regulation of cortical granule docking and secretion

... Ceftriaxone-induced up -regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease Journal of Biomedical Science 2010 17:62 Submit your next manuscript to BioMed Central and take full ... WTs and R6/2s indicate saline treatment, and WTc and R6/2c indicate ceftriaxone treatment N refers to number of animals per group Genotype and CAG repeat length We used PCR for genotyping and ... analyses and genotyping, and helped with data interpretation BRM participated in study design, and helped with data collection and analysis GVR conceptualized and designed the study, and revised...

Ngày tải lên: 10/08/2014, 05:21

... to Article 291 of the Treaty on the Functioning of the European Union and in accordance with Article 15 of Regulation (EU) No 1095/2010 of the European Parliament and the Council of 24 November ... Parliament and of the Council of 18 December 2000 on the protection of individuals with regard to the processing of personal data by the EU institutions and bodies and on the free movement of such ... except for paragraph of Article and paragraph of Article 8, which shall apply from the date of entry into force of this Regulation This Regulation shall be binding in its entirety and directly applicable...

Ngày tải lên: 19/02/2014, 14:20

... examples of added value and of growth and job creating investment that could not have happened without the support of the EU budget However, the results also show the effects of dispersion and lack of ... in the integration of the Single Market whose size delivers markets and economies of scale to all parts of the EU, rich and poor, big and small The Commission's evaluation of past cohesion policy ... efficiency and the use of renewable energy RESULTS OF CONSULTATIONS WITH THE INTERESTED PARTIES AND IMPACT ASSESSMENTS 2.1 Consultation and expert advice EN EN Results of the public consultations of...

Ngày tải lên: 07/03/2014, 16:20

... [1-14C]AA-CoA in the presence of the purified enzyme resulted in the release of AA Km and Vmax values obtained for the reactions were 4.1 and lM and 948 and 193 nmolÆmin)1Æmg)1 for CTE-I and a MTE-I, respectively ... effect of NDGA and triacsin C, an inhibitor of the AA-CoA synthetase Our results are consistent with the involvement of an acyl-CoA synthetase and an acyl-CoA thioesterase as important regulators of ... for BamHI and EcoRI enzymes The subsequent amplified cDNA was cloned into the BamHI and EcoRI sites of vector pGEX-4T3 and used for transformation of XL1 cells Cloning into the BamHI and EcoRI...

Ngày tải lên: 08/03/2014, 09:20

... Regulations: Office of Science and Technology Policy 1984 Proposal for a Coordinated Framework for Regulation of Biotechnology; Notice 49 Fed Reg 50856 (December 31, 1984) Office of Science and ... designation of the transformed line, the category of modification, the phenotype and genotype of each transformant line, and a brief summary of the elements in the constructs Within five days of receipt ... (beer, wine, and liquor) are regulated separately by the Bureau of Alcohol, Tobacco and Firearms of the Department of the Treasury and also are not addressed here a.) Whole Foods and Food Additives...

Ngày tải lên: 13/03/2014, 21:59

... the adoption of a regulation on fees and the amendment of the annexes (19) Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995 on the protection of individuals ... application of substantive rules of CRA Regulation Indicators: • Number of breaches of CRA Regulation • Number of complaints received by the Commission from CRAs/users of ratings • Number of appeals ... structure, format, method and period of reporting, that credit rating agencies shall disclose in accordance with Article 11(2) and point of Part II of Section E of Annex I of the Regulation In order...

Ngày tải lên: 15/03/2014, 07:20

... respond to the presence of IPTG, and such clones were indeed found at a frequency of 22% of the second cross over event Southern blot analysis and DNA sequencing of one of these clones in the ... of gyrase activity and gyrase expression for supercoiling are negative (i.e the activity and expression of DNA gyrase is inhibited not stimulated by higher levels of supercoiling) and those of ... study the regulation of cell function both comprehensively and fairly quantitatively Yet it is of crucial importance to evaluate how much of a given regulation is effected at the level of gene...

