rationale for studying particle shape 157
Particle development for drug delivery
Ngày tải lên :
17/09/2015, 17:19
... Roles of D50 and D99 157 B4 Shape Determination By Image Analysis 157 B4.1 Rationale for Studying Particle Shape 157 B4.2 Rationale for the Choice of Method 158 B4.3 Rationale for the Choice of ... Rate A3 Particle Shape and Dissolution B Particle Shape B1 Concept of Particle Shape B2 Shape Factors B2.1 Static Shape Factors B2.1.1 Geometric Shape Factors B2.1.2 Fourier Series in Shape Generation ... A1 Rationale for the Choice of Equipment and Method Employed 112 A1.1 Rationale for Choosing FB Hammer Mill 112 A1.2 Rationale for Choosing Laser Diffraction for Particle Sizing 113 A1.3 Rationale...
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Research " Essays on the Equilibrium Valuation of IPOs and Bonds " pdf
Ngày tải lên :
07/03/2014, 02:20
... University of California at Berkeley Professor Mark Rubinstein, Chair Chapter of this dissertation provides rational explanations for the IPO underperformance puzzle IPO underperformance is shown ... preference for positive skewness Pricing implication of preference -for- skewness is important, for at least two reasons One, if the skewness of IPO returns is priced, then the right benchmark for measuring ... Underperformance: Benchmarks and Sources To assess IPO performance, it is necessary to use some benchmark Depending on the benchmark used, performance measurement may be di¤erent Severe underperformance...
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Báo cáo khoa học: Equilibrium distribution of skeletal actin–tropomyosin– troponin states, determined by pyrene–tropomyosin fluorescence potx
Ngày tải lên :
07/03/2014, 09:20
... hydrolysis, have been published previously [14,15] The formalism for a parallel pathway model was originally dened for two functional states of actin, for simplicity [14,16] Despite early concerns that ... rmax and rmin are the rates for the active and inactive actin species, respectively A correction to this equation can be made for the small difference in afnity of S1-ATP for actin in states and ... blocked in the absence of Ca2+ We have an alternative explanation for that effect [37] However, for the present exercise we forced the t to populate the blocked state in EGTA in accordance with...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx
Ngày tải lên :
07/03/2014, 10:20
... different ways For example, deep-out-of-the-money put options are extremely sensitive to market crashes Options with varying degrees of moneyness therefore provide a wealth of information for us to ... one for risk aversion and the other for elasticity of intertemporal substitution Similarly, in our framework, the utility function also has two parameters: one for risk aversion and the other for ... option pricing for this model is a modification of the Black and Scholes (1973) formula, and has been established in Merton (1976) For completeness of the article, the pricing formula is provided...
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Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf
Ngày tải lên :
08/03/2014, 08:20
... r.p.m for 2.5 h The SEDFIT software was used for data analysis [22] Sedimentation equilibrium measurements were performed at two speeds, 18 000 r.p.m and 20 000 r.p.m ORIGIN software was used for ... protein form was resolved, including a form eluting earlier than the native tetramer and a form of intermediate size between the tetramer and monomer, which was ascribed to a dimeric form also ... time is therefore essential for allowing the denaturation reaction to reach equilibrium [31] Acknowledgements We thank Matthew D Lloyd (University of Bath) for reading this manuscript before publication...
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Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx
Ngày tải lên :
23/03/2014, 07:20
... #1-1 (157 aa) #1-9 (157 aa) #1-21 (157 aa) #1-33(143 aa) #1-40 (157 aa) % R1 #2-1 (157 aa) #2-5 (157 aa) #2-6 (157 aa) #2-13 (157 aa) #2-30 (157 aa) % R2 #3-15 (157 aa) #3-6 (157 aa) #3-8 (157 aa) #3-10 (157 ... #3-15 (157 aa) #3-6 (157 aa) #3-8 (157 aa) #3-10 (157 aa) #3-15 (157 aa) #3-20 (157 aa) #3-22 (157 aa) #3-30 (157 aa) #3-37 (157 aa) #3-40 (157 aa) % R3 R166G V169A E171G D271N Y209H H217R 20 20 20 C263Y ... fragments found after screening for the domain boundary These fragments correspond to deletions of 127, 143, 144, 157 and 212 amino acids, respectively The DNA for the AMPP fragments was isolated...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
Ngày tải lên :
23/03/2014, 21:20
... constructs were transformed into BL21 (B834 DE3) strain of E coli by the heat shock method and transformants grown in LB broth in presence of carbenicillin (50 mgÆmL)1) and 0.2% glucose For protein production, ... (…TTS) Therefore, the terminal three residues are identical to the ones in Pfg27A Stability and solubility of various MBP-Pfg27 proteins The Pfg27A–F construct DNAs were freshly transformed into ... used for each construct so that the yield differences were normalized All experiments were conducted in 100 mL cultures and the data presented in Table has been scaled to represent the yields for...
