recql4 gene mutation in patients with rts

... escape mechanism in this single patient WT1 mutations have been reported in about 10% of patients with AML [23] They were frequently observed in DNA binding portions of the WT1 protein and may therefore ... binding, T cell recognition or proteasomal processing Therefore, mutation analysis was performed in both samples obtained before vaccination and during progression However, no mutation leading ... peptide vaccination in acute myeloid leukaemia (AML) Methods Patients Patients were treated within a phase II vaccination trial (NCT00153582) [8] and received sequential vaccinations with the HLA-A2-restricted...

Ngày tải lên: 18/06/2014, 16:20

... welding fumes 20 pack-years < 25 of missense mutations is different in the two groups with 68% of missense mutations corresponding to transversion in somatic mutations vs 35% in germline mutations ... F, Duh FM, et al.: Mutations of the VHL tumour suppressor gene in renal carcinoma Nat Genet 1994, 7:85-90 Kim WY, Kaelin WG: Role of VHL gene mutation in human cancer J Clin Oncol 2004, 22:4991-5004 ... 15 ppm in screw cutting industry during c.332 G>A 58 years women no c.463+1 G>C 42 years man no Other occupational exposures identified cutting oils asbestos cutting oils in screw cutting industry...

Ngày tải lên: 20/06/2014, 00:20

... cytokine interleukin-6 (IL-6), anti-inflammatory cytokine interleukin-10 (IL-10), chemokine interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractive protein-1 ... threshold, to promote and maintain rolling interactions [28] In our study, expression of L-selectin was depressed in the HT group This finding is consistent with previous findings and suggests that ... the inflammatory response in sepsis is heterogeneous depending on the source and the infecting organism In conclusion, we have shown that in septic shock patients, hypertonic fluid, compared with...

Ngày tải lên: 20/06/2014, 23:20

... silencing by RNA interference, suggesting that the SPP1 gene may be a target of the BCL11B gene in transcriptional regulation (unpublished data) SPP1 gene silencing in vitro significantly increased ... genes was found in T-ALL samples This suggested that BCL2L1 was affected by the BCL11B gene in transcriptional regulation, and both participated in the same protein-protein interactions, acting ... apoptosis in BCL11B and its related genes (a) BCL2L1 is affected by the BCL11B gene in transcriptional regulation (b, d) BCL11B and BCL2L1 participate in the same protein-protein interactions, along with...

Ngày tải lên: 10/08/2014, 22:21

... association with the CCAAT/enhancer binding protein (C/ERP) binding site Interleukin-18 has been found in synovial tissue, and enhanced levels of IL-18 were measured in the joint and in the serum ... development of RA 23 1.1.10 IL-18 binding protein (IL-18BP) Interleukin-18 binding protein (IL-18BP), a constitutively secreted protein that binds mature IL-18 with high affinity, provides a potential ... number of other regulatory proteins including inhibins, activins and bone morphogenetic proteins The TGF-β cytokines are produced by every leukocyte lineage, including lymphocytes (T-helper cell),...

Ngày tải lên: 14/09/2015, 18:28

... negative influence on respiratory and metabolic parameters in patients not intubated Another recent study also indicated that delaying ALS in critically injured patients until arrival in the trauma ... severity of injury or illness index (NACA) [16] Score Definition No injury or disease Injuries/diseases without any need for acute physician care Injuries/diseases requiring examination and therapy ... HEMS system, and the validity of our findings in other systems is, therefore, uncertain However, our finding that a large proportion of patients with an indication for pre-hospital ETI did not...

Ngày tải lên: 25/10/2012, 09:56

... increase in urine Cu levels in patients suffering from myocardial infarction (MI) (15) Reunanen et al (1996) found increased levels of serum Cu in patients with CAD (14) In contrast, in our study, ... values for retinol were significantly lower in patients with CAD compared to the control group Other investigators have also reported decreased retinol levels in patients with CAD (31,32) In other ... tended to be lower in patients with CAD Epidemiological investigations that associate body Fe stores with CAD risk have produced conflicting results; these may in part be explained by the use of...

Ngày tải lên: 25/10/2012, 10:51

... CABG In the 11 patients with vessel disease a stenosis > 50% was found in the circumflex artery in patients and in the right coronary artery in patients Complete revascularization in the patients ... exclude segments in which the tracking failed (feasibility 71%) One could also criticize the intra-individual comparison instead of considering a control group In our opinion, as the infarct is a ... circumferential strain and strain rate by 2DST in normo-, hypo-, akinetic and dyskinetic segments of post-infarct patients 8-13, 30-37, which were not reliably accessible by TDI Radial strain also allowed...

Ngày tải lên: 25/10/2012, 11:15

... related increased oxidative activity in RA patients Anti-CCP antibodies are directed against antigens containing the nonstandard amino acid citrulline, for example, citrullinated fibrin, which ... found in the rheumatoid joint [21] The citrulline moiety, which is the essential part of the antigenic determinant in these antigens, is post-translationally generated by peptidyl arginine deiminases ... from patients with rheumatoid arthritis Clin Rheumatol 2000;19:275-277 29 Bandt MD, Grossin M, Driss F, Pincemail J, Babin-Chevaye C, Pasquier C Vitamin E uncouples joint destruction and clinical...

Ngày tải lên: 25/10/2012, 11:15

... gastrointestinal tract in patients with iron deficiency anemia N Engl J Med 1993; 329: 1691–5 29 Bini EJ, Micale PL, Weinshel EH Evaluation of the gastrointestinal tract in premenopausal women with ... associated with GI lesions in all patients In addition, we determine the yield of endoscopy evaluations in pre-menopausal and age < 50 women with iron deficiency anemia but without any clinically ... deficiency patients could be fully investigated And, in 20% of patients with IDA a routine upper and lower GI endoscopy may not ascertain GI cause during hospital admission [18] Cancer was diagnosed in...

