rational therapeutics for alzheimer s disease and other dementias

... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression ... hereditary diseases like Wilson s disease Huntington s disease is an involuntary movement disorder that is often associated with dementia Parkinson s disease is a progressive brain disorder and a ... years but as many as 20 years or more from the onset of symptoms.6 Families with 13 14 Alzheimer s Disease and Other Dementias members who suffer from Alzheimer s disease or other dementias are...

Ngày tải lên: 14/02/2014, 18:20

... Medical School Massachusetts Alzheimer s Disease Research Center Massachusetts General Hospital, Boston, MA USA Preface This book provides a comprehensive review of Alzheimer s disease and other dementias ... treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease Research Centers were established with ... 1990 and before differs in many ways from what Alzheimer s Disease 31 neuropathologists are now confirming as Alzheimer s disease (Consensus recommendations for the postmortem diagnosis of Alzheimer s...

Ngày tải lên: 14/03/2014, 21:20

... THERAPEUTICS of PARKINSON S DISEASE and OTHER MOVEMENT DISORDERS Therapeutics of Parkinson s Disease and Other Movement Disorders Edited by Mark Hallett and Werner Poewe © 2008 John Wiley & Sons, ... Parkinson (French for Parkinson s disease) T-sub-type PD patients have a better prognosis and slower disease progression than AR-sub-type patients (Jankovic et al., 1990) Interestingly, most forms ... as opposed to other PD symptoms The classic PD tremor is a rest tremor, since its amplitude decreases during voluntary action PD tremor increases during mental and emotional stress and is absent...

Ngày tải lên: 14/02/2014, 17:20

... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS THE COST OF ALZHEIMER S DISEASE As you can imagine, Alzheimer s disease is very expensive The cost of medical care for its victims is only ... teenagers The second factor to consider is human memory Memory loss—one of the most obvious and distressing symptoms of Alzheimer s disease is much more serious than forgetting the answers on a history ... dementia caused by medical conditions such as head injuries, diseases caused by the human immunodeficiency virus (HIV), Parkinson s disease, and Huntington s disease; and substance-induced persisting...

Ngày tải lên: 05/03/2014, 23:20

... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... accurately diagnose dementia as early as possible This chapter outlines the basic elements of a clinical diagnostic evaluation for Alzheimer s disease (AD) and other dementias; and also addresses how to ... deficits are prominent and become more severe and global as AD progresses Behavioral and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses...

Ngày tải lên: 05/03/2014, 23:20

... neurons Reports of movement disorders secondary to extrastriatal pathology should therefore come as no surprise 3.1 Parkinson s Disease Early idiopathic Parkinson s disease (PD) is a well-circumscribed ... and/ or striosomes have been less successful and failed to establish simple relations between striatal compartments and different subdivisions of the SNc in nonhuman primates (52,53,56) Ultrastructural ... interpretations of the different movement disorders, because of the existence of movement disorders such as Huntington s disease (HD) or dystonia, which seem to cross the boundary between these diseases...

Ngày tải lên: 05/03/2014, 23:20

... Butyrylcholinesterase is also present in neurofibrillary tangles In Alzheimer s disease the expression of butyrylcholinesterase increases substantially in Alzheimer s disease patient s brain [47] ... Mesulam MM (1993) Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer s disease Ann NY Acad Sci 695, 65–68 Nakamura S, Kawashima ... processes in Alzheimer s disease: role of Ab–AChE complexes and Wnt signaling In Cholinergic Mechanism Function and Dysfunction (Silman I, Soreq H, Anglister L, Michaelson D & Fisher A, eds),...

Ngày tải lên: 23/03/2014, 07:20

... University Scale for Psychopathology in Alzheimer s Disease, is brief and effective in assessing psychotic symptoms, but is not appropriate for assessing changes in severity of symptoms (Devanand, ... Americans now have Alzheimer s Disease (Alzheimer s Association, 2008), an increase of 25% since the previous version of this Guideline was published Alzheimer s Disease destroys brain cells, causing ... presentation or history of depression is atypical or complex (Lyketsos & Lee) Since administering assessment tests for depression to Alzheimer s Disease patients is often challenging (Warshaw,...

Ngày tải lên: 23/03/2014, 23:21

... diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association ... diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association ... individuals; IA = neuropathologic diagnosis is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and...

Ngày tải lên: 28/03/2014, 22:21

... by Aβ was at least partially responsible for AD-associated degeneration, others had pointed to microglial phagocytosis as a desirable consequence of activation For the purposes of discussion, the ... expression of neurotrophic factors under many of the same conditions in which they show inflammationrelated responses such as phagocytosis, retraction of processes, release of excitotoxins, and ... Humphrey J, Quadros A, Patel N, Crescentini R, Crawford F, Mullan M: Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer' s disease: role of inflammation...

