recommendations for the future
Veterinary Medical Specialization: Bridging Science and Medicine Volume 39 doc
Ngày tải lên :
29/03/2014, 15:20
... club Nevertheless, there is no reason to doubt the validity of the survey findings for two reasons First, the diseases listed as most important to the breeders are the same ones that the veterinary ... listed among the top diseases for the other groups The fourth most common concern was allergies Allergies were listed as the most important problem for 78% of the Terrier Group and 67% of the Nonsporting ... diseases The present volume reviews the historical, current, and future needs for specialization in the veterinary profession, discusses the emerging importance of appropriate informed consent for...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
Ngày tải lên :
16/03/2014, 21:20
... in the study population The strongest genetic association for Type (DM) is with the HLA class I and II genes, with a 30–50% of the genetic risk for progression of the disease Therefor in the ... Other Therapies the optimal future treatment for MS current therapies are focused on agents that are disease modifying Over the last three decades a number of broad acting immune modifying therapeutic ... efforts have therefore been made to identify non-HLA genetic risk factors for Type (DM) Interestingly enough, many of the genetic factors are important to the function of the immune system For...
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Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
Ngày tải lên :
09/08/2014, 06:22
... provide direct information about the specificity of the T cells that mediate autoimmunity Although there are examples of discordance of the fine peptide epitope specificity of the autoreactive ... predictive of the specificity of the overall autoimmune response at the level of whole autoantigens Further studies will be necessary to determine whether this powerful and enabling hypothesis is, ... impact on the diagnosis, monitoring, and therapy of autoimmune disease Acknowledgements The authors thank Dr H de Vegvar, J Tom and other members of the Utz and Steinman laboratories for scientific...
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Báo cáo y học: "Amplification of autoimmune disease by infection" potx
Ngày tải lên :
09/08/2014, 06:22
... immunoglobulin for parvovirus could be tried Note that there are few data on the efficacy of antibiotics for chronic Chlamydia infections [126] Careful monitoring for the presence of the microbial ... administered therapeutically in the form of intravenous immunoglobulin to immunodeficient patients [66] It is not known whether this virus uses hematopoietic cells for dissemination within the body, ... small number of cells that carry these organisms in dormant forms There is some circumstantial evidence for this hypothesis First, several studies aimed at discovering the autoantigen in human autoimmune...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
Ngày tải lên :
09/08/2014, 13:22
... versions of the proteins and peptides, depending on their availability from the collaborators that provided these antigens Their origins are indicated in additional files and Many of the polypeptide ... determine the median pixel intensity for each feature on the array Each feature contained four to 12 replicates so the final intensity (antigen reactivity) of a unique feature was the median of these ... the antigens with statistical differences in array reactivity between the timepoints For example, multiclass SAM analysis was performed and SAM identified the specific set of antigens (from the...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... APP695 isoform, designed like the C3-3 line, but with both the Swedish and Indiana mutations The mice were crossed with animals expressing the tetracycline transactivator under the control of the calciumcalmodulin ... [141] Therefore, to avoid overinterpreting therapeutic studies in transgenic mice, it is important to record the age and evaluate the stage of neuropathology when the animals were first given the ... likely decisively influence the future of immunotherapy, and also the procedures whereby immunotherapeutic strategies are evaluated at the preclinical stage Reduction of Ab synthesis with inhibitors...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
Ngày tải lên :
19/06/2014, 10:20
... onto the base of the sidewalls of the walking compartment avoiding the moving treadmill belt Only the forelimbs execute coordinated stepping sequences B Gait signals of the left and right forelimbs ... attempted to walk, but failed to engage the hind limbs in coordinated stepping Rather, these mice braced their hind paws onto the base of the sidewalls of the walking compartment (Figure 4, upper ... file 2), avoiding the moving treadmill belt The forelimbs of these 3NPtreated mice, however, executed coordinated stepping on the moving treadmill belt Forelimb stride dynamics in these 3NP-treated...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... members appear under the same node The farther one needs to travel across the tree to reach another member, the greater the dissimilarity therefore omitted from the dendrograms Of all the cytokines, ... nontransgenic littermates as controls for the TgAPPsw mice and the PS1 animals as controls for the PS1/APPsw mice as the PS1 animals were the littermates of the PS1/APPsw mice There were no significant differences ... members under the same node The farther one needs to traverse across the tree to reach another member, the higher the dissimilarity represented The distance from the base in the y-axis represents dissimilarity...
