receptor and tumor necrosis factor receptor p55 in liver regeneration
Báo cáo y học: "Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients" ppt
Ngày tải lên :
11/08/2014, 03:20
... of smoking status (current smoking or no-smoking) and presence of disease (COPD) with systemic inflammation (TNF-α, IL-6, IL-8 and CRP) using a multiple linear regression with robust standard ... TNF-α: tumor necrosis factor- alpha; IL-6: interleukin 6; IL-8: interleukin 8; CRP: C-reactive protein; SpO2: peripheral saturation; FFM: fat free mass Multiple regression with robust standard ... diseases or using regular medication and 34 neversmoker controls were also recruited Smokers and neversmoker controls underwent routine clinical assessments including spirometry and chest X-ray...
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Báo cáo y học: " Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients" pps
Ngày tải lên :
11/08/2014, 06:22
... of smoking status (current smoking or no-smoking) and presence of disease (COPD) with systemic inflammation (TNF-α, IL-6, IL-8 and CRP) using a multiple linear regression with robust standard ... TNF-α: tumor necrosis factor- alpha; IL-6: interleukin 6; IL-8: interleukin 8; CRP: C-reactive protein; SpO2: peripheral saturation; FFM: fat free mass Multiple regression with robust standard ... diseases or using regular medication and 34 neversmoker controls were also recruited Smokers and neversmoker controls underwent routine clinical assessments including spirometry and chest X-ray...
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Báo cáo y học: "Green tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats" pdf
Ngày tải lên :
11/08/2014, 08:21
... factors (insulin, insulin-like growth factor I, epidermal growth factor, fibroblast growth factor, platelet-derived growth factor, and fetal calf serum) [3,4], cytokines (TNFα, GM-CSF, and interferon-gamma) ... and Ttp gene expression is induced by insulin [3], we hypothesized that TTP and/ or its homologues might be involved in the inflammatory response induced by a high-fructose diet in rat liver and ... determinants of insulin resistance in skeletal muscle [26,27] A high fructose diet was also shown to activate inflammatory pathways in the liver [28] Since liver and muscle are two of the most insulin-responsive...
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Báo cáo y học: "Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-a blockade in the knee joint" doc
Ngày tải lên :
12/08/2014, 14:22
... [14,15] and immunopathological mechanisms common to psoriasis and psoriatic joint inflammation [16,17] Genetic risk factors have implicated the interleukin (IL)-23 pathway and the induction and regulation ... Articular Index (mRAI), a sum of scores assessing 30 joints for tenderness (0 to 3) including hand and foot Distal Interphalangeal Joints (DIP) with each side considered as a group score (DIP involvement ... activity The expression of proinflammatory cytokine/chemokine at baseline in the SF of the PsA patients is consistent with previous findings in the SF [31,32] and in the ST [5-7,11,33] of these...
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Báo cáo khoa học: Nuclear factor kappa B and tumor necrosis factor-alpha modulation of transcription of the mouse testis- and pre-implantation development-specific Rnf33⁄Trim60 gene pot
Ngày tải lên :
29/03/2014, 00:20
... embryo and in the testis, as reported in this work In the Rnf35 promoter, an Inr element, two binding sites for nuclear factor Y (NF-Y) and one binding site for the CCAAT-displacement protein (CDP) ... untranslated 5¢ exons and the acquired associated introns in activating expression of intronless protein-encoding genes, as for retrogenes [24–26] Interestingly, mutating both the Inr element and the aTATA ... transcriptional modulation was investigated in the testis and in two testicular cell lines The question remains whether NF-jB is also involved in Rnf33 transcription in the oocyte and in the preimplantation...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
Ngày tải lên :
09/08/2014, 08:23
... murine model of IBD, trinitrobenzen sulfonic acid (TNBS)-induced colitis, is exacerbated in TNFα transgenic mice [9], and is ameliorated in tumor necrosis factor receptor 2-knockout mice [10] In ... expression of IL-32 is increased in synovial tissues from RA patients, and the administration of recombinant IL-32γ into mice joints provokes cellular infiltration in the joint spaces [16] We choose ... however, were obtained from patients in the progressed stage during total joint replacement surgery In the severely damaged joint, the cytokine-producing functions of synovial lining cells are impaired...
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Báo cáo y học: "Active immunization to tumor necrosis factor-α is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis" pps
Ngày tải lên :
12/08/2014, 11:22
... staining and thinning down of the lateral superficial layer; = depletion of staining and thinning down of the central superficial layer; = severe and mostly complete depletion of staining in ... phosphate-buffered human tumor necrosis factor- alpha transgenic (TTg) mice immunized with tumor necrosis with kinoid (TNF-K) Clinical evaluation ofsaline (PBS) or treatedfactorinfliximab (IFX) or ... promising results in several fields, and in the case of active immunotherapy against cytokines (AIC), the choice of the target cytokine is informed by the longterm experience with mAbs, receptors,...