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báo cáo hóa học:" Research Article Strong Convergence for Mixed Equilibrium Problems of Infinitely Nonexpansive Mappings Jintana Joomwong" pot
Ngày tải lên :
21/06/2014, 10:20
... paper, for solving the mixed equilibrium problem, let us give the following assumptions for a bifunction Θ, ϕ and the set C: A1 Θ x, x for all x ∈ C; A2 Θ is monotone, that is, Θ x, y Θ y, x ≤ for ... upper-hemicontinuous, that is, for each x, y, z ∈ C, lim sup Θ tz t→0 − t x, y ≤ Θ x, y ; A4 Θ x, · is convex and lower semicontinuous for each x ∈ C; 2.6 Fixed Point Theory and Applications B1 for each x ∈ H ... or (B2) holds For r > and x ∈ H, define a mapping Tr : H → C as follows: Tr x z ∈ C : Θ z, y ϕ y r y − z, z − x ≥ ϕ z , ∀y ∈ C 2.8 for all x ∈ H Then, the following conditions hold: for each x ∈...
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Báo cáo hóa học: "Research Article Stability of Equilibrium Points of Fractional Difference Equations with Stochastic Perturbations" pdf
Ngày tải lên :
22/06/2014, 11:20
... conditions at the same time are 47–49 conditions for stability in the probability of the trivial solution of nonlinear equation 2.2 and therefore for stability in probability of the equilibrium ... in the form |q| < |p q|, |q| < p 2q sign p q , σ2 < p p 3q p q p 2q 4.11 or p∈ − ∞, − 3q − θ|q| ∪ − 3q θ|q| , ∞ , θ − σ2 − σ2 4.12 Example 4.2 For example, from 4.12 it follows that for q −1, ... condition P{supn∈Z |yn φ | > 1 } < for any initial function φ such that P{supj∈Z0 |φj | ≤ δ} Definition 2.2 The trivial solution of 2.3 is called mean square stable if for any > there exists δ > such...
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Báo cáo y học: "Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients" potx
Ngày tải lên :
09/08/2014, 08:22
... not for citation purposes) Genotyping methods For genotyping, cellular DNA was isolated from 10 ml of peripheral blood using standard procedures, and 0.5 µg DNA were used in the PCR reactions For ... instances For HLA-DRB1 typing, genomic DNA was PCR amplified using two primers specific for the second exon of DRB1 as described previously [26] Low resolution typing of DRB1 specificities was performed ... oligonucleotide hybridization of the PCR products to probes specific for DRB1*01 through *18 Hybridization was performed in a dot-blot format with digoxigenin-11-ddUTP-labeled oligonucleotides After...
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Báo cáo y học: "Explicit equilibrium modeling of transcription-factor binding and gene regulation" pdf
Ngày tải lên :
14/08/2014, 14:22
... cellcycle dependence in a fkh1∆fkh2∆ mutant lacking forkhead transcription factors [7,10] To assess the association of forkhead binding sites with forkhead-dependent cell-cycle regulation, we used ... we used GOMER to score all putative regulatory sequences using a forkhead PWM that was defined by binding data for Fkh1p The data for Fkh2p is not as complete but the proteins have similar specificity ... Schematics of a conventional uniform weight function and a Gaussian weight function (c) Comparison of the uniform weight function and (d) the Gaussian weight function for several hundred combinations...
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Thermochemical equilibrium modeling of biomass downdraft gasifier: Stoichiometric models
Ngày tải lên :
01/08/2016, 09:31
... MJ/kg for biomass and MJ/Nm3 for syngas specific Gibbs free energy of formation in molar basis, at standard pressure, kJ/mol specific enthalpy in molar basis, kJ/mol specific enthalpy of formation ... synthesis gas aforementioned processes For instance, a descending particle may be going through devolatilization in its outer layers while it is drying in the inner layers In addition, a particle may ... Jarungthammachote and Dutta [37] the equilibrium constant for the methane formation reaction was multiplied by 11.28 and the equilibrium constant for the wateregas homogeneous reaction by 0.91 In work...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
Ngày tải lên :
05/09/2013, 09:08
... contaminated water provides a simple technique for the oxidation and mineralization of water contaminants without the addition of supplementary oxidants For example, it has being used in the treatment ... water, oxygen, and H2O2, respectively Development of the proposed conceptual model The driving forces for the decomposition of organics in aqueous solutions in a 185nm VUV Direct photolysis and ... excitement of H2O OH· indirect oxidation generated from the excitement of H2O2 Figure The driving forces for the decomposition of organics in aqueous solutions in a 185nm UV Direct photolysis and VUV/H2O2...