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Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
Ngày tải lên :
09/08/2014, 01:22
... only the area of interest, the medial side of the left knee The surgery began with a small skin incision starting from the distal femur and extending to the proximal tibia on the medial side of the ... release the MM (e) The partial meniscectomy has been completed and the cut edge of the MM can be seen Note that in order to visualise the cut edge of the meniscus, for pictorial purposes, the anterior ... of the joint including the medial collateral ligament (MCL) and the joint capsule In the partial meniscectomy (PMX) surgical paradigm both the MCL and the joint capsule were incised to reveal the...
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Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot
Ngày tải lên :
09/08/2014, 01:23
... binding The ligands are the dimeric CD80 and the monomeric CD86 Binding of CD80 to the divalent CTLA-4 leads to the formation of a lattice-like structure on the cell surface This pattern formation ... proliferation a mandatory prerequisite for CTLA-4 expression Furthermore, the instruction for a T cell to express surface CTLA-4 days after the onset of the activation requires less than 12 hours ... addition, the induction of IL-2 leads to autocrine support for the activation of the cell cycle machinery; the IL-2 signal induces the degradation of the cell cycle inhibitor p27 and expression of G1kinases,...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
Ngày tải lên :
09/08/2014, 01:23
... expressed in the same cell, but their binding to the consensus sequence is dependent on their relative levels and their affinity for the adaptor CBFβ (core binding factor β), with which all of the three ... with which they could show the allelic effect of the polymorphisms on gene expression in reporter assays and their effect by cotransfection of RUNX1 In spite of these experiments, the possibility ... RUNX1 the transcription factor that is binding to the altered sites, but that it might also be any of its sisters, RUNX2 or RUNX3 The reason for this is that the consensus sequence that is the...
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Báo cáo y học: "The current status of targeting BAFF/BLyS for autoimmune diseases" pps
Ngày tải lên :
09/08/2014, 01:24
... survive in vivo in the presence of BAFF blockade [26] BAFF and APRIL enhance the survival of plasmablasts, but there are still conflicting data about whether they are required for the survival of ... BAFF-R-Ig and might therefore not be a useful therapeutic agent [39] A BCMA-Ig mutant that blocks only APRIL has been generated and might be useful for further dissecting the function of APRIL ... that the levels of BAFF can influence the selection and differentiation of autoreactive B cells in the periphery [23,24]; this should be a fruitful area for further investigation Germinal centers...
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báo cáo khoa học: " Multi-locus models of genetic risk of disease" pptx
Ngày tải lên :
11/08/2014, 12:20
... between the other two The steeper the risk function the higher the broad sense heritability H 01, so this is usually highest for the CRisch model and least for the Probit model This effect of the ... heritability on the risk scale, H01 (H2 in the legend) The shape of the risk functions is achieved with other combinations of n and p for the same K and hL H 01 is a function of K, whereas for the CRisch ... τ together with K, n and p as the input parameters for the Risch, CRisch and Odds models Models are compared for the shape of the risk function, gx and on the broad sense heritability on the risk...
