regulatory basis for process validation

... evidence base It is unclear, therefore, which clubhouse elements are effective and which standards are necessary for success 175 Social factors as a basis for treatment Conclusion Social factors ... for people with psychosis until the 1970s (Bond, 1992; Lehman, 1995) Traditional ‘train and place’ vocational services designed for people with physical disabilities have proven ineffective for ... States 173 Social factors as a basis for treatment A jail diversion programme People suffering from both substance abuse disorder and serious mental illness form a significant component of the...

Ngày tải lên: 01/11/2013, 09:20

... measurement The decibel level indicates the relationship of one power level to another The formula for calculating decibel is : dB = 10 log Po/Pi = 10 log 1000mW/10mW = 10 log 100 = 10 x =20 ... power levels such as 10 thousandth of a watt (10 mW) The milliwatt is the unit of measure used for power in telecommunications circuits Rather than absolute measure of power, we often concerned ... comparison of one power level to another Such as the output power of an amplifier (RF or AF) is 1000 mW for an input power of 10 mW We can say this whole this output with one unit, such as the output...

Ngày tải lên: 10/12/2013, 08:15

... Chemistry of side reactions and by-products may also offer opportunities for increasing the inherent safety of a process For example, a process involving a caustic hydrolysis step uses ethylene dichloride ... solution in sulfuric acid) for sulfonation reactions If a chemical process requires the concentrated form of a material, it may be feasible to store it as a more dilute form and concentrate the ... generate only small quantities of methyl isocyanate as an in -process intermediate (Kletz 199Id) DuPont has developed a proprietary process for manufacture of carbamate insecticides which generates...

Ngày tải lên: 13/12/2013, 03:15

... Center for Chemical Process Safety TP155.5.G765 1993 66(T 2804—dc20 93-3154 CIP This book is available at a special discount when ordered in bulk quantities For information, contact the Center for ... Loss Containment for Different Process Equipment Table 4-2 Basic Considerations for All Fired Equipment Table 4-3 Process Vessels: Special Material Concerns Table 4-4 Checklist for Design and Operation ... 9-1 Ranking of Process Operability and Process Safety Table 9-2 Characterization of Process Sensitivity and Process Hazard Table 9-3 Comparison of Instrument Type Features Table 9-4 Process Control...

Ngày tải lên: 13/12/2013, 03:15

... for Process Plants Volume Major Process Equipment Maintenance and Repair Gulf Publishing Company Houston, Texas SECOND EDITION Practical Machinery Management for Process Plants Volume Major Process ... the pouring process b Dimensionally checked (and rechecked) versus the foundation drawings for proper length, diameter, thread length, etc c Checked for proper projection; Le., checked for correct ... at before actually starting up the equipment The list is by no means complete for all types of machinery but should act as a mind jogger before initial startup Refer also to Appendix 1B For pumps...

Ngày tải lên: 23/12/2013, 00:15

... made (Figure 1-8) 28 Major Process Equipment Maintenance and Repair RADIAL BEARING RADIAL BEARING Figure 1-8 Checking for whip or deflection T Figure 1-9 Checking for stuffing box squareness ... square Stuffing box faces should always be checked for pitting, nicks, burrs, and possible erosion before installing the seal (Figure 1-9) 17 Check for bore concentricity: The concentricity of a ... 1-12 shows the characteristic performance curves for an example pump; all scales are shown as a percentage of the design conditions The solid curves indicate performance of the pump in new condition...

Ngày tải lên: 20/01/2014, 00:20

... equalized for gel loading on the basis of b-galactosidase reporter gene activity Densitometry readings for individual signals are adjusted relative to DmEcRB2 (equals 1.0) Immunoblots were also performed ... described below After transfection for h, cells were incubated with or without agonists and ⁄ or JHIII for 24 h, cells were harvested, and extracts were processed for the studies The reagents tested ... characteristics seen among ecdysteroid receptors from various insect species suggests a basis for identifying and screening for compounds that perturb normal receptor function [12,13,15,16] Ecdysteroid...

Ngày tải lên: 18/02/2014, 08:20

... [11,15] A common drastic conformational change is found in this protein family, which participates in switching from an open form to a closed form [16] In EcoMBP, the closed form has been observed ... defined in terms not of the affinities for sugars but of whether the protein adopts the open form or the closed form TvuCMBP–c-CD complex is seen as the closed form (Fig 2A,B), and this structure ... shows the high affinities for not only CDs but also higher maltooligosaccharides It is impossible to determine, however, whether TvuCMBP adopts the open form or the closed form with the sugars listed...

Ngày tải lên: 19/02/2014, 00:20

... intermediate Rate constant for decay of intermediate Lag phase preceding MgDME product formation Magnitude of burst in product formation Rate constant for MgDME product formationa a ChlM ChlM + ... kinetic parameters for Synechocystis ChlM, and the effects of the magnesium chelatase ChlH subunit (rate constants refer to Scheme 1) Parameter MgD K app Rate constant for formation of catalytic ... chromatograms for each timepoint (B) The evolution ⁄ depletion of the putative intermediate was followed by integrating the peaks at 12.7 on the HPLC chromatograms for each timepoint The data for the...

