... Irvingtonian Unknown Probably Irvingtonian Unknown Probably Irvingtonian Unknown Probably Irvingtonian Mixed Contains specimens of potential Blancan age as well as Irvingtonian At least as old as ... its ability to maintain the baseline functions that define it Maintaining these baseline functions is, in fact, integral to an operational definition of ecosystem health In the words of Haskell ... in naturally varying systems Therefore they may be useful as an ecological baseline against which future changes can be measured As global warming continues into the coming decades, changes in...
... obtain data that may have had an impact on vaccine response, including living situation (institutionalized or community living), medical history, vaccine-specific factors such as antigen dose and ... responses toin uenza vaccination in the elderly using an immunostimulant patch Vaccine 2005;23(7):946– 50 [42] Hara M, Tanaka K, Hirota Y Immune responsetoin uenza vaccine in healthy adults and ... over the age of 75 We also compared the vaccine response for each individual adjustment factor related to the vaccine and study participants (vaccine: vaccine type, vaccine dosage, new vaccine component;...
... blood alexa-488 labeled MCP-1 internalization assay was validated here for use in clinical trials investigating a CCR2 antagonist by examining a standard reagent concentration to use, the stability ... than 10% across all individuals and all days (Table 5) In- study results This assay was used as a pharmacodynamic marker for biological activity of a CCR2 antagonist ina clinical trial consisting ... [16] Using the guidance for ligand binding assays [12] as a foundation in which to base the validation of a flow cytometry pharmacodynamic assay and applying the "appropriate" parameters for a cell...
... MS patients' responseto therapy, witha surrogate marker, may have additional value as particularly effective immunomodulatory activity, such as that observed with natalizumab, may have a potential ... Center in Shreveport and signed informed consent was obtained from all participants Measurement of soluble HLA A solid phase ELISA was used to quantitate s-HLA-I and sHLA-II in the saliva obtained ... (Figures 1A and 1B) All study subjects with RRMS had measurable amounts of sHLA-II in their saliva and in all subjects increases in saliva sHLA-II levels following treatment with IFN-β 1a (at month...
... [2] Baradat P., Pastuszka P., Le pin maritime, in: Gallais A. , Bannerot H (Eds.), Amélioration des Espèces Végétales Cultivées, INRA, Paris, 1992, pp 695–709 [3] Blum A. , Towards standard assays ... ΨΠ, and the ΨΠ value varie with both investigator and species, summarize the effects of the variations in the ln RWC/(–ln (–ΨΠ)) relationship, and are calculated by many authors as an indicator ... Osmotic adjustment in maritime pine cuttings [11] Fernandez M., Gil L., Pardos J .A. , Response of Pinus pinaster Ait provenances at early age to water supply I Water relation parameters, Ann For...
... obtained from animals cannot always be extrapolated to humans Bjelle [36] has analysed the mechanical response of human knees and found an increase in glycosaminoglycan production in loadbearing ... protein analysis The cartilage used for RNA quantification was diced and incubated with RNAlater (Qiagen Inc., Valencia, CA, USA) overnight at 4°C prior to storage Available online http://arthritis-research.com/content/8/5/R149 ... joint loads maintain healthy cartilage witha specific protein composition according to loading demands [32,35] In contrast, inappropriate loads alter the compositional properties of cartilage,...
... 3'-accaatagagagaccaggaagaa-5'; GTSE1: 5'acgtgaacatggatgacccta-3' and 3'-gttcgggaaccggattattta-3'; CDC2: 5'-ggtcaagtggtagccatgaaa-3' and 3'-ccaggagggatagaatccaag-5'; and MKI67: 5'-ccccaaccaaaagaaagtctc-3' ... -actin: 5'-ggcatcgtgatggactccg-3' and 3'-ctggaaggtggacagcga-5'; LTB: 5'-gaggaggagccagaaacagat-3' and 3'-tagccgacgagacagtagagg-5'; CCL5: 5'-catattcctcggacaccacac-3' and 3'-gatgtactcccgaac- Page ... following primers: IL-7R: 5'-ttcttggaggatgcagctaaa-3' and 3'aagcccaaccaacaaagagtt-5'; IL-6: 5'-gcccagctatgaactccttct-3' and 3'-tgaagaggtgagtggctgtct-5'; INDO: 5'-ggtcatggagatgtccgtaa-3' and 3'-accaatagagagaccaggaagaa-5';...
... the mean )lay o for and a and for the variance can be written separately With s i instance, b tends to introducing 2 or2 , = = = tends to infinity and if at’ than a half, and tends to 1/2 as as ... and their expressions as ratios of a covariance toa variance indicate that they can also be obtained from a linear approximation This comment makes it possible to extend easily the approximate ... means and standard deviations over generations of canalising selection Several aspects appear: witha high heritability h!, the population mean tends ina linear manner towards the optimum in a...
