reconstruction restoration of what structure is critical
Báo cáo y học: "Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice" pot
Ngày tải lên :
10/08/2014, 09:20
... clear discrepancies that could be caused if one is misaligned relative to the other This misalignment issue exists regardless of whether these are temperature data or are activity data mistakenly ... The critical behavioral evidence for functional rescue of food-entrained rhythms is therefore missing from the paper 2c A third claim critical to the substantive conclusions of this paper is that ... versions of these data this software Regardless, the fact that a significant misalignment occurred raises concerns about the accuracy of other figures in the paper 1b Careful examination of the...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
Ngày tải lên :
18/02/2014, 13:20
... Kit-8 is a colorimetric method in which the intensity of the dye is proportional to the number of the viable cells Briefly, 200 lL of a suspension of PC-9 cells was seeded into each well of a 96-well ... FEBS K Takeuchi et al JNK activation is critical for AG1478-induced apoptosis A A B B C Fig Effect of AG1478 on phosphorylation of MKK4 and MKK7, and expression of MKP-1 and MKP-2 A, PC-9 cells were ... the expression of MKP-1, but not that of MKP-2, is controlled by signals via EGFRs Brondello et al reported that activation of the ERK cascade is sufficient to promote the expression of MKP-1 and...
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Báo cáo khoa học: The F13 residue is critical for interaction among the coat protein subunits of papaya mosaic virus doc
Ngày tải lên :
07/03/2014, 05:20
... Therefore, on the basis of our results, it is likely that a deletion of 32 amino acids will be tolerated by PVX without disturbing the assembly process Alignment of this F residue is also shared with ... of CP6– 215 (Fig 3A), but showed a lower ratio of NLPs (16%), a similar amount of disks (33%), and an increase in the monomeric form of the protein (51%) This might indicate lower stability of ... F13 critical for interaction among the CP subunits spectrum This suggests that the structure of both truncated forms is very similar Moreover, the presence of several peaks in the middle of the...
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Báo cáo khoa học: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is a-D-Gal-(1fi3)-a-D-GalNAc pot
Ngày tải lên :
23/03/2014, 13:20
... calculated monoisotopic [M-2CO2-H]– mass of 1840.42 Da) The mass shift of Da (MR ) M) confirms the formation of the two disulfide bridges However, comparison of the retention times of the hydrophilic ... corresponding MALDI resolved isotope distributions of the [M-CO2-H]– species Ó FEBS 2004 Glycopeptide tx5a synthesis and NMR analysis (Eur J Biochem 271) 4945 Table Comparison of the reverse-phase HPLC ... even in the synthesis of nondisulfide bridge-containing glycopeptides the yield is dramatically affected by the scale of the reaction, the excess of amino acids used, and the level of purity desired...
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Báo cáo Y học: Barley a-amylase Met53 situated at the high-affinity subsite )2 belongs to a substrate binding motif in the bfia loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate specificity pot
Ngày tải lên :
31/03/2014, 08:20
... with respect to structure [15,16] and mutational analysis of structure/ function relationships [3538] Two isozyme families, AMY1 and AMY2, distinguished as the low and high pI isozymes, are de ... Subsite mapping of enzymes Studies on Bacillus subtilis amylase Biochemistry 9, 17681775 34 Suganuma, T., Matsuno, R., Ohnishi, M & Hiromi, K (1978) A study of the mechanism of action of Taka-amylase ... spent to distort of the bound glucose residue in catalysis SD of Met52AMY2 (Met53AMY1) in a computed AMY2/malto decaose complex was 3.4 A from O6 of glucose at subsite )2 [45] reminiscent of the...
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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc
Ngày tải lên :
20/06/2014, 07:20
... 2009, 324:938-941 Lochner A, Marais E, Genade S, Huisamen B, du Toit EF, Moolman JA: Protection of the ischaemic heart: investigations into the phenomenon of ischaemic preconditioning Cardiovasc ... H89, SB203580 or U0126 on rate of oocyte exhibiting GVBD Effect of4 Effect of H89, SB203580 or U0126 on rate of oocyte exhibiting GVBD Values are mean +/- SEM of replicates *: The significant ... played dual roles in cumulus cells One role is the induction of EGF-like factor and TACE/ADAM17 expression The other is direct induction of cumulus expansion of porcine COCs In granulosa cell specific...