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Báo cáo y học: "Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock" ppt
Ngày tải lên :
13/08/2014, 11:23
... response In severe sepsis and septic shock, neuroendocrine systems are activated Sympathetic activation is associated with increasing plasma concentrations of epinephrine and norepinephrine [7] and ... with Saponine (0.1%) (Sigma-Aldrich) in phosphate-buffered saline containing 5% milk powder and 0.1% bovine serum albumin (Sigma-Aldrich) Cell surface markers and intracellular cytokines were ... discrepancy remains unclear The use of epinephrine or norepinephrine instead of isoprenaline is unlikely to account for this difference since it has been shown previously that epinephrine-induced stimulation...
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Báo cáo y học: "A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis" pps
Ngày tải lên :
12/08/2014, 12:20
... Jasin HE, Kinne RW: Preferential induction of prodestructive matrix metalloproteinase-1 and proinflammatory interleukin and prostaglandin E2 in rheumatoid arthritis synovial fibroblasts via tumor ... hairpin non specific; HpTNFR1: hairpin construct targeting tumor necrosis factor receptor 1; i.a.: intra-articular; IFNγ: interferon-gamma; IHC: immunohistochemistry; IL: interleukin; i.v.: intravenous; ... suppressor of cytokine signaling-3; TCRβ: T-cell receptor beta; Th: T helper; TNFα: tumor necrosis factor- alpha; TNFR: tumor necrosis factor receptor 10 11 12 13 14 Competing interests The authors...
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Báo cáo y học: " Serum levels of soluble Fas, soluble tumor necrosis factor-receptor II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4." pps
Ngày tải lên :
13/08/2014, 13:20
... and metastasis, including soluble Fas (sFas), soluble tumor necrosis factor receptor- II (sTNFR-II), interleukin-2 receptor (IL-2R) and interleukin-8 (IL-8) As the knowledge of tumor biology becomes ... (CD95) in patients with hepatocellular carcinoma Clin Exp Immunol 1998, 112:166-171 47 Pinkoski MJ, Brunner T, Green DR, Lin T: Fas and Fas ligand in gut and liver Am J Physiol Gastrointest Liver ... X, Durand JM, Harlé JR, Bongrand P, Piette JC, Cacoub P: Increased soluble p55 and p75 tumour necrosis factor- a receptors in patients with hepatitis C-associated mixed cryoglobulinaemia Clin Exp...
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Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
Ngày tải lên :
21/02/2014, 15:20
... overexpression and are also found with other TRAF proteins containing a RING– zinc finger domain (data not shown and Fig 6) Interestingly, both a C-terminal deletion mutant lacking the TRAF domain [T4(1–268)–YFP] ... TRAF4-interacting protein-sorting Nexin 6–TRAF4–associated factor from the cytoplasm to the nucleus [19] Thus, it will be interesting to see in the future whether Pim-1 and sorting Nexin regulate ... tumor necrosis factor (TNF) receptor- associated factor gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-jB and c-Jun N-terminal kinase...
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Báo cáo y học: " γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease" pptx
Ngày tải lên :
09/08/2014, 01:23
... treatment on serum levels of tumor necrosis factor- alpha, tumor necrosis alpha receptor, interleukin-2, interleukin-2 receptor, and e-selectin in Behçet’s disease Rheumatol Intern 1999, 19:11-14 37 ... tumour necrosis factor receptor II and γ δ interleukin-12 receptor β1 on Vγ9/Vδ2 T cells We investigated the expression of TNF receptor II and IL-12 receptor β1, as cell activation markers, in the ... TNF receptor II and IL-12 receptor β1 expression was increased after 10 days in all studied groups In particular, the proportion of cells coexpressing Vγ9/Vδ2 and TNF receptor II or IL-12 receptor...
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Báo cáo y học: " Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?" ppsx
Ngày tải lên :
12/08/2014, 18:20
... proteins that are involved in maintaining calcium homeostasis TNF-α stimulates the expression of a calcium-binding protein, calbindin-D28K, in neuronal cells [12], and increases activity of proteins ... nonspecific increase in calcium TNF-α enhances the contractile response to carbachol in murine tracheal rings Murine tracheal rings were harvested and placed in culture overnight in an equal ... generation in cultured murine tracheal rings, it is interesting to note that carbachol-induced increases in force generation were also increased as compared with those obtained in freshly harvested...