Ngày tải lên: 18/03/2014, 01:20

... technical standards by means of implementing acts pursuant to Article 291 of the Treaty on the Functioning of the European Union and in accordance with Article 15 of Regulation (EU) No 1095/2010 of the ... Parliament and of the Council of 18 December 2000 on the protection of individuals with regard to the processing of personal data17 by the EU institutions and bodies and on the free movement of such ... accordance with Article of Directive 2009/65/EC of the European Parliament and of the Council of 13 July 2009 on the coordination of laws, regulations, and adminstrative provisions, relating to undertakings...

Ngày tải lên: 23/03/2014, 08:21

... number of beneficial owners of the outstanding securities of a private fund under Section 3(c)(1) of the Investment Company Act, or considered in determining if the outstanding securities of a ... principal office and place of business is the location where the adviser controls, or has ultimate responsibility for, the management of private fund assets, and this will be the place where all of ... VC Funds that were grandfathered A non-U.S all of its clients, whether U.S or even if it does not meet all of the has represented to investors at the time of the offering of its securities that...

Ngày tải lên: 23/03/2014, 12:21

... the percentage of lysine in true proteins by assuming the lysine content of nonzeins is independent of genotype and equal to g per 100 g of proteins, and based on the distribution of the endosperm ... between that of Oh43fl1, similar to that of the wild type, and that of Oh43o2 From these results it was possible to assess the importance of lysine-rich nonzeins with accuracy, because of the quantitation ... accuracy, because of the quantitation of nonprotein N and the exhaustive extraction of zeins Thus, the ratio of the nonzein content of the mutants compared with that of Oh43+ varied from 1.2 to 1.5...

Ngày tải lên: 23/03/2014, 15:21

... structural and biological activities of these proteins [8,9,11] Mechanical modulation of CTGF and Cyr61 gene expression in vitro and in vivo Mechanical regulation in bone and cartilage Cartilage and ... up -regulation of Cyr61 and CTGF appeared to be both rapid and long lasting in the affected tissues [2,57] Identification of all factors that either prevent or allow down -regulation of Cyr61 and ... structures [93] Regulation of CTGF by mechanical forces may thus add to the complexity and variability of the regulation of cellular communication Collectively, both the expression and function of the...

Ngày tải lên: 30/03/2014, 10:20

... impacts of investments Improving confidence in and comparability of information in this area can be considered a key driver of growing trust in social investments and understanding of and familiarity ... providing standards and processes that should lead to meaningful improvements in the operations and governance of micro-credit providers from the point of view of consumers, investors, funders and regulators ... dominated by grant funding, both in terms of the amount of supply and the cultural dominance of this form of funding … There is a finite supply of charitable money, and insufficient to go round – a situation...

Ngày tải lên: 30/03/2014, 12:20

... of JAK2 V617F and the development of MPD [1,9] Further characterization of the molecular changes in MPD neutrophils could lead to a better understanding of the development of these diseases and ... proteins including copies of RPL10, copies of RPL3, and RPS9, RPS10P3, and RPL12P6; proteosome proteins including copies of PSMD2 and PSMC; and cytochrome c oxidases COX5B and COX7A2 To further explore ... comparison of normal pancreas with 33 other tissues found that the expression of miR-216 and miR-217 and the lack of expression of miR-133a were characteristic of pancreatic tissue [36] Page of 17...

Ngày tải lên: 18/06/2014, 15:20

... stem state of MSCs [14] and other stem cells [15] LIF also activates and represses osteoblast and osteoclast activities [20] The bipotency of LIF suggests that the cellular environment and the developmental ... morphogenetic protein (BMP), growth and differentiation factor (GDF) [33] and Wnt [34] ligands Recombinant proteins and/ or adenoviral infection of MSCs with TGF-β1 and TGF-β3, BMP-2, BMP-4, BMP-6 ... territory and is crucial to an understanding of the molecular basis of the interactions between the MSC and its neighbors Soluble components That the bone marrow milieu is hypoxic in nature is of particular...

