receptor channel targets of drugs and pesticides

... review of information provided to individual recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information about shipment and storage of drugs, disposition of unused ... development or acquisition of drugs and biologics for CBW defense It also recommends organizational changes in the Office of the Secretary of iii iv The Acquisition of Drugs and Biologics for CBW ... have been reordered by the events of September 11, 2001; officials in the Department of Health and Human Services and in the Department of Homeland Security; and the interested public This research...

Ngày tải lên: 17/02/2014, 11:20

... because adolescent addictions are different than those of adults He describes the process of counseling, denial and compliance, and surrender and recovery Nowinski stresses the need for family intervention ... dramatic rise in the use of marijuana and more use of stimulants, LSD and inhalants It also describes how this trend was a reversal from the recent downward patterns of drug use among teens D) ... adolescents is a prevalent and dangerous problem The use of these substances is dangerous and stupid I'm not going to be a hypocrite and say that I have never tried any drugs or alcohol I'd be lying...

Ngày tải lên: 02/04/2014, 17:48

... delivery of vaccines, genes, drugs and other biomolecules in the body They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, ... number of biomolecules, drugs, genes and vaccines to the site of interest in-vivo During the 1980’s and 1990’s several drug delivery systems were developed to improve the efficiency of drugs and ... nanoparticles and chemical binding of the drug to the polymer can be accomplished using incorporation/adsorption techniques The amount of drugs bound to NPs and the type of interaction –between drugs and...

Ngày tải lên: 11/08/2014, 08:20

... of genes and individual candidates that are involved in the perturbation of mechanisms of iron homeostasis that results from Hfe disruption, and to identify differences in gene expression profiles ... the release of excess iron [21] Somewhat unexpectedly, we observed significant downregulation of the sideroflexin gene (Sfxn2) and upregulation of the mitoferrin gene (Slc25a37) and the Bcrp ... the mitochondrial import/traffic of iron and heme export Also worthy of mention are several strain-specific modifications of the messengers of some regulators of iron metabolism in Hfedeficient...

Ngày tải lên: 14/08/2014, 08:20

... anti-inflammation and anti-cancer effects, in live cancer cells We identified a spectrum of specific targets of Andro, which furthered our understanding of the mechanism of action of the drug We found that Andro ... degradation Atg5 WT and KO MEFs (A) and Atg7 WT and KO MEFs Figure 3.12 Western confirmations of Autophagy inhibition and deficiency in Atg WT and KO MEFs Atg5 WT and KO MEFs Figure 5.1 66 67 Drugs that ... potentials of drugs by uncovering knowledge on their specific targets and mechanisms of action The specific target of andrographolide will be identified using this newly developed method and validated...

Ngày tải lên: 10/09/2015, 09:26

... of 0.4 mL of blank blood and 0.4 mL of IS- containing pentane solution in a glass vial with a Teflon-septum screw cap, which has been cooled with ice, and vortex-mixed for s; a 3-µL aliquot of ... Assessment and some comments on the method > Figure 8.1 shows gas chromatograms of isobutyl nitrite (injected amount µg) and isobutyl alcohol (injected amount 10 µg); they appeared at 3.4 and 7.4 of ... detection limits of isobutyl nitrite and isobutyl alcohol in liquid specimens were 62 ng and 1.9 µg/mL, respectively [7] > Figure 8.2 shows EI mass spectra of isobutyl nitrite (A) and isobutyl alcohol...

Ngày tải lên: 18/10/2013, 00:15

... analysis of DAEMS, various concentrations of DAEMS are spiked into blank serum specimens containing a fixed amount of DAEMO (IS) each and extracted as described before Since the base peaks of DAEMS and ... Trace Analysis of Chemical Warfare Agents An Approach to the Environmental Monitoring of Nerve Agents Ministry of Foreign Affairs of Finland, Helsinki, pp 27, 28, 37–39, 59–64, 72–79 and 90–99 2) ... serum (a) a total ion chromatogram (TIC) and a mass chromatogram; (b) an EI mass spectrum of DAEMS; (c) a CI mass spectrum of DAEMS Poisoning case, and toxic and fatal concentrations VX is much less...

