role for new dna repair systems in helicobacter pylori diversity persistence
Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
Ngày tải lên :
18/06/2014, 16:20
... by inhibition of PAR-2 expression using PAR-2 AS ODN in AGS cells Additionally, inhibition of PAR-2 activity using trypsin inhibitor increased cell death and DNA fragmentation in H pylori- infected ... death and DNA fragmentation Soybean trypsin inhibitor (SBTI) suppresses H pyloriinduced activation of MAPK in gastric epithelial cells H pylori -induced increases in phospho-specific forms of ... activated by trypsin, may be involved in the activation of MAPK in H pylori- infected gastric epithelial cells Discussion In the present study, we found that H pylori- induced cell death and DNA fragmentation...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
Ngày tải lên :
14/02/2014, 19:20
... also involves tyrosine dephosphorylation of cortactin, vinculin and ezrin, which are three wellknown actin-binding proteins [6] The phosphatases involved in this scenario, however, remain unknown ... bacteria gain access to integrins and inject CagA The basal injection model of CagA can also explain why H pylori does not cause more gastric damage in infected individuals and may only inject virulence ... Therefore, it is clear that CagA and the T4SS play a central role in the pathogenesis of H pylori in vivo H pylori in vitro infection models: T4SS-dependent but CagA-independent cellular signalling...
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ADAS for the Car of the Future - Interface Concepts for Advanced Driver Assistant Systems in a Sustainable Mobility Concept of 2020 pptx
Ngày tải lên :
23/03/2014, 10:20
... Determine action Determine local speed Determine risk Acquire interface input Calculate braking time Processing ISA Detect vehicles Input LDW/LKS Acquire interface input Acquire interface input ... windshield display The information changes according to system states. When driving manually, traditional information is shown, when driving in the controlling state, ADAS information is shown. The windshield display can be used to show path predictions, car tracking and ... support, and support increases as the level of state increases, as explained in the following state definitions. State 1 Informing In state 1 the driver has complete vehicle control. The system will only inform the driver about unsafe situations, by ...
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Handbook for New Public Library Directors in New York State pdf
Ngày tải lên :
24/03/2014, 01:20
... Management Page Handbook for New Public Library Directors in New York State Introduction This handbook is intended as a jumping-off point, to aid a new public library director in New York State to get ... toward getting input from both segments Input collection techniques: For the in- house” audience: o Routinely check in with your front line staff to find out what patrons are talking about ... you should always be looking forward and around – what’s going on in the community, in the publishing industry, in technology, and what factors could influence your funding – at the local, county...
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Báo cáo hóa học: " Adaptive antenna selection and Tx/Rx beamforming for large-scale MIMO systems in 60 GHz channels" pptx
Ngày tải lên :
21/06/2014, 01:20
... summarized in Algorithm In what follows we discuss the form of the objective function j(·) in (8) and its calculation 3.2 Estimating the principal singular value using Gerschgorin circle The Gerschgorin ... until all nt + nr antennas are updated Instead of keeping records for all candidates, we dynamically allocate and maintain record in π for the new subset found in each iteration If a subset already ... to one RF chain in the current subset, is selected again for another RF chain In other words, feedback is necessary only in subiterations in which the current subset has changed for the transmit...
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A Role for the International Criminal Court in the Fight against Terrorism? potx
Ngày tải lên :
10/07/2014, 13:21
... would be a tool for crime fighting in areas of long-standing international concern Trinidad and Tobago conceived of the Court as a tool for crime fighting in areas of long-standing international ... Lockerbie proceedings and the proceedings before the International Criminal Tribunal for Former Yugoslavia indicate that prosecutions by international criminal tribunals are certainly not always ... grounds for disqualification in Rule 34, 1, and, again, includes inter alia as a ground for disqualification the “expression of opinions, through the communications media, in writing or in public...
