risk factors associated with alzheimer s disease table 3

... Common variants at MS4A4/MS4A6E, CD2AP, CD 33 and EPHA1 are associated with late-onset Alzheimer s disease Nat Genet 2011, 43: 436 -441 28 Zuccolo J, Bau J, Childs SJ, Goss GG, Sensen CW, Deans JP: Phylogenetic ... these five GWAS datasets using the meta-analysis tool in Plink selecting only those markers common to at least four of these studies (1,098,485 SNPs) The most promising and consistent results ... polymorphisms within the MS4A2 gene have been associated with susceptibility to aspirin-intolerant asthma [30 ], and some epidemiological studies suggest a link between asthma and AD [31 ] Consequently,...

Ngày tải lên: 11/08/2014, 12:21

... automorphisms) of all poses obtained (A) AChE Poses Pose Pose Pose Pose RMSDaverage 1 .39 4 Pose Pose 1.4 73 6.61 6.471 3. 987 6.941 1.4 73 6.928 4.184 6.61 1.51 4. 134 6.874 5 .39 2 Pose 1 .39 4 Pose 1.4 73 6.941 ... cleft-spanning ligands such as DECA, Phe 330 assumes an open access position in which the side chain is shifted 3. 5 Å towards the exterior and parallel to the DECA, resulting in a wider space ... complexes, seven and six sodium ions were added to the AChE and BChE systems, respectively, with subsequent solvation by TIP3P rectangular box around the solute unit Both boxes resulted in a system...

Ngày tải lên: 13/08/2014, 16:20

... cells in substantia nigra in normal subjects and in patients with Parkinson s disease estimated with an unbiased stereological method J Neurol Neurosurg Psychiatry 54, 30 33 55 Bezard E, Gross ... neurodegenerative disease? Insights from an animal model of Parkinsonism Neurobiol Dis 4, 247–2 53 16 Dauer W & Przedborski S (20 03) Parkinson s disease: mechanisms and models Neuron 39 , 889–909 17 ... disease Ann Neurol 53( Suppl 3) , S2 6 S3 6 35 Mastore M, Kohler L & Nappi AJ (2005) Production and utilization of hydrogen peroxide associated with melanogenesis and tyrosinase-mediated oxidations...

Ngày tải lên: 07/03/2014, 05:20

... diagnosis of Alzheimer' s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer' s disease Neurology 1984, 34 : 939 -944 ... those early studies [16,17] reported an increased risk of AD associated with HLA-B7 Of the 17 studies, only three had more than 60 AD cases: one Japanese study [18] (122 AD cases) and two Caucasian, ... NINCDS-ADRDA, National Institute of Neurological, Communicative Diseases and Stroke -Alzheimer' s Disease and Related Diseases Association; NK, natural killer; OPTIMA, Oxford Project to Investigate...

Ngày tải lên: 19/06/2014, 22:20

... 14(Suppl 2) :34 -38 11 Shardlow DL, Giannoudis PV, Matthews SJ, Smith RM: Stabilisation of acute femoral fractures in Paget 's disease Int Orthop 1999, 23: 2 83- 285 12 Ramos L, Santos JA, Devesa F, ... Kellingray S, Guyer P, Barker D: Epidemiology of Paget 's disease of bone Bone 1999, 24: 3S- 5S Ankrom MA, Shapiro JR: Paget 's disease of bone (osteitis deformans) J Am Geriatr Soc 1998, 46:1025-1 033 Thomas ... techniques of internal fixation This unusual case of delayed union of the femur fracture associated with Paget 's disease of the bone for which functional bracing was ultimately successful illustrates...

Ngày tải lên: 20/06/2014, 04:20

... adopted similar outcome measures The standard psychometric tool used to assess cognition in the majority of these studies is the Alzheimer' s Disease Assessment Scale (ADAS) [15] The section of the scale ... purposes) Annals of General Hospital Psychiatry 20 03, 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Birks JS, Melzer D and Beppu H Donepezil for mild and moderate Alzheimer' s disease ... Alzheimer' s Disease Cooperative StudyClinical Global Impression of Change The Alzheimer' s Disease Cooperative Study Alzheimer Dis Assoc Disord 1997, 11(suppl 2) :S2 2 -S3 2 Rogers SL, Doody RS, Pratt...