Ngày tải lên: 09/08/2014, 10:20

... actin-adjusted level of bax and bcl-2 and changes in the ratio of bax to bcl-2 in HL-60 cells treated for 48 h with increasing dose of LA (E) Subcellular distribution of immunoreactive AIF and Cyt C in ... 2B and 2C, and Figure 3B–E, TCH carried out the studies in Figure 2A, Figure 3A and Figure 4, TCH conceived of the study, and participated in its design and coordination All authors read and ... of extracts of Coriolus versicolor (I'm-Yunity) on cell-cycle progression and expression of interleukins-1 beta,-6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and...

Ngày tải lên: 10/08/2014, 22:20

... 1211 Geneva 14, Switzerland and 2Department of Pathology and Immunology, Geneva University Hospital and School of Medicine, rue Michel Servet 1, 1211 Geneva 14, Switzerland 19 Received: 10 December ... Specificity of the experiments was controlled by assessing binding of c-Jun or SP1 to the ORF of the MMP-1 (a) and COL1A2 (b) genes, respectively The data represent the mean ± standard deviation of three ... representation of the effect of bortezomib (left), TGF-β (middle), and bortezomib plus TGF-β (right) on transcription of the MMP-1, COL1A1, and COL1A2 genes See the Discussion section of the text...

Ngày tải lên: 12/08/2014, 12:20

... Physiological and pathological roles of NHE1 33 1.4.5 Regulation of NHE1 37 1.4.6 Regulation of NHE1 gene transcription 39 1.5 AIM OF STUDY 41 CHAPTER 2: MATERIALS AND ... REDOX REGULATION OF ERα 58 3A.1 H2O2 AND THE EXPRESSION OF ERα PROTEIN 58 3A.1.1 Morphology and growth of MCF7 cells upon exposure to H2O2 58 3A.1.2 Effect of H2O2 on the expression of ... 3A.4.2 Role of MAPK activation in H2O2 down -regulation of ERα 84 3A.4.3 Role of caspases in H2O2 down -regulation of ERα 87 3A.4.4 Oxidation is involved in the down -regulation of ERα by H2O2...

Ngày tải lên: 10/09/2015, 15:49

... Maintenance and Handling of Tissue Culture Cells 37 2.2 Preparation of Competent Bacterial Cells 37 2.3 Transformation and Maintenance of Plasmid DNA 38 Methods v Clones 2.4 Mini- and Maxi-scale ... integration and transcriptional regulation by TRIP-Br 130 FIGURE 28: TRIP-Br integrator function in the regulation of E2F-dependent transcription and cell cycle progression 140 xiv FIGURE 29: Regulation ... illustration of the PHD zinc finger and the bromodomain Top panel: The secondary structure of a bromodomain encoding helices Z, A, B and C Source of figure: Bottom panel: The primary structure of a PHD...

Ngày tải lên: 16/09/2015, 17:12

... processing and secretion of IL-1β 50 3.1 Phenotypic properties of monocytes and moDCs 75 3.2 IL-1β and TNF-α secretion from LPS-stimulated moDCs and monocytes 77 3.3 IL-1β secretion from moDCs and monocytes ... 50 1.5.2.2 Translational regulation of IL-1β 52 1.5.2.3 Post-translational cleavage of IL-1β 53 1.5.2.4 Secretion of IL-1β 54 1.6 Aims of the study 56 Chapter Materials and Methods III 2.1 Molecular ... the phosphorylation and degradation of IκB, resulting in the release and translocation of NF-κB into the nucleus The activation of TAK1 also leads to activation of p38, JNK and p42/p44 mitogen-activated...

Ngày tải lên: 08/11/2015, 17:01

... 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of ... owner of a vessel registered with a state party and carrying over 2,000 tons 87 88 89 90 91 92 94 95 See Arts 1(4), and 7(4) of the NSR Regulations; Art 14 of the Economic Zone Edict; and Art of ... shall establish periods and areas closed for navigation, and also other measures ensuring the safety of shipping and the prevention, reduction, and control of pollution of the marine environment...

Ngày tải lên: 01/11/2013, 09:20