relaxin an emerging therapy for fibroproliferative disorders
nanocarriers as an emerging platform for cancer therapy
Ngày tải lên :
28/05/2014, 15:07
... Box Rational design of nanocarriers for cancer therapy Nanocarriers can offer many advantages over free drugs They: For rapid and effective clinical translation, the nanocarrier should: • • • ... inorganic nanoparticles include nanoshells and gold nanoparticles Nanoshells (100–200 nm) may use the same carrier for both imaging and therapy (Table 2) They are composed of a silica core and ... membrane proteins, known as MDR transporters, which transport a variety of anticancer drugs out of the cancer cell and produce resistance against chemotherapy11 The molecular basis of cancer...
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gene therapy for hematological disorders
Ngày tải lên :
10/04/2014, 22:10
... blood stem cell transplantation for multiple myeloma and breast cancer Bone 142 GENE THERAPY FOR HEMATOLOGICAL DISORDERS marrow and peripheral blood CD34-enriched cells were transduced with different ... blood, and cord blood and can be cultured and transduced ex vivo before intravenous reinfusion These features have made HSCs an ideal target for gene therapy of a wide variety of congenital disorders ... appropriate for target cells that cannot REQUIREMENTS FOR GENE TRANSFER INTO HEMATOPOIETIC CELLS 135 TABLE 6.1 Relevant Targets and Applications for Gene Therapy of Hematopoietic or Immune System Disorders...
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Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
Ngày tải lên :
18/06/2014, 16:20
... immortalization For infusion protocols, the impact on quantity is incremental and manageable (versus the quantum changes for engraftment) and likely does not create new types of risks for 1st or 2nd ... Gene Therapy of Cancer) Cancer Gene Ther 1998, 5:S1-S2 Junghans RP, Safar M, Huberman MS, Ma Q, Ripley R, Leung S, Beecham EJ: Preclinical and phase I data of anti-CEA "designer T cell" therapy for ... persistence and antitumor activity in individuals with neuroblastoma Nat Med 2008, 14:1264-70 Scheinberg DA, Mulford DA, Jurcic JG, Sgouros G, Junghans RP: Antibody therapies of cancer In Cancer Chemotherapy...
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Báo cáo y học: "tromal Vascular Fraction Transplantation as an Alternative Therapy for Ischemic Heart Failure: Anti-inflammatory Role" doc
Ngày tải lên :
10/08/2014, 09:21
... add another dimension to understanding the anti-inflammation role of SVF and BM-MNC transplantation in cardiac dysfunction The potential anti-inflammation role of both SVF and BM-MNC transplantation ... on the protective effects of SVF transplantation compared to those of BM-MNC transplantation and the anti-inflammatory role of transplanted cells after implanted into a rat chronic myocardial ... Figure 7) Discussion Cell therapy may be an alternative treatment for heart failure The optimal cell for transplantation and the source of the cells to be isolated are important considerations It...
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Báo cáo khoa học: "Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials" ppt
Ngày tải lên :
13/08/2014, 03:20
... median and range All statistical comparisons were two-tailed, and P less than 0.05 was considered significant Comparison between the two groups was performed using the WilcoxonMann-Whitney rank ... PI, YK, RR, and MT made substantial contributions to the conception and design of the study and to the analysis and interpretation of data and were involved in drafting the manuscript and revising ... Hodges-Lehman shift with 95% CI Patients who died within 48 hours were assigned the highest rank for the Wilcoxon-Mann-Whitney test and the Hodges-Lehman estimate bTwo-sided Wilcoxon-Mann-Whitney rank...
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Báo cáo y học: "NGAL: an emerging tool for predicting severity of AKI is easily detected by a clinical assay" potx
Ngày tải lên :
13/08/2014, 20:22
... 10:R73 Devarajan P: Neutrophil gelatinase-associated lipocalin an emerging troponin for kidney injury Nephrol Dial Transplant 2008, 23:3737-3743 Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz ... subsequent studies and a meta-analysis have confirmed the utility of both urinary and plasma/serum NGAL for the early detection of AKI in other patient populations, including adults [4] and in mixed ... 0.95 and a corresponding sensitivity and specificity of 0.82 and 0.90 Furthermore, this same 2-hour NGAL level correlated with severity and duration of AKI, length of stay, dialysis requirement, and...
