risk factors for the development of breast cancer include

... Discussion The American Society of Breast Surgeons and the American Brachytherapy Society have published guide- lines for the screening and selection of patients for APBI [22,23], and these g uideline ... R, Taylor C, Wang Y, Early Breast Cancer Trialists’ Collaborative Group (EBCTCG): Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence ... criteria and were treated. The majority of the 21 patients not eligible for treatment were disqualified at the time of implantation for inadequate balloon conformance to the tumor cavity or inadequate

Ngày tải lên: 09/08/2014, 01:24

... were due to breast cancer With the increase in age, the risk for breast cancer and death rates due to it generally increases [1] The highest incidence of breast cancer was in Northern America ... also responsible for the genesis of endometrial cancer [9] II Women who take toremifene for a longer period to treat breast cancer are at higher risk of development of endometrial cancer III Raloxifene ... linked at 3rd position of furan for the breast cancer therapy The synthesized furan derivatives were determined for their anticancer potential Zhao et  al [16], designed and synthesized selective

Ngày tải lên: 29/05/2020, 13:21

... increased risk of breast cancer, and this is one of the highest risk factors for the prediction of breast cancer risk Therefore, a useful and accurate breast imaging method is necessary The development ... analysis for determining cut-off value of TNR in detection of breast cancer b TNR of BSGI distribution in breast malignant and benign disease c Sensitivity of BSGI, US, MMG and MRI for detecting breast ... of breast cancer Yu et al BMC Cancer (2016) 16:450 Page of 10 Fig a Sensitivity of BSGI in different characteristics of breast cancer b TNR of BSGI distribution for different breast cancer molecular

Ngày tải lên: 21/09/2020, 01:57

... mutation of the Sp1-4 or the Sp1-2 site reduced the progesterone-dependent transactivation of the p21 or p27 promoter, respectively However, mutation of each of these sites prevented the synergistic ... Desprez PY: Reduction of human metastatic breast cancer cell aggressiveness on introduction of either form a or B of the progesterone receptor and then treatment with progestins Cancer Res 2004, 64(21):7886–7892 ... branching and the lobulo-alveolar development of the mammary gland [6] More recently, selective ablation of each receptor isoform has indicated that PR-B is specifically required for the progesterone-dependent

Ngày tải lên: 05/11/2020, 01:56

... in the world has early developed; as a result, foreign scholars pioneered the research of correlative theories and the application of O2O mode techniques to bring forward studying the O2O risk ... platform for the digital economy where emergence of the electronic commerce (e-commerce) has taken place Since the 1990s, the Internet had entered gradually into the business environment and the ... e-commerce in Vietnam according to the O2O model, and the application of the ? ?the last Kilometer” solution of Chinese e-commerce is appropriate with the development trend of logistics in Vietnam Keywords:

Ngày tải lên: 15/10/2022, 14:29

... integration of these findings into the routine pathology diagnostic workup led to the development of a 50 gene signature for the determination of the intrinsic subtypes [7] and the transfer of this ... on the Primary Therapy of Early Breast Cancer since 2011 as a novel paradigm for the classification of patients for therapeutic purposes [2] These surrogate definitions require a small panel of ... use of RT-qPCR as an alternative to breast cancer biomarker detection by IHC has been the risk of false-negatives resulting from dilution of tumor cell RNA by other sources of RNA or the risk of

Ngày tải lên: 04/12/2022, 10:31

... analyses of data from the DMET™ chip were performed using the DMET™ console software The samples with QC call rates ≥99 % were considered for further analyses The analysis included 13 patients with breast ... type of breast cancer event during the 11-year follow-up period Of these, 22 presented with distant metastases A Kaplan-Meier LogRank test was used for univariable analyses of the risk of early ... not significant in the analysis based on the DMET™ chip data, therefore no further analyses was performed here While the role of CYP1A2 rs762551 with respect to breast cancer risk seems weak or

Ngày tải lên: 21/09/2020, 09:43

... model for the development of composite indicators of quality of care. Among its key premises, the model proposes identifying structural, process, and outcome metrics for each of the Institute of ... certain cells of the matrix; the latter measure- ment state clearly indicates the need for future metric development research. For example, the absence of equity metrics in Table 3’ smatrixisofnoteandcould ... threaten the external validity of the composite indicator. Prevention metrics Much of the job of pediatric health professionals is to prevent illness or illnes s exacerbation. Therefore, metrics of

Ngày tải lên: 11/08/2014, 05:21

... model for the development of composite indicators of quality of care. Among its key premises, the model proposes identifying structural, process, and outcome metrics for each of the Institute of ... certain cells of the matrix; the latter measure- ment state clearly indicates the need for future metric development research. For example, the absence of equity metrics in Table 3’ smatrixisofnoteandcould ... threaten the external validity of the composite indicator. Prevention metrics Much of the job of pediatric health professionals is to prevent illness or illnes s exacerbation. Therefore, metrics of

Ngày tải lên: 11/08/2014, 16:20

... the purge of the latent reservoirs Nucleosomal organization of the 5'LTR of HIV-1 Our laboratory... [274] These observations strengthen the hypothesis that the formation of ... provirus can switch off the transcription of the host gene within which it has integrated or can allow the coexistence of expression of both host and viral genes. Further analy- sis of the mechanisms ... cytoplasm of these cells for only one day and cannot account for the forma- tion of long-term latently-infected CD4 + T-cell reservoirs) [48-50]. Of note, unintegrated DNA remains stable for at