Ngày tải lên: 19/06/2014, 22:20

... postmortem interval (hours) for AD cases was 2.59 ± 0.45 and for ND cases was 2.63 ± 0.62 (mean ± SD) Stimulation of sPLA2-IIA mRNA expression in astrocytes from human post-mortem brains Astrocytes ... was used for determination of levels of sPLA2-IIA mRNA in brain tissues Taqman primers and probes specific for human sPLA2-IIA and ribosomal 1 8S RNA were obtained from Applied Biosystems (Foster ... plates Each analysis contained a series of diluted samples for standard curve purposes, as well as negative template and negative reverse transcriptase control samples The real time PCR was carried...

Ngày tải lên: 19/06/2014, 22:20

... each sample was used for first-strand cDNA synthesis using the Invitrogen SuperScript III reverse transcription system cDNA was amplified using quantitative real-time PCR with Assays-onDemand ... AM: Alzheimer s disease: the challenge of the second century Sci Transl Med 2011, 3:77sr1 De Strooper B: Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process ... Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer s disease Brain Res 2001,...

Ngày tải lên: 19/06/2014, 22:20

... BCA is a sensitive analytical method for detection of AD and other diseases It can also be used as a diseasemonitoring device and for the analysis of disease markers [39,100] Moreover, BCA system ... to isolate cell samples from blood and other sources [122] As we discussed in Section 1, obtaining sample from the CSF is very Figure Sample preparation using microfluidic system: Cell lysis and ... helpful for genetic level analysis and early stage analysis of diseases This single chip will be useful for multiple analyses of DNA hybridization, protein analysis, and other quantitative-based...

Ngày tải lên: 10/08/2014, 05:21

... of synthetic peptides, a bacterial expression system allows isotope labeling, which is essential for high-resolution structural analysis of Ab using NMR spectroscopy and allows use of high specific ... gels (A,C) and 1% agarose gels (B,D), and proteins were visualized by Coomassie stain Lanes HS and LS are molecular mass standards, with the molecular mass in kDa given on the left (E) 1% agarose ... Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems Procise 492 cLC sequenator (Applied Biosystems, Framingham, MA, USA) employing standard...

Ngày tải lên: 18/02/2014, 13:20

... mechanism for Alzheimer s Disease and Down syndrome Proc Natl Acad Sci USA 2010, 107:6538-6543 40 Brites P, Waterham HR, Wanders RJA: Functions and biosynthesis of plasmalo­ ens in health and disease ... Acad Sci USA 2002, 99:6364-6369 13 Mudher A, Lovestone S: Alzheimer s disease- do tauists and baptists finally shake hands? Trends Neurosci 2002, 25:22-26 14 Mattsson N, Zetterberg H, Hansson O, Andreasen ... for this disease A similar strategy could also be useful in the studies involving transgenic mouse models of AD [56] Conclusions The pathogenesis of AD is complex and there is a strong case for...

Ngày tải lên: 11/08/2014, 12:21

... Information from the neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based ... of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of the ... M.-X, Cross P, Andrews H, Jacobs DM, Small S, Bell K, Merchant C, Lantigua R, Costa R, Stern Y, Mayeux R In Press Incidence Rates for Alzheimer s Disease Among Black, Caribbean Hispanic and White...

Ngày tải lên: 05/03/2014, 21:20

... PARKINSON 'S DISEASE AND MOVEMENT DISORDERS: DIAGNOSIS AND TREATMENT GUIDELINES FOR THE PRACTICING PHYSICIAN CURRENT CLINICAL PRACTICE Parkinson s Disease and Movement Disorders: Diagnosis and Treatment ... includes discussion of the roles of oxidative stress, mitochondrial dysfunction, and neurotoxins and addresses etiologic mechanisms that have received less publicity, such as possible autoimmune and ... paresis, however, has sinister implications; it is typical of certain multisystem cerebral disorders, such as progressive supranuclear palsy, variants of Niemann-Pick disease, and, sometimes,...

Ngày tải lên: 05/03/2014, 23:20

... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... enzymes because activity of the enzymes is dependent on optimal metal loading Cu deficiency is central to the recessive Menkes and Wilson diseases, and has been implicated in AD Just as excess Cu ... pathology in Alzheimer disease and other tauopathies Biochim Biophys Acta 1739, 198–210 Barnham KJ, Masters CL & Bush AI (2004) Neurodegenerative diseases and oxidative stress Nat Rev Drug Discov 3,...

Ngày tải lên: 07/03/2014, 10:20

... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected with both constructs ... Francisco, CA, USA) Results Assay design This novel c-secretase assay involves cotransfection of a substrate-activator and a reporter gene into mammalian cells, as outlined in Fig 1A The substrate-activator...

Ngày tải lên: 08/03/2014, 08:20