... amassed by theEuropeanCourt (the Court) and Commission ofHumanRights in their interpretation and application of Articles andoftheEuropean Convention on HumanRights (ECHR) But acceptance of this ... Conclusions TheRightsofthe Defence: Lessons from the Nineteenth Century A The Institutional Nature oftheRightsofthe Accused B TheRightsofthe Defence at Trial (i) The Presence ofthe Accused ... involve the interrogation and defence ofthe accused, the hearing and discussion ofthe evidence of witnesses, the examination of all ofthe facts andthe assessment ofthe evidence Further, it...
... ofthe study andthe revision ofthe manuscript JB participated in the design ofthe study, appraised the guideline with eGLIA, and participated in the telephone conference andthe revision of ... Sweden, the Netherlands, and New Zealand Appraisal ofthe guideline We asked the panel members to read the ESHRE guideline for the diagnosis and treatment of endometriosis and to assess it with the ... Discussion The aim of this study was to investigate the implementability ofthe ESHRE guideline for the diagnosis and treatment of endometriosis with the aid ofthe eGLIA tool In general, the appraisers...
... point in the string In the language just given there are only two relevant terminal symbols, but if there were a thousand symbols that could appear in the ~ and ~ strings, then the vocabulary of recursive ... proportion (The second clause in the definition of profligacy makes it irrelevant whether there are other terminals in the language, like g in the language cited, that not have to participate in the ... subset ofthe CF-PSG's The claim that human languages always have ECPO CF-PSG's is a claim about the strong generative capacity that an appropriate theory ofhuman language should have one of the...
... by law solely for the purpose of securing due recognition and respect for therightsand freedoms of others andof meeting the just requirements of morality, public order andthe general welfare ... respect for humanrightsand fundamental freedoms It shall promote understanding, tolerance and friendship among all nations, racial or religious groups, and shall further the activities ofthe United ... participate in the cultural life ofthe community, to enjoy the arts and to share in scientific advancement and its benefits (2) Everyone has the right to the protection ofthe moral and material...
... stereochemistry ofthe model has been assessed using the program procheck [23] Ninety per cent ofthe residues fall in the most favoured regions ofthe Ramachandran plot, with Asn148 and His269 falling ... in the crystal, and a mixture of monomeric and dimeric forms in solution [18] Therefore, the available structural data suggest Fig Ribbon representation ofthe overall structure of hACMSD The ... as the amino acid numbers The alternative conformations ofthe Trp–Met couple can be observed; the arrows indicate the unidirectional movement ofthe two protein residues upon ligand binding The...
... Model structure ofhuman LPL All model structures of dimeric human LPL were constructed using the INSIGHT II program and were based on the crystal structures ofthe human, porcine, and horse PLs ... illustrates the overall saddle shape ofthe dimeric structure andthe key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top ofthe hollow (Fig 1A) The ... the C-terminal domain of apoCII interacts with the interface ofthe N- and C-terminal domains of LPL and part ofthe lid surface [32] Because the functional importance of LPL’s C-terminal domain...
... report on the activities ofthe ESCB and on the monetary policy of both the previous andthe current year to theEuropean Parliament, the Council andthe Commission, and also to theEuropean Council ... 17 ofthe Act concerning the conditions of Accession ofthe Czech Republic, the Republic of Estonia, the Republic of Cyprus, the Republic of Latvia, the Republic of Lithuania, the Republic of ... accord ofthe governments ofthe Member States at the level of Heads of State or Government, on a recommendation from the Council and after consulting theEuropean Parliament andthe Council of the...
... unattractive to the traditional banking sector Some ofthe challenges in the sector are developing a common definition ofthe terms used in the microfinance sector and involving all the actors in the development ... EMN, to future European initiatives in the field of microcredit, as well as ofthe commitment and willingness of savings banks to increase their participation in the field of microfinance ... such as the JEREMIE andthe JASMINE programmes Savings banks have a particular role to play in the development of microfinance, since they finance the local economy in the communities where they...
... major function ofthe t peptides is that they allow the assembly of tetramers of AChET [7] andof BChET [8] and their association with the structural proteins ColQ and PRiMA [9,10] These heteromeric ... critically to the oligomerization and to the efficiency of secretion Results Exchange of t peptides between human AChE and BChE The T variants ofhuman AChE andhuman BChE are composed of a catalytic ... Oligomerization and secretion of AChE and BChE D Liang et al A B Fig Structures of AChE and BChE t peptides (A) Sequences ofthe C-terminal t peptides ofhuman AChE and BChE These peptides (a and b) are...
... studies ofthe catalytic subunit ofthe cAMP-dependent protein kinase Its ability to readily alter the PKI coding sequence could permit further studying ofhuman PKIb and understanding ofthe function ... component bands, determined by band fitting ofthe absorbance spectrum of Fig 4A, are shown in Fig and Table From Table 2, the sum of individual amide I¢ intensity andthe intensity percent of each ... indicated by the presence of a very strong negative band at 198 nm The negative band near 220 nm results from overlapping ofthe bands of b-sheet (215 nm) and a-helix Table Fractional composition of secondary...