Ngày tải lên: 12/08/2014, 23:22

... a high -risk type of blood-cell cancer. We describe the improvement of a candidate therapeutic virus for virotherapy of leukemic cells. Virotherapy is based on the exclusive replication of a virus ... remain for the development of therapeutic viruses based on the human pathogen HIV-1. One of the major concerns is the high mutation and recombination rate of HIV-1 that allows the generation of escape ... explanation for the improved replica- tion of the mini-HIV-rtTAs is provided by inspection of the sizes of these viral genomes. The RNA genome of the wild-type HIV-1 LAI isolate is 9,229 nt, but the

Ngày tải lên: 13/08/2014, 09:20

... 6 of 11 (page number not for citation purposes) The spatial maximum of the force F is always in the cross section x = 0. Of great importance is further the magnitude of the temporal maximum of ... place of the chosen one for the computation of the forces F 1 , F 2 , and F 3 . If the force F is not transmitted to tissues surrounding the vessel upstream of the stenosis (see Fig. 3b), then ... forces onto the inner surfaces of the constriction and expansion cones, and in the throat of the stenosis. We consider only the axial components of these forces. When flow is zero, the two forces

Ngày tải lên: 13/08/2014, 16:21

... genotypes for the rest of the population in the estimation set. For each compari- son, we correlated the predicted value of an animal in the validation set with its phenotype (which was not used in the ... related. Therefore, prediction was performed across full-sib families. In ten replicates, the phenotypes for a validation set (~50% of the population) were predicted from the estima- tion based on the ... used simultaneously. Therefore, we sampled 10,000 inde- pendent pairs for each relationship k for each trait. The number of pairs for relationship k, and the average num- ber of pairs in 10,000

Ngày tải lên: 14/08/2014, 13:21

... prognostic factors 27 1.1.7 Breast cancer subtypes 28 1.1.8 Tests for molecular profile of breast cancer 29 1.2 Treatment of breast cancer 31 1.2.1 Surgery 31 1.2.2 Chemotherapy 32 1.2.3 Radiotherapy ... standardise breast cancer treatment in the UK [56] The treatment of breast cancer varies depending on the characteristics of the tumour such as size and the presence of certain ... Breast cancer risk factors There are several factors that have been found to increase the risk of breast cancer Many of these factors are linked to exposure to the hormone oestrogen,

Ngày tải lên: 22/12/2014, 21:49

... List of tables vii PART A - INTRODUCTION 1.1 Rationale for the study 1.2 Aims of the study 1.3 Scope of the study 1.4 Methods of the study 1.4.1 Research questions 1.4.2 Research approach 1.4.3 The ... words However they not always sound as natural as they want to The problem is most often the use of the wrong intonation of sentences As a teacher of English at Quang Ninh University of Industry, ... interested in this aspect of pronunciation For the above reasons, the study entitled: “Strategies to enhance the understanding of English intonation for the development of communicative language

Ngày tải lên: 28/02/2015, 11:55

... detection of the pulmonary form of TB... natural killer cells, at the site of infection which seal off the infection and prevent further spread of the bacteria (20) The granuloma, ... TECHNOLOGY FOR THE DEVELOPMENT OF ANTI-LIPID ANTIBODIES FOR TUBERCULOSIS DIAGNOSIS CONRAD CHAN EN ZUO BSc. (Hons.), MRes. Imperial College London A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... of the Xpert MTB/RIF NAAT platform for simultaneous detection of TB infection along with... over 80% of the national TB budget of these countries alone (69) This could limit the

Ngày tải lên: 10/09/2015, 09:05

... the calculations for the variant (iii), it is observed that the bottom of the potential well and the Fermi level show oscillations of the amplitude less than eV. The ionization potential of the ... applies the models for the development of a novel test interface for wafer level packages (WLP) operating at multi-gigahertz frequencies given the tight geometrical constraints of fine pitch (of the ... that the ionization potential depends only on the geometry of the wire and is independent of the direction of electron emission. The size dependent behavior of Fermi energy, work function and the

Ngày tải lên: 11/09/2015, 14:24

... [81-85]. Most likely the observed effect depends on the nature of the cancer cells, the characteristics of the used MSC, on the integrity of the immune system and on the timing and site of injection. Two ... prerequisite step before clinical use of stem cell based medicinal products. The risk profile of stem cell based medicinal products depends on many risk factors, which include the type of stem cells, their ... potential risks and risk factors obtained with other/existing stem cell based medicinal products may contribute to the risk evaluation of new stem cell based therapies. The potential risk of tumour formation...

Ngày tải lên: 18/06/2014, 19:20

... One of the weaknesses of this study is the small sample size. In addition, the majority of the le- sions examined appear to be of the Class I type, rather than Class II lesions for which the ... only 14 of these evaluated the ability of the dye to identify oral cancers that would not otherwise have been diagnosed by unaided clinical examination. Unfortu- nately, these studies are of limited ... indicative of cancer and 92.9% specificity if atypical or positive results were consid- ered indicative of cancer. The strengths of the study include its multicenter nature, enhancing generalizability of...

Ngày tải lên: 06/03/2014, 02:21