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IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMO-RESISTANCE
Ngày tải lên :
24/08/2014, 09:51
... Dr May Khanna, Lanmin Zhai, Cindy Morgan, Dr Vimbai Chikwana, Dr Ann Kimble Hill, Cameron Buchman and Krishna Kishore Mahalinghan for their friendship and support I could not have asked for a better ... chemotherapeutic agent and in the mobilization and conditioning regimens for blood and marrow transplantation Reviewing the chemistry and pharmacology of cyclophosphamide is crucial for understanding its ... (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMORESISTANCE ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs Despite...
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Tài liệu The Copenhagen Neuroaesthetics conference: Prospects and pitfalls for an emerging field doc
Ngày tải lên :
19/02/2014, 17:20
... music, dance and film) and a range of humanistic, cognitive, neuroscientific, and evolutionary approaches Third, the atmosphere invited attendants to exchange ideas and perspectives, and to contribute ... gender and sexual orientation on ratings of attractiveness for male and female faces Participants included heterosexual and homosexual men and women The results showed that for heterosexual women and ... preference for cheesecake derives from an evolved preference for the fats and oils that were advantageous to survival in the moderate quantities naturally occurring in nuts and seeds but are disadvantageous...
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báo cáo hóa học:" Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer" pdf
Ngày tải lên :
18/06/2014, 15:20
... Pharmingen, San Diego, CA) and PEmouse anti-human CD144 antibody (eBioscience, San Diego, CA) CD52 expression was confirmed with using FITC-anti-human CD52 (GeneTex San Antonio, TX) For qRT-PCR experiments, ... ovarian flank tumor model As above, animals with established tumors were treated with anti-CD52 therapy twice-weekly for three weeks Therapy was then discontinued and tumor growth was monitored for ... both CD14+ and CD3+ cells in treated animals A(2) Quantification of absolute numbers of CD14+ and CD3+ cells in peripheral blood of control and anti-CD52 treated animals B (1 and 2) Quantification...
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Báo cáo khoa học: "An investigation of intensity-modulated radiation therapy versus conventional two-dimensional and 3D-conformal radiation therapy for early stage larynx cancer" ppt
Ngày tải lên :
09/08/2014, 09:20
... plan The beam arrangement for the 3D and IMRT plans was the same as those used for treatment However, for consistency, the plans were re-optimized to all conform to the same constraints All plans ... were turned on and the plan was recalculated for comparison to the other plans 3D planning/IMRT Relevant structures were manually contoured on each axial CT scan slice by a head and neck radiation ... target volume (CTV), and 3) IMRT, utilizing the same definition as 3D planning for the CTV The 3D and 2D plans utilized the same beam configuration, but the conformal plan used 3D information to design...
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Báo cáo y học: "Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study" pps
Ngày tải lên :
09/08/2014, 14:22
... Hannover, Germany Furthermore, they thank Dr Mei Fang Ong (Institute of Medical Biostatistics, Saarland University, Homburg, Germany) for professional support in performing the statistical analyses ... might compromise compliance with therapy, and contraindications for administration of azithromycin, doxycycline, and clindamycin, including a history of allergy to any antibiotics We enrolled ... incubated for a minimum of 14 days at 35 ± 2°C for detection of aerobic, microaerophilic, and anaerobic microorganisms, including fastidious microorganisms Their susceptibility to antibiotics...
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Báo cáo y học: "Hyperbaric oxygen therapy as an adjunctive treatment for sternal infection and osteomyelitis after sternotomy and cardiothoracic surgery" pptx
Ngày tải lên :
10/08/2014, 09:22
... Taiwan Authors’ contributions WKY and YWC both participated in the design of the study and drafted the manuscript HGS and TCL both obtained data and performed the statistical analysis HKK and ... director of Scandinavian Health Limited Group, for his help in language editing Author details Department of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, Taiwan 2National Yang-Ming ... antimicrobial treatment and adjunctive HBO2 therapy [10] Three of them improved significantly and the authors concluded that HBO2 therapy was safe and effective for the management of infection...
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Báo cáo y học: "Effective cardiac resynchronization therapy for an adolescent patient with dilated cardiomyopathy seven years after mitral valve replacement and septal anterior ventricular exclusio" ppsx
Ngày tải lên :
10/08/2014, 09:22
... Echocardiogram before and after the CRT placement Each panel shows the short axis view of the LV cavity Upper panels: The LVDd was 59.3 mm and LVEF was 31.2% before the CRT placement Lower panels: The ... Consent Written informed consent was obtained from this patient and her mother for publication of this case report and any accompanying images A copy of the written consent is available for review by ... university hospital, and gave most comments for this manuscript NY is an attending physician in the pediatric ward in Kyoto university hospital SK is an attending physician in the pediatric outpatient...