Ngày tải lên: 18/10/2013, 00:15

... 2.4 Mass spectra of the methyl ester plus TMS and TMS derivatives of ∆9-THC-11-oic acid The Substance Abuse and Mental Service Administration (SAMSA) in USA set the cutoff value of ∆9-THC-11-oic ... Methods for analysis of cannabis and its components In: The Pharmaceutical Society of Japan (ed) Standard Methods of Chemical Analysis in Poisoning – With Commentaries, 4th edn., Nanzando, Tokyo, pp ... purpose, the mass spectra of ∆9-THC, CBD, CBN and 5α-cholestane (IS) are shown in > Fig 2.3 ⊡ Figure 2.3 EI mass spectra of ∆9-THC, CBD, CBN and 5α-cholestane 189 190 Cannabinoids and their metabolites...

Ngày tải lên: 24/10/2013, 19:15

... analysis is made by the comparison of the retention time of a peak of a specimen with that of the authentic standard and also by the confirmation of the absence of such a peak in a blank specimen ... HPLC analysis Reagents and their preparation • • Standard solutions of morphine for a calibration curve (2, and 20 µg/mL): see “Reagents and their preparation”, above of GC and GC/MS analysis section ... of morphine, codeine and 6-acetylmorphine, the extraction is made as follows A 2-mL volume of urine is diluted 2-fold with purified water and mixed with 0.1 mL of the IS solution and 0.2 mL of...

Ngày tải lên: 24/10/2013, 19:15

... volume of the supernatant solution is transferred to a new polypropylene tube of the same type, followed by addition of 0.5 mL of concentrated sulfuric acid f and 0.5 mL of mesitylene Nitrate and ... addition of 20 mg of anhydrous sodium carbonate and vortex-mixed for After centrifugation at 3,000 rpm for min, 1- or 4-µL of the upper layer is injected into GC Various known amounts of nitrate and ... He; flow rate: 2.1 mL/min Procedures i Analysis of nitrate i ii iii iv v vi A 0.2-mL volume of a test specimen, 20 µL of IS solution and 0.2 mL of the saturated silver acetate solution e are placed...

Ngày tải lên: 24/10/2013, 19:15

... A and B, a 0.5-mL volume each of distilled water is added To cuvettes C and D, a 0.5-mL volume each of % potassium ferricyanide solution is added vi To cuvettes A and C, a 3-mL volume each of ... cuvettes to stand for min, the absorbances of cuvettes B and D at 630 nm are read using cuvettes A and C as references, respectively These readings are A2 and A4, respectively x The percentage of Met-Hb ... Assessment and some comments on the method The present method for analysis of Met-Hb in blood is simple and rapid, and is not interfered with by the coexistence of high concentrations of CO-Hb...

Ngày tải lên: 24/10/2013, 19:15

... mixture of chloroform and isopropanol or ethanol should be used The simultaneous analysis can be made using chloroform/isopropanol (9:1) or (3:1), and using columns of Bond Elut Certify® and Extrelut® ... amounts of unchanged cocaine, EME and BE excreted into urine are 1–14 %, 12–60 % and 14–55 % of total amount of cocaine administered, respectively [16, 18, 19] Because of the basicity of cocaine, ... using the ratio of cocaine to BE and the brain-to-blood ratios of cocaine and BE The ratios only give rough estimation of them References 1) Editorial Committee of the Manual of the Japanese...

Ngày tải lên: 29/10/2013, 01:15

... detection and quantitation of both therapeutic and toxic levels of pentazocine in blood The recovery of pentazocine using the Sep-Pak C18 cartridge was close to 100 % for both whole blood and urine ... history of intravenous use of pentazocine and tripelennamine, T,s and Blues J Forensic Sci 28:489–495 3) Kintz P, Tracqui A, Lugnier AJ et al (1990) Simultaneous screening and quantification of several ... 3–7 and 7–8 min, respectively The amount of pentazocine and IS spiked into mL of blank whole blood or urine was equally 50 ng ⊡ Figure 5.2 222 Pentazocine Pentazocine In two autopsy cases of pentazocine...