Ngày tải lên: 25/10/2012, 11:18

... disinfection with popidone iodine, bed rest, and administration of ritodrine and an ulinastatin vaginal suppository were continued as a new follow-up modality for pregnant patients who received RT Finally, ... artificial intrauterine insemination She was admitted to our hospital with a diagnosis of threatened abortion at 17 weeks of gestation In spite of bed rest, disinfection therapy, and the administration ... discussed Patients and methods In the period from January 2003 through December 2009, a total of 20 women with early-stage invasive uterine cancer underwent vaginal RT with lymphadenectomy in Sapporo...

Ngày tải lên: 25/10/2012, 11:48

... their written informed consent Handedness was determined using a Chinese translation of the Edinburgh Handedness Inventory 29 Such an inventory has been used in two previous Chinese studies 30,31 ... were found in our study Discussion In the present study, patients scored higher on Neuroticism-Anxiety (with GAD patients scoring highest) and on depression (with TRD patients scoring highest) ... in our GAD patients was due to the severity of anxiety itself merits further investigation In our TRD patients, the depression score was correlated negatively with Magnitude This finding is in...

Ngày tải lên: 26/10/2012, 08:57

... disturbances in the form of episodic blurring of vision were seen in 4/9(44%) patients Sensory disturbances including numbness, tingling, pins and needles sensation in extremities were seen in 4/9(44%) patients ... experience with the management of patients with POTS Initial therapy consisted of an increase in salt and fluid intake as well as aerobic reconditioning with resistance training to increase lower ... group of patients Management of POTS in patients with MS The pharmacological management of POTS in patients of MS was similar to that in patients without a history of MS In our small group of patients, ...

Ngày tải lên: 26/10/2012, 09:39

... responses in patients with staphylococcal septicemia against two Staphylococcus aureus fibrinogen binding proteins: clumping factor and an extracellular fibrinogen binding protein Clin Diagn Lab Immunol ... response against PG in some of the patients with deep infection might be due to impaired immunity of advancing age, poor expression of virulence determinants by the infecting strain or changes in the ... to those with superficial infections (Fig; 2B) The banding patterns within each group of patients were grossly similar with minor individual variations The most prominent band present in both...

Ngày tải lên: 02/11/2012, 11:08

... in the research phase In conclusion, chorioretinal involvement, frequently asymptomatic and self-limited, is present in almost 80% of patients with WNV infection associated with neurologic disease ... the routine evaluation of patients with clinically suspected WNV infection References Hayes EB, Gubler DJ West Nile virus: epidemiology and clinical features of an emerging epidemic in the United ... al Chorioretinal involvement in patients with West Nile virus infection Ophthalmology 2004;111:2065-70 Garg S, Jampol LM Systemic and intraocular manifestations of West Nile virus infection Surv...

Ngày tải lên: 03/11/2012, 11:17

... witnessing these episodes The study included only patients with unexplained syncope and thus the results can not be generalized Conclusion In the group of patients with recurrent unexplained syncope, ... associated with bradycardic responses during ILR monitoring Interestingly, some of the patients in our study were labeled as having psychogenic syncope for years before the ILR monitoring revealed ... to be inconclusive In view of negative initial inconclusive work-up patients received implantable loop recorders The average duration of monitoring with an ILR was months The baseline clinical...

Ngày tải lên: 03/11/2012, 11:17

... and mortality in CKD 3-5 patients in Spain (31) Our study extends this finding to patients with more preserved renal function in American population Our hypothesis that serum albumin is a significant ... Inflammation and dietary protein intake exert competing effects on serum albumin and creatinine in hemodialysis patients Kidney Int 2001; 60: 333-340 46 Himmelfarb J, Stenvinkel P, Ikizler TA, and ... electrocardiogram in the prediction of cardiac death in dialysis patients Arch Intern Med 1988; 148: 2381-2385 20 Aronow Ws Usefulness of serum creatinine as a marker for coronary events in elderly patients with...

Ngày tải lên: 03/11/2012, 11:52

... Researchers in the experimental group received training in the PRECEDE model before patients were included in the study This specific training involved two steps: first they were instructed about ... subsequently trained in the procedure to be used in the study in three sessions These covered the criteria for including/excluding patients, collecting variables, collecting biochemical/ Salinero-Fort ... mmHg), indicating that our results cannot be compared However, on comparing the increase in the proportion of patients with metabolic control in the PRECEDE model obtained in our study with those...

Ngày tải lên: 05/03/2014, 22:21

... CRP in patients with tuberculosis in relation to its status is shown in Table Ninety two (72%) patients belonged to rural area whereas thirty five (28%) were from urban areas of the Sindh province ... Hopstaken, K Hood and G.J Dinant, 2009 Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised ... Brinke, J Van Brakel, Y.B De Rijke and M.Y Berger, 2006 Point-of-care C-reactive protein testing in febrile children in general practice Clin Chem Lab Med., 44: 1428-1432 20 Cohen, R., O Romain,...

Ngày tải lên: 15/03/2014, 03:20

... organ involvement in patients with pulmonary TB was more common in patients with bilateral lung involvement but without cavity formation or low levels of serum albumin Clinicians should keep in mind ... one organ involved, all of them were counted independently; � patients with intestinal TB diagnosed based , on typical colonosopic findings and the other patients with TB laryngitis without AFB ... analysis for predicting combined extra-pulmonary involvement in patients with pulmonary TB EPTB, pulmonary TB with extra-pulmonary involvement; sAlbumin, serum level of albumin regarded as a marker...

Ngày tải lên: 15/03/2014, 03:20