recent studies in’a’scid mouse model

... while many mediators of inflammation have been detected in the AD brain [12] Further, recent studies in AD mouse models have shown that chronic treatment with a subset of NSAIDs (e.g ibuprofen, flurbiprofen, ... an additive anti-amyloidogenic effect in the Tg2576 mouse model of AD-like Aβ brain amyloidosis, one of the most extensively studied mouse models of AD [15] Significantly, we found for the first ... these signatures of oxidative stress have been shown in animal models of AD-like brain amyloidosis, i.e the Tg2576 transgenic mouse model thereof [8-10] Chronic neuroinflammation is another constant...

Ngày tải lên: 19/06/2014, 22:20

... an immunocompetent mouse model To test the therapeutic application of cord lining cells in ex vivo insulin gene therapy using a streptozocin (STZ) induced type diabetic mouse model Chapter Literature ... low immunogenicity of the ESCs in more comprehensive in vivo studies (Drukker et al 2006) Their studies included a humanized mouse model reconstituted with human PBMCs This was probably a more ... 2004; Le Blanc et al 2007) Recently, BM-MSCs have been reported to exert immunomodulatory functions, and this has opened new areas of potential clinical applications Recent studies have focused on...

Ngày tải lên: 11/09/2015, 10:02

... accumulation in the Fabry mouse, make this a feasible approach In order to begin to address this potential, we determined the effect of CsA on Gb3 synthesis in the Fabry mouse model Our studies have further ... – endothelial staining in Fabry mouse; (C, D) lung – epithelial cell staining increased in Fabry mouse; (E, F) brain microvascular endothelial staining in Fabry mouse Magnification ·16 no VT1 staining ... the Fabry mouse suggests increased susceptibility to this toxin compared with wild-type, but the retained lack of glomerular binding indicates that the Fabry mouse will not serve as a model of...

Ngày tải lên: 19/02/2014, 07:20

... contrast Figure Prototype of the Benchtop-MRI system “MARAN DRX2” (Oxford Instruments) A nude mouse xenograft model of different human tumors was used to determine the image sensitivity and quality ... experimental results clearly proof that BT-MRI can be used to visualise organs and tumors in nude mouse xenograft models Subcutaneous xenografts were easily identified as relative hypointense areas in transaxial ... One critical aspect using orthotopic/metastatic tumor models could be the visualization of metastasis in tissues and organs depending on the model This may require Caysa et al Journal of Experimental...

Ngày tải lên: 10/08/2014, 10:21

... runs Coreference Resolution Models In this section, we present a sequence of generative coreference resolution models for document corpora All are essentially mixture models, where the mixture ... from various models The output from (a) is from the infinite mixture model of section 3.2 It incorrectly labels both boxed cases of anaphora The output from (b) uses the pronoun head model of section ... be seen in (c) 3.1 A Finite Mixture Model Our first, overly simplistic, corpus model is the standard finite mixture of multinomials shown in figure 1(a) In this model, each document is independent...

Ngày tải lên: 08/03/2014, 02:21

Ngày tải lên: 15/03/2014, 14:20

... contrast with the single processor model employed by Johnson, the system we propose consists of a number of processors over subsets of the grammar Central to the model is a declarative specification ... in a Principle-Based Model of Sentence Processing Presented at The Workshop on GB-Parsing, Geneva, Switzerland, 1990 [4] M Crocker Multiple Meta-Interpreters in a Logical Model of Sentence Processing ... transformations can be used to affect the manner in which a logic grammar is parsed [10] [1i], Recently, there has been an attempt to extend the PAD hypothesis beyond its application to simple...

Ngày tải lên: 18/03/2014, 02:20

... and Pre-Default Equity Dynamics 2.2 Market Model 2.2.1 Risk-Neutral Measures and Model Completeness 2.3 Modified Market Model ... the arbitrage-free property of this model, as well as its completeness The model considered in this work appears as the simplest equity-to-credit reduced-form model, in which the connection between ... specification of the model at hand (non-parametric model with arbitrary local volatility and/or default intensity functions σ and γ or versus parameterized sub-classes of models with specific parametric...

Ngày tải lên: 22/03/2014, 20:20

... earlier theoretical and empirical studies concentrated mostly on the aggregate level of credit to the private sector or the value of corporate credit, more recent studies focus on the problem of ... Credit risk incorporated in the model could be further used to identify credit booms in the banking sector more efficiently with econometric models, as it was done in the recent paper of Serwa (2011) ... proposing a life-cycle model with individual income uncertainty that can be used to assess how various macroeconomic factors affect the equilibrium value of household credit The model describes the...

Ngày tải lên: 29/03/2014, 06:21

... members [20] This raises the possibility of additive or antagonistic effects Exploring this issue, model studies on SK-N-MC neuroblastoma cells illustrated the potential of other galectins, especially ... sialylation, have a bearing on protein functions in general and on integrins in particular [5–8], glycan remodeling affords an attractive level of regulation of integrin functionality The assumption of a ... factor in growth inhibition by Gal-1 at the level of cell-surface ligand binding [21,22] Having recently delineated a direct connection between p16INK4a and Gal-1 [9], the question arises as to...

Ngày tải lên: 29/03/2014, 21:20

... for modelling symmetry in conjunct structure, for modelling the dependency between noun phrase conjunct head words and for incorporating a measure of word similarity in the estimation of a model ... however there are two heads, though in the parsing model just one is chosen, somewhat arbitrarily, to head the entire noun phrase In the baseline model there is essentially one parameter class for ... is not captured for NPBs We look at how we might improve the model s handling of coordinate headhead dependencies by altering the model so that a common parameter class in (4) is used for coordinate...