Ngày tải lên: 29/10/2013, 02:15

... (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) Cody JT (2000) Hallucinogens In: Bogusz MJ (ed) Handbook of Analytical ... about 10 µg and LSD is rapidly metabolized in human bodies As metabolites of LSD, 2-oxo-LSD, 3-, 13- and 14-hydroxy-LSDs and an N-de-ethyl-LSD are known [3] After oral ingestion of 160 µg LSD, ... Darmstadt, Germany and other manufacturers) Developing solvents: (A) acetone/chloroform (4:1, v/v); (B) chloroform/methanol/n-hexane (4:2:1, v/v) Assessment of the method The Rf values of LSD were 0.29...

Ngày tải lên: 08/11/2013, 01:15

... O-methylation and conjugation; HMMA is the major urinary metabolite of MDMA [6–9] For more reliable and effective proof of the use of MDAs, their metabolites with the cleavage of methylenedioxy ... disorders, and drug-related accidents or suicides The effects of other MDAs are similar to those of MDMA Symptoms, and toxic and fatal concentrations ⊡ Table 7.2 Acute and chronic effects of MDMA ... successively preconditioned with mL of methanol, mL of distilled water and mL of 25 mM KH2PO4 solution ii The hydrolyzed urine sample is mixed with mL of 75 mM KH2PO4 solution and loaded on the preconditioned...

Ngày tải lên: 08/11/2013, 01:15

... fluid, vitreous humor and urine than in blood Villain et al [21] and Elliott [31] have tentatively set positive cutoff limits of GHB at 50 and 30 µg/mL for postmortem blood, and 10 and 20 µg/mL for ... (PCP) and at m/z 246 plus 232 plus 218 (IS) were used at the retention time of 4–12 The amounts of PCP and IS spiked into mL blank whole blood were 25 and 100 ng, respectively Poisoning case, and ... utilizing the ETS® analyzer and a 25-ng/ mL cutoff J Anal Toxicol 16:107–108 8) Diosi DT, Harvey DC (1993) Analysis of whole blood for drugs of abuse using EMIT d.a.u reagents and a Monarch 1000 chemistry...

Ngày tải lên: 08/11/2013, 01:15

... amount of IS and various concentrations of a target compound are added to mL each of blank whole blood or urine, and processed as above At least vials containing different concentrations of the ... Assessment of the method > Figure 1.1 shows a TIC and MCs for phenothiazine drugs obtained by GC/MS Panels A and B show a TIC and an MC for the authentic compounds, respectively; panels C and D those ... 10–100 fold k) As probable reasons of such a phenomenon, the slight thermal decomposition of the authentic standard during the step of GC, and/ or protection of the target phenothiazine from its...

Ngày tải lên: 15/12/2013, 12:15

... volume of urine or blood, 0.05 mL IS and 0.5 mL of M NaOH are placed in a 15-mL volume glass centrifuge tube with a ground-in stopper and mixed well, followed by addition of mL of the mixture of ... in 0.1 mL of the mobile phase of HPLC or LC/MS For HPLC-DAD and LC/MS, 50 and 20 µL of the above solution are injected, respectively For the SIM of LC/MS, the ions at m/z 376, 378 and 422 are ... detection of haloperidol, reduced haloperidol and bromperidol, respectively For both HPLC and LC/MS, bromperidol is used as IS for quantitation of haloperidol, and vice versa For both HPLC and LC/MS,...

Ngày tải lên: 15/12/2013, 12:15

... detection of the peak of lofepramine Poisoning cases, and toxic and fatal concentrations In > Table 3.1, the therapeutic and toxic blood concentrations of each compound are shown [4] For all drugs, ... resulting in changes of composition ratio of the mobile phase i) According to the kinds of columns used (manufacturer, type, internal diameter and length), the turn of drugs to be eluted and also the ... (A) and (B) should be used according to needs For tentative identification of drugs, a UV absorbance spectrum can be measured together with the confirmation of coincidence of retention time of...

Ngày tải lên: 15/12/2013, 12:15