... practiced Summary In this article, we outline a model for thinking about how organizations can influence community clinicians’ decision-making about becoming or remaining involved inclinical research ... should increase the likelihood that clinicians will choose – in a sustained way – to incorporate into their practices research that could inform clinical questions, methods, analyses, andclinical ... be most effective in transmitting additional information to clinicians who are interested or involved inclinical research and are seeking more specific information (e.g., maintenance phase) Healthcare...
... a syringe, rinsing and straining with saline and then re-injection Again, both we and our patients were disappointed with the results About years ago, after hearing of successes with the injection ... species; insufficient capacity to accommodate excess energy-intake leading to ectopic fat storage in tissues andin turn insulin resis ance and t hyperinsulinemia; and augmented macrop age infil ... ive amounts of insulin resistance s M A Shiffman inducing inflammaory and atherosclerosis-provoking t cytokines, and fail to secrete normal amounts of insulin-sensitizing cyto ines k The adipocyte...
... feelings, encompassing both subjective and psycho-physiological responses Part III (Clinical Applications) turns to clinical implications of understanding and modifying irrational beliefs and instating ... stressful and nonstressful situation in health promoting behaviors, cognitive-behavioral therapy, and psychotherapy in general In Chapter 11, Mellinger examines the ways that mindfulness has been integrated ... Continued research will determine whether major cognitive restructuring strategies from REBT and CBT will largely remain intact or will be integrated with other thinking, feeling, and behaving...
... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinicaland laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... cell lines Six NSCLC cell lines consisting of three adenocarcinoma cell lines (A549, H522 and H358), two large carcinoma cell lines (H460, H661), and one squamous cell carcinoma cell line (H226),...
... resistance in MDR K pneumoniae strains Colistin’s pharmacokinetic properties The main pharmacokinetics (PK) of colistin are presented in Table Few studies have addressed the PKs of CMS and colistin in ... samples containing colistin < μg/ml resulted in complete bacterial killing Based on these findings, the currently used colistin dosing regimens might not provide the most effective therapyand therefore ... understanding of colistin PK-PD properties is urgently needed to determine the optimal dosing regimen in colistin monotherapy or combination therapy for the effective management of life-threatening...
... classification accuracy rate Since each sample is excluded from the training set in turn, the independence between the test set and the training set is maintained In a database with N examples, ... rock-like musicand classical-like musicIn order to look more into the characteristics demonstrated by rock-like music samples and classical-like music samples, and define the discriminatory features ... user’s guide,” in User Manual, SPSS Inc., Chicago, Ill, USA, 1990 [12] M Shan, F Kuo, and M Chen, Music style mining and classification by melody,” in Proceedings of the IEEE International Conference...
... are beginning to be addressed in medical education, introducing palliative medicine module in medical schools curicula A large segment of people claims belief in a higher being, and studies indicate ... questions ; eliciting and responding to patients' fears ; assessing spiritual needs as part of the initial assessment and ongoing care Contemporary and Innovative Practicein Palliative Care ... as chemotherapy or radiation therapy, and includes those investigations needed to better understand and manage distressing clinical complications 2.3 Family medicine and palliative care The reason...
... others (having warm, satisfying, trusting relationships with others), (3) autonomy (self-determination and independence), (4) environmental mastery (a sense of mastery and competence in handling one's ... scores decreased with increasing participant age The above findings were virtually the same even after controlling for age and gender (one and two cases were missing for age and gender, respectively) ... the IPO inclinicaland non -clinical populations If future studies agree with our findings, the Japanese version of the IPO will prove an excellent tool to screen for personality pathology in busy...
... production in RP patients [15,16] Surprisingly, a more prominent response was seen for CIX and CXI in a patient presenting a fatal tracheomalacia, indicating CIX and CXI rather than CII as being involved ... dominating symptom is inflammation in the peripheral joints characterized by redness, swelling and pain, which mimic the symptoms of arthritis in RP patients In the majority of the rodent strains, ... have not yet been investigated in RP patients Adjuvants and oils can induce arthritis in many rat strains [33–36] and auricular chondritis in Wistar rats [21] Finally, in FH and Wistar rats, chondritis...
... of clinical research into clinical practice, ranging from the need to evaluate whether treatments shown to be efficacious inclinical trials continue to be effective in real-world practice, and ... Explanatory and practical clinical trials: Two options for clinical trials in community settings [7,42] Explanatory clinical trials: Practical clinical trials: Hypothesis and design Hypothesis and study ... clinical research or clinicalpractice networks, and representatives of organizations that recruit, train, or support community clinician involvement inclinical trials and/ or clinical research networks...