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Báo cáo toán học: "On the Smoothness of Solutions of the First Initial Boundary Value Problem for Schr¨dinger o Systems in Domains with Conical Points" pps
Ngày tải lên :
06/08/2014, 05:20
... hand, since the principal coefficients apq are continuous in x ∈ Ω uniformly with respect to t ∈ [0, ∞) and the constant a0 in (1.1) is independent of t, by repeating the proof of Garding’s inequality ... Schr¨dinger systems in o non-smooth domains, Diff Urav 34 (1998) 1546–1556 (in Russian) N M Hung and C T Anh, On the solvability of the first initial boundary value problem for Schr¨dinger systems in infinite ... Theorems in Elasticity Theory, Mir, Moscow 1974 (in Russian) A Friedman, Partial Differential Equations, Holt - Rinehart - Winston, 1969 N M Hung, The first initial boundary value problem for Schr¨dinger...
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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
Ngày tải lên :
09/08/2014, 10:21
... well contain the causative SNP The EIRA study included mainly individuals born in Sweden Taking those born outside Sweden into consideration also, 97% were of Caucasian origin In order to minimize ... (SAS Institute, Cary, NC, USA), and P values for association with RA were calculated using χ2 tests for genotype frequencies The sample set was stratified for sex in the initial analysis, and for ... that different combinations of genes are involved in the disease progression in different RA subclasses defined, for instance, by sex or autoantibody status The most striking aspect of the identified...
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Báo cáo y học: "A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors" ppsx
Ngày tải lên :
12/08/2014, 01:21
... of vector DNA with HDAC4, HDAC4 also associates with vector DNA prior to integration, in an integration-independent manner Retroviral integration induces the formation of HDAC4 foci in infected ... necessary for the last step of the integration process, termed post-integration repair (PIR), since PIR failure results in a loss of cells in which integrase-mediated joining occurred, and thus again ... Chromatin Immunoprecipitation HeLa cells were infected at a multiplicity of infection (m.o.i.) 0.1 for the indicated time intervals In some cases, an integrase inhibitor was added at the time of infection...
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Báo cáo khoa học:" A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" docx
Ngày tải lên :
12/08/2014, 04:21
... STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines [51] STAT1-deficient ... temperature in PBS containing 0.05% v/ v Tween-20 (PBS-T) Slides were then blocked for 30 at ambient temperature in PBS-T containing 1% w/v BSA (PBS-TB) Immunostaining was done according to a direct ... immunostaining 24 h after HSV-1 GFP-VP22 infection Briefly, cells were fixed by incubating slides in methanol for 10 followed by acetone for at 20°C Afterwards, slides were rinsed three times for...
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Báo cáo khoa học: " A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages" pps
Ngày tải lên :
12/08/2014, 04:21
... STAT1 gene in mice revealed a role for STAT1 in the JAK-STAT signaling pathway [40] The JAK-STAT signaling pathway is involved in mediating biologic responses induced by many cytokines [51] STAT1-deficient ... temperature in PBS containing 0.05% v/ v Tween-20 (PBS-T) Slides were then blocked for 30 at ambient temperature in PBS-T containing 1% w/v BSA (PBS-TB) Immunostaining was done according to a direct ... immunostaining 24 h after HSV-1 GFP-VP22 infection Briefly, cells were fixed by incubating slides in methanol for 10 followed by acetone for at 20°C Afterwards, slides were rinsed three times for...
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Báo cáo y học: "Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus" pot
Ngày tải lên :
12/08/2014, 15:23
... perception category included ATPase/ ATPase domain-containing genes and two excision repair cross-complementing genes (ERCC2, ERCC5) Six mitochondrial DNA (mtDNA)-encoded genes - including ATP synthase ... (XPG), also encodes a DNA repair protein ERCC5 is involved in excision repair of UV-induced DNA damage Mutations of this gene cause XPG syndrome or Cockayne syndrome Worth noting is the fact that ... M, Valensin S, Tieri P, Monti D, Ottaviani E, Franceschi C: Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology...
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Báo cáo khoa học: "Bench-to-bedside review: Current evidence for extracorporeal albumin dialysis systems in liver failure" ppt
Ngày tải lên :
13/08/2014, 03:21
... to bind toxins [4] Recent artificial liver support technologies have used albumin as a binding and scavenging molecule Albumin dialysis involves dialyzing blood against an albumin-containing ... reviewed original articles, drafted the manuscript, and was involved in revising the manuscript NG and JW reviewed original articles and were involved in revising the manuscript DK outlined the format ... review and was involved in revising the manuscript VGB initiated the review, reviewed original articles, and was involved in revising the manuscript All authors read and approved the final manuscript...