... Font A, Gonzalez-Larriba JL, Berrocal A, Garcia-Ribas I, Marfa X, Fabregat X, Albanell J, Bellmunt J: Gemcitabine and oxaliplatin combination: a multicenter phase II trial in unfit patients with ... Frassineti GL, Oliva C, Pacini M, De Lena M: A phase II study of gemcitabine in patients with transitional cell carcinoma of the urinary tract previously treated with platinum Italian Co-operative ... clinical trials are examining this, no treatment has been established as secondary therapy after failure of G-C or M-VAC chemotherapy Oxaliplatin is more potent than cisplatin in vitro and has...
... Cite this article as: Kang: Responseto imatinib rechallenge ina patient witha recurrent gastrointestinal stromal tumor after adjuvant therapy: a case report Journal of Medical Case Reports ... tolerated, as the only adverse events experienced by our patient were grade edema, anemia and fatigue Our patient maintained a stable PR for over two and a half years after being rechallenged with ... medical editorial assistance was provided by Novartis Pharmaceuticals I thank Jinling Wu, MD, PhD, for her medical editorial assistance with this manuscript Competing interests YKK is a consultant...
... Ethical reasons also dissuaded us from performing a coronary angiograph His family history for cardiovascular events was negative A brain MRI revealed mild cortical atrophy with bilateral lacunar ischemic ... used to evaluate his macrophage response An abnormal reactivity of macrophages to LPS, exacerbated by our patient’s own serum, was found; in fact this reaction mainly caused foam cell formation ... was referred to the Department of Internal Medicine at the University Teaching Hospital in Cagliari His clinical manifestations started in 2002 witha sudden onset of neurological symptoms Magnetic...
... of gastric contents, which is associated with endothelial cell damage, increased capillary permeability, and scattered intraalveolar hemorrhage Several hours later, an acute inflammatory response ... fluid aspirations and with data analysis BL carried out the cytokine analysis, and helped prepare figures for the manuscript CH assisted with animal care and organ preparation for histologic examination, ... bronchiolitis pattern described by Teabeaut that occurred in some instances following an acute aspiration event in rabbits [18] Analysis of BAL specimens revealed a substantial increase in macrophages and...
... Smolen J, Aletaha D, van Riel PLCM: Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression ... progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate Ann Rheum Dis 2009, 68:954-960 Inoue E, Yamanaka H, Hara M, Tomatsu T, Kamatani ... doi:10.1186/ar3393 Cite this article as: Yoshida K, et al.: Responseto ‘Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study’ Arthritis...
... responsein the asthmatic might be that myosin bridges never see strains that large This is perhaps because the majority of the mechanical strain in the asthmatic airway during a DI is taken up by increased ... cytoskeleton are surely important factors, but how they interact and details about underlying mechanisms remain unclear Muscle shortening velocity also seems to be an important factor [4,25,26] In addition, ... among airway–parenchymal interactions, lung responsivness, and inflammation in asthma Chest 1995, 107(3):148S-152S Loring SH, Ingram RH Jr, Drazen JM: Effects of lung inflation on airway and tissue...
... of etomidate and the interval between intubation and the test were associated with low responsein univariate analysis but not in multivariate analysis Mechanical ventilation did not predict a ... [14] also used blood albumin level as a surrogate marker of plasma cortisol binding capacity Low albumin levels were associated with low baseline cortisol values and increases However, hypoalbuminaemia ... platelets toa low response, independent of sepsis or infection, may be caused by circulating factors promoting platelet aggregation and impairing adrenal function; alternatively, it may be associated...
... (UPAO) Town government (Barangay) Barangay Baesa, Quezon City, Metro Manila Barangay Bagong Silangan, Quezon City, Metro Manila Barangay San Isidro, Montalban, Rizal Barangay San José, Montalban, ... Manila includes the following 16 cities and municipality: City of Manila, Caloocan, Las Piñas, Makati, Malabon, Mandaluyong, Marikina, Muntinlupa, Navotas, Pasay, Pasig, Parañaque, Quezon, San Juan, ... global warming are likely to cause a myriad of climate change impacts, including: increasing warm spells and heatwave frequency for most land areas; increasing intensity and frequency of heavy...
... 3.5THE Tocantins-Araguaia River Basin in the Greater Amazon Description of the Basin The Tocantins-Araguaia River basin (TARB) is situated in the north-central portion of Brazil in the greater Amazon ... ensure auto-adaptation of ecosystems and species • Instituting environmental flow plans aimed at maintaining the natural flow regime (and a more natural sediment load) of the Tocantins, Araguaia, and ... precipitation are likely to lead to changes in demand for water In irrigated agriculture, increased temperatures are likely to lead to increased evapotranspiration, increasing water demand, and decreasing...