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Tài liệu THE PRINCIPLES OF CHEMICAL EQUILIBRIUM doc
Ngày tải lên :
12/02/2014, 16:20
... important in the present volume, together with their symbols, are as follows: for for for for for energy the joule (J); kg m•s-1 force the newton (N); kg m s- = J m-1 pressure the pascal (Pa.); kg ... 139 4·5 The equilibrium constant for a ga.s rea.ction 140 4·6 The temperature dependence of the equilibrium constant 143 4·7 Other forms of equilibrium constant for perfect ga.s mixtures 146 Free ... Jonathan and Philip Denbigh, for help with the proof correcting, and to my wife for help in many other ways K.G.D CAMBRIDGE Ocloba- 1954 PREFACE TO THE FOURTH EDITION My work for this edition has been...
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Tài liệu Correspondence & Conversations of Alexis de Tocqueville with Nassau William Senior from 1834 to 1859, Vol. 2 docx
Ngày tải lên :
18/02/2014, 08:20
... years before them.' 'That is true,' said Tocqueville, 'and therefore their rage will break out in a more direct, and perhaps more formidable, form Depend on it, this Government can exist, even for ... chosen not for their fitness but for their birth and connections, but I am ready to submit to this inconvenience for the sake of its freedom and stability I had rather have Malmesbury at the Foreign ... again and look forward to it with pleasure On the whole I think that I shall go But it is impossible for me to settle my route beforehand Even if I were stronger it would be difficult, for such an...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
Ngày tải lên :
19/02/2014, 00:20
... experiments We ran the forward reaction (the formation of HP) using both DHNP and DHMP as the substrates and the reverse reaction (the formation of DHNP and DHMP) with HP and GA For the forward reaction, ... fluorimetric analysis Because GA has a very low affinity for the enzymes (data not shown) and exists in solution in multiple forms, of which the correct form for the reaction is a minor one [19,20], we focused ... product HPO) Finally, the Kd value of SaDHNA for NP was slightly higher than that for MP, whereas the Kd value of EcDHNA for NP was lower than that for MP Stopped-flow analysis We then measured...
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On the Segregation of Genetically Modified, Conventional, and Organic Products in European Agriculture: A Multi-market Equilibrium Analysis doc
Ngày tải lên :
05/03/2014, 20:20
... There are at least four reasons for that First, here we explicitly allow for differentiated consumer preferences, specifically for some consumers to have a preference for non-GM products Second, ... explicitly for the production of two and three products (before and after the GM innovation, respectively) The quality enhancement of organic production is modelled as deriving from additional efforts ... accounts for only a small share of overall production The modelling avenue that we postulate to account for such stylized facts is that organic production requires an additional input in the form...
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24,185 OUTLETS - The number of JApAN pOST BANk outlets in Japan docx
Ngày tải lên :
06/03/2014, 10:20
... on ordinary deposits, and the interest rate at the point the deposit is made can be applied for up to 10 years. For the depositor, TEIGAkU deposits offer liquidity and attractive interest rates. TEIGAkU deposits accounted for 51.70% of the Bank’s deposits as of March 31, 2010. Consequently, fixed-term ... that extends back more than 130 years. Other reasons include our extensive network, which gives us a close-by presence for customers throughout Japan. For this reason, the Bank is known in Japan as “the people’s savings bank” Customers also trust the Bank because of its high capital adequacy ratio ... withdraw cash in yen The Bank’s ATMs are also easy to use for physically challenged customers Braille and voice guidance systems are available for visually challenged customers (These services are...
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AN ECONOMIC HISTORY OF THE ENGLISH POOR LAW 1750-1850 pptx
Ngày tải lên :
07/03/2014, 03:20
... 1760-1829, for selected parishes For each parish, 1782 = 100 (Sources: Relief expenditure data from Essex Record Office: Stansted Mountfitchet [D/P 109/8/4-5]; Stanford Rivers [D/P 140/8/1-4]; Stapleford ... extent of allotments for any year before 1832 It is therefore not possible to determine the magnitude of the decline in allotments over the period from 1780 to 1832 34 Wage data for the early 1790s ... the form of outdoor relief) were cost-minimizing for farmers The extent of seasonal fluctuations in labor demand is a key determinant of the nature of the optimal contract The model therefore...
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Báo cáo Y học: The folding of dimeric cytoplasmic malate dehydrogenase Equilibrium and kinetic studies doc
Ngày tải lên :
08/03/2014, 23:20
... a 0.1-cm pathlength cuvette for far-UV and 1.0 cm pathlength cuvette for near-UV region Protein concentration was typically 100 lgÆmL)1 for far-UV and 200 lgÆmL)1 for near-UV CD measurements ... is due to particle dissociation, rather than a shift in structural conformation Therefore, this must be reflecting the compact monomer Increasing GdnHCl concentration beyond 0.75 M, the particle ... sets CD spectra were corrected for background absorbance Biological activity of any protein depends strictly on its properly folded three-dimensional conformation Therefore reactivation experiments...
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