response to epidermal growth factor receptor kinase inhibitors

... Yatabe Y (2007) Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer ... (2006) Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib Cancer ... of the kinase domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations,...

Ngày tải lên: 16/02/2014, 09:20

... tyrosine kinase inhibitors (TKIs) and triggered the development of this class of agents for targeting growth factor receptors frequently expressed in epithelial cancers [9] Two such inhibitors of ... Hirsch FR, Franklin WA & Eckhardt SG (2009) KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection J Clin ... tyrosine kinase activity of EGFR (EGFR-TKIs), gefitinib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity...

Ngày tải lên: 16/02/2014, 09:20

... of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor J Biol Chem 277, 27643–27650 10 Janmaat ML, Kruyt FA, Rodriguez JA & Giaccone G (2003) Response to ... Yamamoto N, Yamamoto N, Takeda K, Swaisland H, Nakatani I, Hirose M et al (2003) Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ... Giaccone G (2003) Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent...

Ngày tải lên: 18/02/2014, 13:20

... of the epidermal growth factor and nerve growth factor receptors J Biol Chem 271, 30505–30509 Browaeys-Poly E, Cailliau K & Vilain JP (1998) Fibroblast and epidermal growth factor receptor expression ... Calmodulin inhibits the epidermal growth factor receptor tyrosine kinase J Biol Chem 267, 15237–15245 52 Martı´ n-Nieto J & Villalobo A (1998) The human epidermal growth factor receptor contains a juxtamembrane ... The epidermal growth factor receptor ligands at a glance J Cell Physiol 218, 460–466 ´ 21 Villalobo A, Ruano MJ, Palomo-Jimenez PI, Li H & Martı´ n-Nieto J (2000) The epidermal growth factor receptor...

Ngày tải lên: 06/03/2014, 09:22

... JR, Ashton SE, Curry BJ, Scarlett L et al (2001) Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted ... Girard L, Shigematsu H, Peyton M, Juroske D, Huang Y, Stuart Salmon J et al (2005) Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer ... cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor ⁄ extracellular signalregulated kinase ⁄ and EGF receptor ⁄ Akt pathway for proliferation Mol Cancer Ther...

Ngày tải lên: 07/03/2014, 00:20

... EGF receptors with two ligands that have different properties While EGF remains bound to the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor ... Src to activated growth factor receptors Science 250, 979–982 Rahimi, N., Hung, W., Tremblay, E., Saulnier, R & Elliott, B (1998) c-Src kinase activity is required for hepatocyte growth factor- induced ... (1992) Growth factor signaling by receptor tyrosine kinases Neuron 9, 383–391 Komada, M & Kitamura, N (1995) Growth factor- induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein...

Ngày tải lên: 17/03/2014, 11:20

... negative regulator of the epidermal growth factor receptor signal Biol Chem 382, 1649–1662 Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P & Segatto O (2000) ... 1205–1215 Quian XL, Decker SJ & Greene MI (1992) p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases Proc Natl Acad Sci USA 89, 330–334 Graus-Porta ... Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG et al (2004) Activating 5250 15 16 17 18 19 20 21 22 23 mutations in the epidermal growth factor receptor underlying...

Ngày tải lên: 30/03/2014, 01:20

... the epidermal growth factor receptor by immunohistochemestry J Clin Oncol 2005, 23(9):1803-1811 Moroni M, veronese S, Benvenuti S, et al.: Gene copy number for epidermal growth factor receptor ... of the ErbB/HER signaling network of growth factor receptors Adv Cancer Res 2000, 77:25-79 Diasio RB, Furie J: Targeting the epidermal growth factor receptor in the treatment of colorectal cancer ... potentiation of apoptosis; it seems also to mediate antibody-dependent cellular cytotoxicity [5] In preclinical studies Cetuximab was able to overcome resistance to CPT-11 and to radiotherapy in...

Ngày tải lên: 18/06/2014, 16:20

... of epidermal growth factor receptors in meningiomas J Neurosurg 1997, 87(2):315-323 Diedrich U, Lucius J, Baron E, Behnke J, Pabst B, Zoll B: Distribution of epidermal growth factor receptor ... The epidermal growth factor receptor is associated with phospholipase C-gamma in meningiomas Hum Pathol 1994, 25(2):146-153 Jones NR, Rossi ML, Gregoriou M, Hughes JT: Epidermal Growth Factor Receptor ... strategy to overcome the mechanisms of resistance to inhibitors of EGFR signaling Curr Pharm 2007, 13(33):3358-3367 Lee J, Chu E: First-line use of anti -epidermal growth factor receptor monoclonal...

Ngày tải lên: 09/08/2014, 09:20

... signal-regulated kinases: association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti -epidermal growth factor receptor ... head and neck 10 RT: radiation therapy EGF: epidermal growth factor EGFR: epidermal growth factor receptor 11 TGF-α: transforming growth factor alpha 12 RTOG: Radiation Therapy Oncology Group ATP: ... 354:567-578 Cohen S, Carpenter G, King L Jr: Epidermal growth factorreceptor-protein kinase interactions: co-purification of receptor and epidermal growth factor- enhanced phosphorylation activity J...