Ngày tải lên: 08/08/2014, 20:23

... administered structured questionnaire The GHQ-12 was used to assess mental health status of the respondents Scores were calculated with a 0-1-1 scale with a maximum score of and a minimum score ... http://www.annals-general-psychiatry.com/content/4/1/19 Table 3: Socio-economic characteristics and Mental Health Status Characteristics Occupation Senior Professional Junior Professional Skilled Unskilled Students ... prevalence of psychiatric morbidity ranges between 17%–25% [6-8] This study assessed the prevalence of and factors associated with mental illness in Oyo State at community level using the general...

Ngày tải lên: 08/08/2014, 21:20

... mechanisms of different effects of these SSRIs [4-6] although a further detailed study is necessary Delirium is regarded as syndrome that consists of several domains of symptoms, such as disturbance ... patient treated with SSRIs: is old age a risk factor? Isr J Psychiatry Relat Sci 1997, 34 :119-121 12 Byerly MJ, Christensen RC, Evans D: Delirium associated with a combination of sertraline, haloperidol, ... patients with Alzheimer s disease because of the risk of extrapyramidal side effects by antipsychotic drugs More detailed double-blind studies should be performed to clarify the role of sigma-1...

Ngày tải lên: 08/08/2014, 23:21

... progression have the same evolution Even less information is available on the relationship between these lesions and associated risk factors, disease signs and symptoms, and x-ray changes Therefore, ... patients suffering from knee OA and that a number of factors are associated with a risk of more aggressive progression These risk factors include higher body mass index (BMI), meniscal tear/extrusion, ... used to assess predictors of cartilage volume loss independently of potential confounders All statistical analyses were done using Statistica, version (StatSoft, Inc., Tulsa, OK, USA) All tests...

Ngày tải lên: 09/08/2014, 10:20

... analysis was performed with the SPSS-15 statistical software package Results Characteristics of the study participants The final sample consisted of n = 409 participants, which represents a response ... (p = 0.006) Descriptive results Table shows the descriptive statistics for the BCSQ -36 scales and subscales The highest scores were found for the “frenetic” subtype (Md = 4.12; SD = 0.80), followed ... public assistance jobs, such as those performed by ASP group members, seem to have an increased risk [51] This risk is possibly due to the antecedent effect produced by the characteristics of this...

Ngày tải lên: 11/08/2014, 15:22

... bruits were detected With the diagnosis of Takayasu 's arteritis, in association with Crohn 's disease, oral prednisolone (30 mg/day) was started plus continuation of her previous medication, i.e sulfasalazine ... women with early manifestations of TA [2,6] As TA mostly presents in young women [7], it could be suggested that patients with inflammatory bowel diseases would show features of TA in the same ... (Paris) 1996, 31 (6) :33 7-40 Reny JL, Paul JF, Lefebvre C, Champion K, Emmerich J, Bletry O, Piette JC, Fiessinger JN: Association of Takayasu 's arteritis and Crohn 's disease Results of a study...

Ngày tải lên: 11/08/2014, 23:21

... Cook 's distance values Stata software version (StataCorp, College Station, TX, USA) was used for all statistical analyses Results Descriptive summary Data were available for 792 flocks on 33 farms, ... exception (see discussion), interactions were not assessed since there were relatively few farms Model diagnostics included the calculation of Pearson residuals to identify outliers; observations with ... analyses The median age at slaughter of flocks raised during the summer seasons was 37 days (mean 37 , range 31 to 100) The age distribution for flocks included in the multivariable analyses was similar...