... Not of One Mind: Mental Models of ClinicalPractice Guidelines in the VA Health Serv Res 2005, 40:829-847 Pugh JA: Knowledge management andclinicalpractice guideline implementation [Final Report] ... corpus of field notes and informal observations from interviewers to provide interpretive context Selective coding This phase of analysis involves integrating and refining the ordered categories ... just saying, this is it Do it! Heads will roll! We'll chop off one finger and then we'll go for a hand and a foot, kind of thing! C.C., a clinician in a LPF We're down here in the trenches and...
... 3b) practice than others (Figure 6) Following the joint review, discussion of (i) idiosyncratic cases encountered inclinical practice, and (ii) problems with evaluating types of necrosis in both ... 8a-d) Association between outcome andclinical variables For each trial, outcome analyses were undertaken using clinicaland pathological data The following clinical variables were considered: ... resection; black line = CR-Gd II; red line = STR-Gd II; blue line = CR-Gd III; green line = STR-Gd III grade and outcome in an extensive study of children of all ages, including infants, that were...
... findings indicate that the use of RSV A2 in host-pathogen interaction studies might not be representative of recent RSV clinical isolates in terms of virus growth kinetics, CPE and chemokine induction ... syncytium formation in these cells Interestingly, RSV BT4a-infected PBECs and mock-infected controls were indistinguishable in terms of CPE Similar data were obtained following infection at MOI ... not affect growth kinetics Differential chemokine/cytokine secretion following RSV A2 andclinical isolate infection Chemokines/cytokines are important mediators of innate and adaptive immune...
... for setting up and coordinating the study, and drafted the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... Sequencing and analysis of viral genomes All positive samples (environmental and clinical) were confirmed by sequencing of the PCR product The purified PCR products of the clinical HAV strains were ... strains in Barcelona, from both environmental andclinical samples, revealed a 95% prevalence of genotype I, with nearly 50% being either subgenotype IA or subgenotype IB Interestingly, in the...
... clusters in a) the extracellular domain (exons 2-4) and b) the serine/threonine protein kinase domain (exons 9-11) Four mutations occurred in more than one independent patient/family: p.R491W and ... gene (promoter and coding regions including flanking intronic regions) and the coding regions of the ACVRL1, ENDOGLIN, and the SMAD8 genes did not reveal any defect Especially, no point mutations ... species ESEfinder prediction Clinical classification according to family history p.A154G Transmembrane domain Disease causing conserved Not affected IPAH p.E386G Serine/threonine kinase domain Disease...
... to an increasing demand for the development of commercial assays in order to allow the screening of patients in the routine clinical setting The recent development and validation of a line blot ... identified these proteins as small ubiquitin-like modifier activating enzyme and (SAE) that are involved in the post-translational modification of numerous targets, including protein kinases and transcription ... provide insight into the pathogenesis of CADM and ILD and into the reported association between viral infections and myositis The clinical utility and identity of this autoantigen have since been...
... Outcome benefit of intensive insulin therapyin the critically ill: insulin dose versus glycemic control Crit Care Med 2002, 31:359366 Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen ... Townsend S, Resar RK, Clemmer TP, Ramsay G: Sepsis change bundles: converting guidelines into meaningful change in behavior andclinical outcome Crit Care Med 2004, 32 (Suppl):S595-S597 ... SSC and IHI and to submit their anonymized data to the SCC for aggregate analysis in accordance with the instructions on the website The SSC sepsis bundles are an important step in improving...
... for assessment of cough severity and therapeutic efficacy, and can help to guide clinicalpracticeand research in chronic cough Cough symptom score, generic instruments such as the Short form-36 ... source document The Chinese version of LCQ was then finally determined [see Additional file 1] LCQ consists of 19 items, involving physical, psychological and social domains, and each item represents ... RE, GH and RP were affected in the most outstanding way (Table 2) whole, despite that the feelings of embarrassment, frustration and disturbance of sleep were more obvious in women than in men...
... Cytokines, prostaglandin (PG) E2 and leukotriene (LT) B4 were measured in plasma and cytokines and PGE2 in whole blood culture supernatants Cytokines and eicosanoids were measured using enzyme-linked ... only limited, and contradictory, information on the influence of fish oil containing parenteral nutrition in septic ICU patients on markers of inflammation and on clinical endpoints However, ... acids in critical illness: novel mechanisms and an integrated perspective Intens Care Med 2008, 34:1580-159 49 Ariel A, Serhan CN: Resolvins and protectins in the termination program of acute inflammation...
... in healthcare andclinical research Policymakers should deliberate more openly the role of age in distributive justice in healthcare, while boosting awareness of existing ethical guidelines and ... Abbreviations ICU, intensive care unit Competing interests The author declares that he has no competing interests Published: 15 July 2010 References ICH Topic E (R1) Guideline for Good ClinicalPractice ... [6,7], and not on inconclusive evidence and a motivation to save money A serious confounding factor in the whole discourse on the allocation of intensive care is lack of clarity regarding the...