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Báo cáo khoa học: Tumor necrosis factor receptor cross-talk docx
Ngày tải lên :
28/03/2014, 23:20
... nuclear factor kappa B; RIP, receptor interacting protein; TRADD, TNF receptorassociated death domain; TRAF, TNF receptor associate factor; TNF, tumor necrosis factor; TNFR1, tumor necrosis factor receptor- 1 ... proteins that are involved in downstream signaling, for example, TNF receptor associate factor- 2 (TRAF2) It was believed that the death domain kinase, receptor- interacting protein (RIP) can also interact ... autoactivation and is also a prerequisite for ligand binding [31] The intracellular part of TNFR1 contains a protein–protein interaction region called the death domain [32] After ligand binding to the...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
Ngày tải lên :
19/06/2014, 22:20
... abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice Int Immunol 1996, 8:23-36 Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP: Tumor necrosis factor ... in the injured brain has not yet been investigated We sought to determine the interrelationship between intracranial TNF and IL-18 levels in a clinical study on patients with severe CHI and in ... Yoshinaga M, Ohkawara S, Nariuchi H, McCracken Jr, G.H.: Tumor necrosis factor alpha / cachectin and interleukin beta initiate meningeal inflammation J Exp Med 1990, 172:497-507 Saukkonen K, Sande...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... alpha-inducible protein (IFI6) Hs00242571_m1 Interferon, gamma-inducible protein 16 (IFI16) Hs00194261_m1 Interferon, alpha-inducible protein 27 (IFI27) Hs00271467_m1 Interferon, gamma-inducible protein 30 ... CD14, chemokine (C-C motif) receptor 7, IL12B, IL-4 receptor, and prostaglandin E synthase) and 12 upregulated genes (IFIT1, IFIT3, IFIT5, ISG15, IRF7, OASL, OAS1, guanylate binding protein Page ... were included in the first network, including p38 mitogen-activated protein kinase (MAPK) complex and NFB complex depicted at the center of Figure 1a p38 MAPK is phosphorylated in response to inflammatory...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
Ngày tải lên :
09/08/2014, 01:23
... mesenchymal origin that constitute the cellular component of periarticular tendons They play an important role in producing extracellular matrix and in initiating regenerative responses following injury ... domains Fas (CD-95/Apo-1) and the p55 tumour necrosis factor (TNF) receptor I (TNFRI) are prominent examples of such receptors The mechanisms through which stimulation of Fas by the Fas ligand ... clearly defined This is because, in addition to signalling through the death domain of TNFRI, TNF-α activates mainly signalling pathways and transcription factors such as nuclear factor- κB, which...
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Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
Ngày tải lên :
09/08/2014, 01:23
... soluble receptors and Th2 cytokines J Immunol 2001, 167:6015-6020 Katz Y, Nadiv O, Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins 1, 6, and in skin and ... LeGrand A, Fermor B, Fink C, Pisetsky DS, Weinberg JB, Vail TP, Guilak F: Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin ... P: The combination of tumor necrosis factor alpha blockade with interleukin-1 and interleukin-17 blockade is more effective for controlling synovial inflammation and bone resorption in an ex vivo...
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Báo cáo y học: " Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis" ppsx
Ngày tải lên :
09/08/2014, 07:20
... paraformaldehyde for 10 minutes at room temperature, rinsing with 0.1% Tween in PBS and digesting with proteinase K (1 µg/ml; Roche, Mannheim, Germany) After rinsing again with 0.1% Tween in PBS, another ... make TNF an ideal candidate for linking inflammation and bone loss Indeed, the therapeutic blockade of TNF is highly effective in preventing and/ or reducing skeletal damage in conditions of chronic ... revealed several interesting insights into arthritic bone loss, as illustrated in Figure First, bone turnover was massively increased at sites of joint inflammation Arthritis in hTNFtg mice involves...
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Báo cáo y học: "Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes" ppt
Ngày tải lên :
09/08/2014, 10:20
... using flow cytometry according to the following protocol: the monocytes were washed once with PBS and then incubated for 15 minutes at 4°C in mM PBS EDTA and collected by aspirating and refilling ... citation purposes) necrosis factor (TNF)α Mechanisms involved in the regulation of CD36 expression by tumor necrosis factor (TNF)α (a) TNFα inhibits both basal and rosiglitazoneinduced peroxisome ... chemiluminescence in the presence of 5-amino-2,3-dihydro-1,4phthalazinedione (66 mM; Luminol®, Sigma-Aldrich) using a thermostatically (37°C) controlled luminometer (Wallac 1420 Victor2, Finland)...
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