Ngày tải lên: 09/08/2014, 10:20

... 7(3):169-181 27 Inukai M, Toyooka S, Ito S, Asano H, Ichihara S, Soh J, Suehisa H, Ouchida M, Aoe K, Aoe M, Kiura K, Shimizu N, Date H: Presence of epidermal growth factor receptor gene T790M mutation ... predictors of gefitinib antitumor activity in East Asian chemonaive patients with advanced nonsmall cell lung cancer Cancer 2006, 107(8):1873-1882 Byrne BJ, Garst J: Epidermal growth factor receptor ... Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 2004, 350(21):2129-2139 Kobayashi...

Ngày tải lên: 10/08/2014, 05:21

... Danks JA, Chetty R, Burgess AW, Dunn AR: A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on the receptor biochemistry that results in impaired lactation Proceedings ... individuals to be sensitized to phenotypically express abnormal locomotor activities For example, Egfrwa2 homozygotes have variable eye defects [8] that could combine with other factors to contribute to ... transforming growth factor- alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters Brain Research 2005, 1038:171-182 Wakefield LM, Yang Y, Dukhanina O: Transforming growth factor- beta...

Ngày tải lên: 10/08/2014, 09:20

... consent is available for review from the Editor-in-Chief of this journal Abbreviations CT: computed tomography; HER2: human epidermal growth factor receptor 2; MBC: metastatic breast cancer Authors’ ... efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic Syrios et al Journal of Medical Case Reports 2010, 4:401 ... doi:10.1186/1752-1947-4-401 Cite this article as: Syrios et al.: Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab...

Ngày tải lên: 11/08/2014, 02:22

... 95:843–852 Amishima M, Munakata M , Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human ... epidermal growth factor receptors to airway goblet cell production Am J Respir Crit Care Med 2001, 163:1–6 Elovic A, Wong DTW, Weller PF, Matossian K, Galli SJ: Expresα sion of transforming growth ... to the interleukin-4 receptor was reported [25] to prevent ovalbumin-induced goblet-cell metaplasia EGFR inhibitors were also effective, leading Shim et al [26] to suggest that T-helper-2 cytokines...

Ngày tải lên: 12/08/2014, 18:20

... DM: Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3 'kinase ... Quantification of short term signaling by the epidermal growth factor receptor J Biol Chem 1999, 274:30169-30181 Terlau H, Seifert W: Influence of epidermal growth factor on long-term potentiation in the ... Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty Mol Cell Neurosci 1994, 5:246-262 Li X, Sankrithi N, Davis FC: Transforming growth factor- alpha...

Ngày tải lên: 14/08/2014, 16:21

... Caputo R, Blanco R, et al.: Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor ... AE: Epidermal growth factor receptor tyrosine kinase inhibitors Curr Opin Pharmacol 2002, 2:382-387 Wakeling AE, Guy SP, Woodburn JR, et al.: ZD1839 (Iressa): an orally active inhibitor of epidermal ... inhibitor of epidermal growth factor signaling with potential for cancer therapy Cancer Res 2002, 62:5749-5764 Shin DM, Donato NJ, Perez-Soler R, et al.: Epidermal growth factor receptor- targeted therapy...

Ngày tải lên: 14/08/2014, 19:22

... (R)TK (Receptor) Tyrosine kinase 𝑉 𝑒𝑓𝑓 TM Transmembrane Effective volume xiv Chapter Introduction 1.1 Epidermal Growth Factor Receptor (EGFR) The history of studying EGFR can be traced back to the ... cell membrane receptor, namely epidermal growth factor receptor (EGFR) (Carpenter, Lembach et al 1975) Later, Ullrich and colleagues successfully cloned EGFR from cDNA, which leads to the discovery ... traditional model of EGFR activation, the receptors exist as monomers during the resting state When EGF binds to receptors, receptors are able to form a 2:2 back-toback dimer with ligands embedded in...

Ngày tải lên: 10/09/2015, 09:25

... (2000) The M3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase Biochem J 348, 381–387 49 Lahaye, ... Hunter, T (1984) C -kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor- stimulated tyrosine protein kinase activity J Biol Chem 259, 2553–2558 31 ... Saltiel, A.R & Rosner, M.R (1996) Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C J Biol Chem 271, 12891–12896 51 El-Shemerly,...

Ngày tải lên: 19/02/2014, 16:20

... (1993) A 40-kDa epidermal growth factor/ transforming growth factor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor J Biol Chem ... position 13 of human growth factor in receptor binding J Biol Chem 268, 10114–10119 26 Campion, S.R & Niyogi, S.K (1994) Interaction of epidermal growth factor with its receptor Prog Nucleic Acid ... epidermal growth factor receptor J Biochem 127, 65–72 30 Abe, Y., Odaka, M., Inagaki, F., Lax, I., Schlessinger, J & Kohda, D (1998) Disulfide bond structure of human epidermal growth factor receptor...

Ngày tải lên: 24/03/2014, 03:21

... Inhibition of the mitogen-activated protein kinase pathway prevents (EGF)-mediated loss alpha (TNF-α) and epidermal growth factor tumor necrosis factor alpha (TNF-α) and epidermal growth factor (EGF)-mediated ... maintained in the presence of tumor necrosis factor Cell viability is and/or epidermal growth factor (EGF) alpha (TNF-α) and/or epidermal growth factor (EGF) Subconfluent monolayers of chondrocytes ... individual factors and partially protected against the effect of TNF-α and EGF in combination (TNF-α) or epidermal growth factor (EGF) aggrecan of type II kinase C does by tumor necrosis factor alpha...

Ngày tải lên: 09/08/2014, 06:22