results of randomized clinical trials

... number of RCTs, trials were not excluded because of trial quality (design) or insufficient number of patients A trial quality score was assigned (scale of 1-5) according to the method of Jadad ... C, Reynolds DJ, Gavaghan DJ, et al Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17(1):1-12 23 Stammberger U, Klepetko W, Stamatis ... especially of bovine origin Besides, the results of Rathinam’s study [14] also prefer BioGlue to conventional buttresses in terms of reduction in air-leak, chest drainage volumes, duration of chest...

Ngày tải lên: 10/08/2014, 09:22

... feelings of sadness or gloominess) on item (reported sadness) of the MADRS 28 Schz Initial PANSS Total score of ≥ 75, a minimum score of ≥ on one of the PANSS positive, and a minimum score of on ... show results of the KM analyses of olanzapine versus comparator for time to loss of response, http://www.biomedcentral.com/1471-244X/9/13 where loss of response was defined as a ≥ 20% worsening of ... loss of who had where loss of response was defined as a ≥ Meier (KM) Analysis of 1–7 Kaplan Meier (KM) Analysis of olanzapine versus risperidone for days to loss of response, where loss of response...

Ngày tải lên: 11/08/2014, 16:23

... clinical research in the field of sepsis Key messages • Most sepsis clinical trials reviewed did not include hemodynamic goals of therapy Of note, the four largest clinical trials evaluating novel therapies ... exception of a narrowed cardiac index range (data not shown) Discussion The present systematic review of hemodynamic goals in sepsis clinical trials has two major findings First, of the 126 clinical ... of the study procedures Of note, one of these studies that required the use of a pulmonary artery catheter as part of the protocol did not specify treatment goals that would require the use of...

Ngày tải lên: 13/08/2014, 03:21

... [21] The initiation of further ambulant therapy and/or the discussion of possibilities of supervision to perform a professional self-reflection at home was another element of the stationary treatment ... week) Missing data of the MBI (1.4 % of all items; incomplete data sets in 7.5 % of first and 9.3 % of follow-up surveys) were replaced by calculated personal mean values of the corresponding ... study results are the high quota of teachers who resumed their activities (75 %), the essential reduction of days off work due to incapacity to less than one-third and a significant decrease of...

Ngày tải lên: 20/06/2014, 00:20

... al Annals of Intensive Care 2011, 1:38 http://www.annalsofintensivecare.com/content/1/1/38 Page of 12 Table Summary of cohort glycemic performance results STAR pilot trials SPRINT clinical data ... et al Annals of Intensive Care 2011, 1:38 http://www.annalsofintensivecare.com/content/1/1/38 Page of 12 Number of patients with cTIB cutoff >= 0.80 Num patients 2 Days on STAR % of patients with ... doi:10.1186/2110-5820-1-38 Cite this article as: Evans et al.: Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control Annals of Intensive Care 2011 1:38 Submit your manuscript to...

Ngày tải lên: 20/06/2014, 23:20

... interstitial lung disease, randomized controlled trials, observational studies, multicenter studies, clinical trials phase II, clinical trials phase III, and clinical trials phase IV Diffuse alveolar ... was limited by the small number of eligible studies and a lack of variability in quality across studies Results of the meta-analysis In the randomized clinical trials, the FVC mean difference ... pooled analysis of the treatment arms of the randomized clinical trials and of the observational studies suggested that both the FVC and DLCO predicted values improved after 12 months of therapy,...

Ngày tải lên: 09/08/2014, 13:22

... Conclusion Our analysis of 19 randomized controlled clinical trials of single herb ginseng shows that all the trials with both negative and positive results confirm the specific effects of ginseng indicated ... Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996, 17:1-12 Ellis JM, Reddy P: Effects of Panax ginseng on quality of life Ann Pharmacother ... searched and analyzed randomized controlled trials of ginseng in PubMed The inclusion criteria were single herb ginseng trials with a sample size of ≥20 We selected trials of single herb ginseng...

Ngày tải lên: 13/08/2014, 15:21

... were part of a complex treatment or concomitant use of other therapies (n = 89) Five randomized controlled trials (RCTs) [5-9] and two controlled clinical trials (CCTs) [10,11] Page of fulfilled ... between 60 and 240 Assessment of risk of bias All of the included studies (five RCTs and two CCTs) had risks of performance bias, attrition bias and detection bias None of these studies reported ... Page of Table Summary of controlled clinical studies of Guasha for musculoskeletal pain conditions First author (year) Design/sample size Conditions Intervention group (regime) Main outcomes Results...

Ngày tải lên: 13/08/2014, 15:21

... case of heterogeneity, we attempted to identify and explain the heterogeneity using subgroup analysis Subgroup analysis was performed for subsets of Table Summary of randomized clinical studies of ... substantial contents Exclusion criteria were (1) trials of moxibustion coupled with other therapies; (2) trials for ‘warm acupuncture’ (i.e moxibustion on top of an acupuncture needle) Data extraction, ... assessments of change in the patients’ symptoms The other one employed the outcomes with stool frequency and CAS [17] Figure Flowchart of trial selection process RCT: randomized clinical trial...

Ngày tải lên: 13/08/2014, 15:21

... in randomized controlled trials • In the design of randomized controlled trials, investigators must determine a realistic estimate of the effect size (delta) of the therapy on an outcome of interest ... implications for the design of future trials and the practice of critical care medicine Our results accord with the findings of a recent report that found low rates of efficacy in trials in critical care ... the quality of reports of parallel-group randomized trials JAMA 2001, 285:1987-1991 10 Chan KB, Man-Son-Hing M, Molnar FJ, Laupacis A: How well is the clinical importance of study results reported?...