Ngày tải lên: 31/03/2014, 01:20

... (ERK1/2, K-23) and p38 kinase(H-147) polyclonal antibodies; mouse antihuman caspase-3(E-8), mouse anti-Topoisomerase-alpa (Ki-S1), mouse anti-human β-actin monoclonal antibody and phosphorylated ... phosphorylated proteins of ERK1/2(p- ERK1/2(E-4)); Cy3-conjugated goat anti -mouse IgG, goat anti-rabbit immunoglobulin G (IgG) and goat anti -mouse IgG antibodies coupled to horseradish peroxidase were all ... each mouse Ten days after inoculation, mice were divided into a control group and a RES treatment group (each group including four mice; two CAVRNAi-transfected mice and one HepG2-transfected mouse...

Ngày tải lên: 18/06/2014, 15:20

... illustrating the antigenic strucFigure bound gD groups, as model antibodies into A:1 and demonstrating the clustering amino acids Panel A: Hypothetical model illustrating the antigenic structure of gD ... vaginal epithelium only during the stage of estrous at which they are susceptible to HSV Using a mouse model of GH, pre-incubation of HSV-2 with soluble recombinant nectin-1 was shown to block entry ... cluster Hinge Figure predicted structure Single plain view of a 3-D model of DL11 scFv, showing its Single plain view of a 3-D model of DL11 scFv, showing its predicted structure Panel A: Strand...

Ngày tải lên: 18/06/2014, 22:20

... viral transmission would be evaluated in animal models prior to human clinical trials One attractive model is the guinea pig cytomegalovirus (GPCMV) model [reviewed in [6]], since the GPCMV crosses ... transmission Since the guinea-pig model of CMV infection is the most authentic non-primate animal model for study of interventions against congenital CMV infection [14], these studies were Page of (page ... observation from these studies was the demonstration of the utility of using an eGFP-tagged, recombinant CMV in the experimental modelling of congenital CMV infection Previous studies using an eGFPtagged...

Ngày tải lên: 19/06/2014, 08:20

... illustrating the antigenic strucFigure bound gD groups, as model antibodies into A:1 and demonstrating the clustering amino acids Panel A: Hypothetical model illustrating the antigenic structure of gD ... vaginal epithelium only during the stage of estrous at which they are susceptible to HSV Using a mouse model of GH, pre-incubation of HSV-2 with soluble recombinant nectin-1 was shown to block entry ... cluster Hinge Figure predicted structure Single plain view of a 3-D model of DL11 scFv, showing its Single plain view of a 3-D model of DL11 scFv, showing its predicted structure Panel A: Strand...

Ngày tải lên: 20/06/2014, 04:20

... viral transmission would be evaluated in animal models prior to human clinical trials One attractive model is the guinea pig cytomegalovirus (GPCMV) model [reviewed in [6]], since the GPCMV crosses ... transmission Since the guinea-pig model of CMV infection is the most authentic non-primate animal model for study of interventions against congenital CMV infection [14], these studies were Page of (page ... observation from these studies was the demonstration of the utility of using an eGFP-tagged, recombinant CMV in the experimental modelling of congenital CMV infection Previous studies using an eGFPtagged...

Ngày tải lên: 20/06/2014, 04:20

... [2-6] and several biomechanical studies have shown that a volar plate and locking screw system is efficient in the stabilizing of fractures against axial force [7-10] Recently, the Acu-Loc® Targeted ... and return to functional activities Most previously reported studies directly loaded the isolated radius using a cadaver fracture model; [7,8,10] however, a more clinically relevant loading pattern ... the stable fixation of distal radial fractures using a cadaver unstable intra-articular fracture model Methods Specimen and Preparation Six matched pairs of fresh-frozen human cadaver wrists, complete...

Ngày tải lên: 20/06/2014, 04:20

... [2-6] and several biomechanical studies have shown that a volar plate and locking screw system is efficient in the stabilizing of fractures against axial force [7-10] Recently, the Acu-Loc® Targeted ... and return to functional activities Most previously reported studies directly loaded the isolated radius using a cadaver fracture model; [7,8,10] however, a more clinically relevant loading pattern ... the stable fixation of distal radial fractures using a cadaver unstable intra-articular fracture model Methods Specimen and Preparation Six matched pairs of fresh-frozen human cadaver wrists, complete...

Ngày tải lên: 20/06/2014, 07:20

... rodent models of spontaneous ex vivo transformation of OSE have been described [8-10] One of these models, a syngeneic mouse model of EOC [10], has been extensively used for preclinical studies ... Similar studies would be difficult to impossible to conduct in immunodeficient mice The availability of an additional syngeneic mouse model of EOC will allow cross-comparison of mouse models and ... of ovarian cancer by defined multiple genetic changes in a mouse model system Cancer Cell 2002, 1:53-62 26 Xing D, Orsulic S: A mouse model for the molecular characterization of brca1-associated...

Ngày tải lên: 20/06/2014, 07:20

... mathematical model We use a model of the pituitary lactotroph, which produces pseudo-plateau bursting over a range of parameter values [10] To achieve a minimal form, we use the model without ... have previously analyzed pseudo-plateau bursting in a pituitary lactotroph model using canard theory [28] However, the model used was a simplification in which the cytosolic free Ca2+ concentration ... single mouse pancreatic beta-cells by artificial conductances Biophys J 76(3), 1423–1435 (1999) Zhang, M., Goforth, P., Bertram, R., Sherman, A., Satin, L.: The Ca2+ dynamics of isolated mouse...

Ngày tải lên: 20/06/2014, 22:20