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Báo cáo y học: " Coxiella burnetii as a possible cause of autoimmune liver disease: a case report" pps
Ngày tải lên :
11/08/2014, 14:20
... Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor-in-Chief ... and Q-fever serology over time and their correlation with therapy Numbers on the y-axis are x-fold of normal value (40 U/L for alanine aminotransferase; 70 U/L for gamma-glutamyl transferase) IgG ... test have been reported It is not clear whether these autoantibodies are an epiphenomenon without clinical significance or if they are instrumental in the pathogenesis of Q-fever Levy et al [6]...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
Ngày tải lên :
12/08/2014, 12:20
... IgG-HRP for the trypsinized form of APRIL The anti-BLyS blot comprised anti-6x His HRP for the Hisx6-zz12.6 form of BLyS, and anti-BLyS pAb followed by donkey anti-rabbit IgG-HRP for the trypsinized ... detected with the pAb assay because of better capture abilities than the mAb-based assay, or a possible preference for either the A B or the AB forms of the heterotrimers In contrast, the immunoassay ... criteria for SLE and RA Patients were enrolled after obtaining their written informed consent by using a protocol approved by the Human Subjects Committee of the University of Washington and the Committee...
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Báo cáo y học: "Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases'''' pps
Ngày tải lên :
12/08/2014, 15:22
... by the used Syk inhibitor? Do the side effects point to the presence of Syk in additional cells (for example, intestinal epithelial cells) The recorded hypertension in patients treated with the ... observed in the R788 group compared with the placebo group 3.2 Syk inhibition in lupus animal models In systemic lupus erythematosus (SLE), the FcγR-Syk associates with the TCR in lieu of the zeta-chain ... and the extent of clinical improvement call for further clinical trials Obviously, there are serious questions that need attention Is Syk involved in the function of additional cells? What other...
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Báo cáo y học: " Models of chronic obstructive pulmonary disease" pps
Ngày tải lên :
12/08/2014, 18:21
... established in the past years Due to the complexity of the disease, and species-specific differences they are all limited concerning their clinical significance While the induction of the COPD lesions ... transducers in the airways and airwayinnervating neurons [78-80] and may therefore display an http://respiratory-research.com/content/5/1/18 interesting target for COPD research For some cells, the activation ... [120,121] The results of these studies supported the hypothesis that rather than contributing to the pathophysiological manifestations of bronchitis, sensory nerve fibres limit the development of airway...
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Báo cáo y học: "Animal models of copper-associated liver disease" doc
Ngày tải lên :
13/08/2014, 13:20
... and supply it to the Wilson's disease protein (ATP7B) in the trans-Golgi network The ATP7B gene encodes the Wilson's disease p-type ATPase [21] The ATP7B protein is required for incorporation ... and during the hemolysis; the ceruloplasmin levels tend to fluctuate but in most instances there is a two-fold or more increase immediately before and during the hemolytic crisis [108] The histologic ... (GSH) soon after the metal enters the cell [27] The importance of GSH in metal detoxification is supported by its role in the removal of toxic oxygen species [28] Following entry to the hepatocyte,...
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Báo cáo y học: " A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread" ppt
Ngày tải lên :
13/08/2014, 16:20
... may then affect the model behaviour in various ways (e.g., altering the shape of the epidemic curves or changing the predictions of the effectiveness of intervention measures) In particular, the ... and 6.0 for the given test population according to Equation The contact intensity i and the shedding rate q are assumed to be constants We then compare the number of secondary cases SC of the simplified ... the variance explained by this linear model equals 0.249 for R0 = 1.5, 0.339 for R0 = 3.0, 0.493 for R0 = 4.5 and 0.696 for R0 = 6.0 (all four linear regression analyses refuse the null hypothesis...
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Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease"
Ngày tải lên :
26/10/2012, 10:03
... along the anterior border of the sternocleidomastoid muscle A 1-mm catheter was inserted via the facial vein into the jugular vein and advanced up to the level above the skull base, and the facial ... values for all the OXANO concentrations measured during clamping and reperfusion and for the markers sampled before, during and after clamping were used In the PLS models, where values for MMP-9 ... representation of the data In the calculation of principal components, the components of the X-block that produce the strongest linear relation to the Y-variables are extracted The principal difference...
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