eggs [9], and seminal RNase ... detected at the dimer interface of the models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... substrate binding process. This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... that N-linked oligosaccharide side-chains are important for the GABA transport activity. 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... folding of newly synthesized proteins in the ER. If N-glycosylation is inhibited, some glycoproteins fail to fold or assemble efficiently, resulting in a prolonged retention in the ER and an increased...
Ngày tải lên: 19/02/2014, 17:20
The Role of the Media in Promoting and Reducing Tobacco Use doc
Ngày tải lên: 06/03/2014, 01:20