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Báo cáo hóa học: "Recovery and Visualization of 3D Structure of Chromosomes from Tomographic Reconstruction Images" potx
Ngày tải lên :
22/06/2014, 23:20
... 253 Intensity Histogram (d) Histogram of slice 35 Figure 2: (a) Slice is one of the earlier slices of the CT scan images with a unimodal histogram distribution of intensity (c) The histogram for ... of this local minima is selected, and this value is used for region segmentation throughout the process of thresholding A polyline distance threshold value of 25 enables proper distribution of ... types of biological visualization, very high-resolution details of the surface structure may not be necessary In the case of chromosome structural analysis, biologists are looking for a method of...
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Báo cáo khoa học: " Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors" ppsx
Ngày tải lên :
09/08/2014, 09:20
... number of analyzed plans in this study consisting of smaller extents of motion The trajectories of the movements were also plotted as a motion distribution of fp(r) where r is the displacement of ... http://www.ro-journal.com/content/5/1/48 Page 10 of 12 Figure Effects of geometrical uncertainty on the patient with 4D planning (a) & (b) display dose profiles (OAX is the off axis distance) of the static plan ("P") ... the positions of the right and left leaves (relative to the iso-center), respectively, of the kth leaf pair I is the intensity distribution generated from the leaf motion (which is in perpendicular...
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Báo cáo y học: " Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial" potx
Ngày tải lên :
13/08/2014, 21:21
... influenza, aspiration, exacerbation of chronic obstructive airway disease, or other acute lung disorder Statistical analysis On the basis of previous data from a trial of intravenous heparin to limit ... microvascular thrombosis may also cause ischemic damage of alveolar tissue and right Dixon et al Critical Care 2010, 14:R180 http://ccforum.com/content/14/5/R180 Page of 10 Figure Forest plot of the treatment ... doses of systemic heparin were administered to 24% of patients in the heparin group and 32% in the placebo group following enrollment Heparin for deep venous thrombosis prophylaxis was administered...
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TRANSCRIPTIONAL REGULATION OF ATF4 IS CRITICAL FOR CONTROLLING THE INTEGRATED STRESS RESPONSE DURING eIF2 PHOSPHORYLATION
Ngày tải lên :
24/08/2014, 11:02
... domain is conserved in each of the isoforms, but the LAP/ LAP* contain an N-terminal trans-activation domain, which is missing in the short LIP isoform (Figure 6A) The expression of these three isoforms ... translation of ATF4 is induced by eIF2α~P 16 Phosphorylation of eIF2α regulates translation of several ISR genes 21 Translation control of C/EBPβ regulates synthesis of three isoforms 22 ... Expression of the C/EBPβ isoforms is differentially regulated in response to UV and ER stress 69 2.5 LIP is a potent repressor of ATF4 transcription .74 2.6 Loss of the C/EBPβ isoform...
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The small GTPASE ARF like protein 1 (ARL1) is a new regulator of golgi structure and function
Ngày tải lên :
17/09/2015, 17:20
... (ARL1) IS A NEW REGULATOR OF GOLGI STRUCTURE AND FUNCTION LU LEI (B.SC.) UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY INSTITUTE OF MOLECULAR ... association of Arl1 4.3 N-terminal myristoylation of Arl1 is essential for its Golgi association 4.4 Construction of guanine nucleotide binding mutants of Arl1 vi 4.5 Expression of the GDP restricted ... form of Arl1 (Arl1T31N) causes disassembly of the Golgi apparatus 4.6 Expression of GTP restricted form of Arl1 (Arl1Q71L) causes an expansion of the Golgi membrane 4.7 GTP restricted form of Arl1...
