regulatory role of mitochondria in oxidative stress and atherosclerosis
Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx
... concen-trations (5 and 10 mm)ofMg2+inhibited the DNAcleavage activity (Fig. 4C, lane 4 and 5) and weak inhi-bition was observed even in 1 mm of Mg2+(comparelane 2 and 3 in Fig. 4C), indicating a different ... caspase-8- and caspase-9-like activities, which appear to be involved in the finalresorption of the parental macronucleus during PND in T. thermophila, and suggested the involvement of mitochondria in ... becomes acidic in thefinal step of PND [22,23]. DePsipher staining of themacronucleus appeared initially during the stage of autophagosome formation, and persisted until resorp-tion of the parental...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... A rapid and sensitive method forthe quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.CYP2E1 causes apoptosis of cardiomyocytes ... College, Beijing, China2 Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory AnimalScience, Chinese Academy of Medical ... overexpression of CYP2E1 both in vivo and in vitro is associated with several cellular markers of oxidative stress, including products of lipid peroxi-dation (e.g. 4-hydroxynonenal and malondialdehyde),as...
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The role of language in adult education and poverty reduction in Botswan
... examines the role of language in reducing poverty in a community by enhancing its self esteem, image, identity, and encouraging participation in education and civic society. It argues that in ... issues of education involving adults, but it also directly and indirectly influences the education of children because the teaching and learning of children is supervised by the older members of ... enables it to disseminate information, encourage participation in the education and economy of the communities. To achieve its goal of disseminating useful information and eradicating poverty the...
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Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
... deletion abolished binding of an U1snRNP molecule in this position and activated a 3¢ss lying 12 nucleotidesupstream of this element. In the last case, binding of hnRNP E1 and U1snRNP to a silencer ... ItalyIntroductionTowards the end of the 1970s, in the beginning of pre-mRNA splicing research [1,2], defining exons and introns was essentially based on observing the finalcomposition of the ... recognition in the normal splicingprocess [55]. First, U1snRNP binding to an intronicsplicing processing element has been found to inhibitpathological pseudoexon inclusion in intron 20 of theATM...
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NOTES ON THE ROLE OF EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING pot
... subset of different L types) and imposes very few restrictions on it. Aninterpretation of E as an index of embodied quality in different types and vintages of labor, fixed once and for all and independent ... iearnings,aggregating and computing the percentage change.EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING 99TABLE 9Regression Coefficients of the Logarithm of income onSchooling and of ... level, the issue of the quality of labor is the issue of the measurement of labor input in constant prices and a question of correct aggregation. It is standard national-income accounting practice1...
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Báo cáo khoa học: Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins pdf
... localization sig-nal of p53 and its phosphorylation involves S and G2⁄ Mcyclin-dependent kinases [21]. Our results now indicatethat in protein derived from BVEs, an intact serine resi-due at ... manyaspects in common and are linked in the regulation and function of p53 [4,5,22]. The interplay betweenphosphorylation and acetylation of p53 at residuesK373 to K382 is very interesting. These ... recombinant p53 proteins were expressed in Sf9 insect cells by using the baculoviral system and were purified as described previously [15]. Both human and murine p53 proteins were studied and included...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... significant insights into the roles and mechan-isms of PM2.5-associated physiology and pathology. In summary, our data demonstrate the importanteffects of PM2.5exposure on oxidative stress and ... TEMimages of iBAT (Arrows point to mitochondria) . E: The analysis of mitochondrial number per field in the eWAT and iBAT. F: The analysis of mitochondrial area per field in the eWAT and iBAT. ... showsrepresentative TEM images of mitochondria in eWAT(Figures 2A and 2B) and iBAT (Figures 2C and 2D),respectively, and the analyses of mitochondria number(Figure 2E) and area (Figure 2F). In the PM2.5-exposedgroup,...
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Báo cáo khoa học: Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids Kohsuke Honda, Michihiko Kataoka, Eiji Sakuradani and Sakayu Shimizu doc
... at the EcoRI and BglII sites of pADH10. Theresulting plasmid, named pDHEB, contains the geneencoding DCH lacking the C-terminal region, in whichAsp and His residues involved in the catalytic ... expected to result from insertion of asingle copy of the KmRgene.3,4-Dihydrocoumarin-hydrolysing activity, monochloro-dimedon-brominating activity, and peracetic acid-degradingactivity were compared ... Comparison of the enzyme activities of the A. calcoaceticusdchD strain and parent strain F46. Preparation of cell-free extracts and determination of each enzyme activity were performed as described in the...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative ... development.HA-induced oxidative stress activates PARP within5 min (Fig. 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide. Preincubation of cells ... the response of this organism to oxidative stress and the role of PARP during development. We used hydroxylamine (HA)to induce in situ generation of H2O2 and monitored the effect of benzamide,...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... [41], and human U87-MGcell line, a kind gift of Professor C. Martini (Department of Psychiatry, Neurobiology, Pharmacology and Biotechnol-ogy, University of Pisa, Italy), were maintained under ... trypsin treatment and stained for 30 min at 37 °C in fresh medium containingJC1 (final concentration of 10 lgÆmL)1). Cells were thenwashed twice with PBS, suspended in 500 lL of PBS and analyzed ... ultrastructural evidence of membrane rup-ture and were also negative to propidium iodide stain-ing (data not shown), indicating that the plasmamembrane is maintained intact, allowing us to excludeprimary...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... response of the organism to particle-induced oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative ... within-shift variation of 8OHdG (% of initial value) and within-shift reduced species (% of initial value) for smokers and non smokers.Sauvain et al. Journal of Occupational Medicine and Toxicology ... 8OHdG and reducing species. (a) Correlation between urinary levels of 8OHdG ( in μg/g creatinine) and reduced species (in μW/g creatinine) for all collected samples. (b) Correlation between within-shift...
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