Ngày tải lên: 12/08/2014, 18:22

... intestinal manifestations with as many as 36 % of cases having at least one [1] Although association between respiratory disease and IBD has been observed more than three decades ago, clinically significant ... association with IBD In the majority of cases the association is with UC As with idiopathic BOOP, it responds well to corticosteroid therapy Several other parenchymal lung diseases such as other interstitial ... tracheobronchial stenosis in a patient with Crohn s disease Eur Respir J 2000, 15:209-12 doi:10.1186/1745-9974-6-6 Cite this article as: Faruqi et al.: Chronic cough associated with Crohn s disease Cough...

Ngày tải lên: 13/08/2014, 10:20

... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... dysfunction Abbreviations Ab: b-amyloid; AD: Alzheimer s disease; ADAS-cog: Alzheimer s Disease Assessment Scale; APOE: apolipoprotein E; AQT: A Quick Test of cognitive speed; CSF: cerebrospinal ... metalloproteinase Page of and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer s disease in Finns Neurosci Lett 2004, 36 7 :33 6 -33 9 doi:10.1186/alzrt44 Cite this article as: Stomrud...

Ngày tải lên: 22/03/2014, 14:20

... the levels of the two extreme groups Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in ... clinical diagnosis of probable Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the ... difference between MMSE scores obtained at the two visits (Fig 3B, rs = 0.275, p = 0.2 53, n = 19) A similar picture was observed for LSS scores: AOC levels were correlated with LSS scores (rs = 0.540,...

Ngày tải lên: 19/06/2014, 22:20

... standard Edman chemistry, and MS analysis was undertaken using an LCQDECA LC ⁄ MS system (ThermoFinnigan, San Jose, CA, USA) The MS system consisted of a Surveyor HPLC system with a diphenyl 150 ... Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems Procise 492 cLC sequenator (Applied Biosystems, Framingham, MA, USA) employing standard ... procedures described here are also suitable for expression and purification of mutant versions of Alzheimer s disease -associated amyloid b-peptides In this work, we have evaluated this capacity...

Ngày tải lên: 18/02/2014, 13:20

... experiments) (Fig 4E) Discussion We have developed a novel GFP-based assay to characterize c-secretase The advantage of this assay over existing systems is that it allows the isolation of cells with stable ... minus the cytoplasmic domain It has been shown that the SP-LE-A4CT construct is a suitable c-secretase substrate [36 ,37 ] Our rationale behind the design of the substrate-activator construct was ... the cytosol (data not shown) c-Secretase activity correlates with GFP expression Fig The fluorescent reporter c-secretase assay (A) Principle of the assay Cells are cotransfected with a substrate-activator...

Ngày tải lên: 08/03/2014, 08:20

... related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken together with the findings that mTOR phosphorylated at the Ser2481 site has a significant ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... previously measured by indirect ELISA in the same set of tissues as dot blots [6] Immunohistochemistry Immunohistochemical staining was performed on 20-lM formalin-fixed frozen sections (two AD cases,...

Ngày tải lên: 16/03/2014, 22:20

... growth -associated protein- 43 expression J Neurosurg 107, 844–8 53 43 DeMattos RB, Bales KR, Parsadanian M, O’Dell MA, Foss EM, Paul SM & Holtzman DM (2002) Plaqueassociated disruption of CSF and plasma ... loss of synapses are, at least in some models, observed in young transgenic animals devoid of plaque deposits, suggesting that soluble Ab species are deleterious [34 36 ] In aged APP transgenic ... (E693G) causes Alzheimer s disease by enhanced Abeta protofibril formation Nat Neurosci 4, 887–8 93 Englund H, Sehlin D, Johansson AS, Nilsson LN, Gellerfors P, Paulie S, Lannfelt L & Pettersson...

Ngày tải lên: 23/03/2014, 06:20

... increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused on a small number ... PS1/APPsw mouse brain slices Data expressed as picograms/mg protein, mean ± S. E.M for 13 determinations TgAPPsw Soluble Aβ1–40 Soluble Aβ1–42 Insoluble Aβ1–40 Insoluble Aβ1–42 PS1/APPsw 33 1.15 ± 35 .36 ... TgAPPsw and PS1/APPsw mouse brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices,...

Ngày tải lên: 19/06/2014, 22:20