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the success criteria for implementing knowledge management systems in an organization
Ngày tải lên :
13/11/2014, 09:23
... processed/interpreted potentially useful data Knowledge is information and personalized facilitating information assimilation of information State of Mind Knowledge is the KM involves state of knowing ... Decreasing the learning curve of new employees • Responding more rapidly to customer needs and inquiries • Reducing rework and preventing ‘reinvention of the wheel’ • Spawning new ideas for products ... work with Information Systems, processing orders, adding data and information into the system A better way to define a knowledge worker is by the work that they Knowledge work is “solving problems...
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Role of nucleotide excision repair factors in genome maintenance in human cells under oxidative stress
Ngày tải lên :
14/09/2015, 08:45
... and assisting in the formatting of the document i Importantly, I would like to express my sincere appreciation to my examiners for taking the time and effort to examine this thesis For the unconditional ... Other DNA repair proteins including a component of the NER pathway, XPF, have been reported to be involved in telomere dynamics As the importance of the NER pathway in removing oxidative stress-induced ... which is a helicase domaincontaining protein involved in both the NER and basal transcription CSB, which displaces stalled RNA polymerase II, is involved in restoring UV-inhibited transcription...
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The Market for New Ph.D. Economists in 2002
Ngày tải lên :
09/01/2017, 20:45
... degree in economics upon matriculation Also included are indicators for individual Ph.D programs having seven or more graduates in the regression sample, for the sub-field of economics in which ... dissatisfaction, it is surprising that those employed in permanent full-time jobs in business/industry are not much more likely to be seeking a new position than those in comparable jobs in other sectors ... and employed in Had business looking for schools a new job a known? c Median salary full- Median salary time full-time permanent permanent nonacademics academics working in work ing in U.S the...
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Trends in Helicobacter pylori Infection ed. by Bruna Maria Roesler
Ngày tải lên :
06/06/2014, 21:25
... break inducing agents, suggesting that AddAB is involved in the double strand break repair pathway, and RecOR in gap repair Finally, RecOR is involved in intragenomic recombination and AddAB in intergenomic ... interacts with incoming DNA, binding ssDNA and also dsDNA to a lesser extent DprA protects incoming DNA from restriction by Persistence of Helicobacter pylori Infection: Genetic and Epigenetic Diversity ... [143] The initial step in transformation is the binding of extracellular DNA to the surface of the bacterium The ComB machinery may play a role in DNA- binding to the cell as mutants lacking inner-membrane...
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T cell responses in helicobacter pylori associated gastroduodenal diseases 1
Ngày tải lên :
09/09/2015, 18:58
... propria (Chen, Jin et al 2010) The role of Tregs in limiting inflammation is reiterated in the finding that an inadequate Treg response is usually seen in peptic ulcer disease In peptic ulcer ... result in regression of precancerous lesions, possibly by limiting inflammation 1.3.3 Genetic Polymorphisms in Immune Genes Further illustrating the role of inflammation in fuelling carcinogenesis ... NO Increase in NO concentrations in cells induces cellular stress and an increase in p53 levels within the cell Following this, p53-dependent apoptosis follows In addition to this, NO also induces...
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T cell responses in helicobacter pylori associated gastroduodenal diseases 2
Ngày tải lên :
09/09/2015, 18:58
... Figure 3.5 Other pro-inflammatory cytokines and chemokines analysed Milliplex xMAP assay for ex vivo IL-1α, IL-1Ra, IL-2, IL-8, IL-10, IL-12p40, IL-15,...
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T cell responses in helicobacter pylori associated gastroduodenal diseases 3
Ngày tải lên :
09/09/2015, 18:58
... subject groups were not different, indicating that this cytokine was perhaps not involved in chronic inflammation in the gastric mucosa However, in line with its role in innate immunity, CD4+IL-22+ ... chronic 104 inflammatory infiltrate, consisting of lymphocytic infiltrate still remains (Mera, Fontham et al 2005) This observation is in line with the findings presented in this thesis, that in subjects ... chronic inflammatory infiltrate is made up of HP-specific cells and that HP infection plays a role in triggering initial immune responses that have the capacity to persist in the infected individual,...
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