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báo cáo khoa học: " Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain" ppt
Ngày tải lên :
10/08/2014, 10:22
... ATHENA-Opioid Therapy and made suggestions for revisions MC, CS, and JR analysed the Rules Document for concordance with the written CPG and made suggestions for revisions DW revised and upgraded ... 8Center for Human Development, 4211 Rickey's Way, Suite B, Palo Alto, CA 94306, USA and 9Center for Primary Care and Outcomes Research (PCOR), Stanford University, 117 Encina Commons, Stanford, ... Quality and Performance, VA and Quality Management Directorate, US Army MEDCOM; 2003 Yanni LM, Weaver MF, Johnson BA, Morgan LA, Harrington SE, Ketchum JM: Management of chronic nonmalignant pain:...
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Báo cáo y học: "terim prostacyclin therapy for an isolated disconnected pulmonary artery: a case report" docx
Ngày tải lên :
11/08/2014, 12:20
... crucial issue when patients must be transferred And, as in our case, the transfer involved an ambulance trip to the airport, an airplane flight and another ambulance trip Conclusions Our patient, ... in a pediatric cardiac transplant candidate prior to transplantation J Heart Lung Transplant 2001, 20:785-788 Gomberg-Maitland M, Olschewski H: Prostacyclin therapies for the treatment of pulmonary ... failure and severe pulmonary hypertension, stabilized with the help of an epoprostenol infusion and was safely transferred for treatment at a tertiary centre This is an interim method Grech and Grixti...
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Báo cáo y học: "Snow Control - An RCT protocol for a web-based self-help therapy to reduce cocaine consumption in problematic cocaine users" pps
Ngày tải lên :
11/08/2014, 15:22
... Control therapy and the control intervention Author details Research Institute for Public Health and Addiction, Zurich, Switzerland Working Group for the Low-Risk Use of Drugs, Zurich, Switzerland ... responsible for the study design, prepared the first draft of the paper and the final manuscript MS, RS and LS developed the Snow Control self-help therapy and the control condition RS programmed and ... psychotherapy and pharmacotherapy for cocaine dependence Delayed emergence of psychotherapy effects Arch Gen Psychiatry 1994, 51:989-97 15 Carroll KM: Recent advances in the psychotherapy of addictive disorders...
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Báo cáo y học: " Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy" pptx
Ngày tải lên :
12/08/2014, 23:23
... of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy ... for each protein/ligand complex, on residues within a given distance of any ligand pose (6 Å in our study); Prime minimization of the same set of residues and the ligand for each protein-ligand ... culture and in-vivo This finding 1) supports the use of the simian AIDS models for pre-clinical testing of novel INSTIs for HIV1 and HIV-2, and 2) is a basis for a new and effective ART regimen for...
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Oncolytic Virus – an Effective Targeting Therapy for Cancer Treatment
Ngày tải lên :
20/06/2016, 23:12
... Completed phase III for treating melanoma Completed phase III for treating head and neck cancers in combination with paclitaxel and carboplatin Approved for treating head and neck cancer with Cisplatin ... 938-50 15 Liu, T.C and D Kirn, Gene therapy progress and prospects cancer: oncolytic viruses Gene Ther, 2008 15(12): p 877-84 16 Miest, T.S and R Cattaneo, New viruses for cancer therapy: meeting ... Company for the treatment of various cancers and cell proliferative disorders Phase III clinical trial of this virus was completed for treating carcinoma, squamous cell of the head and neck cancer...
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Báo cáo y học: "Oral Rehydration Therapy for Preoperative Fluid and Electrolyte Management"
Ngày tải lên :
25/10/2012, 10:51
... sodium, and urinary creatinine Vital signs were analyzed using the repeated-measures analysis of variance and the Dunnett test (two-sided at =0.05) Blood and urine values and FENa values before and ... Malignant mammary tumors Malignant head and neck tumors Malignant tumors of the stomach Malignant tumors of the respiratory systems Malignant tumors of the urinary and genital organs Malignant ... American Society of Anesthesiologists Figure Changes in blood pressure, pulse rate, and body temperature ORT: oral rehydration therapy Values at each measurement time point were analyzed for changes...
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