Ngày tải lên: 13/08/2014, 20:22

... number of patients included in the trials ranged from 16 to 268, with five trials studying over 100 patients [19-23] Of the smaller trials, six were pilot studies [14,24-27] Three of the trials ... found via computerized searches of the MEDLINE and EMBASE databases and the Cochrane CENTRAL Register of Controlled Trials The search syntax included synonyms of trauma (trauma*, injur*), immunomodulation ... level of evidence [10] Studies scoring four or five points were deemed of lesser quality and thus reporting 2b level of evidence Data from all studies were used to determine the effect of potential...

Ngày tải lên: 13/08/2014, 21:21

... administration of rBPI21 [62] Five trials reported other clinical outcomes Results from the phase II rFVIIa study reported no difference in MOF rates for blunt injury [57], and a trend to reduction of MOF ... http://ccforum.com/content/15/2/R92 Page of 10 the methodology of the trials and to assess a broad range of outcomes focusing on bleeding and transfusion requirements, correction of coagulopathy and mortality generation of random ... groups of patients examined, intervention and comparator arms and main clinical outcomes of each study Additional file 3: Quality assessment of included published randomized controlled trials...

Ngày tải lên: 14/08/2014, 07:21

... criteria” of a study 55 Section 3: Chance One way in which generalizability is discussed is often by using the term efficacy for the results of the samples of patients in clinical trials, and ... or hard data Side effects As a corollary of the need to limit the number of p-values, a common error in assessing the results of a clinical trial or of an observational study is to evaluate side ... hurdles of confounding bias and chance, a reader might conclude that the results of a study are valid The final step is to assess the scope of these valid results We then move to the topic of generalizability,...

Ngày tải lên: 01/11/2013, 11:20

... children in clinical investigation of FDA-regulated 13 products 2004 Textbook of clinical trials, chapter: clinical trials in pediatrics Survey of current guidance for child health clinical trials ... monitor the level of risk of a study and to give advice about early stopping of clinical trials. 23;51 Practical issues Only three guidelines addressed practical issues of clinical trials in children.8;59;61 ... Twenty out of 22 guidelines addressed ethical aspects of clinical research in children, while ethics was the main topic of Survey of current guidance for child health clinical trials 11 of these...

Ngày tải lên: 05/03/2014, 10:20

... Textbook of Clinical Trials Textbook of Clinical Trials Edited by D Machin, S Day and S Green  2004 John Wiley & Sons, Ltd ISBN: 0-471-98787-5 Textbook of Clinical Trials Edited by David ... t.wykes@iop.kcl.ac.uk Preface This Textbook of Clinical Trials is not a textbook of clinical trials in the traditional sense Rather, it catalogues in part both the impact of clinical trials – particularly the ... interaction of statistical and clinical disciplines The impact of the results from clinical trials, particularly the randomised controlled trial, on the practice of clinical medicine and other areas of...

Ngày tải lên: 23/03/2014, 01:20

... identify the common features of qigong (Brown and Knoferl, 2001) There are three main features of qigong: postures and movement, state of mind, and breathing The aim of practicing qigong is to ... questionnaire consists of 28 questions on a five-point scale This indicated that the whole spectrum of the five-point scales was utilized in the reflection of quality of life of the participants (Leung ... measures The results of the self-concept scale and quality of life measure are summarized in Tables and There is no significant difference in terms of time and group effects DISCUSSION Results from...

Ngày tải lên: 28/03/2014, 19:21

... report [10] dealing with the tracking of off-shore clinical trials was telling It reported that the number of foreign clinical investigators conducting clinical research under an IND increased ... meeting the Nation's goal of improving the health of its citizens *NIH definition of Clinical Studies: "The definition of Clinical Studies for this study is taken from 45CFR46 Clinical research is ... pstable.htm] 10 Rehnquist J, Office of the Inspector General: The Globalization of Clinical Trials A Growing Challenge in Protecting Human Subjects, US Department of Health and Human Services,...

Ngày tải lên: 18/06/2014, 16:20

... processing of blood and cryopreservation of PBMC at off-site locations is expensive and requires oversight and quality control of the processing lab at each center Thus, for many multicenter clinical trials ... facility of the University of Virginia Data were analyzed with FlowJo software (Treestar, Ashland OR) Testing of Blood Shipping Packages The standard shipping container used in our clinical trials ... isolation and cryopreservation of PBMC at each participating clinical center and indeed, optimization of cryopreservation media and of thawing practices has improved recovery of immunological responses...

Ngày tải lên: 18/06/2014, 19:20

... and social functioning of the patient in terms of the impact of disease is "an essential part of clinical diagnosis, a major determinant of therapeutic choices, a measure of their efficacy, and ... implementation of HRQoL measurement in clinical practice Practical barriers that have been reported include general lack of time, money and human resources, impracticality of instruments, disruption of clinical ... clinical routine, lack of IT support and health professionals' lack of knowledge in this area Attitudinal barriers may include health professionals' scepticism of the validity of HRQoL questionnaires,...

Ngày tải lên: 18/06/2014, 19:20

... open-label non -randomized clinical trials [15,16] These trials evaluated the safety and efficacy of the new AcrySof® ReSTOR® multi-focal IOL (model MA60D3) compared to the AcrySof® mono-focal ... with the SAS software (SAS Institute; NC), release 9.2, and SPAD software V6.5 Results Description of the pooled population at baseline Among the patients included in the clinical trials, 672 patients ... I: Frequency of wearing glasses Range of scale and answer choices Frequency of wearing glasses from "always" to "never" Frequency of wearing glasses for distance tasks Frequency of wearing glasses...

Ngày tải lên: 18/06/2014, 22:20