Ngày tải lên: 20/02/2014, 02:21

Ngày tải lên: 21/02/2014, 05:20

... strong form of the axiom of infinity (the existence of a supercompact cardinal) that the class of uncountable linear orders has a five element basis In fact such a basis follows from the Proper Forcing ... C and C ∗ form a five element basis for the uncountable linear orders whenever X is a set of reals of cardinality ℵ1 and C is a Countryman line Notice that by our observations such a basis is necessarily ... in [24] serve as good concise references on the subject See [15] for information on the Mapping Reflection Principle For basic forcing technology, the reader is referred to [11] and [14] Part...

Ngày tải lên: 06/03/2014, 08:21

... D0 = 99 The formula in paragraph 98 must be the basis for all inputs into the bank’s approved VaR model for bonds when calculating the CVA risk capital charge for a counterparty For example, ... in its own right Basel III: A global regulatory framework for more resilient banks and banking systems 19 criteria for classification as common shares for regulatory capital purposes; and (2) ... date and on a forward looking basis does not meet the new criteria for inclusion in Tier or Tier 2, it will be fully derecognised in that tier of regulatory capital from January 2013 – For an instrument...

Ngày tải lên: 06/03/2014, 09:20

... at 15 minute intervals for h and then hourly intervals for h At each time interval, samples were surface-spread on to nutrient agar plates, which were incubated at 37 C for 12 h As a FEBS Journal ... user-friendly software for the analysis of aminoacid sequences Biotechniques 26, 11701172 Keller RC, Killian JA & de Kruijff B (1992) Anionic phospholipids are essential for alpha-helix formation of the ... (GLFGAIAGFIENG), which is key to its structure and underlying hydrophobicity gradient, was used as a basis for the hydrophobicity gradient of the AP1 peptide, thereby giving these peptides 62% sequence...

Ngày tải lên: 07/03/2014, 12:20

... sufficient basis not to provide the information at the unit process level, we strongly recommend that other information be included in the aggregated process dataset, for example, information ... provision of LCI information for processes, technologies, and materials where no LCI data previously existed or which were not in an accessible form Especially for new (non-commercial) processes, technologies, ... verifications be carried out for the unit process dataset and for the product system model used to generate aggregated process datasets The documentation of aggregated process datasets is highly...

Ngày tải lên: 07/03/2014, 23:20

... matters For exam- are high enough to be sustainable The requi- ple, the most popular methods for sending or rement for government assistance is solely for receiving money within Kenya are informal ... particular for microfinance in WAEMU and for the use of information and communication technologies and more broadly e-commerce in certain countries (Senegal and Cameroon), the adaptation of the regulatory ... conditions for prosperity In 1999 the AfDB consolidated its efforts through the establishment of the African Development Fund Microfinance Initiative for Africa (AMINA) on a pilot basis AMINA...

Ngày tải lên: 08/03/2014, 06:20

... equivalent to estimating the truthfulness of the validation statement “The capital of the USA is Washington” Therefore, the answer validation task could be reformulated as a problem of statement reliability ... Likelihood Ratio (MLHR) is also used for word co-occurrence mining (Dunning, 1993) We decided to check MLHR for answer validation because it is supposed to outperform PMI in case of sparse data, ... said before, AltaVista was used as search engine A baseline for the answer validation experiment was defined by considering how often an answer occurs in the top 10 documents among those (1000 for...

Ngày tải lên: 08/03/2014, 07:20

... on a weekly or monthly basis Systems also may be run daily for adding new materials or parts, for daily stock status reporting or for processing receipts and issues information Maintenance people ... are vital for analysis and control of plant maintenance costs These systems provide a framework for the capture of cost-related information and processing capability for analyzing such information ... plants whereas each plant on its own basis could not provide a payout for process computer monitoring This upto-date process monitoring and reporting allows for prompt management attention to plant...

Ngày tải lên: 14/03/2014, 16:20

... into bonds on a voluntary basis The bonds were issued in paper format and thus were liable to forgery and theft The non-electronic format of bonds proved to be complicated for trading and clearing ... intuitive interpretation, conforms to stylized facts, and can be used for forecasting, we use it as a starting point to formulate a model specification suitable for analyzing the term structure ... the National Bank of Serbia for year 2005, Article 3 Regulatory Environment for Bond Trading and Related Institutions 17 Bond Markets in Serbia determines which information shall be submitted...

Ngày tải lên: 15/03/2014, 09:20

... performance programs • Validation Specialists qualify for each skill level required by the corresponding validation task before granting privilege to perform said task • Validation Specialists ... – Draft 11 CA/BROWSER FORUM GUIDELINES FOR EXTENDED VALIDATION CERTIFICATES 18 GUIDELINES FOR Extended Validation Certificates Version 1.0, as adopted by the CA/Browser Forum on Notice ... town information; and so forth Country information MUST be specified using the applicable ISO country code State or province information, and city or town information (where applicable) for the...

Ngày tải lên: 16/03/2014, 00:20

... before each run by washing with 0.2 m sodium hydroxide, water, and running buffer, each for Samples were introduced by pressure injection for s (for reaction composition analysis) or 24 s (for ... GDP-6-deoxy-d-lyxo-hexos-4-ulose, a GMD reaction was performed for h, the enzyme was removed by filtration, and then enzyme and cofactor for the second reaction were added To determine the optimal pH for enzyme-catalyzed reactions, ... nearly identical to those reported for GDP-d-Rha [5] On the basis of these NMR findings, compound D was concluded to be GDP-a-d-Rha These results for His6-RMDPa therefore confirm that this enzyme is...

Ngày tải lên: 16/03/2014, 01:20