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ON THE DETERMINANTS OF CAPITAL STRUCTURE: AN EMPIRICAL STUDY OF VIETNAMESE LISTED FIRMS
Ngày tải lên :
09/09/2013, 23:46
... can take advantage of scale to exploit the benefits of tax shields to increase enterprise value This is consistent with the "trade-off theory of capital structure" This is consistent with the reality ... companies’ capital structure The trade-off theory advances that the choice of capital structure in a firm is a result of a trade-off theory between the benefits of debt, such as those arising from interest ... One of the many objectives of corporate financial manager is to ensure the lower cost of capital and thus maximize the wealth of shareholders Capital structure is one of the effective tools of...
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ON THE DETERMINANTS OF CAPITAL STRUCTURE: AN EMPIRICAL STUDY OF VIETNAMESE LISTED FIRMS
Ngày tải lên :
09/09/2013, 23:50
... research TABLE OF CONTENTS Page TITLEPAGE DECLARETION ACKNOWLEDGEMENT ABSTRACT TABLE OF CONTENTS LIST OF TABLES LIST OF FIGURE LIST OF ACRONYMS 10 Chapter INTRODUCTION 11 1.1 Background of the Study ... maximum • Ownership is divided into ordinary shares and several types of classes of preferential shares • May issue securities for fund raising and go listed if satisfying listing requirements ... PRESENTATION, ANALYSIS AND INTERPRETATION OF DATA This chapter presents, analyses and interprets the data gathered in the conduct of this study 4.1 Descriptive Statistic: Descriptive statistic is commonly...
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CRITICAL THINKING IS CRITICAL
Ngày tải lên :
25/10/2013, 16:20
... this the right thing to State Senator Lawlor is the best candidate running this year Besides, if he isn’t reelected, a number of my close friends will be out of jobs This development project is ... evidence is being offered, is it convincing? Why? Why not? Write your comments on another sheet of paper and discuss them with classmates Dr Jones is an excellent laser eye surgeon A number of prominent ... SPOONERISMS A spoonerism, named after Reverend William Archibald Spooner (1844–1930), is an unintentional transposition (switching) of sounds in spoken language An example of a spoonerism is “a...
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Tài liệu Chapter 2: Indicators of Financial Structure, Development, and Soundness ppt
Ngày tải lên :
17/12/2013, 05:15
... financial savings The ratio of private sector bank credit to GDP is a common measure of the provision of credit to the economy, as well as of banking depth Often, this indicator is supplemented by information ... relevance could vary across countries.12 The list of FSIs discussed herein consists mainly of aggregate balance sheet measures This type of aggregation of individual institution-level indicators ... solvency of financial institutions most often derive from impairment of assets, the second category of FSIs is asset quality FSIs in this category monitor loan quality and exposure concentrations of...
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Tài liệu What it is and How to Prepare pdf
Ngày tải lên :
20/12/2013, 23:15
... you can • Listen for reports on the television, radio or Internet • Go to www.pandemicflu.gov or www.ohiopandemicflu.gov for current information This may only be available in English 1/2007 Content ... Wash your hands often with soap and water Use alcohol-based hand sanitizer when soap and water are not available • Avoid touching your eyes, nose, and mouth The flu often spreads this way • Cover ... spreads this way • Cover your mouth and nose with a tissue when you cough or sneeze Throw the tissue away and wash your hands If you not have a tissue, cough or sneeze into your shoulder or arm •...
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an economic analysis of financial structure
Ngày tải lên :
05/01/2014, 16:56
... Intermediation Asymmetric Information Conflicts of Interest • Conflicts of Interest is a type of moral hazard problem caused by economies of scope • Arise when an institution has multiple objectives ... Financial Structure I Stocks are not the most important sources of external financing for businesses Eight Basic Facts About Financial Structure II Issuing marketable debt and equity securities is ... contemporaneously with an impermissible audit Conflicts of Interest: Remedies II • Sarbanes-Oxley Act of 2002 (cont’d) – Beefs up criminal charges for white-collar crime and obstruction of official investigations...
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