... fragment, andthe 10 kDa COOH-terminal fragment [28] At a low surface concentration of protein, the binding enthalpy of intact apoE4 was consistent with the sum ofthe enthalpies for the 22 kDa and ... in the distribution, the mean andthe quantiles enclosing 95% ofthe values from the analyses ofthe simulated distributions were determined Apolipoprotein-emulsion binding assay Samples of emulsion ... EggPtdCho/TO fraction in the presence of both apoE isoforms However, a greater increase in the ordinate maximum and area under the curve is obvious in the presence ofthe apoE4 isoform (Fig 7C, open...
... thermal stability Furthermore, there is a clear correlation between thermostability and molecular volume occupied by the tetramers (Table 1) The difference between the tetrameric volume andthe ... by DSC to be the Tm ofthe protein These fibrils are amyloidogenic, as determined from their Stability and fibril formation of TTR and TRP tinctorial properties in the ThT-binding and CR-binding ... heating These fibrils are similar both in shape and in dimension to the fibrils of hTTR and sbTTR formed by heating The thick and straight morphology of heat-induced fibrils of hTTR, sbTTR and ecTRP...
... E M Franklin et al A Probing the verdin site of BVR-A and -B Fig Spectra ofthe BVR-A catalysed reactions ofthe locked conformers of biliverdin-IXa The spectra ofthe fixed isomers are shown in ... suggest that they may interact with the ‘roof’ and ‘floor’ of a hypothetical ‘verdin binding site’, with the nicotinamide ring forming part ofthe floor If the bound conformation is helical, there would ... The angle of attack is likely to be the same such that the reaction centre for both BVR-B and BVR-A is likely to involve the B-face hydrogen atom attached to C4 ofthe nicotinamide ring and the...
... conformation and hydrogen bonding network ofthe pterin cofactor in the three structures Superpositions ofthe binary and ternary complexes of hPAH onto the crystal structure ofthe ligand-free dimeric ... concentrations (Fig 3B) ofthe biopterin cofactors or dopamine the rate of phosphorylation was decreased, and at 200 lM ofthe ligands the inhibition was more pronounced for H4biopterin ( 26%) and dopamine ... required for the cofactor inhibition of phosphorylation (data not shown) The molecular basis for the negative modulatory effects ofthe pterin cofactor and dopamine binding to wt-hPAH and their reversal...
... andthe strengthening ofthe economic role ofthe state at the domestic level’.40 The creation ofthe ECSC in 1951 andthe EEC (and Euratom) in 1957, in the name ofthe ideal of peacemaking and ... important strengthening ofthe social rights- basis ofthe EU, in the form ofthe proposed embedding ofthe 2000 Charter of Fundamental Rights as Part II ofthe Constitutional Treaty, agreed by the Member ... changes of our era – the centrality ofthe values of labour law and welfare institutions, as the common heritage ofEuropean democracies, which was at the very basis ofthe construction ofthe Community...
... with the large size ofthe cavity easily allowing substrate entry However, the side chains of residues Tyr988 and Lys987 ofthe second molecule ofthe ‘dimer’ clash with the region where the adenosyl ... Titration ofthe activation domain of MS (both the D963E ⁄ K1071N mutant and wild-type proteins) with the FMN domain ofhuman MSR resulted in a quenching ofthe fluorescence emission spectra ofthe ... concentration ofthe activation domain andthe curves show the best fit ofthe data to the quadratic Eqn (1) Table lists the calculated dissociation constants for the wild-type and D963E ⁄ K1071N alone and...
... some of these factors – statism, legalism and epistemology – that inhibit the use ofhumanrights discourse in non-state contexts, and asks what sort ofhumanrightsand what sort ofhumanrights ... forms The very idea ofrights is closely tied to the concept of rules and entitlements, andhuman rights, as the most important of rights, are tightly associated with the strongest mode of rules and ... have equal human rights) vastly transcend the spheres ofhumanrightsand take in the whole landscape of distributive justice And while some humanrights are focussed on the exclusion of certain...
... ofthe proposed critical shortage threshold The focus on doctors, nurses and midwives reflects the greater reliability of estimated numbers of these cadres In practice, the contribution of other ... support the improvement and expansion of other child health services delivery of ART should reduce demands on the health care system for the treatment of opportunistic infections and end -of- life ... out ofthe many possible configurations that could be theoretically predicted Among the evident synergies is the contribution ofthe EHRP to increasing the availability of staff for the expanding...
... for the number of beneficiaries and number of courses, assumptions were made to derive the number of beneficiaries, on the basis ofthe analysis of courses offered to date andofthe specialties ... recognised the importance ofthe issue, and launched initiatives such as the Working Group on Tools and Guidelines to strengthen the analysis ofthe costs of HRH development [5], and to propose ... costing ofthe national scaling-up ofthe health workforce The context, process and actors involved in the Mozambique and Guinea Bissau case studies are then presented along with the results of the...